DE69431164T2 - Gegenläufige oligonukleotide mit hemmender wirkung auf tumorbildung - Google Patents

Gegenläufige oligonukleotide mit hemmender wirkung auf tumorbildung

Info

Publication number
DE69431164T2
DE69431164T2 DE69431164T DE69431164T DE69431164T2 DE 69431164 T2 DE69431164 T2 DE 69431164T2 DE 69431164 T DE69431164 T DE 69431164T DE 69431164 T DE69431164 T DE 69431164T DE 69431164 T2 DE69431164 T2 DE 69431164T2
Authority
DE
Germany
Prior art keywords
inhibiting effect
tumor formation
tumorigenicity
inhibiting
oligonucleotides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69431164T
Other languages
English (en)
Other versions
DE69431164D1 (de
Inventor
Hofe Eric Von
Moshe Szyf
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
McGill University
Aceragen Inc
Original Assignee
McGill University
Hybridon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by McGill University, Hybridon Inc filed Critical McGill University
Publication of DE69431164D1 publication Critical patent/DE69431164D1/de
Application granted granted Critical
Publication of DE69431164T2 publication Critical patent/DE69431164T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/315—Phosphorothioates

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE69431164T 1993-12-01 1994-11-30 Gegenläufige oligonukleotide mit hemmender wirkung auf tumorbildung Expired - Fee Related DE69431164T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/161,673 US5578716A (en) 1993-12-01 1993-12-01 DNA methyltransferase antisense oligonucleotides
PCT/US1994/013685 WO1995015378A1 (en) 1993-12-01 1994-11-30 Antisense oligonucleotides having tumorigenicity-inhibiting activity

Publications (2)

Publication Number Publication Date
DE69431164D1 DE69431164D1 (de) 2002-09-12
DE69431164T2 true DE69431164T2 (de) 2003-05-08

Family

ID=22582230

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69431164T Expired - Fee Related DE69431164T2 (de) 1993-12-01 1994-11-30 Gegenläufige oligonukleotide mit hemmender wirkung auf tumorbildung

Country Status (10)

Country Link
US (3) US5578716A (de)
EP (1) EP0731835B1 (de)
JP (1) JPH09511125A (de)
AT (1) ATE221914T1 (de)
CA (1) CA2177732C (de)
DE (1) DE69431164T2 (de)
DK (1) DK0731835T3 (de)
ES (1) ES2180622T3 (de)
PT (1) PT731835E (de)
WO (1) WO1995015378A1 (de)

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US7138384B1 (en) 1997-08-29 2006-11-21 The Regents Of The University Of California Modulators of DNA cytosine-5 methyltransferase and methods for use thereof
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EP0575518A1 (de) * 1991-03-06 1993-12-29 Board Of Regents, The University Of Texas System Verfahren und zusammensetzungen fuer die selektive hemmung von genexpression

Also Published As

Publication number Publication date
ATE221914T1 (de) 2002-08-15
CA2177732A1 (en) 1995-06-08
EP0731835A1 (de) 1996-09-18
PT731835E (pt) 2002-11-29
ES2180622T3 (es) 2003-02-16
AU1296195A (en) 1995-06-19
DK0731835T3 (da) 2002-10-28
DE69431164D1 (de) 2002-09-12
US5578716A (en) 1996-11-26
CA2177732C (en) 2004-04-27
JPH09511125A (ja) 1997-11-11
AU700264B2 (en) 1998-12-24
WO1995015378A1 (en) 1995-06-08
US5919772A (en) 1999-07-06
US6054439A (en) 2000-04-25
EP0731835B1 (de) 2002-08-07

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