DE69533693D1 - Impfstoffe, die paucilamelläre Lipidvesikel als Adjuvans enthalten - Google Patents
Impfstoffe, die paucilamelläre Lipidvesikel als Adjuvans enthaltenInfo
- Publication number
- DE69533693D1 DE69533693D1 DE69533693T DE69533693T DE69533693D1 DE 69533693 D1 DE69533693 D1 DE 69533693D1 DE 69533693 T DE69533693 T DE 69533693T DE 69533693 T DE69533693 T DE 69533693T DE 69533693 D1 DE69533693 D1 DE 69533693D1
- Authority
- DE
- Germany
- Prior art keywords
- adjuvant
- lipid vesicles
- vaccines containing
- paucilamellar lipid
- containing paucilamellar
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/145—Orthomyxoviridae, e.g. influenza virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5252—Virus inactivated (killed)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/70—Multivalent vaccine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16211—Influenzavirus B, i.e. influenza B virus
- C12N2760/16234—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Nanotechnology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pulmonology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Organic Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Medical Informatics (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US20134694A | 1994-02-24 | 1994-02-24 | |
US201346 | 1994-02-24 | ||
PCT/US1995/000475 WO1995022989A1 (en) | 1994-02-24 | 1995-01-11 | Vaccines containing paucilamellar lipid vesicles as immunological adjuvants |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69533693D1 true DE69533693D1 (de) | 2004-12-02 |
DE69533693T2 DE69533693T2 (de) | 2005-12-22 |
Family
ID=22745474
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69533693T Expired - Lifetime DE69533693T2 (de) | 1994-02-24 | 1995-01-11 | Impfstoffe, die paucilamelläre Lipidvesikel als Adjuvans enthalten |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP0746338B1 (de) |
JP (1) | JP3836874B2 (de) |
AT (1) | ATE280585T1 (de) |
AU (1) | AU1566095A (de) |
BR (1) | BR9506885A (de) |
CA (1) | CA2183435C (de) |
DE (1) | DE69533693T2 (de) |
WO (1) | WO1995022989A1 (de) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE9602280D0 (sv) * | 1996-06-10 | 1996-06-10 | Pharmatrix Ab | Immunstimulerande lipidformulering |
NZ508013A (en) * | 1998-05-07 | 2003-08-29 | Corixa Corp | Adjuvant composition for use with an antigen in a vaccine composition |
GB9923176D0 (en) * | 1999-09-30 | 1999-12-01 | Smithkline Beecham Biolog | Novel composition |
EP1467771B1 (de) * | 2001-11-14 | 2008-04-16 | Novavax, Inc. | Mycobakterieller impfstoff |
US8080255B2 (en) | 2003-07-11 | 2011-12-20 | Novavax Inc. | Functional influenza virus like particles (VLPs) |
US8992939B2 (en) | 2003-07-11 | 2015-03-31 | Novavax, Inc. | Highly efficient influenza matrix (M1) proteins |
US8592197B2 (en) | 2003-07-11 | 2013-11-26 | Novavax, Inc. | Functional influenza virus-like particles (VLPs) |
US8506967B2 (en) | 2003-07-11 | 2013-08-13 | Novavax, Inc. | Functional influenza virus like particles (VLPs) |
SG153871A1 (en) * | 2004-06-25 | 2009-07-29 | Id Biomedical Corp Quebec | Compositions and methods for treating neurological disorders |
EP2669002A1 (de) * | 2005-01-28 | 2013-12-04 | Japan Science and Technology Agency | Molekulares, für Phasenübergang durch Dehydrierungskondensation fähiges Aggregat und Verfahren zum Phasenübergang davon |
PT1861120T (pt) | 2005-03-23 | 2016-08-18 | Glaxosmithkline Biologicals Sa | Utilização de um vírus influenza e de um adjuvante de emulsão óleo-em-água para induzir células t cd4 e/ou melhorar a resposta de células b de memória |
DE602006020738D1 (de) * | 2005-08-01 | 2011-04-28 | Hisamitsu Pharmaceutical Co | Adjuvans oder pharmazeutische zubereitung zur transdermalen oder transmukosalen verabreichung |
MX2009000660A (es) | 2006-07-17 | 2009-04-08 | Glaxosmithkline Biolog Sa | Vacuna de influenza. |
FR2906141B1 (fr) * | 2006-09-26 | 2010-12-10 | St Hubert | Structure uni-ou multivesciculaire enfermant une phase hydrophobe. |
