DE69510791D1 - DNA, WELCHE FÜR DEN VORLÄUFER DER INTERLEUKIN-1-BETA ÜBERFÜHRENDEN ENZYM-VERWANDTEN PROTEINASE III (ICE rel-III) KODIERT - Google Patents

DNA, WELCHE FÜR DEN VORLÄUFER DER INTERLEUKIN-1-BETA ÜBERFÜHRENDEN ENZYM-VERWANDTEN PROTEINASE III (ICE rel-III) KODIERT

Info

Publication number
DE69510791D1
DE69510791D1 DE69510791T DE69510791T DE69510791D1 DE 69510791 D1 DE69510791 D1 DE 69510791D1 DE 69510791 T DE69510791 T DE 69510791T DE 69510791 T DE69510791 T DE 69510791T DE 69510791 D1 DE69510791 D1 DE 69510791D1
Authority
DE
Germany
Prior art keywords
iii
icerel
cdna
recombinant
dna
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69510791T
Other languages
English (en)
Other versions
DE69510791T2 (de
Inventor
Donald W Nicholson
Ambereen Ali
Neil A Munday
John P Vaillancourt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Canada Inc
Original Assignee
Merck Frosst Canada and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Frosst Canada and Co filed Critical Merck Frosst Canada and Co
Publication of DE69510791D1 publication Critical patent/DE69510791D1/de
Application granted granted Critical
Publication of DE69510791T2 publication Critical patent/DE69510791T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6472—Cysteine endopeptidases (3.4.22)
    • C12N9/6475—Interleukin 1-beta convertase-like enzymes (3.4.22.10; 3.4.22.36; 3.4.22.63)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Oncology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
DE69510791T 1994-04-08 1995-04-04 DNA, WELCHE FÜR DEN VORLÄUFER DER INTERLEUKIN-1-BETA ÜBERFÜHRENDEN ENZYM-VERWANDTEN PROTEINASE III (ICE rel-III) KODIERT Expired - Lifetime DE69510791T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/224,930 US5552536A (en) 1994-04-08 1994-04-08 DNA encoding precursor of interleukin-1 beta converting enzyme - related cysteine proteinase III (ice rel-III)
PCT/CA1995/000187 WO1995027792A1 (en) 1994-04-08 1995-04-04 DNA ENCODING PRECURSOR OF INTERLEUKIN-1β CONVERTING ENZYME-RELATED CYSTEINE PROTEINASE III (ICErel-III)

Publications (2)

Publication Number Publication Date
DE69510791D1 true DE69510791D1 (de) 1999-08-19
DE69510791T2 DE69510791T2 (de) 1999-12-30

Family

ID=22842824

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69510791T Expired - Lifetime DE69510791T2 (de) 1994-04-08 1995-04-04 DNA, WELCHE FÜR DEN VORLÄUFER DER INTERLEUKIN-1-BETA ÜBERFÜHRENDEN ENZYM-VERWANDTEN PROTEINASE III (ICE rel-III) KODIERT

Country Status (10)

Country Link
US (2) US5552536A (de)
EP (1) EP0759079B1 (de)
JP (1) JP3815572B2 (de)
AT (1) ATE182177T1 (de)
CA (1) CA2187162C (de)
DE (1) DE69510791T2 (de)
DK (1) DK0759079T3 (de)
ES (1) ES2136284T3 (de)
GR (1) GR3031474T3 (de)
WO (1) WO1995027792A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8715645B2 (en) * 1994-05-27 2014-05-06 The Regents Of The University Of Colorado Viral vectors encoding apoptosis-inducing proteins and methods for making and using the same
FR2723378B1 (fr) * 1994-08-02 1996-10-31 Roussel Uclaf Sequence d'adn codant pour une proteine humaine tx apparentee a l'enzyme de conversion de l'interleukine-1beta, proteine tx, procede de production, compositions pharmaceutiques et leurs applications
US6835555B1 (en) 1994-11-01 2004-12-28 Human Genome Sciences, Inc. Interleukin-1 β converting enzyme like apoptosis protease-3 and 4
US6538121B1 (en) * 1994-11-01 2003-03-25 Human Genome Sciences, Inc. Interleukin-1 β converting enzyme like apoptosis protease-3 and 4
US5654146A (en) * 1995-05-31 1997-08-05 Incyte Pharmaceuticals, Inc. Human ice homolog
US6416753B1 (en) * 1996-03-15 2002-07-09 The General Hospital Corporation Method for modulating apoptosis
US5840509A (en) * 1996-07-22 1998-11-24 Eli Lilly And Company Protease and related nucleic acid compounds
US6063600A (en) * 1997-05-23 2000-05-16 Uab Research Foundation DNA encoding canine interleukin-1 receptor antagonist
CZ20024085A3 (cs) 2000-06-15 2003-05-14 Smithkline Beecham Corporation Způsob přípravy fyziologicky aktivního IL-18 polypeptidu
EP4082761B1 (de) 2021-04-30 2024-03-27 DB Imagineering BV. Reparaturinjektor mit stützvorrichtung für laminiertes glas

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5416013A (en) * 1990-04-04 1995-05-16 Sterling Winthrop Inc. Interleukin 1β protease and interleukin 1β protease inhibitors
WO1993025685A1 (en) * 1992-06-12 1993-12-23 Massachusetts Institute Of Technology Cloning and characterization of the cell death genes ced-3 and ced-4
WO1993025694A1 (en) * 1992-06-12 1993-12-23 Massachusetts Institute Of Technology Inhibitors of ced-3 and related proteins
WO1994006906A1 (en) * 1992-09-18 1994-03-31 Merck & Co., Inc. DNA ENCODING MURINE PRECURSOR INTERLEUKIN 1β CONVERTING ENZYME

Also Published As

Publication number Publication date
CA2187162A1 (en) 1995-10-19
EP0759079B1 (de) 1999-07-14
JPH09511645A (ja) 1997-11-25
WO1995027792A1 (en) 1995-10-19
ATE182177T1 (de) 1999-07-15
CA2187162C (en) 2008-06-17
GR3031474T3 (en) 2000-01-31
ES2136284T3 (es) 1999-11-16
EP0759079A1 (de) 1997-02-26
US5552536A (en) 1996-09-03
DK0759079T3 (da) 1999-11-29
JP3815572B2 (ja) 2006-08-30
US5760180A (en) 1998-06-02
DE69510791T2 (de) 1999-12-30

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: MERCK FROSST CANADA LTD., KIRKLAND, QUEBEC, CA