DE69429000D1 - Einwegspritze mit automatischer nadelabdeckung - Google Patents

Einwegspritze mit automatischer nadelabdeckung

Info

Publication number
DE69429000D1
DE69429000D1 DE69429000T DE69429000T DE69429000D1 DE 69429000 D1 DE69429000 D1 DE 69429000D1 DE 69429000 T DE69429000 T DE 69429000T DE 69429000 T DE69429000 T DE 69429000T DE 69429000 D1 DE69429000 D1 DE 69429000D1
Authority
DE
Germany
Prior art keywords
needle cover
disposable syringe
automatic needle
syringe
molded
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69429000T
Other languages
English (en)
Other versions
DE69429000T2 (de
Inventor
R Firth
R Perez
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Safety Syringes Inc
Original Assignee
Safety Syringes Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22299083&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69429000(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Safety Syringes Inc filed Critical Safety Syringes Inc
Application granted granted Critical
Publication of DE69429000D1 publication Critical patent/DE69429000D1/de
Publication of DE69429000T2 publication Critical patent/DE69429000T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/15Devices for taking samples of blood
    • A61B5/153Devices specially adapted for taking samples of venous or arterial blood, e.g. with syringes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/15Devices for taking samples of blood
    • A61B5/150007Details
    • A61B5/150015Source of blood
    • A61B5/15003Source of blood for venous or arterial blood
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/15Devices for taking samples of blood
    • A61B5/150007Details
    • A61B5/150206Construction or design features not otherwise provided for; manufacturing or production; packages; sterilisation of piercing element, piercing device or sampling device
    • A61B5/150236Pistons, i.e. cylindrical bodies that sit inside the syringe barrel, typically with an air tight seal, and slide in the barrel to create a vacuum or to expel blood
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/15Devices for taking samples of blood
    • A61B5/150007Details
    • A61B5/150206Construction or design features not otherwise provided for; manufacturing or production; packages; sterilisation of piercing element, piercing device or sampling device
    • A61B5/150244Rods for actuating or driving the piston, i.e. the cylindrical body that sits inside the syringe barrel, typically with an air tight seal, and slides in the barrel to create a vacuum or to expel blood
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/15Devices for taking samples of blood
    • A61B5/150007Details
    • A61B5/150206Construction or design features not otherwise provided for; manufacturing or production; packages; sterilisation of piercing element, piercing device or sampling device
    • A61B5/150259Improved gripping, e.g. with high friction pattern or projections on the housing surface or an ergonometric shape
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/15Devices for taking samples of blood
    • A61B5/150007Details
    • A61B5/150374Details of piercing elements or protective means for preventing accidental injuries by such piercing elements
    • A61B5/150534Design of protective means for piercing elements for preventing accidental needle sticks, e.g. shields, caps, protectors, axially extensible sleeves, pivotable protective sleeves
    • A61B5/150633Protective sleeves which are axially extensible, e.g. sleeves connected to, or integrated in, the piercing or driving device; pivotable protective sleeves
    • A61B5/150641Protective sleeves which are axially extensible, e.g. sleeves connected to, or integrated in, the piercing or driving device; pivotable protective sleeves comprising means to impede repositioning of protection sleeve from covering to uncovering position
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/15Devices for taking samples of blood
    • A61B5/150007Details
    • A61B5/150732Needle holders, for instance for holding the needle by the hub, used for example with double-ended needle and pre-evacuated tube
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/41Detecting, measuring or recording for evaluating the immune or lymphatic systems
    • A61B5/411Detecting or monitoring allergy or intolerance reactions to an allergenic agent or substance
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00Catheters; Hollow probes
    • A61M25/01Introducing, guiding, advancing, emplacing or holding catheters
    • A61M25/06Body-piercing guide needles or the like
    • A61M25/0612Devices for protecting the needle; Devices to help insertion of the needle, e.g. wings or holders
    • A61M25/0631Devices for protecting the needle; Devices to help insertion of the needle, e.g. wings or holders having means for fully covering the needle after its withdrawal, e.g. needle being withdrawn inside the handle or a cover being advanced over the needle
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/31Details
    • A61M5/32Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/3205Apparatus for removing or disposing of used needles or syringes, e.g. containers; Means for protection against accidental injuries from used needles
    • A61M5/321Means for protection against accidental injuries by used needles
    • A61M5/3243Means for protection against accidental injuries by used needles being axially-extensible, e.g. protective sleeves coaxially slidable on the syringe barrel
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/15Devices for taking samples of blood
    • A61B5/150007Details
    • A61B5/150374Details of piercing elements or protective means for preventing accidental injuries by such piercing elements
    • A61B5/150381Design of piercing elements
    • A61B5/150389Hollow piercing elements, e.g. canulas, needles, for piercing the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/15Devices for taking samples of blood
    • A61B5/150007Details
    • A61B5/150374Details of piercing elements or protective means for preventing accidental injuries by such piercing elements
    • A61B5/150381Design of piercing elements
    • A61B5/150473Double-ended needles, e.g. used with pre-evacuated sampling tubes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/31Details
    • A61M5/3129Syringe barrels
    • A61M5/3137Specially designed finger grip means, e.g. for easy manipulation of the syringe rod
    • A61M2005/3139Finger grips not integrally formed with the syringe barrel, e.g. using adapter with finger grips
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00General characteristics of the apparatus
    • A61M2205/58Means for facilitating use, e.g. by people with impaired vision
    • A61M2205/581Means for facilitating use, e.g. by people with impaired vision by audible feedback
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00General characteristics of the apparatus
    • A61M2205/58Means for facilitating use, e.g. by people with impaired vision
    • A61M2205/582Means for facilitating use, e.g. by people with impaired vision by tactile feedback
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00General characteristics of the apparatus
    • A61M2205/58Means for facilitating use, e.g. by people with impaired vision
    • A61M2205/583Means for facilitating use, e.g. by people with impaired vision by visual feedback
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00General characteristics of the apparatus
    • A61M2205/59Aesthetic features, e.g. distraction means to prevent fears of child patients
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/24Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/31Details
    • A61M5/32Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/3205Apparatus for removing or disposing of used needles or syringes, e.g. containers; Means for protection against accidental injuries from used needles
    • A61M5/321Means for protection against accidental injuries by used needles
    • A61M5/3243Means for protection against accidental injuries by used needles being axially-extensible, e.g. protective sleeves coaxially slidable on the syringe barrel
    • A61M5/3271Means for protection against accidental injuries by used needles being axially-extensible, e.g. protective sleeves coaxially slidable on the syringe barrel with guiding tracks for controlled sliding of needle protective sleeve from needle exposing to needle covering position

