DE69430365D1 - Isolierung fötaler erythrozyten - Google Patents
Isolierung fötaler erythrozytenInfo
- Publication number
- DE69430365D1 DE69430365D1 DE69430365T DE69430365T DE69430365D1 DE 69430365 D1 DE69430365 D1 DE 69430365D1 DE 69430365 T DE69430365 T DE 69430365T DE 69430365 T DE69430365 T DE 69430365T DE 69430365 D1 DE69430365 D1 DE 69430365D1
- Authority
- DE
- Germany
- Prior art keywords
- erythrocytes
- maternal blood
- nfes
- isolation
- maternal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 210000003743 erythrocyte Anatomy 0.000 title abstract 4
- 230000001605 fetal effect Effects 0.000 title abstract 2
- 238000002955 isolation Methods 0.000 title 1
- 230000008774 maternal effect Effects 0.000 abstract 5
- 210000004369 blood Anatomy 0.000 abstract 4
- 239000008280 blood Substances 0.000 abstract 4
- 208000026350 Inborn Genetic disease Diseases 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 208000016361 genetic disease Diseases 0.000 abstract 1
- 238000007901 in situ hybridization Methods 0.000 abstract 1
- 210000000265 leukocyte Anatomy 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000002093 peripheral effect Effects 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5002—Partitioning blood components
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/49—Blood
- G01N33/491—Blood by separating the blood components
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/962—Prevention or removal of interfering materials or reactants or other treatment to enhance results, e.g. determining or preventing nonspecific binding
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
- Y10T436/107497—Preparation composition [e.g., lysing or precipitation, etc.]
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
- Y10T436/25125—Digestion or removing interfering materials
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
- Y10T436/25375—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
- Y10T436/25375—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]
- Y10T436/255—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.] including use of a solid sorbent, semipermeable membrane, or liquid extraction
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Physics & Mathematics (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Urology & Nephrology (AREA)
- Organic Chemistry (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Food Science & Technology (AREA)
- Zoology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Wood Science & Technology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cell Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Ecology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/007,479 US5457024A (en) | 1993-01-22 | 1993-01-22 | Isolation of fetal erythrocytes |
PCT/US1994/000644 WO1994017209A1 (en) | 1993-01-22 | 1994-01-18 | Isolation of fetal erythrocytes |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69430365D1 true DE69430365D1 (de) | 2002-05-16 |
DE69430365T2 DE69430365T2 (de) | 2002-11-21 |
Family
ID=21726425
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69430365T Expired - Lifetime DE69430365T2 (de) | 1993-01-22 | 1994-01-18 | Isolierung fötaler erythrozyten |
Country Status (8)
Country | Link |
---|---|
US (1) | US5457024A (de) |
EP (1) | EP0681614B1 (de) |
JP (1) | JPH08505777A (de) |
AT (1) | ATE215992T1 (de) |
AU (1) | AU6125094A (de) |
CA (1) | CA2154460A1 (de) |
DE (1) | DE69430365T2 (de) |
WO (1) | WO1994017209A1 (de) |
Families Citing this family (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5629147A (en) * | 1992-07-17 | 1997-05-13 | Aprogenex, Inc. | Enriching and identifying fetal cells in maternal blood for in situ hybridization |
NZ292756A (en) * | 1994-08-31 | 1998-10-28 | Activated Cell Therapy Inc | Cell separation apparatus and method using centrifugation and density mediums |
GB9417912D0 (en) * | 1994-09-06 | 1994-10-26 | Univ Leeds | Diagnostic apparatus |
US5662813A (en) * | 1994-10-21 | 1997-09-02 | Bioseparations, Inc. | Method for separation of nucleated fetal erythrocytes from maternal blood samples |
GB9422504D0 (en) * | 1994-11-08 | 1995-01-04 | Robertson Patricia M B | Blood testing |
ES2189869T3 (es) * | 1995-03-08 | 2003-07-16 | Bioseparations Inc | Procedimiento para el enriquecimiento de poblaciones de celulas raras. |
US6153186A (en) * | 1995-09-15 | 2000-11-28 | Duke University Medical Center | Red blood cells loaded with S-nitrosothiol and uses therefor |
US5731156A (en) * | 1996-10-21 | 1998-03-24 | Applied Imaging, Inc. | Use of anti-embryonic hemoglobin antibodies to identify fetal cells |
EP0944829B1 (de) * | 1996-12-11 | 2003-07-02 | Amersham plc | Selektives verfahren zur lyse von zellen |
US5962234A (en) * | 1997-10-20 | 1999-10-05 | Applied Imaging Corporation | Use of anti-embryonic epsilon hemoglobin antibodies to identify fetal cells |
US6733967B1 (en) | 1998-04-21 | 2004-05-11 | Interleukin Genetics, Inc. | Fetal testing for prediction of low birth weight |
FR2781055B1 (fr) * | 1998-07-09 | 2000-10-13 | Immunotech Sa | Reactif et methode pour la permeabilisation et l'identification des erythrocytes |
US20040152190A1 (en) * | 2001-05-31 | 2004-08-05 | Masaya Sumita | Method of separating and concentrating cells for kidney regfneration |
CN100468058C (zh) * | 2001-12-11 | 2009-03-11 | 株式会社奈特克 | 血细胞分离体系 |
CA2500392C (en) | 2002-09-27 | 2012-11-27 | The General Hospital Corporation | Microfluidic device for cell separation and uses thereof |
ES2784011T3 (es) | 2002-10-16 | 2020-09-21 | Streck Inc | Procedimiento y dispositivo para recoger y preservar las células para su análisis |
US20050208501A1 (en) * | 2004-03-16 | 2005-09-22 | Ambion, Inc. | Process and reagents for extraction of RNA from fractionated blood leukocytes |
WO2006078470A2 (en) | 2005-01-18 | 2006-07-27 | Biocept, Inc. | Cell separation using microchannel having patterned posts |
US20090136982A1 (en) | 2005-01-18 | 2009-05-28 | Biocept, Inc. | Cell separation using microchannel having patterned posts |
US8158410B2 (en) | 2005-01-18 | 2012-04-17 | Biocept, Inc. | Recovery of rare cells using a microchannel apparatus with patterned posts |
US20060252087A1 (en) * | 2005-01-18 | 2006-11-09 | Biocept, Inc. | Recovery of rare cells using a microchannel apparatus with patterned posts |
EP1874920A4 (de) * | 2005-04-05 | 2009-11-04 | Cellpoint Diagnostics | Vorrichtungen und verfahren zur anreicherung und veränderung zirkulierender tumorzellen und anderer partikel |
US20070196820A1 (en) | 2005-04-05 | 2007-08-23 | Ravi Kapur | Devices and methods for enrichment and alteration of cells and other particles |
US8921102B2 (en) | 2005-07-29 | 2014-12-30 | Gpb Scientific, Llc | Devices and methods for enrichment and alteration of circulating tumor cells and other particles |
US7695956B2 (en) * | 2006-01-12 | 2010-04-13 | Biocept, Inc. | Device for cell separation and analysis and method of using |
US20100167271A1 (en) * | 2008-12-30 | 2010-07-01 | Streck, Inc. | Method for screening blood using a preservative that may be in a substantially solid state form |
US11634747B2 (en) | 2009-01-21 | 2023-04-25 | Streck Llc | Preservation of fetal nucleic acids in maternal plasma |
DE202010018561U1 (de) | 2009-01-21 | 2017-08-28 | Streck Inc. | Blutsammelröhrchen |
WO2010096323A1 (en) | 2009-02-18 | 2010-08-26 | Streck, Inc. | Preservation of cell-free nucleic acids |
JP5846609B2 (ja) | 2010-01-21 | 2016-01-20 | バイオセップ リミテッド | 希少細胞の磁気分離 |
US8774488B2 (en) | 2010-03-11 | 2014-07-08 | Cellscape Corporation | Method and device for identification of nucleated red blood cells from a maternal blood sample |
US9956281B2 (en) | 2011-05-04 | 2018-05-01 | Streck, Inc. | Inactivated virus compositions and methods of preparing such compositions |
ES2938048T3 (es) | 2013-07-24 | 2023-04-04 | Streck Llc | Composiciones y procedimientos para estabilizar las células tumorales circulantes |
US11168351B2 (en) | 2015-03-05 | 2021-11-09 | Streck, Inc. | Stabilization of nucleic acids in urine |
US20170145475A1 (en) | 2015-11-20 | 2017-05-25 | Streck, Inc. | Single spin process for blood plasma separation and plasma composition including preservative |
US11506655B2 (en) | 2016-07-29 | 2022-11-22 | Streck, Inc. | Suspension composition for hematology analysis control |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4185964A (en) * | 1977-02-08 | 1980-01-29 | Central Laboratories of Associated Maryland Pathologists, Ltd. | Lysing reagent |
US4190535A (en) * | 1978-02-27 | 1980-02-26 | Corning Glass Works | Means for separating lymphocytes and monocytes from anticoagulated blood |
US4255256A (en) * | 1978-12-13 | 1981-03-10 | Antonio Ferrante | Medium for the separation of human blood leucocytes |
US4861705A (en) * | 1983-01-31 | 1989-08-29 | Yeda Research And Development Company, Ltd. | Method for removing components of biological fluids |
US4675286A (en) * | 1985-01-28 | 1987-06-23 | Aspen Diagnostics, Inc. | Fetal cell separation and testing |
US4888278A (en) * | 1985-10-22 | 1989-12-19 | University Of Massachusetts Medical Center | In-situ hybridization to detect nucleic acid sequences in morphologically intact cells |
US4927750A (en) * | 1986-04-09 | 1990-05-22 | Jeanette Simpson | Cell separation process |
US4925572A (en) * | 1987-10-20 | 1990-05-15 | Pall Corporation | Device and method for depletion of the leukocyte content of blood and blood components |
US4923620A (en) * | 1987-10-20 | 1990-05-08 | Pall Corporation | Device for depletion of the leukocyte content of blood and blood components |
US4976861A (en) * | 1987-10-20 | 1990-12-11 | Pall Corporation | Method for determining the wetting characteristic of a porous medium |
US4880548A (en) * | 1988-02-17 | 1989-11-14 | Pall Corporation | Device and method for separating leucocytes from platelet concentrate |
ATE161960T1 (de) * | 1988-12-06 | 1998-01-15 | Flinders Technologies Pty Ltd | Isolierung von fetalen zellen aus mütterlichem blut zur ausführung von pränataler diagnostik |
ATE162631T1 (de) * | 1989-11-13 | 1998-02-15 | Childrens Medical Center | Ein nichtinvasives verfahren zur trennung und zum nachweis von fetaler dna |
US5153117A (en) * | 1990-03-27 | 1992-10-06 | Genetype A.G. | Fetal cell recovery method |
WO1991016452A1 (en) * | 1990-04-23 | 1991-10-31 | Cellpro Incorporated | A method for enriching fetal cells from maternal blood |
AU4685593A (en) * | 1992-07-17 | 1994-02-14 | Aprogenex, Inc. | Enriching and identyfying fetal cells in maternal blood for in situ hybridization |
US5275933A (en) * | 1992-09-25 | 1994-01-04 | The Board Of Trustees Of The Leland Stanford Junior University | Triple gradient process for recovering nucleated fetal cells from maternal blood |
-
1993
- 1993-01-22 US US08/007,479 patent/US5457024A/en not_active Expired - Lifetime
-
1994
- 1994-01-18 DE DE69430365T patent/DE69430365T2/de not_active Expired - Lifetime
- 1994-01-18 AT AT94907836T patent/ATE215992T1/de not_active IP Right Cessation
- 1994-01-18 JP JP6517158A patent/JPH08505777A/ja active Pending
- 1994-01-18 AU AU61250/94A patent/AU6125094A/en not_active Abandoned
- 1994-01-18 EP EP94907836A patent/EP0681614B1/de not_active Expired - Lifetime
- 1994-01-18 WO PCT/US1994/000644 patent/WO1994017209A1/en active IP Right Grant
- 1994-01-18 CA CA002154460A patent/CA2154460A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US5457024A (en) | 1995-10-10 |
CA2154460A1 (en) | 1994-08-04 |
ATE215992T1 (de) | 2002-04-15 |
EP0681614A1 (de) | 1995-11-15 |
AU6125094A (en) | 1994-08-15 |
EP0681614A4 (de) | 1997-06-04 |
DE69430365T2 (de) | 2002-11-21 |
EP0681614B1 (de) | 2002-04-10 |
JPH08505777A (ja) | 1996-06-25 |
WO1994017209A1 (en) | 1994-08-04 |
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