ATE182177T1 - Dna, welche für den vorläufer der interleukin-1- beta überführenden enzym-verwandten proteinase iii (ice rel-iii) kodiert - Google Patents

Dna, welche für den vorläufer der interleukin-1- beta überführenden enzym-verwandten proteinase iii (ice rel-iii) kodiert

Info

Publication number
ATE182177T1
ATE182177T1 AT95914255T AT95914255T ATE182177T1 AT E182177 T1 ATE182177 T1 AT E182177T1 AT 95914255 T AT95914255 T AT 95914255T AT 95914255 T AT95914255 T AT 95914255T AT E182177 T1 ATE182177 T1 AT E182177T1
Authority
AT
Austria
Prior art keywords
iii
icerel
cdna
recombinant
interleukin
Prior art date
Application number
AT95914255T
Other languages
English (en)
Inventor
Donald W Nicholson
Ambereen Ali
Neil A Munday
John P Vaillancourt
Original Assignee
Merck Frosst Canada Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Frosst Canada Inc filed Critical Merck Frosst Canada Inc
Application granted granted Critical
Publication of ATE182177T1 publication Critical patent/ATE182177T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6472—Cysteine endopeptidases (3.4.22)
    • C12N9/6475—Interleukin 1-beta convertase-like enzymes (3.4.22.10; 3.4.22.36; 3.4.22.63)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Communicable Diseases (AREA)
  • Cardiology (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AT95914255T 1994-04-08 1995-04-04 Dna, welche für den vorläufer der interleukin-1- beta überführenden enzym-verwandten proteinase iii (ice rel-iii) kodiert ATE182177T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/224,930 US5552536A (en) 1994-04-08 1994-04-08 DNA encoding precursor of interleukin-1 beta converting enzyme - related cysteine proteinase III (ice rel-III)

Publications (1)

Publication Number Publication Date
ATE182177T1 true ATE182177T1 (de) 1999-07-15

Family

ID=22842824

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95914255T ATE182177T1 (de) 1994-04-08 1995-04-04 Dna, welche für den vorläufer der interleukin-1- beta überführenden enzym-verwandten proteinase iii (ice rel-iii) kodiert

Country Status (10)

Country Link
US (2) US5552536A (de)
EP (1) EP0759079B1 (de)
JP (1) JP3815572B2 (de)
AT (1) ATE182177T1 (de)
CA (1) CA2187162C (de)
DE (1) DE69510791T2 (de)
DK (1) DK0759079T3 (de)
ES (1) ES2136284T3 (de)
GR (1) GR3031474T3 (de)
WO (1) WO1995027792A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8715645B2 (en) * 1994-05-27 2014-05-06 The Regents Of The University Of Colorado Viral vectors encoding apoptosis-inducing proteins and methods for making and using the same
FR2723378B1 (fr) * 1994-08-02 1996-10-31 Roussel Uclaf Sequence d'adn codant pour une proteine humaine tx apparentee a l'enzyme de conversion de l'interleukine-1beta, proteine tx, procede de production, compositions pharmaceutiques et leurs applications
US6835555B1 (en) 1994-11-01 2004-12-28 Human Genome Sciences, Inc. Interleukin-1 β converting enzyme like apoptosis protease-3 and 4
US6538121B1 (en) 1994-11-01 2003-03-25 Human Genome Sciences, Inc. Interleukin-1 β converting enzyme like apoptosis protease-3 and 4
US5654146A (en) * 1995-05-31 1997-08-05 Incyte Pharmaceuticals, Inc. Human ice homolog
US6416753B1 (en) * 1996-03-15 2002-07-09 The General Hospital Corporation Method for modulating apoptosis
US5840509A (en) * 1996-07-22 1998-11-24 Eli Lilly And Company Protease and related nucleic acid compounds
US6063600A (en) * 1997-05-23 2000-05-16 Uab Research Foundation DNA encoding canine interleukin-1 receptor antagonist
EP1292697B1 (de) 2000-06-15 2009-07-22 SmithKline Beecham Corporation Verfahren zur herstellung eines physiologisch aktiven il-18 polypeptids
EP4082761B1 (de) 2021-04-30 2024-03-27 DB Imagineering BV. Reparaturinjektor mit stützvorrichtung für laminiertes glas

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5416013A (en) * 1990-04-04 1995-05-16 Sterling Winthrop Inc. Interleukin 1β protease and interleukin 1β protease inhibitors
EP0672151A1 (de) * 1992-06-12 1995-09-20 Massachusetts Institute Of Technology Inhibitoren von ced-3 und verwandte proteine
WO1993025685A1 (en) * 1992-06-12 1993-12-23 Massachusetts Institute Of Technology Cloning and characterization of the cell death genes ced-3 and ced-4
AU5102993A (en) * 1992-09-18 1994-04-12 Merck & Co., Inc. Dna encoding murine precursor interleukin 1beta converting enzyme

Also Published As

Publication number Publication date
EP0759079B1 (de) 1999-07-14
EP0759079A1 (de) 1997-02-26
WO1995027792A1 (en) 1995-10-19
CA2187162C (en) 2008-06-17
DK0759079T3 (da) 1999-11-29
GR3031474T3 (en) 2000-01-31
DE69510791D1 (de) 1999-08-19
DE69510791T2 (de) 1999-12-30
ES2136284T3 (es) 1999-11-16
US5760180A (en) 1998-06-02
JP3815572B2 (ja) 2006-08-30
US5552536A (en) 1996-09-03
CA2187162A1 (en) 1995-10-19
JPH09511645A (ja) 1997-11-25

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Legal Events

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