DE69433844T2 - Lösliche t-zell rezeptoren alpha ketten und derivate verwendet als prophylaktische und therapeutische mittel gegen autoimmune krankheiten - Google Patents
Lösliche t-zell rezeptoren alpha ketten und derivate verwendet als prophylaktische und therapeutische mittel gegen autoimmune krankheiten Download PDFInfo
- Publication number
- DE69433844T2 DE69433844T2 DE69433844T DE69433844T DE69433844T2 DE 69433844 T2 DE69433844 T2 DE 69433844T2 DE 69433844 T DE69433844 T DE 69433844T DE 69433844 T DE69433844 T DE 69433844T DE 69433844 T2 DE69433844 T2 DE 69433844T2
- Authority
- DE
- Germany
- Prior art keywords
- soluble
- prophylactic
- autoimmune diseases
- therapeutic agents
- cell receptors
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 208000023275 Autoimmune disease Diseases 0.000 title abstract 2
- 239000003814 drug Substances 0.000 title abstract 2
- 230000000069 prophylactic effect Effects 0.000 title abstract 2
- 229940124597 therapeutic agent Drugs 0.000 title abstract 2
- 108091008874 T cell receptors Proteins 0.000 title 1
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 title 1
- 210000001744 T-lymphocyte Anatomy 0.000 abstract 2
- 102000006707 alpha-beta T-Cell Antigen Receptors Human genes 0.000 abstract 2
- 108010087408 alpha-beta T-Cell Antigen Receptors Proteins 0.000 abstract 2
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP3150193 | 1993-02-22 | ||
| JP17906293A JP3875730B2 (ja) | 1993-02-22 | 1993-07-20 | 自己免疫疾患の予防治療剤 |
| PCT/IB1994/000029 WO1994019470A1 (en) | 1993-02-22 | 1994-02-22 | Soluble t-cell receptor alpha chain and derivatives used as prophylactic and therapeutic agents for autoimmune diseases |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69433844D1 DE69433844D1 (de) | 2004-07-22 |
| DE69433844T2 true DE69433844T2 (de) | 2005-04-21 |
Family
ID=26369980
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69433844T Expired - Lifetime DE69433844T2 (de) | 1993-02-22 | 1994-02-22 | Lösliche t-zell rezeptoren alpha ketten und derivate verwendet als prophylaktische und therapeutische mittel gegen autoimmune krankheiten |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US5648332A (de) |
| EP (1) | EP0667908B1 (de) |
| JP (1) | JP3875730B2 (de) |
| KR (1) | KR100333148B1 (de) |
| AT (1) | ATE269409T1 (de) |
| AU (1) | AU686134B2 (de) |
| CA (1) | CA2134083C (de) |
| DE (1) | DE69433844T2 (de) |
| DK (1) | DK0667908T3 (de) |
| ES (1) | ES2224105T3 (de) |
| PT (1) | PT667908E (de) |
| WO (1) | WO1994019470A1 (de) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH08149981A (ja) * | 1993-12-13 | 1996-06-11 | La Jolla Inst For Allergy & Immunology | Ｔ細胞α鎖による抗原特異的免疫制御の方法 |
| WO1997043411A1 (fr) * | 1996-05-10 | 1997-11-20 | Kirin Beer Kabushiki Kaisha | Peptides a regions constantes de chaine alpha de recepteur des cellules t, leurs procedes de production et leur utilisation |
| US6162609A (en) * | 1997-12-31 | 2000-12-19 | The Brigham And Women's Hospital, Inc. | Diagnostic and therapeutic methods based upon Vα24JαQT cells |
| EP2158923B1 (de) | 1998-08-06 | 2013-02-27 | Mountain View Pharmaceuticals, Inc. | Peg-uricase Konjugate und Verwendung davon |
