DE69525686D1 - Verfahren zur Reinigung von 23-E Isomeren von 23-Imino LL-F28249 Derivate - Google Patents

Verfahren zur Reinigung von 23-E Isomeren von 23-Imino LL-F28249 Derivate

Info

Publication number
DE69525686D1
DE69525686D1 DE69525686T DE69525686T DE69525686D1 DE 69525686 D1 DE69525686 D1 DE 69525686D1 DE 69525686 T DE69525686 T DE 69525686T DE 69525686 T DE69525686 T DE 69525686T DE 69525686 D1 DE69525686 D1 DE 69525686D1
Authority
DE
Germany
Prior art keywords
purification
imino
isomers
derivatives
isomer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69525686T
Other languages
English (en)
Other versions
DE69525686T2 (de
Inventor
Kenneth Alfred Martin Kremer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth Holdings LLC
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Application granted granted Critical
Publication of DE69525686D1 publication Critical patent/DE69525686D1/de
Publication of DE69525686T2 publication Critical patent/DE69525686T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE69525686T 1994-06-22 1995-06-19 Verfahren zur Reinigung von 23-E Isomeren von 23-Imino LL-F28249 Derivate Expired - Lifetime DE69525686T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/263,967 US5478951A (en) 1994-06-22 1994-06-22 Method for the purification of 23-E isomers of 23-imino derivatives of LL-F28249 compounds

Publications (2)

Publication Number Publication Date
DE69525686D1 true DE69525686D1 (de) 2002-04-11
DE69525686T2 DE69525686T2 (de) 2002-09-12

Family

ID=23004003

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69525686T Expired - Lifetime DE69525686T2 (de) 1994-06-22 1995-06-19 Verfahren zur Reinigung von 23-E Isomeren von 23-Imino LL-F28249 Derivate

Country Status (20)

Country Link
US (1) US5478951A (de)
EP (1) EP0688775B1 (de)
JP (1) JP3817756B2 (de)
KR (1) KR100367947B1 (de)
CN (1) CN1063445C (de)
AT (1) ATE214071T1 (de)
AU (1) AU681785C (de)
BR (1) BR9502869A (de)
CA (1) CA2152249A1 (de)
CZ (1) CZ288894B6 (de)
DE (1) DE69525686T2 (de)
DK (1) DK0688775T3 (de)
ES (1) ES2172554T3 (de)
HU (1) HU216278B (de)
IL (1) IL114246A (de)
PT (1) PT688775E (de)
SI (1) SI0688775T1 (de)
SK (1) SK283198B6 (de)
TW (1) TW319770B (de)
ZA (1) ZA955106B (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7348417B2 (en) * 2003-08-07 2008-03-25 Wyeth Method of purifying moxidectin through crystallization
CN104277050B (zh) * 2013-07-04 2016-05-04 北大方正集团有限公司 一种制备莫西克汀的方法
CN103601735B (zh) * 2013-11-08 2015-12-09 大连九信生物化工科技有限公司 一种提纯莫西克汀的方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4916154A (en) * 1986-09-12 1990-04-10 American Cyanamid Company 23-Imino derivatives of LL-F28249 compounds
GB8721377D0 (en) * 1987-09-11 1987-10-21 Glaxo Group Ltd Chemical compounds
NZ233680A (en) * 1989-05-17 1995-02-24 Beecham Group Plc Avermectins and milbemycins and compositions thereof
US4988824A (en) * 1989-09-11 1991-01-29 Maulding Donald R Process for the preparation of 23-(C1-C6 alkyloxime)-LL-F28249 compounds

Also Published As

Publication number Publication date
SK283198B6 (sk) 2003-03-04
DE69525686T2 (de) 2002-09-12
JPH0853456A (ja) 1996-02-27
KR100367947B1 (ko) 2003-03-26
ES2172554T3 (es) 2002-10-01
ATE214071T1 (de) 2002-03-15
EP0688775B1 (de) 2002-03-06
SI0688775T1 (en) 2002-06-30
PT688775E (pt) 2002-07-31
KR960000890A (ko) 1996-01-25
HUT72831A (en) 1996-05-28
CN1063445C (zh) 2001-03-21
AU681785B2 (en) 1997-09-04
CZ288894B6 (cs) 2001-09-12
DK0688775T3 (da) 2002-06-03
CN1117969A (zh) 1996-03-06
IL114246A (en) 1998-10-30
CA2152249A1 (en) 1995-12-23
BR9502869A (pt) 1996-11-05
JP3817756B2 (ja) 2006-09-06
US5478951A (en) 1995-12-26
HU216278B (hu) 1999-05-28
TW319770B (de) 1997-11-11
AU681785C (en) 2007-11-01
IL114246A0 (en) 1995-10-31
AU2176695A (en) 1996-01-04
HU9501834D0 (en) 1995-08-28
SK82495A3 (en) 1996-01-10
ZA955106B (en) 1996-12-20
EP0688775A1 (de) 1995-12-27
CZ153895A3 (en) 1996-01-17

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: WYETH HOLDINGS CORP., MADISON, N.J., US