DE69429468D1 - Antikrebs-Mitoxantrone-Polymer Zusammensetzung - Google Patents

Antikrebs-Mitoxantrone-Polymer Zusammensetzung

Info

Publication number
DE69429468D1
DE69429468D1 DE69429468T DE69429468T DE69429468D1 DE 69429468 D1 DE69429468 D1 DE 69429468D1 DE 69429468 T DE69429468 T DE 69429468T DE 69429468 T DE69429468 T DE 69429468T DE 69429468 D1 DE69429468 D1 DE 69429468D1
Authority
DE
Germany
Prior art keywords
mitoxantrone
cancer
polymer composition
antitumor
mve
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69429468T
Other languages
English (en)
Other versions
DE69429468T2 (de
Inventor
Hwei-Ru Tsou
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth Holdings LLC
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of DE69429468D1 publication Critical patent/DE69429468D1/de
Application granted granted Critical
Publication of DE69429468T2 publication Critical patent/DE69429468T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/765—Polymers containing oxygen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Pyrane Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
DE69429468T 1993-03-25 1994-02-17 Antikrebs-Mitoxantrone-Polymer Zusammensetzung Expired - Lifetime DE69429468T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/037,149 US5378456A (en) 1993-03-25 1993-03-25 Antitumor mitoxantrone polymeric compositions

Publications (2)

Publication Number Publication Date
DE69429468D1 true DE69429468D1 (de) 2002-01-31
DE69429468T2 DE69429468T2 (de) 2002-08-14

Family

ID=21892713

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69429468T Expired - Lifetime DE69429468T2 (de) 1993-03-25 1994-02-17 Antikrebs-Mitoxantrone-Polymer Zusammensetzung

Country Status (11)

Country Link
US (1) US5378456A (de)
EP (1) EP0616813B1 (de)
JP (1) JPH06321927A (de)
KR (1) KR100348380B1 (de)
AT (1) ATE210996T1 (de)
CA (1) CA2119675A1 (de)
DE (1) DE69429468T2 (de)
DK (1) DK0616813T3 (de)
ES (1) ES2169049T3 (de)
PT (1) PT616813E (de)
SG (1) SG52340A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ533467A (en) * 1993-07-19 2006-02-24 Angiotech Pharm Inc Anti-angiogenic compositions and methods of use
US20030203976A1 (en) 1993-07-19 2003-10-30 William L. Hunter Anti-angiogenic compositions and methods of use
US5609867A (en) 1994-11-01 1997-03-11 American Cyanamid Company Polymeric antitumor agents
US6624317B1 (en) 2000-09-25 2003-09-23 The University Of North Carolina At Chapel Hill Taxoid conjugates as antimitotic and antitumor agents
HUP0303719A2 (hu) * 2000-10-16 2004-03-01 Neopharm, Inc. Mitoxantron hatóanyag-tartalmú liposzómás gyógyszerkészítmények és eljárás az előállításukra
GB0123232D0 (en) * 2001-09-26 2001-11-21 Smith & Nephew Polymers
US7939054B2 (en) * 2006-10-27 2011-05-10 Giuseppe Trigiante Compositions for removing hair
WO2015013579A1 (en) 2013-07-26 2015-01-29 Update Pharma Inc. Compositions to improve the therapeutic benefit of bisantrene
EP4349325A1 (de) * 2021-05-28 2024-04-10 CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd. Verwendung von mitoxantronhydrochloridliposomen zur herstellung von arzneimitteln zur behandlung fortgeschrittener solider tumoren

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4182800A (en) * 1977-07-16 1980-01-08 Hercules Incorporated Methotrexate-divinyl ether--maleic anhydride copolymer reaction product
JPS6067490A (ja) * 1983-09-24 1985-04-17 Agency Of Ind Science & Technol アントラサイクリン系抗生物質誘導体及びその製造方法
JPS6067426A (ja) * 1983-09-24 1985-04-17 Agency Of Ind Science & Technol 低毒性制ガン剤
US4520162A (en) * 1983-09-24 1985-05-28 Director-General Of The Agency Of Industrial Science & Technology Polymeric compounds with sustained anti-tumor activity and a method for the preparation thereof
GB8413464D0 (en) * 1984-05-25 1984-07-04 Erba Farmitalia Anthracycline-anionic polymer conjugates
EP0265719B1 (de) * 1986-10-07 1991-03-06 Boehringer Mannheim Italia S.P.A. Pharmazeutische Zusammensetzungen mit antineoplastischer Wirkung
PT93772A (pt) * 1989-04-17 1991-01-08 Searle & Co Processo para a preparacao de composicoes para o tratamento de neoplasias, contendo um agente anti-neoplastico, por exemplo doxorubicina e um agente protector para reduzir os efeitos secundarios, por exemplo carbetimer
JPH0762049B2 (ja) * 1991-03-18 1995-07-05 工業技術院長 高分子マイトマイシンｃ誘導体及びその製造方法
JP3069646B2 (ja) * 1991-05-28 2000-07-24 三共株式会社 ５−フルオロウリジン−高分子複合体

Also Published As

Publication number Publication date
JPH06321927A (ja) 1994-11-22
KR940021068A (ko) 1994-10-17
DE69429468T2 (de) 2002-08-14
PT616813E (pt) 2002-06-28
KR100348380B1 (ko) 2004-03-25
DK0616813T3 (da) 2002-04-15
ATE210996T1 (de) 2002-01-15
EP0616813A2 (de) 1994-09-28
CA2119675A1 (en) 1994-09-26
US5378456A (en) 1995-01-03
ES2169049T3 (es) 2002-07-01
SG52340A1 (en) 1998-09-28
EP0616813B1 (de) 2001-12-19
EP0616813A3 (de) 1995-03-29

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Legal Events

Date Code Title Description
8327 Change in the person/name/address of the patent owner

Owner name: WYETH HOLDINGS CORP., MADISON, N.J., US