| PL3321359T3 (pl) | 2005-04-11 | 2021-06-28 | Horizon Pharma Rheumatology Llc | Wariantowe postacie oksydazy moczanowej i ich zastosowanie |
| US8148123B2 (en) | 2005-04-11 | 2012-04-03 | Savient Pharmaceuticals, Inc. | Methods for lowering elevated uric acid levels using intravenous injections of PEG-uricase |
| RU2435847C2 (ru) | 2005-04-11 | 2011-12-10 | Савиент Фармасьютикалз, Инк. | Вариантная форма урат-оксидазы и ее использование |
| US9078843B2 (en) | 2005-09-22 | 2015-07-14 | Irun R. Cohen | Immunogenic fragments of T-cell receptor constant domains and peptides derived therefrom |
| KR101861547B1 (ko) | 2009-06-25 | 2018-07-02 | 크레알타 파마슈티칼스 엘엘씨 | 페길화된 유리카아제 치료 중에 혈청 요산을 모니터링하여 주입 반응의 위험성 및 반응의 항체매개 상실을 예측하는 방법 및 키트 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL86278A (en) * | 1988-05-04 | 2003-06-24 | Yeda Res & Dev | Endowing cells with antibody specificity using chimeric t cell receptor |
| US5216132A (en) * | 1990-01-12 | 1993-06-01 | Protein Design Labs, Inc. | Soluble t-cell antigen receptor chimeric antigens |
| US6416971B1 (en) * | 1990-05-15 | 2002-07-09 | E.R. Squibb & Sons, Inc. | Soluble single chain T cell receptors |
| ES2271940T3 (es) * | 1991-02-08 | 2007-04-16 | Aventis Pharma S.A. | Secuencias nucleotidicas que codifican regiones variables de cadenas alfa de los receptores de linfocitos humanos asi como sus aplicaciones. |
| WO1992016234A1 (en) * | 1991-03-22 | 1992-10-01 | The Trustees Of The University Of Pennsylvania | Method of modulating mammalian t-cell response |
-
1993
- 1993-07-20 JP JP17906293A patent/JP3875730B2/ja not_active Expired - Fee Related
-
1994
- 1994-02-22 EP EP94906987A patent/EP0667908B1/de not_active Expired - Lifetime
- 1994-02-22 DE DE69433844T patent/DE69433844T2/de not_active Expired - Lifetime
- 1994-02-22 AT AT94906987T patent/ATE269409T1/de active
- 1994-02-22 KR KR1019940703738A patent/KR100333148B1/ko not_active IP Right Cessation
- 1994-02-22 DK DK94906987T patent/DK0667908T3/da active
- 1994-02-22 WO PCT/IB1994/000029 patent/WO1994019470A1/en active IP Right Grant
- 1994-02-22 ES ES94906987T patent/ES2224105T3/es not_active Expired - Lifetime
- 1994-02-22 US US08/318,881 patent/US5648332A/en not_active Expired - Lifetime
- 1994-02-22 CA CA002134083A patent/CA2134083C/en not_active Expired - Fee Related
- 1994-02-22 AU AU60428/94A patent/AU686134B2/en not_active Ceased
- 1994-02-22 PT PT94906987T patent/PT667908E/pt unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU6042894A (en) | 1994-09-14 |
| KR950701387A (ko) | 1995-03-23 |
| PT667908E (pt) | 2004-09-30 |
| DE69433844D1 (de) | 2004-07-22 |
| KR100333148B1 (ko) | 2002-12-02 |
| WO1994019470A1 (en) | 1994-09-01 |
| ATE269409T1 (de) | 2004-07-15 |
| ES2224105T3 (es) | 2005-03-01 |
| EP0667908A1 (de) | 1995-08-23 |
| JPH06298662A (ja) | 1994-10-25 |
| DK0667908T3 (da) | 2004-10-11 |
| EP0667908B1 (de) | 2004-06-16 |
| CA2134083A1 (en) | 1994-09-01 |
| AU686134B2 (en) | 1998-02-05 |
| US5648332A (en) | 1997-07-15 |
| JP3875730B2 (ja) | 2007-01-31 |
| CA2134083C (en) | 2000-06-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |