DE69506383D1 - 4-n substituierte sialinsäuren und deren sialoside - Google Patents

4-n substituierte sialinsäuren und deren sialoside

Info

Publication number
DE69506383D1
DE69506383D1 DE69506383T DE69506383T DE69506383D1 DE 69506383 D1 DE69506383 D1 DE 69506383D1 DE 69506383 T DE69506383 T DE 69506383T DE 69506383 T DE69506383 T DE 69506383T DE 69506383 D1 DE69506383 D1 DE 69506383D1
Authority
DE
Germany
Prior art keywords
sialinic
sialosides
acids
substituted
substituted sialinic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69506383T
Other languages
English (en)
Other versions
DE69506383T2 (de
Inventor
Subramaniam Sabesan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
EIDP Inc
Original Assignee
EI Du Pont de Nemours and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by EI Du Pont de Nemours and Co filed Critical EI Du Pont de Nemours and Co
Application granted granted Critical
Publication of DE69506383D1 publication Critical patent/DE69506383D1/de
Publication of DE69506383T2 publication Critical patent/DE69506383T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/14—Acyclic radicals, not substituted by cyclic structures attached to a sulfur, selenium or tellurium atom of a saccharide radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE69506383T 1994-02-25 1995-02-24 4-n substituierte sialinsäuren und deren sialoside Expired - Fee Related DE69506383T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US20191794A 1994-02-25 1994-02-25
PCT/US1995/002329 WO1995023157A1 (en) 1994-02-25 1995-02-24 4-n-substituted sialic acids and their sialosides

Publications (2)

Publication Number Publication Date
DE69506383D1 true DE69506383D1 (de) 1999-01-14
DE69506383T2 DE69506383T2 (de) 1999-06-17

Family

ID=22747826

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69506383T Expired - Fee Related DE69506383T2 (de) 1994-02-25 1995-02-24 4-n substituierte sialinsäuren und deren sialoside

Country Status (6)