US20100047327A1 (en) * | 2007-01-31 | 2010-02-25 | Tetsuji Kuwahara | Adjuvant for Transdermal or Transmucosal Administration and Pharmaceutical Preparation Containing the Same |
PE20090146A1 (es) | 2007-04-20 | 2009-03-23 | Glaxosmithkline Biolog Sa | Composicion inmunogenica contra el virus influenza |
CN101827613A (zh) | 2007-09-27 | 2010-09-08 | 免疫疫苗技术有限公司 | 在包括连续疏水相的载体中的脂质体在体内输送多核苷酸中的应用 |
EP2296696B1 (de) | 2008-06-05 | 2014-08-27 | ImmunoVaccine Technologies Inc. | Zusammensetzungen mit liposomen, einem antigen, einem polynucleotid und einem träger mit einer kontinuierlichen phase einer hydrophoben substanz |
AU2012321022B2 (en) | 2011-10-06 | 2017-03-23 | Immunovaccine Technologies Inc. | Liposome compositions comprising an adjuvant that activates or increases the activity of TLR2 and uses thereof |
JP2014040396A (ja) * | 2012-08-23 | 2014-03-06 | Chemo-Sero-Therapeutic Research Institute | 脂質異常症治療薬を含有するアジュバント組成物 |
JP6114401B2 (ja) | 2013-10-31 | 2017-04-12 | 久光製薬株式会社 | アジュバント組成物、これを含むアジュバント製剤、及びキット |
GR1008481B (el) * | 2013-12-05 | 2015-05-12 | Συμβουλοι Αναπτυξης Πωλησεων Επε, | Μεθοδος εγκλωβισμου φυτικων ελαιων και ιδιαιτερα ελαιολαδου με τη χρηση εξειδικευμενων βρωσιμων λιποσωματων, χωρις φωσφολιπιδια, για εφαρμογες στον τομεα τροφιμων και ειδικοτερα προϊοντων αλλαντοποιιας, γαλακτοκομικων και ιχθυοσκευασματων |
WO2023022384A1 (ko) * | 2021-08-17 | 2023-02-23 | 한국과학기술원 | 면역 유도용 다층 소포체, 이를 포함하는 면역 유도용 약학 조성물 및 면역 유도용 다층 소포체의 제조방법 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4241046A (en) * | 1978-11-30 | 1980-12-23 | Papahadjopoulos Demetrios P | Method of encapsulating biologically active materials in lipid vesicles |
JPH0688911B2 (ja) * | 1985-06-06 | 1994-11-09 | 国立予防衛生研究所長 | インフルエンザワクチン及びその製造方法 |
US5147723A (en) * | 1987-07-28 | 1992-09-15 | Micro-Pak, Inc. | Paucilamellar lipid vesicles |
US4911928A (en) * | 1987-03-13 | 1990-03-27 | Micro-Pak, Inc. | Paucilamellar lipid vesicles |
US5000960A (en) * | 1987-03-13 | 1991-03-19 | Micro-Pak, Inc. | Protein coupling to lipid vesicles |
US5234767A (en) * | 1987-03-13 | 1993-08-10 | Micro-Pak, Inc. | Hybrid paucilamellar lipid vesicles |
US5032457A (en) * | 1988-03-03 | 1991-07-16 | Micro Vesicular Systems, Inc. | Paucilamellar lipid vesicles using charge-localized, single chain, nonphospholipid surfactants |
AU631377B2 (en) * | 1988-08-25 | 1992-11-26 | Liposome Company, Inc., The | Affinity associated vaccine |
NZ230424A (en) * | 1988-08-25 | 1992-05-26 | Liposome Co Inc | Liposomal composition comprising an externally disposed antigen |
US5100662A (en) * | 1989-08-23 | 1992-03-31 | The Liposome Company, Inc. | Steroidal liposomes exhibiting enhanced stability |
CA2153780C (en) * | 1993-01-15 | 2004-04-13 | Micro Vesicular Systems, Inc. | Method of inhibiting viral reproduction |
-
1995
- 1995-01-11 DE DE69533693T patent/DE69533693T2/de not_active Expired - Lifetime
- 1995-01-11 JP JP52233695A patent/JP3836874B2/ja not_active Expired - Fee Related
- 1995-01-11 AT AT95907423T patent/ATE280585T1/de not_active IP Right Cessation
- 1995-01-11 BR BR9506885A patent/BR9506885A/pt not_active Application Discontinuation
- 1995-01-11 WO PCT/US1995/000475 patent/WO1995022989A1/en active IP Right Grant
- 1995-01-11 CA CA002183435A patent/CA2183435C/en not_active Expired - Fee Related
- 1995-01-11 AU AU15660/95A patent/AU1566095A/en not_active Abandoned
- 1995-01-11 EP EP95907423A patent/EP0746338B1/de not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
AU1566095A (en) | 1995-09-11 |
CA2183435C (en) | 2008-05-13 |
JPH10500662A (ja) | 1998-01-20 |
EP0746338A1 (de) | 1996-12-11 |
DE69533693T2 (de) | 2005-12-22 |
CA2183435A1 (en) | 1995-08-31 |
EP0746338A4 (de) | 2001-08-22 |
EP0746338B1 (de) | 2004-10-27 |
BR9506885A (pt) | 1997-08-19 |
WO1995022989A1 (en) | 1995-08-31 |
JP3836874B2 (ja) | 2006-10-25 |
ATE280585T1 (de) | 2004-11-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8327 | Change in the person/name/address of the patent owner |
Owner name: NOVAVAX INC.(N.D.GES.D.STAATES DELAWARE), COLUMBIA |
|
8364 | No opposition during term of opposition |