DE69430121D1 - Verfahren und zusammemsetzungen aehnlich den bindungsprotein des sterol-regulationselements - Google Patents
Verfahren und zusammemsetzungen aehnlich den bindungsprotein des sterol-regulationselementsInfo
- Publication number
- DE69430121D1 DE69430121D1 DE69430121T DE69430121T DE69430121D1 DE 69430121 D1 DE69430121 D1 DE 69430121D1 DE 69430121 T DE69430121 T DE 69430121T DE 69430121 T DE69430121 T DE 69430121T DE 69430121 D1 DE69430121 D1 DE 69430121D1
- Authority
- DE
- Germany
- Prior art keywords
- binding protein
- regulation element
- compositions similar
- sterol regulation
- sterol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 229930182558 Sterol Natural products 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 102000004169 proteins and genes Human genes 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 title 1
- 150000003432 sterols Chemical class 0.000 title 1
- 235000003702 sterols Nutrition 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/525—Tumour necrosis factor [TNF]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/61—Growth hormone [GH], i.e. somatotropin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/67—General methods for enhancing the expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6456—Plasminogen activators
- C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21069—Protein C activated (3.4.21.69)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/001—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
- C12N2830/002—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination inducible enhancer/promoter combination, e.g. hypoxia, iron, transcription factor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/15—Vector systems having a special element relevant for transcription chimeric enhancer/promoter combination
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/80—Vector systems having a special element relevant for transcription from vertebrates
- C12N2830/85—Vector systems having a special element relevant for transcription from vertebrates mammalian
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Endocrinology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/061,697 US5498696A (en) | 1993-05-13 | 1993-05-13 | Sterol regulatory element binding proteins and their use in screening assays |
US08/131,365 US5527690A (en) | 1987-03-30 | 1993-10-01 | Methods and compositions relating to sterol regulatory element binding proteins |
PCT/US1994/005300 WO1994026922A2 (en) | 1993-05-13 | 1994-05-13 | Methods and compositions relating to sterol regulatory element binding proteins |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69430121D1 true DE69430121D1 (de) | 2002-04-18 |
DE69430121T2 DE69430121T2 (de) | 2002-08-01 |
Family
ID=26741384
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69430121T Expired - Lifetime DE69430121T2 (de) | 1993-05-13 | 1994-05-13 | Verfahren und zusammemsetzungen aehnlich den bindungsprotein des sterol-regulationselements |
Country Status (5)
Country | Link |
---|---|
US (2) | US5527690A (de) |
EP (1) | EP0698115B1 (de) |
AU (1) | AU6911194A (de) |
DE (1) | DE69430121T2 (de) |
WO (1) | WO1994026922A2 (de) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5527690A (en) * | 1987-03-30 | 1996-06-18 | Board Of Regents, The University Of Texas System | Methods and compositions relating to sterol regulatory element binding proteins |
JPH09506629A (ja) * | 1993-12-17 | 1997-06-30 | キュビッチョッティ,ロジャー・エス | ヌクレオチドに支配された生体分子および多分子薬物の集合並びに装置 |
WO1999005161A1 (en) | 1997-07-25 | 1999-02-04 | Ligand Pharmaceuticals Incorporated | HUMAN PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA (PPARη) GENE REGULATORY SEQUENCES AND USES THEREFOR |
DE19816902A1 (de) * | 1998-04-16 | 1999-10-28 | Wilhelm Krone | SREBP-1 und SREBP-2 in phosphorylierter Form |
DE19816894C1 (de) * | 1998-04-16 | 2000-03-02 | Wilhelm Krone | SREBP-2-defiziente Zellinien |
US6322962B1 (en) | 1998-08-14 | 2001-11-27 | Board Of Regents, The University Of Texas System | Sterol-regulated Site-1 protease and assays of modulators thereof |
US6602710B1 (en) * | 1998-08-27 | 2003-08-05 | Chugai Seiyaku Kabushiki Kaisha | Screening method for SREBP pathway-specific inhibitors |
US7189506B1 (en) * | 1999-03-03 | 2007-03-13 | Genelabs Technologies, Inc. | DNA binding compound-mediated molecular switch system |
US6781028B1 (en) | 1999-06-14 | 2004-08-24 | Exelixis, Inc. | Animal models and methods for analysis of lipid metabolism and screening of pharmaceutical and pesticidal agents that modulate lipid metabolism |
EP1194589B1 (de) * | 1999-07-09 | 2008-10-29 | André R. Miserez | Dna-polymorphismen in sterol-regulator element-bindenden proteinen |
AU2002321989A1 (en) * | 2001-02-02 | 2002-12-03 | Bayer Corporation | Methods of modulating surfactant phospholipid production |
AU2002332130A1 (en) * | 2001-10-16 | 2003-04-28 | Exelixis, Inc. | Msrebps as modifiers of the srebp pathway and methods of use |
US20030224515A1 (en) * | 2002-06-04 | 2003-12-04 | Isis Pharmaceuticals Inc. | Antisense modulation of sterol regulatory element-binding protein-1 expression |
US20050215504A1 (en) * | 2002-04-02 | 2005-09-29 | Bennett C F | Antisense modulation of sterol regulatory element-binding protein-1 expression |
NZ560887A (en) * | 2005-02-04 | 2009-10-30 | New Ind Res Organization | Method for evaluating quality of beef such as taste and texture through genotyping of SREBP-1 gene |
US8217025B2 (en) * | 2006-11-17 | 2012-07-10 | Harbor Therapeutics, Inc. | Drug screening and treatment methods |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4935363A (en) * | 1987-03-30 | 1990-06-19 | Board Of Regents, The University Of Texas System | Sterol regulatory elements |
US5215910A (en) * | 1987-03-27 | 1993-06-01 | Board Of Regents, The University Of Texas | Host cells transformed with sterol regulatory elements |
US5498696A (en) * | 1993-05-13 | 1996-03-12 | Board Of Regents, The University Of Texas System | Sterol regulatory element binding proteins and their use in screening assays |
US5527690A (en) * | 1987-03-30 | 1996-06-18 | Board Of Regents, The University Of Texas System | Methods and compositions relating to sterol regulatory element binding proteins |
US5256545A (en) * | 1987-03-30 | 1993-10-26 | Board Of Regents, The University Of Texas System | Sterol Regulatory Elements |
-
1993
- 1993-10-01 US US08/131,365 patent/US5527690A/en not_active Expired - Lifetime
-
1994
- 1994-05-13 WO PCT/US1994/005300 patent/WO1994026922A2/en active IP Right Grant
- 1994-05-13 EP EP94917367A patent/EP0698115B1/de not_active Expired - Lifetime
- 1994-05-13 AU AU69111/94A patent/AU6911194A/en not_active Abandoned
- 1994-05-13 DE DE69430121T patent/DE69430121T2/de not_active Expired - Lifetime
-
1996
- 1996-06-14 US US08/668,123 patent/US5891631A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
WO1994026922A3 (en) | 1995-01-05 |
EP0698115A1 (de) | 1996-02-28 |
EP0698115B1 (de) | 2002-03-13 |
DE69430121T2 (de) | 2002-08-01 |
US5891631A (en) | 1999-04-06 |
US5527690A (en) | 1996-06-18 |
WO1994026922A2 (en) | 1994-11-24 |
AU6911194A (en) | 1994-12-12 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |