DE69534041D1 - Verfahren zur herstellung von beta lactam antibiotika durch mikroorganismen mit erhoehter ligaseaktivitaet - Google Patents
Verfahren zur herstellung von beta lactam antibiotika durch mikroorganismen mit erhoehter ligaseaktivitaetInfo
- Publication number
- DE69534041D1 DE69534041D1 DE69534041T DE69534041T DE69534041D1 DE 69534041 D1 DE69534041 D1 DE 69534041D1 DE 69534041 T DE69534041 T DE 69534041T DE 69534041 T DE69534041 T DE 69534041T DE 69534041 D1 DE69534041 D1 DE 69534041D1
- Authority
- DE
- Germany
- Prior art keywords
- lactam antibiotics
- microorganisms
- preparation
- beta
- ligase activity
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000003782 beta lactam antibiotic agent Substances 0.000 title abstract 3
- 239000002132 β-lactam antibiotic Substances 0.000 title abstract 3
- 229940124586 β-lactam antibiotics Drugs 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 102000003960 Ligases Human genes 0.000 title 1
- 108090000364 Ligases Proteins 0.000 title 1
- 244000005700 microbiome Species 0.000 title 1
- 102000004190 Enzymes Human genes 0.000 abstract 2
- 108090000790 Enzymes Proteins 0.000 abstract 2
- 230000015572 biosynthetic process Effects 0.000 abstract 2
- 238000000338 in vitro Methods 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 230000009466 transformation Effects 0.000 abstract 1
- 150000003952 β-lactams Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/93—Ligases (6)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
- C12P35/04—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin by acylation of the substituent in the 7 position
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P37/00—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin
- C12P37/04—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin by acylation of the substituent in the 6 position
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Mycology (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK111794 | 1994-09-28 | ||
| DK111794 | 1994-09-28 | ||
| PCT/EP1995/003857 WO1996010085A1 (en) | 1994-09-28 | 1995-09-27 | PROCESS OF PRODUCING β-LACTAM ANTIBIOTICS APPLYING MICROORGANISMS WITH INCREASED LIGASE ACTIVITY |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69534041D1 true DE69534041D1 (de) | 2005-04-07 |
| DE69534041T2 DE69534041T2 (de) | 2006-04-13 |
Family
ID=8101208
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69534041T Expired - Lifetime DE69534041T2 (de) | 1994-09-28 | 1995-09-27 | Verfahren zur herstellung von beta lactam antibiotika durch mikroorganismen mit erhoehter ligaseaktivitaet |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US5942411A (de) |
| EP (1) | EP0783582B1 (de) |
| JP (1) | JPH10506287A (de) |
| KR (1) | KR970706393A (de) |
| CN (1) | CN1271208C (de) |
| AT (1) | ATE290084T1 (de) |
| AU (1) | AU701665B2 (de) |
| CA (1) | CA2201485A1 (de) |
| DE (1) | DE69534041T2 (de) |
| ES (1) | ES2236714T3 (de) |
| HU (1) | HUT77042A (de) |
| MX (1) | MX9702270A (de) |
| WO (1) | WO1996010085A1 (de) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUT77042A (hu) * | 1994-09-28 | 1998-03-02 | Gist-Brocades B.V. | Eljárás béta-laktám antibiotikumok előállítására fokozott ligázaktivitású mikroorganizmusokkal |
| GB9513403D0 (en) * | 1995-06-30 | 1995-09-06 | Smithkline Beecham Plc | Novel product |
| AU2508897A (en) * | 1996-04-04 | 1997-10-29 | Gist-Brocades B.V. | An enzyme with high adipoyl-coenzyme a synthetase activity and uses thereof |