Country Link
US (1) US5674988A (de)
EP (1) EP0746564B1 (de)
JP (1) JPH09509664A (de)
CA (1) CA2181237A1 (de)
DE (1) DE69506383T2 (de)
WO (1) WO1995023157A1 (de)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4102022B2 (ja) * 1997-12-17 2008-06-18 バイオクリスト・ファマシューティカルズ インク． ノイラミニダーゼ阻害剤として有用な置換シクロペンタン及びシクロペンテン化合物
US7960139B2 (en) 2007-03-23 2011-06-14 Academia Sinica Alkynyl sugar analogs for the labeling and visualization of glycoconjugates in cells
JP5702600B2 (ja) * 2007-07-03 2015-04-15 チルドレンズ ホスピタル アンド リサーチ センター アット オークランド オリゴシアル酸誘導体、製造方法および免疫学的使用
CA2692419C (en) * 2007-07-03 2017-12-05 Children's Hospital & Research Center At Oakland Inhibitors of polysialic acid de-n-acetylase and methods for using the same
EP2183261A4 (de) 2007-07-03 2010-09-15 Childrens Hosp & Res Ct Oak Polysialylsäurederivate, herstellungsverfahren und anwendungen bei der steigerung von produktion und targeting von krebsantigenen
EP2318832B1 (de) 2008-07-15 2013-10-09 Academia Sinica Glycan-arrays auf objektträgern mit ptfe-aluminiumbeschichtung und entsprechende verfahren
JP5855566B2 (ja) 2009-07-15 2016-02-09 ザ ユニヴァーシティ オヴ ブリティッシュ コロンビア ノイラミニダーゼ阻害剤としての２，３−フッ化グリコシド及び抗ウイルス薬としてのその使用
US11377485B2 (en) 2009-12-02 2022-07-05 Academia Sinica Methods for modifying human antibodies by glycan engineering
US10087236B2 (en) 2009-12-02 2018-10-02 Academia Sinica Methods for modifying human antibodies by glycan engineering
WO2011130332A1 (en) 2010-04-12 2011-10-20 Academia Sinica Glycan arrays for high throughput screening of viruses
CN107954963A (zh) * 2012-01-19 2018-04-24 不列颠哥伦比亚大学 3’平伏氟取代的神经氨酸酶抑制剂化合物、组合物及其用作抗病毒剂的方法
US10130714B2 (en) 2012-04-14 2018-11-20 Academia Sinica Enhanced anti-influenza agents conjugated with anti-inflammatory activity
AU2013306098A1 (en) 2012-08-18 2015-02-12 Academia Sinica Cell-permeable probes for identification and imaging of sialidases
WO2014031762A1 (en) 2012-08-21 2014-02-27 Academia Sinica Benzocyclooctyne compounds and uses thereof
US10086054B2 (en) 2013-06-26 2018-10-02 Academia Sinica RM2 antigens and use thereof
WO2014210564A1 (en) 2013-06-27 2014-12-31 Academia Sinica Glycan conjugates and use thereof
US9782476B2 (en) 2013-09-06 2017-10-10 Academia Sinica Human iNKT cell activation using glycolipids with altered glycosyl groups
US10150818B2 (en) 2014-01-16 2018-12-11 Academia Sinica Compositions and methods for treatment and detection of cancers
EP3094352B1 (de) 2014-01-16 2020-09-23 Academia Sinica Zusammensetzungen und verfahren zur behandlung und zum nachweis von krebs
WO2015148915A1 (en) 2014-03-27 2015-10-01 Academia Sinica Reactive labelling compounds and uses thereof
KR20220151036A (ko) 2014-05-27 2022-11-11 아카데미아 시니카 항-ｃｄ20 글리코항체 및 이의 용도
AU2015267045B2 (en) 2014-05-27 2021-02-25 Academia Sinica Anti-HER2 glycoantibodies and uses thereof
US10118969B2 (en) 2014-05-27 2018-11-06 Academia Sinica Compositions and methods relating to universal glycoforms for enhanced antibody efficacy
CA2950577A1 (en) 2014-05-27 2015-12-03 Academia Sinica Fucosidase from bacteroides and methods using the same
KR102494193B1 (ko) 2014-05-28 2023-01-31 아카데미아 시니카 항-ｔｎｆ-알파 글리코항체 및 이의 용도
EP3191500A4 (de) 2014-09-08 2018-04-11 Academia Sinica Aktivierung menschlicher inkt-zellen mithilfe von glykolipiden
US10495645B2 (en) 2015-01-16 2019-12-03 Academia Sinica Cancer markers and methods of use thereof
US9975965B2 (en) 2015-01-16 2018-05-22 Academia Sinica Compositions and methods for treatment and detection of cancers
EP3248005B1 (de) 2015-01-24 2020-12-09 Academia Sinica Neuartige glycankonjugate und verfahren zur verwendung davon
WO2017156192A1 (en) 2016-03-08 2017-09-14 Academia Sinica Methods for modular synthesis of n-glycans and arrays thereof
CN109963868B (zh) 2016-08-22 2023-11-14 醣基生医股份有限公司 抗体、结合片段及使用方法
WO2018098342A1 (en) * 2016-11-23 2018-05-31 The Regents Of The University Of California N-acetylated sialic acids and related sialosides

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE145673T1 (de) * 1989-12-29 1996-12-15 Symex Corp Verfahren zur diagnostizierung von menschlicher grippe und in position 4 modifizierte chromogene n-acetylneuraminsäure substrate zur verwendung in diesen verfahren
US5243035A (en) * 1990-02-27 1993-09-07 Drug Delivery System Institute, Ltd. Sialic acid-containing glycolipid derivatives
WO1992006691A1 (en) * 1990-10-19 1992-04-30 Biota Scientific Management Pty. Ltd. Anti-viral compounds that bind the active site of influenza neuramidase and display in vivo activity against orthomyxovirus and paramyxovirus
JPH04300890A (ja) * 1991-03-29 1992-10-23 Nisshin Oil Mills Ltd:The シアル酸部分を変換したガングリオシドｇｍ３類縁体
US5220008A (en) * 1991-11-22 1993-06-15 E. I. Du Pont De Nemours And Company Oligosaccharide inhibitors for influenza virus

Also Published As

Publication number Publication date
US5674988A (en) 1997-10-07
EP0746564A1 (de) 1996-12-11
JPH09509664A (ja) 1997-09-30
DE69506383T2 (de) 1999-06-17
CA2181237A1 (en) 1995-08-31
EP0746564B1 (de) 1998-12-02
WO1995023157A1 (en) 1995-08-31

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee