DE69429569D1 - Bis(hydroxymethyl)cyclopropylmethyl Pyrimidin Derivate, deren Herstellung und deren Verwendung als anti-virale Mittel - Google Patents

Bis(hydroxymethyl)cyclopropylmethyl Pyrimidin Derivate, deren Herstellung und deren Verwendung als anti-virale Mittel

Info

Publication number
DE69429569D1
DE69429569D1 DE69429569T DE69429569T DE69429569D1 DE 69429569 D1 DE69429569 D1 DE 69429569D1 DE 69429569 T DE69429569 T DE 69429569T DE 69429569 T DE69429569 T DE 69429569T DE 69429569 D1 DE69429569 D1 DE 69429569D1
Authority
DE
Germany
Prior art keywords
cyclopropylmethyl
hydroxymethyl
bis
preparation
pyrimidine derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69429569T
Other languages
English (en)
Other versions
DE69429569T2 (de
Inventor
Tomoyuki Onishi
Chika Mukai
Takaaki Sekiyama
Takashi Tsuji
Satoshi Iwayama
Masahiko Okunishi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ajinomoto Co Inc
Original Assignee
Ajinomoto Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ajinomoto Co Inc filed Critical Ajinomoto Co Inc
Publication of DE69429569D1 publication Critical patent/DE69429569D1/de
Application granted granted Critical
Publication of DE69429569T2 publication Critical patent/DE69429569T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/553—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms with halogen atoms or nitro radicals directly attached to ring carbon atoms, e.g. fluorouracil
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
DE69429569T 1993-10-21 1994-10-21 Bis(hydroxymethyl)cyclopropylmethyl Pyrimidin Derivate, deren Herstellung und deren Verwendung als anti-virale Mittel Expired - Lifetime DE69429569T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP26349093 1993-10-21

Publications (2)

Publication Number Publication Date
DE69429569D1 true DE69429569D1 (de) 2002-02-07
DE69429569T2 DE69429569T2 (de) 2002-09-19

Family

ID=17390246

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69429569T Expired - Lifetime DE69429569T2 (de) 1993-10-21 1994-10-21 Bis(hydroxymethyl)cyclopropylmethyl Pyrimidin Derivate, deren Herstellung und deren Verwendung als anti-virale Mittel

Country Status (7)

Country Link
US (1) US5496824A (de)
EP (1) EP0649840B1 (de)
KR (1) KR950011530A (de)
CN (1) CN1106392A (de)
CA (1) CA2134050A1 (de)
DE (1) DE69429569T2 (de)
TW (1) TW271438B (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU710490B2 (en) * 1996-02-22 1999-09-23 Samjin Pharmaceutical Co., Ltd. New antiviral substituted pyrimidinedione homocarbocyclic nucleoside derivatives and methods for the preparation thereof and compositions containing the same as active ingredients
EP3020712B1 (de) 2011-11-10 2018-07-04 Aratana Therapeutics NV Verfahren zur herstellung von cyclopropan-derivaten
US9107943B2 (en) 2012-01-20 2015-08-18 Aratana Therapeutics Nv Eye drop composition

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4863927A (en) * 1987-05-11 1989-09-05 Merck & Co., Inc. 1-(2-hydroxymethyl)cycloalkylmethyl)-5-substituted uracils
AU635642B2 (en) * 1990-05-24 1993-03-25 E.R. Squibb & Sons, Inc. Fluorinated bis(hydroxymethyl) cyclobutyl purines and pyrimidines
USH1142H (en) * 1990-11-05 1993-02-02 Optically active cyclobutyl pyrimidine
ATE187173T1 (de) * 1991-03-05 1999-12-15 Ajinomoto Kk Cyclopropanderivat

Also Published As

Publication number Publication date
KR950011530A (ko) 1995-05-15
US5496824A (en) 1996-03-05
TW271438B (de) 1996-03-01
EP0649840A1 (de) 1995-04-26
EP0649840B1 (de) 2002-01-02
CN1106392A (zh) 1995-08-09
CA2134050A1 (en) 1995-04-22
DE69429569T2 (de) 2002-09-19

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Legal Events

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