DE69434269T2 - Opioid-rezeptoren, verfahren zu deren herstellung und zusammensetzungen die diese rezeptoren enthalten - Google Patents
Opioid-rezeptoren, verfahren zu deren herstellung und zusammensetzungen die diese rezeptoren enthalten Download PDFInfo
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- DE69434269T2 DE69434269T2 DE69434269T DE69434269T DE69434269T2 DE 69434269 T2 DE69434269 T2 DE 69434269T2 DE 69434269 T DE69434269 T DE 69434269T DE 69434269 T DE69434269 T DE 69434269T DE 69434269 T2 DE69434269 T2 DE 69434269T2
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- opioid receptor
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- opioid
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- 235000020183 skimmed milk Nutrition 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 238000005063 solubilization Methods 0.000 description 1
- 230000007928 solubilization Effects 0.000 description 1
- 230000003381 solubilizing effect Effects 0.000 description 1
- 210000000278 spinal cord Anatomy 0.000 description 1
- 210000004989 spleen cell Anatomy 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
- 210000003523 substantia nigra Anatomy 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 229960002180 tetracycline Drugs 0.000 description 1
- 229930101283 tetracycline Natural products 0.000 description 1
- 235000019364 tetracycline Nutrition 0.000 description 1
- 150000003522 tetracyclines Chemical class 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 229940126585 therapeutic drug Drugs 0.000 description 1
- 108010061238 threonyl-glycine Proteins 0.000 description 1
- 229940113082 thymine Drugs 0.000 description 1
- 239000003104 tissue culture media Substances 0.000 description 1
- 238000012876 topography Methods 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 230000001131 transforming effect Effects 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 108010044292 tryptophyltyrosine Proteins 0.000 description 1
- 210000004881 tumor cell Anatomy 0.000 description 1
- 238000000108 ultra-filtration Methods 0.000 description 1
- 229940035893 uracil Drugs 0.000 description 1
- 108010073969 valyllysine Proteins 0.000 description 1
- 238000012795 verification Methods 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/033—Fusion polypeptide containing a localisation/targetting motif containing a motif for targeting to the internal surface of the plasma membrane, e.g. containing a myristoylation motif
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/32—Fusion polypeptide fusions with soluble part of a cell surface receptor, "decoy receptors"
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Cell Biology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Compositions Of Oxide Ceramics (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US100694 | 1987-09-24 | ||
| US6629693A | 1993-05-20 | 1993-05-20 | |
| US66296 | 1993-05-20 | ||
| US10069493A | 1993-07-30 | 1993-07-30 | |
| US147592 | 1993-11-05 | ||
| US08/147,592 US6096513A (en) | 1993-05-20 | 1993-11-05 | Polynucleotides encoding KAPPA opiod receptors |
| PCT/US1994/005747 WO1994028132A2 (en) | 1993-05-20 | 1994-05-20 | Opioid receptors: compositions and methods |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69434269D1 DE69434269D1 (de) | 2005-03-17 |
| DE69434269T2 true DE69434269T2 (de) | 2006-03-30 |
Family
ID=27370939
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69434269T Expired - Fee Related DE69434269T2 (de) | 1993-05-20 | 1994-05-20 | Opioid-rezeptoren, verfahren zu deren herstellung und zusammensetzungen die diese rezeptoren enthalten |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US6096513A (enExample) |
| EP (1) | EP0700438B1 (enExample) |
| JP (2) | JPH09501307A (enExample) |
| AU (1) | AU678266B2 (enExample) |
| CA (1) | CA2163350A1 (enExample) |
| DE (1) | DE69434269T2 (enExample) |
| WO (1) | WO1994028132A2 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6258556B1 (en) * | 1993-02-26 | 2001-07-10 | The United States Of America As Represented By The Department Of Health And Human Services | cDNA and genomic clones encoding human μ opiate receptor and the purified gene product |
