DE69429569T2 - Bis(hydroxymethyl)cyclopropylmethyl Pyrimidin Derivate, deren Herstellung und deren Verwendung als anti-virale Mittel - Google Patents
Bis(hydroxymethyl)cyclopropylmethyl Pyrimidin Derivate, deren Herstellung und deren Verwendung als anti-virale MittelInfo
- Publication number
- DE69429569T2 DE69429569T2 DE69429569T DE69429569T DE69429569T2 DE 69429569 T2 DE69429569 T2 DE 69429569T2 DE 69429569 T DE69429569 T DE 69429569T DE 69429569 T DE69429569 T DE 69429569T DE 69429569 T2 DE69429569 T2 DE 69429569T2
- Authority
- DE
- Germany
- Prior art keywords
- cyclopropylmethyl
- hydroxymethyl
- bis
- preparation
- pyrimidine derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
- C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/553—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms with halogen atoms or nitro radicals directly attached to ring carbon atoms, e.g. fluorouracil
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP26349093 | 1993-10-21 |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69429569D1 DE69429569D1 (de) | 2002-02-07 |
DE69429569T2 true DE69429569T2 (de) | 2002-09-19 |
Family
ID=17390246
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69429569T Expired - Lifetime DE69429569T2 (de) | 1993-10-21 | 1994-10-21 | Bis(hydroxymethyl)cyclopropylmethyl Pyrimidin Derivate, deren Herstellung und deren Verwendung als anti-virale Mittel |
Country Status (7)
Country | Link |
---|---|
US (1) | US5496824A (de) |
EP (1) | EP0649840B1 (de) |
KR (1) | KR950011530A (de) |
CN (1) | CN1106392A (de) |
CA (1) | CA2134050A1 (de) |
DE (1) | DE69429569T2 (de) |
TW (1) | TW271438B (de) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2217026C (en) * | 1996-02-22 | 2001-11-20 | Samjin Pharmaceutical Co., Ltd. | New antiviral substituted pyrimidinedione homocarbocyclic nucleoside derivatives and methods for the preparation thereof and compositions containing the same as active ingredients |
ES2574785T3 (es) | 2011-11-10 | 2016-06-22 | Aratana Therapeutics Nv | Procedimiento para preparar derivados de ciclopropano |
BR112014017163A8 (pt) | 2012-01-20 | 2017-07-04 | Aratana Therapeutics Nv | composição de colírio |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4863927A (en) * | 1987-05-11 | 1989-09-05 | Merck & Co., Inc. | 1-(2-hydroxymethyl)cycloalkylmethyl)-5-substituted uracils |
CA2042931A1 (en) * | 1990-05-24 | 1991-11-25 | Robert Zahler | Fluorinated bis (hydroxymethyl) cyclobutyl purines and pyrimidines |
USH1142H (en) * | 1990-11-05 | 1993-02-02 | Optically active cyclobutyl pyrimidine | |
ES2139588T3 (es) * | 1991-03-05 | 2000-02-16 | Ajinomoto Kk | Derivado de ciclopropano. |
-
1994
- 1994-10-19 KR KR1019940026704A patent/KR950011530A/ko not_active Application Discontinuation
- 1994-10-21 US US08/327,851 patent/US5496824A/en not_active Expired - Lifetime
- 1994-10-21 CA CA002134050A patent/CA2134050A1/en not_active Abandoned
- 1994-10-21 CN CN94117485A patent/CN1106392A/zh active Pending
- 1994-10-21 DE DE69429569T patent/DE69429569T2/de not_active Expired - Lifetime
- 1994-10-21 EP EP94307743A patent/EP0649840B1/de not_active Expired - Lifetime
- 1994-10-21 TW TW083109777A patent/TW271438B/zh active
Also Published As
Publication number | Publication date |
---|---|
KR950011530A (ko) | 1995-05-15 |
CA2134050A1 (en) | 1995-04-22 |
EP0649840B1 (de) | 2002-01-02 |
US5496824A (en) | 1996-03-05 |
DE69429569D1 (de) | 2002-02-07 |
CN1106392A (zh) | 1995-08-09 |
EP0649840A1 (de) | 1995-04-26 |
TW271438B (de) | 1996-03-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |