DE69524093D1 - Kombination von prokoagulans und cytokin oder induktor seiner produktion für die behandlung von tumoren - Google Patents

Kombination von prokoagulans und cytokin oder induktor seiner produktion für die behandlung von tumoren

Info

Publication number
DE69524093D1
DE69524093D1 DE69524093T DE69524093T DE69524093D1 DE 69524093 D1 DE69524093 D1 DE 69524093D1 DE 69524093 T DE69524093 T DE 69524093T DE 69524093 T DE69524093 T DE 69524093T DE 69524093 D1 DE69524093 D1 DE 69524093D1
Authority
DE
Germany
Prior art keywords
prokoagulans
cytokin
tumors
inductor
treatment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69524093T
Other languages
English (en)
Other versions
DE69524093T2 (de
Inventor
A Vehar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genentech Inc
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Application granted granted Critical
Publication of DE69524093D1 publication Critical patent/DE69524093D1/de
Publication of DE69524093T2 publication Critical patent/DE69524093T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06—Tripeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4833—Thrombin (3.4.21.5)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Organic Chemistry (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Endocrinology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
DE69524093T 1994-06-16 1995-06-08 Kombination von prokoagulans und cytokin oder induktor seiner produktion für die behandlung von tumoren Expired - Lifetime DE69524093T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26085094A 1994-06-16 1994-06-16
PCT/US1995/007305 WO1995034319A1 (en) 1994-06-16 1995-06-08 Compositions and methods for the treatment of tumors

Publications (2)

Publication Number Publication Date
DE69524093D1 true DE69524093D1 (de) 2002-01-03
DE69524093T2 DE69524093T2 (de) 2002-07-11

Family

ID=22990887

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69524093T Expired - Lifetime DE69524093T2 (de) 1994-06-16 1995-06-08 Kombination von prokoagulans und cytokin oder induktor seiner produktion für die behandlung von tumoren

Country Status (11)

Country Link
US (2) US5830448A (de)
EP (1) EP0765168B1 (de)
JP (1) JPH10501813A (de)
KR (1) KR970703783A (de)
AU (1) AU696003B2 (de)
CA (1) CA2191065A1 (de)
DE (1) DE69524093T2 (de)
FI (1) FI119677B (de)
IL (1) IL114119A (de)
WO (1) WO1995034319A1 (de)
ZA (1) ZA954984B (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5965132A (en) 1992-03-05 1999-10-12 Board Of Regents, The University Of Texas System Methods and compositions for targeting the vasculature of solid tumors
US6749853B1 (en) * 1992-03-05 2004-06-15 Board Of Regents, The University Of Texas System Combined methods and compositions for coagulation and tumor treatment
US6156321A (en) 1997-01-22 2000-12-05 Board Of Regents, The University Of Texas System Tissue factor methods and compositions for coagulation and tumor treatment
US6719977B1 (en) 1998-02-12 2004-04-13 The General Hospital Corporation Methods to potentiate cancer therapies
WO1999040929A1 (en) * 1998-02-12 1999-08-19 The General Hospital Corporation Methods to potentiate cancer therapies
ATE355029T1 (de) * 1998-04-01 2006-03-15 Univ Columbia Verfahren zur thrombosehemmung bei patienten deren blut extrakorporaler zirkulation ausgesetzt ist
AU771224B2 (en) 1998-07-13 2004-03-18 Board Of Regents, The University Of Texas System Cancer treatment methods using antibodies to aminophospholipids
IL140700A0 (en) * 1998-07-13 2002-02-10 Univ Texas Cancer treatment methods using therapeutic conjugates that bind to aminophospholipids
US6818213B1 (en) * 1998-07-13 2004-11-16 Board Of Regents, The University Of Texas System Cancer treatment compositions comprising therapeutic conjugates that bind to aminophospholipids
US6406693B1 (en) 1998-07-13 2002-06-18 Board Of Regents, The University Of Texas System Cancer treatment methods using antibodies to aminophospholipids
US20030211075A1 (en) * 2001-09-27 2003-11-13 Thorpe Philip E. Combined compositions for tumor vasculature coagulation and treatment
WO2003030613A2 (en) * 2001-10-05 2003-04-17 Intermune, Inc. Methods of treating liver fibrosis and hepatitis c virus infection
EP1819731A4 (de) * 2004-12-08 2013-02-13 Immunomedics Inc Verfahren und zusammensetzung zur immuntherapie und für den nachweis von entzündungs- und dysregulatorischen immunerkrankungen, infektionserkrankungen, pathologischer angiogenese und krebs
WO2012160031A1 (en) 2011-05-24 2012-11-29 Institut National De La Sante Et De La Recherche Medicale (Inserm) Method for prognosing solid tumor outcome
US10575774B2 (en) 2017-02-27 2020-03-03 Case Western Reserve University Predicting immunotherapy response in non-small cell lung cancer with serial radiomics

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4506009A (en) * 1982-03-30 1985-03-19 University Of California Heterogeneous immunoassay method
WO1990000400A1 (en) * 1988-07-15 1990-01-25 The Trustees Of Columbia University In The City Of New York Tumor necrosis enhancing factor and methods of preparation and use
US5147638A (en) * 1988-12-30 1992-09-15 Oklahoma Medical Research Foundation Inhibition of tumor growth by blockade of the protein C system
JPH04505554A (ja) * 1989-02-17 1992-10-01 コドン 可溶性トロンボモジュリン類似体
US5196404B1 (en) * 1989-08-18 1996-09-10 Biogen Inc Inhibitors of thrombin
CA2131528C (en) * 1992-03-05 2004-07-13 Philip E. Thorpe Methods and compositions for targeting the vasculature of solid tumors
FR2695562B1 (fr) * 1992-09-11 1994-10-14 Synthelabo Utilisation d'un inhibiteur direct de la thrombine pour la fabrication d'un médicament à activité thrombolytique.

Also Published As

Publication number Publication date
CA2191065A1 (en) 1995-12-21
DE69524093T2 (de) 2002-07-11
FI965008A (fi) 1996-12-13
EP0765168A1 (de) 1997-04-02
EP0765168B1 (de) 2001-11-21
US5762921A (en) 1998-06-09
FI119677B (fi) 2009-02-13
AU2821295A (en) 1996-01-05
FI965008A0 (fi) 1996-12-13
AU696003B2 (en) 1998-08-27
IL114119A (en) 2000-09-28
KR970703783A (ko) 1997-08-09
IL114119A0 (en) 1995-10-31
ZA954984B (en) 1996-12-17
WO1995034319A1 (en) 1995-12-21
JPH10501813A (ja) 1998-02-17
US5830448A (en) 1998-11-03

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