| EP0914463A2 (de) * | 1996-07-16 | 1999-05-12 | Gist-Brocades B.V. | Verfahren zur herstellung von cephalosporinen durch anwendung von acremonium chrysogenum |
| US6133227A (en) * | 1997-06-23 | 2000-10-17 | The Procter & Gamble Company | Enzymatic detergent compositions |
| US6284483B1 (en) * | 1999-10-06 | 2001-09-04 | Board Of Trustees Operating Michigan State University | Modified synthetases to produce penicillins and cephalosporins under the control of bicarbonate |
| WO2003065706A2 (en) * | 2002-01-30 | 2003-08-07 | Roher Larry E | Multipoint audiovisual conferencing system |
| NZ536963A (en) * | 2002-06-07 | 2008-04-30 | Trillium Therapeutics Inc | Use of the discovery that Fc gamma receptor IIA transgenic animals are susceptible to autoimmune disease, to suppress aberrant immune activity and to treat or prevent autoimmune disease |
| CN115337308B (zh) * | 2022-07-15 | 2024-03-22 | 山东省农业科学院家禽研究所（山东省无特定病原鸡研究中心） | Acss2抑制剂在制备抗h1n1亚型猪流感病毒药物中的应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2016476A6 (es) * | 1989-07-10 | 1990-11-01 | Antibioticos Sa | Procedimientos para sintetizar fenilacetil-coa y para producir bencilpenicilina. |
| WO1992007079A1 (en) * | 1990-10-15 | 1992-04-30 | Gist-Brocades N.V. | Transformation selection marker system adapted for penicillium |
| ES2033590A6 (es) * | 1991-04-19 | 1993-03-16 | Antibioticos Sa | Procedimientos para sintetizar fenilacetil-coa y para producir bencilpenicilina |
| HUT77042A (hu) * | 1994-09-28 | 1998-03-02 | Gist-Brocades B.V. | Eljárás béta-laktám antibiotikumok előállítására fokozott ligázaktivitású mikroorganizmusokkal |
| GB9513403D0 (en) * | 1995-06-30 | 1995-09-06 | Smithkline Beecham Plc | Novel product |
-
1995
- 1995-09-27 HU HU9701925A patent/HUT77042A/hu unknown
- 1995-09-27 AT AT95935410T patent/ATE290084T1/de not_active IP Right Cessation
- 1995-09-27 KR KR1019970702038A patent/KR970706393A/ko not_active Application Discontinuation
- 1995-09-27 JP JP8511394A patent/JPH10506287A/ja active Pending
- 1995-09-27 EP EP95935410A patent/EP0783582B1/de not_active Expired - Lifetime
- 1995-09-27 AU AU37440/95A patent/AU701665B2/en not_active Ceased
- 1995-09-27 ES ES95935410T patent/ES2236714T3/es not_active Expired - Lifetime
- 1995-09-27 WO PCT/EP1995/003857 patent/WO1996010085A1/en active IP Right Grant
- 1995-09-27 CA CA002201485A patent/CA2201485A1/en not_active Abandoned
- 1995-09-27 CN CNB951960016A patent/CN1271208C/zh not_active Expired - Fee Related
- 1995-09-27 MX MX9702270A patent/MX9702270A/es not_active IP Right Cessation
- 1995-09-27 US US08/817,010 patent/US5942411A/en not_active Expired - Fee Related
- 1995-09-27 DE DE69534041T patent/DE69534041T2/de not_active Expired - Lifetime
-
1999
- 1999-06-15 US US09/333,645 patent/US6180360B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JPH10506287A (ja) | 1998-06-23 |
| MX9702270A (es) | 1997-07-31 |
| ES2236714T3 (es) | 2005-07-16 |
| WO1996010085A1 (en) | 1996-04-04 |
| CN1271208C (zh) | 2006-08-23 |
| AU3744095A (en) | 1996-04-19 |
| KR970706393A (ko) | 1997-11-03 |
| HUT77042A (hu) | 1998-03-02 |
| US5942411A (en) | 1999-08-24 |
| DE69534041T2 (de) | 2006-04-13 |
| CA2201485A1 (en) | 1996-04-04 |
| US6180360B1 (en) | 2001-01-30 |
| EP0783582A1 (de) | 1997-07-16 |
| CN1162337A (zh) | 1997-10-15 |
| EP0783582B1 (de) | 2005-03-02 |
| AU701665B2 (en) | 1999-02-04 |
| ATE290084T1 (de) | 2005-03-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |