DE69429721D1 - Verwendung von neuronalen fötalen zellinien für transplantationstherapie - Google Patents
Verwendung von neuronalen fötalen zellinien für transplantationstherapieInfo
- Publication number
- DE69429721D1 DE69429721D1 DE69429721T DE69429721T DE69429721D1 DE 69429721 D1 DE69429721 D1 DE 69429721D1 DE 69429721 T DE69429721 T DE 69429721T DE 69429721 T DE69429721 T DE 69429721T DE 69429721 D1 DE69429721 D1 DE 69429721D1
- Authority
- DE
- Germany
- Prior art keywords
- cell lines
- neuronal
- fetal cell
- transplantation therapy
- svg
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/48—Reproductive organs
- A61K35/54—Ovaries; Ova; Ovules; Embryos; Foetal cells; Germ cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0618—Cells of the nervous system
- C12N5/0622—Glial cells, e.g. astrocytes, oligodendrocytes; Schwann cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y114/00—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
- C12Y114/13—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14) with NADH or NADPH as one donor, and incorporation of one atom of oxygen (1.14.13)
- C12Y114/13041—Tyrosine N-monooxygenase (1.14.13.41)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y114/00—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
- C12Y114/16—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14) with reduced pteridine as one donor, and incorporation of one atom of oxygen (1.14.16)
- C12Y114/16002—Tyrosine 3-monooxygenase (1.14.16.2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K2035/126—Immunoprotecting barriers, e.g. jackets, diffusion chambers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
- C12N2510/04—Immortalised cells
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/948—Microorganisms using viruses or cell lines
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Medicinal Chemistry (AREA)
- Developmental Biology & Embryology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Virology (AREA)
- Immunology (AREA)
- Reproductive Health (AREA)
- Gynecology & Obstetrics (AREA)
- Ophthalmology & Optometry (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US4652793A | 1993-04-13 | 1993-04-13 | |
PCT/US1994/003938 WO1994023754A1 (en) | 1993-04-13 | 1994-04-11 | Use of neuro-derived fetal cell lines for transplantation therapy |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69429721D1 true DE69429721D1 (de) | 2002-03-14 |
DE69429721T2 DE69429721T2 (de) | 2002-09-05 |
Family
ID=21943916
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69429721T Expired - Fee Related DE69429721T2 (de) | 1993-04-13 | 1994-04-11 | Verwendung von neuronalen fötalen zellinien für transplantationstherapie |
Country Status (11)
Country | Link |
---|---|
US (3) | US5869463A (de) |
EP (1) | EP0696205B1 (de) |
JP (1) | JPH08509215A (de) |
AT (1) | ATE212237T1 (de) |
AU (1) | AU690548B2 (de) |
CA (1) | CA2159738A1 (de) |
DE (1) | DE69429721T2 (de) |
DK (1) | DK0696205T3 (de) |
ES (1) | ES2170096T3 (de) |
PT (1) | PT696205E (de) |
WO (1) | WO1994023754A1 (de) |
Families Citing this family (56)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5753491A (en) * | 1993-04-13 | 1998-05-19 | Us Health | Use of neuro-derived fetal cell lines for transplantation therapy |
ATE163006T1 (de) * | 1993-06-01 | 1998-02-15 | Ono Pharmaceutical Co | Pentansäurederivate |
FR2714061B1 (fr) * | 1993-12-16 | 1996-03-08 | Genset Sa | Procédé de préparation de polynucléotides sur support solide et appareil permettant sa mise en Óoeuvre. |
US6469157B1 (en) * | 1993-12-16 | 2002-10-22 | Proligo Llc | Process for preparing polynucleotides on a solid support |
US20010049143A1 (en) * | 1994-11-08 | 2001-12-06 | Stringer Bradley Michael John | Human cell-lines |
US6653134B2 (en) * | 1995-03-28 | 2003-11-25 | Cp Hahnemann University | Isolated stromal cells for use in the treatment of diseases of the central nervous system |
AU742824C (en) * | 1995-06-06 | 2003-03-20 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Use of neuro-derived fetal cell lines for transplantation therapy |
GB9518606D0 (en) * | 1995-09-12 | 1995-11-15 | Inst Of Psychiatry | Neural transplantation |
US6232119B1 (en) * | 1997-06-13 | 2001-05-15 | University Technology Corporation | Immortalized human fetal neuronal cell line |
WO1998057663A1 (en) | 1997-06-17 | 1998-12-23 | University Technology Corporation | Neural transplantation for treating neurological disease |
WO1999056759A1 (en) * | 1998-05-07 | 1999-11-11 | University Of South Florida | Bone marrow cells as a source of neurons for brain and spinal cord repair |
US20080206206A1 (en) | 1998-05-07 | 2008-08-28 | University Of South Florida | Bone marrow-derived neuronal cells |
US6787356B1 (en) | 1998-07-24 | 2004-09-07 | The United States Of America As Represented By The Department Of Health And Human Services | Cell expansion system for use in neural transplantation |
CN1261158C (zh) * | 1998-09-03 | 2006-06-28 | 诺兰兹公司 | 生长激素在制备用于诱导神经保护作用的药剂中的应用 |
GB9907243D0 (en) * | 1999-03-29 | 1999-05-26 | Reneuron Ltd | Therapy |
DK1176970T3 (da) * | 1999-04-30 | 2010-09-20 | Neurotrophincell Pty Ltd | Xenotransplantat til CNS-terapi |
US20040213768A1 (en) * | 1999-04-30 | 2004-10-28 | Elliott Robert Bartlett | Preparation for biotransplantation and xenotransplantion and uses thereof |
US20050265977A1 (en) * | 1999-04-30 | 2005-12-01 | Elliott Robert B | Xenotransplant for CNS therapy |
US20090047325A1 (en) * | 1999-04-30 | 2009-02-19 | Neurotrophincell Pty. Limited | Xenotransplant for cns therapy |
CA2373808C (en) * | 1999-05-14 | 2011-04-19 | Henry Ford Health System | Bone marrow transplantation for treatment of central nervous system damage |
US20050169896A1 (en) * | 1999-05-14 | 2005-08-04 | Henry Ford Health System | Bone marrow transplantation for treatment of stroke |
US8017112B2 (en) | 1999-05-14 | 2011-09-13 | Henry Ford Health System | Transplantation of bone marrow stromal cells for treatment of neurodegenerative diseases |
EP1248640B1 (de) * | 2000-01-20 | 2006-10-04 | Diabcell Pty Limited | Präparation und xenotransplantation von inseln aus schweinen |
EP1263930A4 (de) * | 2000-03-09 | 2004-07-21 | Saneron Ccel Therapeutics Inc | Menschliches nabelschnurblut als quelle für neurales gewebe zur heilung von gehirn und rückenmark |
RU2160112C1 (ru) * | 2000-04-10 | 2000-12-10 | Сухих Геннадий Тихонович | Способ приготовления клеточного трансплантата из фетальных тканей |
EP1272203B1 (de) | 2000-04-13 | 2006-10-18 | The Board Of Regents, The University Of Texas System | Behandlung von neurodegenerativen gastrointestinalen krankheiten durch implantation von neuralen stammzellen und/oder deren nachkommen in gastrointestinalorgane |
AU2001268106A1 (en) * | 2000-06-28 | 2002-01-08 | The Board Of Trustees Of The Leland Stanford Jr. University | Imaging methods for visualizing implanted living cells |
US20090209831A1 (en) * | 2000-06-28 | 2009-08-20 | Nexgen Medical Systems, Incorporated | Imaging methods for visualizing implanted living cells |
US7831305B2 (en) | 2001-10-15 | 2010-11-09 | Advanced Neuromodulation Systems, Inc. | Neural stimulation system and method responsive to collateral neural activity |
US7112570B2 (en) | 2000-08-24 | 2006-09-26 | Neuren Pharmaceuticals, Ltd. | GPE analogs |
EP1333846B1 (de) * | 2000-10-17 | 2012-04-18 | Diabcell Pty Limited | Zubereitung und xenotransplantation von langerhans-inseln von schweinen |
US7041283B1 (en) * | 2001-02-16 | 2006-05-09 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Methods of using immunophilin binding drugs to improve integration and survival of neuronal cell transplants |
EP1370134B1 (de) * | 2001-03-23 | 2016-03-23 | University Of Ottawa | Verfahren und zusammensetzungen zur kryokonservierung von dissoziirten primären tierzellen |
JP2004536069A (ja) | 2001-05-24 | 2004-12-02 | ニューロンズ・リミテッド | Gpe類縁体及びペプチドミメティック |
US7605177B2 (en) | 2001-05-24 | 2009-10-20 | Neuren Pharmaceuticals Limited | Effects of glycyl-2 methyl prolyl glutamate on neurodegeneration |
US7714020B2 (en) | 2001-05-24 | 2010-05-11 | Neuren Pharmaceuticals Limited | Treatment of non-convulsive seizures in brain injury using G-2-methyl-prolyl glutamate |
US20040092013A1 (en) * | 2001-08-14 | 2004-05-13 | Snyder Evan Y. | Method of treating alzheimer's disease with cell therapy |
US20050042746A1 (en) * | 2001-09-28 | 2005-02-24 | Olga Garkavenko | Growing xenotransplant material in culture |
NZ515310A (en) * | 2001-11-07 | 2004-08-27 | Diabcell Pty Ltd | Methods of treatment and delivery modes |
DE60335490D1 (de) | 2002-10-22 | 2011-02-03 | Eisai R&D Man Co Ltd | Spezifisch in postmitotischen dopamin-produzierenden neuronalen vorläuferzellen exprimiertes gen |
JP2006517101A (ja) * | 2003-01-13 | 2006-07-20 | エス. ラオ、マヘンドラ | 治療用産物を送達するための、増殖性の幹細胞および前駆細胞における候補分子の持続的発現 |
US20050048041A1 (en) * | 2003-01-13 | 2005-03-03 | Rao Mahendra S. | Persistent expression of candidate molecule in proliferating stem and progenitor cells for delivery of therapeutic products |
CA2529573A1 (en) * | 2003-06-24 | 2004-12-29 | Diabcell Pty Limited | Porcine islets cultured with porcine sertoli cells for xenotransplantation |
US8579908B2 (en) * | 2003-09-26 | 2013-11-12 | DePuy Synthes Products, LLC. | Device for delivering viscous material |
US20080199437A1 (en) | 2004-07-22 | 2008-08-21 | Eisai Co., Ltd. | Lrp4/Corin Dopaminergic Neuron Progenitor Cell Markers |
ATE373081T1 (de) * | 2004-09-30 | 2007-09-15 | Reneuron Ltd | Zelllinie |
US7643864B2 (en) * | 2005-02-03 | 2010-01-05 | Case Western Reserve University | Adaptive imaging parameters with MRI |
NZ540597A (en) * | 2005-06-08 | 2007-02-23 | Neurotrophincell Pty Ltd | A method for preventing the onset of type I diabetes comprising administering an implantable composition comprising living choroid plexus cells |
WO2007021003A1 (ja) | 2005-08-18 | 2007-02-22 | Eisai R & D Management Co., Ltd. | ドーパミン産生ニューロン増殖前駆細胞マーカーNato3 |
EP1930429A4 (de) | 2005-08-18 | 2009-03-11 | Eisai R&D Man Co Ltd | Msx1/2, MARKER FÜR WACHSENDE VORLÄUFERZELLE EINES DOPAMIN PRODUZIERENDEN NEURONS |
JP5033121B2 (ja) | 2006-04-11 | 2012-09-26 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | ドーパミン産生ニューロン前駆細胞マーカー187a5 |
WO2007133757A2 (en) * | 2006-05-15 | 2007-11-22 | Diasys Corporation | Reusable slide assembly |
US20090090214A1 (en) * | 2007-10-04 | 2009-04-09 | Chung Yuan Christian University | Method for forming nano-scale metal particles |
US9101570B1 (en) | 2009-02-13 | 2015-08-11 | Endocellutions, Inc. | Adult and neonatal stem cell therapy to treat diabetes through the repair of the gastrointestinal tract |
WO2011044216A1 (en) * | 2009-10-08 | 2011-04-14 | Neurotech Usa, Inc. | Use of pedf in an encapsulated cell-based delivery system |
JP6090937B2 (ja) | 2011-07-27 | 2017-03-08 | 国立大学法人京都大学 | 新規ドーパミン産生神経前駆細胞マーカー |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4707448A (en) * | 1984-10-04 | 1987-11-17 | The United States Of America As Represented By The Department Of Health And Human Services | Immortal line of human fetal glial cells |
US5032407A (en) * | 1987-01-16 | 1991-07-16 | Ohio University Edison Animal Biotechnology Center | Gene transfer using transformed, neodetermined, embryonic cells |
US5202120A (en) * | 1987-09-11 | 1993-04-13 | Case Western Reserve University | Methods of reducing glial scar formation and promoting axon and blood vessel growth and/or regeneration through the use of activated immature astrocytes |
US4892538A (en) * | 1987-11-17 | 1990-01-09 | Brown University Research Foundation | In vivo delivery of neurotransmitters by implanted, encapsulated cells |
WO1989009816A1 (en) * | 1988-04-12 | 1989-10-19 | Massachusetts Institute Of Technology | Method for manipulation of the cell types of eukaryotes |
EP0445218A4 (en) * | 1988-11-23 | 1991-11-13 | Baylor College Of Medicine | Neural cell transplantation |
US5082670A (en) * | 1988-12-15 | 1992-01-21 | The Regents Of The University Of California | Method of grafting genetically modified cells to treat defects, disease or damage or the central nervous system |
-
1994
- 1994-04-11 ES ES94912975T patent/ES2170096T3/es not_active Expired - Lifetime
- 1994-04-11 DE DE69429721T patent/DE69429721T2/de not_active Expired - Fee Related
- 1994-04-11 EP EP94912975A patent/EP0696205B1/de not_active Expired - Lifetime
- 1994-04-11 JP JP6523361A patent/JPH08509215A/ja active Pending
- 1994-04-11 PT PT94912975T patent/PT696205E/pt unknown
- 1994-04-11 AU AU65312/94A patent/AU690548B2/en not_active Ceased
- 1994-04-11 CA CA002159738A patent/CA2159738A1/en not_active Abandoned
- 1994-04-11 WO PCT/US1994/003938 patent/WO1994023754A1/en active IP Right Grant
- 1994-04-11 DK DK94912975T patent/DK0696205T3/da active
- 1994-04-11 AT AT94912975T patent/ATE212237T1/de not_active IP Right Cessation
-
1995
- 1995-06-02 US US08/458,384 patent/US5869463A/en not_active Expired - Fee Related
- 1995-06-02 US US08/459,136 patent/US5690927A/en not_active Expired - Fee Related
-
2001
- 2001-10-10 US US09/973,198 patent/US20020110546A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
JPH08509215A (ja) | 1996-10-01 |
WO1994023754A1 (en) | 1994-10-27 |
AU6531294A (en) | 1994-11-08 |
ATE212237T1 (de) | 2002-02-15 |
EP0696205A1 (de) | 1996-02-14 |
DE69429721T2 (de) | 2002-09-05 |
ES2170096T3 (es) | 2002-08-01 |
US5869463A (en) | 1999-02-09 |
US20020110546A1 (en) | 2002-08-15 |
AU690548B2 (en) | 1998-04-30 |
EP0696205B1 (de) | 2002-01-23 |
US5690927A (en) | 1997-11-25 |
PT696205E (pt) | 2002-07-31 |
DK0696205T3 (da) | 2002-05-13 |
CA2159738A1 (en) | 1994-10-27 |
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