| US5747279A (en) * | 1993-11-05 | 1998-05-05 | Sloan-Kettering Institute For Cancer Research | Nucleic acid molecules encoding kappa3 opioid receptors, receptors encoded thereby, and uses thereof |
| FR2722209B1 (fr) * | 1994-07-11 | 1996-08-14 | Univ Pasteur | Recepteur opioide kappa humain, acides nucleiques et utilisations |
| CA2206192A1 (en) | 1996-06-13 | 1997-12-13 | F. Hoffmann-La Roche Ag | Modulation of lc132 (opioid-like) receptor function |
| US20030104572A1 (en) * | 1997-12-05 | 2003-06-05 | Pasternak Gavril W. | Nucleic acid molecules encoding kappa3, opioid receptors, receptors encoded thereby, and uses thereof |
| WO2000004151A2 (en) * | 1998-07-16 | 2000-01-27 | Memorial Sloan-Kettering Cancer Center | Identification and characterization of splice variants of kappa3-related opioid receptor (kor3) gene |
| US6306576B1 (en) * | 1999-02-19 | 2001-10-23 | Cleveland Clinic Foundation | Diagnostic methods for asthma |
| EP1537110B1 (en) * | 1999-12-06 | 2007-01-17 | Euro-Celtique, S.A. | Triazospiro compounds having nociceptin receptor affinity |
| US7033759B2 (en) * | 2000-07-14 | 2006-04-25 | The Rockfeller University | Variants of the human kappa opioid receptor gene |
| WO2005015242A1 (en) * | 2003-08-06 | 2005-02-17 | Bayer Healthcare Ag | Diagnostics and therapeutics for diseases associated with g protein-coupled opioid receptor kappa 1 (opkr1) |
| WO2005045042A1 (ja) * | 2003-11-06 | 2005-05-19 | Banyu Pharmaceutical Co., Ltd. | サルｏｒｌ１遺伝子及び化合物の評価方法 |
| US20060069086A1 (en) * | 2004-09-23 | 2006-03-30 | Alexander Michalow | Methods for regulating neurotransmitter systems by inducing counteradaptations |
| US20070110786A1 (en) * | 2005-11-15 | 2007-05-17 | Boston Scientific Scimed, Inc. | Medical articles having enhanced therapeutic agent binding |
| WO2010022145A2 (en) * | 2008-08-19 | 2010-02-25 | The University Of North Carolina At Chapel Hill | Alternatively-spliced isoform of mu-opioid receptor gene with cell excitatory function |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0508221A1 (en) * | 1991-03-28 | 1992-10-14 | American Cyanamid Company | Somatostatin receptor |
| WO1993019086A1 (en) * | 1992-03-23 | 1993-09-30 | American Cyanamid Company | Purified opioid receptor |
| AU5012393A (en) * | 1992-08-13 | 1994-03-15 | Regents Of The University Of California, The | Opioid receptor genes |
| FR2697850B1 (fr) * | 1992-11-10 | 1994-12-02 | Univ Pasteur | Nouveaux polypeptides ayant une activité de récepteur opioïde, acides nucléiques codant pour ces polypeptides et utilisations. |
| EP0612845A3 (en) * | 1993-02-26 | 1994-09-21 | American Cyanamid Co | Purified opioid receptor. |
-
1993
- 1993-11-05 US US08/147,592 patent/US6096513A/en not_active Expired - Lifetime
-
1994
- 1994-05-20 CA CA002163350A patent/CA2163350A1/en not_active Abandoned
- 1994-05-20 EP EP94920679A patent/EP0700438B1/en not_active Expired - Lifetime
- 1994-05-20 JP JP7500850A patent/JPH09501307A/ja active Pending
- 1994-05-20 AU AU71382/94A patent/AU678266B2/en not_active Ceased
- 1994-05-20 DE DE69434269T patent/DE69434269T2/de not_active Expired - Fee Related
- 1994-05-20 WO PCT/US1994/005747 patent/WO1994028132A2/en not_active Ceased
- 1994-08-19 US US08/292,694 patent/US6319686B1/en not_active Expired - Lifetime
-
2004
- 2004-10-21 JP JP2004307483A patent/JP2005124574A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| WO1994028132A3 (en) | 1995-05-04 |
| EP0700438B1 (en) | 2005-02-09 |
| US6319686B1 (en) | 2001-11-20 |
| JPH09501307A (ja) | 1997-02-10 |
| US6096513A (en) | 2000-08-01 |
| EP0700438A1 (en) | 1996-03-13 |
| CA2163350A1 (en) | 1994-12-08 |
| DE69434269D1 (de) | 2005-03-17 |
| AU678266B2 (en) | 1997-05-22 |
| JP2005124574A (ja) | 2005-05-19 |
| AU7138294A (en) | 1994-12-20 |
| WO1994028132A2 (en) | 1994-12-08 |
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| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |