DE69523586D1 - Verfahren zum screening für die erkrankung crohn durch die verwendung von tnf-mikrosatelliten allelen - Google Patents

Verfahren zum screening für die erkrankung crohn durch die verwendung von tnf-mikrosatelliten allelen

Info

Publication number
DE69523586D1
DE69523586D1 DE69523586T DE69523586T DE69523586D1 DE 69523586 D1 DE69523586 D1 DE 69523586D1 DE 69523586 T DE69523586 T DE 69523586T DE 69523586 T DE69523586 T DE 69523586T DE 69523586 D1 DE69523586 D1 DE 69523586D1
Authority
DE
Germany
Prior art keywords
crohn
disease
allels
tnf microsatellite
screening method
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69523586T
Other languages
English (en)
Other versions
DE69523586T2 (de
Inventor
E Plevy
I Rotter
R Targan
Hiroo Toyoda
Huiying Yang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cedars Sinai Medical Center
Original Assignee
Cedars Sinai Medical Center
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cedars Sinai Medical Center filed Critical Cedars Sinai Medical Center
Application granted granted Critical
Publication of DE69523586D1 publication Critical patent/DE69523586D1/de
Publication of DE69523586T2 publication Critical patent/DE69523586T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/6858—Allele-specific amplification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/172—Haplotypes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
DE69523586T 1994-05-17 1995-05-17 Verfahren zum screening für die erkrankung crohn durch die verwendung von tnf-mikrosatelliten allelen Expired - Fee Related DE69523586T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24529794A 1994-05-17 1994-05-17
PCT/US1995/006107 WO1995031575A1 (en) 1994-05-17 1995-05-17 Methods of screening for crohn's disease using tnf microsatellite alleles

Publications (2)

Publication Number Publication Date
DE69523586D1 true DE69523586D1 (de) 2001-12-06
DE69523586T2 DE69523586T2 (de) 2002-07-18

Family

ID=22926104

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69523586T Expired - Fee Related DE69523586T2 (de) 1994-05-17 1995-05-17 Verfahren zum screening für die erkrankung crohn durch die verwendung von tnf-mikrosatelliten allelen

Country Status (9)

Country Link
US (2) US6001569A (de)
EP (1) EP0760010B1 (de)
AT (1) ATE207967T1 (de)
AU (1) AU698604B2 (de)
CA (1) CA2190586A1 (de)
DE (1) DE69523586T2 (de)
DK (1) DK0760010T3 (de)
ES (1) ES2166822T3 (de)
WO (1) WO1995031575A1 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6300060B1 (en) 1995-11-09 2001-10-09 Dana-Farber Cancer Institute, Inc. Method for predicting the risk of prostate cancer morbidity and mortality
WO1997039147A1 (en) * 1996-04-12 1997-10-23 Cedars-Sinai Medical Center Methods of identifying and diagnosing inflammatory bowel disease
WO1997039146A1 (en) * 1996-04-12 1997-10-23 Cedars-Sinai Medical Center Methods of identifying and diagnosing inflammatory bowel disease
US6183951B1 (en) 1997-04-11 2001-02-06 Prometheus Laboratories, Inc. Methods of diagnosing clinical subtypes of crohn's disease with characteristic responsiveness to anti-Th1 cytokine therapy
US5968741A (en) * 1997-04-11 1999-10-19 Cedars-Sinai Medical Center Methods of diagnosing a medically resistant clinical subtype of ulcerative colitis
US20030148288A1 (en) * 2002-02-01 2003-08-07 Yi-Wei Tang Colorimetric genetic test for clinically significant TNF polymorphism and methods of use thereof
US6881983B2 (en) * 2002-02-25 2005-04-19 Kopin Corporation Efficient light emitting diodes and lasers
ES2347239T3 (es) 2002-12-02 2010-10-27 Amgen Fremont Inc. Anticuerpos dirigidos al factor de necrosis tumoral y usos de los mismos.
US20070041905A1 (en) * 2005-08-19 2007-02-22 Hoffman Rebecca S Method of treating depression using a TNF-alpha antibody
WO2008116150A2 (en) 2007-03-21 2008-09-25 Cedars-Sinai Medical Center Ileal pouch-anal anastomosis (ipaa) factors in the treatment of inflammatory bowel disease
US20110229471A1 (en) 2008-11-26 2011-09-22 Cedars-Sinai Medical Center Methods of determining responsiveness to anti-tnf alpha therapy in inflammatory bowel disease
WO2010075579A2 (en) 2008-12-24 2010-07-01 Cedars-Sinai Medical Center Methods of predicting medically refractive ulcerative colitis (mr-uc) requiring colectomy
GB201223223D0 (en) 2012-12-21 2013-02-06 Norinnova Technology Transfer As Inflammatory bowel disease
CN112870368A (zh) 2013-03-27 2021-06-01 西达-赛奈医疗中心 通过抑制tl1a的功能和相关信号传导途径来减轻并逆转纤维化和炎症
EP3022295A4 (de) 2013-07-19 2017-03-01 Cedars-Sinai Medical Center Signatur des tl1a (tnfsf15)-signalweges
EP3094973B1 (de) 2013-11-07 2020-07-29 Diagnodus Limited Biomarker
EP3430172A4 (de) 2016-03-17 2019-08-21 Cedars-Sinai Medical Center Verfahren zur diagnose einer entzündlichen darmerkrankung durch rnaset2
EP3755813B1 (de) * 2018-02-20 2023-08-09 F. Hoffmann-La Roche AG Verbesserte detektion von mikrosatelliteninstabilität
CN112831558B (zh) * 2021-03-10 2022-12-20 北京科力丹迪生物医疗科技有限公司 克罗恩病易感基因的早筛方法及试剂盒

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993007485A1 (en) * 1991-10-10 1993-04-15 The Regents Of The University Of California Rare immunoglobulin framework regions associated with human disease
US5225329A (en) * 1991-10-18 1993-07-06 Yale University Method for early detection of intestinal ischemia

Also Published As

Publication number Publication date
DK0760010T3 (da) 2002-02-25
DE69523586T2 (de) 2002-07-18
EP0760010B1 (de) 2001-10-31
EP0760010A1 (de) 1997-03-05
AU698604B2 (en) 1998-11-05
CA2190586A1 (en) 1995-11-23
ES2166822T3 (es) 2002-05-01
AU2638495A (en) 1995-12-05
US6534263B1 (en) 2003-03-18
WO1995031575A1 (en) 1995-11-23
US6001569A (en) 1999-12-14
ATE207967T1 (de) 2001-11-15

Similar Documents

Publication Publication Date Title
DE69523586D1 (de) Verfahren zum screening für die erkrankung crohn durch die verwendung von tnf-mikrosatelliten allelen
DE3481775D1 (de) Verfahren zum raschen nachweis von mikroorganismen in klinischen proben.
DE3587597T2 (de) Lymphotoxin, dafür kodierende Nukleinsäure, die Nukleinsäure enthaltenden Vektoren und damit transformierte Zellen, Verfahren zum Erhalten von Lymphotoxin und Lymphotoxin neutralisierender Antikörper.
DE3764899D1 (de) Verfahren zur reduktion feinkoerniger, eisenhaltiger materialien mit festen kohlenstoffhaltigen reduktionsmitteln.
WO1992017152A3 (en) Method for detecting and treating alzheimer's disease
DE69632887D1 (de) Verfahren zur zweckmässige Herstellung von Transglutaminase durch DNA-Rekombination
DK0858467T3 (da) Materialer og fremgangsmåder angående identifikationen og sekventeringen af BRCA2 cancerfölsomhedsgen og anvendelser deraf
DE3576369D1 (de) Elektrolyt zur elektrochemischen behandlung von metallplatten sowie verfahren zur herstellung anodisierter metallplatten, vorzugsweise fuer die verwendung als druckplattentraeger.
DE69718054T2 (de) Verfahren zur aufreinigung von dns
DE3682149D1 (de) Verfahren zur quantitativen bestimmung von 1,5-anhydroglucitol.
DE3483252D1 (de) Verfahren zur induktion von antitumorimmunozyten, verfahren zur herstellung von antitumorimmunozyten und durch das verfahren hergestellte antitumorimmunozyten.
DK0948604T3 (da) Screeningsmetoder for forbindelser som binder til PYK2-polypeptidet
DE69737812D1 (de) Diagnose durch Bestimmung von Polymorphismen in der Promoterregion des TGF-Beta 1 Gens
DE68917441T2 (de) Verfahren zur Unterdrückung der Bildung von Polymerkrusten in Apparaten für die Alpha-Olefinpolymerisation.
DE69021742T2 (de) Verfahren zum Nachweis von kleinzelligem Carzinom und die Verwendung von Sequenzen, die Acylpeptid-Hydrolase codieren, für diesen zweck.
DE59203628D1 (de) Verfahren zur Verbesserung der Lichtechtheit von Leder.
ATE307340T1 (de) Verfahren für die feststellung von asthma suszeptibilität
EP0398709A3 (de) Genetische Diagnose von Torsion-Dystonia
DE69018500D1 (de) Verfahren zur Schmelzreduktion von Nickelerzen.
AU2904197A (en) Diagnostic method and apparatus based on polymorphism in an IL-6 gene
DE58904756D1 (de) Verfahren zur herstellung von tert.-amylalkohol (taa).
DE3483624D1 (de) Verfahren zur herstellung von kornorientiertem siliziumstahl.
DE68908550D1 (de) Verfahren zur herstellung von korrosions-, waerme- und verschleissbestaendigen werkstuecken und so hergestellte werkstuecke.
AU7300998A (en) Receptor tyrosine kinase genes
DE68906565T2 (de) Verfahren zur Herstellung von elektrolytisch chromatiertem Stahlblech.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee