DE69429396T2 - Verfahren zur Herstellung von Trans-4-Hydroxy-L-Prolin - Google Patents

Verfahren zur Herstellung von Trans-4-Hydroxy-L-Prolin

Info

Publication number
DE69429396T2
DE69429396T2 DE69429396T DE69429396T DE69429396T2 DE 69429396 T2 DE69429396 T2 DE 69429396T2 DE 69429396 T DE69429396 T DE 69429396T DE 69429396 T DE69429396 T DE 69429396T DE 69429396 T2 DE69429396 T2 DE 69429396T2
Authority
DE
Germany
Prior art keywords
proline
hydroxy
trans
preparation
useful
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69429396T
Other languages
English (en)
Other versions
DE69429396D1 (de
Inventor
Akio Ozaki
Hideo Mori
Takeshi Shibasaki
Katsuhiko Ando
Shigeru Chiba
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kyowa Hakko Bio Co Ltd
Original Assignee
Kyowa Hakko Kogyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Kogyo Co Ltd filed Critical Kyowa Hakko Kogyo Co Ltd
Publication of DE69429396D1 publication Critical patent/DE69429396D1/de
Application granted granted Critical
Publication of DE69429396T2 publication Critical patent/DE69429396T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/14—Glutamic acid; Glutamine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/24—Proline; Hydroxyproline; Histidine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y114/00—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
    • C12Y114/11—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14) with 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors (1.14.11)
    • C12Y114/11002—Procollagen-proline dioxygenase (1.14.11.2), i.e. proline-hydroxylase

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE69429396T 1993-09-07 1994-09-06 Verfahren zur Herstellung von Trans-4-Hydroxy-L-Prolin Expired - Lifetime DE69429396T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP22194093 1993-09-07
JP33256193 1993-12-27

Publications (2)

Publication Number Publication Date
DE69429396D1 DE69429396D1 (de) 2002-01-24
DE69429396T2 true DE69429396T2 (de) 2002-06-13

Family

ID=26524587

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69429396T Expired - Lifetime DE69429396T2 (de) 1993-09-07 1994-09-06 Verfahren zur Herstellung von Trans-4-Hydroxy-L-Prolin

Country Status (7)

Country Link
EP (1) EP0641862B1 (de)
KR (1) KR100356926B1 (de)
CN (2) CN1085253C (de)
AT (1) ATE210729T1 (de)
DE (1) DE69429396T2 (de)
ES (1) ES2164675T3 (de)
HK (1) HK1051218A1 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996027669A1 (fr) * 1995-03-07 1996-09-12 Kyowa Hakko Kogyo Co., Ltd. Procede de production de trans-4-hydroxy-l-proline
JP3739143B2 (ja) * 1996-09-03 2006-01-25 協和醗酵工業株式会社 トランス−４−ヒドロキシ−ｌ−プロリンの製造法
CA2234412C (en) * 1997-06-09 2008-09-02 Kyowa Hakko Kogyo Co., Ltd. Method for producing optically active compound
HUE042605T2 (hu) 2012-05-08 2019-07-29 Codexis Inc Biokatalizátorok és kémiai vegyületek hidroxilálására szolgáló eljárások
HUE036947T2 (hu) 2012-05-11 2018-08-28 Codexis Inc Átalakított iminreduktázok és eljárások keton- és aminvegyületek reduktív aminálására
CN106232619B (zh) 2013-11-13 2022-09-09 科德克希思公司 工程化的亚胺还原酶和用于酮和胺化合物的还原胺化的方法
US10370648B2 (en) 2014-11-25 2019-08-06 Codexis, Inc. Engineered imine reductases and methods for the reductive amination of ketone and amine compounds
CN105483069B (zh) * 2015-12-09 2019-01-18 浙江绿创生物科技有限公司 一株生产反式-4-羟基-l-脯氨酸的重组菌株及其构建与应用
CN109715817B (zh) 2016-06-09 2022-12-09 科德克希思公司 用于化合物的羟基化的生物催化剂和方法
SG11201810998WA (en) 2016-06-15 2019-01-30 Codexis Inc Engineered beta-glucosidases and glucosylation methods
US11046936B2 (en) 2016-08-26 2021-06-29 Codexis, Inc. Engineered imine reductases and methods for the reductive amination of ketone and amine compounds
CN116855551A (zh) * 2023-08-22 2023-10-10 石家庄市冀荣药业有限公司 一种生物法转化生产l-羟脯氨酸的方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0190350A1 (de) * 1984-07-31 1986-08-13 NAGAI, Yoshiki Verfahren zur herstellung menschlicher hydroxylase
WO1993004181A1 (en) * 1991-08-26 1993-03-04 Kyowa Hakko Kogyo Co., Ltd. Process for producing 4-hydroxy-l-proline
JPH05236980A (ja) * 1991-12-17 1993-09-17 Sankyo Co Ltd トランス−４−ヒドロキシ−ｌ−プロリンの製造法

Also Published As

Publication number Publication date
ATE210729T1 (de) 2001-12-15
EP0641862A2 (de) 1995-03-08
KR950008692A (ko) 1995-04-19
HK1051218A1 (en) 2003-07-25
CN1106457A (zh) 1995-08-09
EP0641862A3 (de) 1997-06-04
CN1085253C (zh) 2002-05-22
DE69429396D1 (de) 2002-01-24
KR100356926B1 (ko) 2003-01-10
CN1171992C (zh) 2004-10-20
ES2164675T3 (es) 2002-03-01
EP0641862B1 (de) 2001-12-12
CN1392257A (zh) 2003-01-22

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Legal Events

Date Code Title Description
8327 Change in the person/name/address of the patent owner

Owner name: KYOWA HAKKO BIO CO., LTD., TOKYO, JP