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Manufacturing & Machinery (AREA)
  • Anesthesiology (AREA)
  • Vascular Medicine (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Environmental & Geological Engineering (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
DE69429000T 1993-08-09 1994-08-08 Einwegspritze mit automatischer nadelabdeckung Expired - Fee Related DE69429000T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/104,182 US5437647A (en) 1990-05-09 1993-08-09 Disposable self-shielding aspirating syringe
PCT/US1994/008966 WO1995004565A1 (en) 1993-08-09 1994-08-08 Disposable self-shielding aspirating syringe

Publications (2)

Publication Number Publication Date
DE69429000D1 true DE69429000D1 (de) 2001-12-13
DE69429000T2 DE69429000T2 (de) 2002-06-20

Family

ID=22299083

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69429000T Expired - Fee Related DE69429000T2 (de) 1993-08-09 1994-08-08 Einwegspritze mit automatischer nadelabdeckung

Country Status (7)

Country Link
US (1) US5437647A (de)
EP (1) EP0713404B1 (de)
JP (1) JP3704349B2 (de)
AT (1) ATE208219T1 (de)
CA (1) CA2168567A1 (de)
DE (1) DE69429000T2 (de)
WO (1) WO1995004565A1 (de)

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FR2733687B1 (fr) * 1995-05-04 1997-10-03 Brunel Marc Procede de fabrication d'un dispositif d'injection du type pre-rempli renfermant une dose de liquide a injecter, et dispositif d'injection realise
EP0894014A4 (de) * 1996-02-20 1999-12-22 Abbott Lab Spritzenhalter mit einem wegwerfbaren körper für subkutane injektionen
USD420129S (en) * 1996-09-04 2000-02-01 Nmt Group Plc Syringe barrel
US6171283B1 (en) * 1997-03-10 2001-01-09 Safety Syringes, Inc. Disposable self-shielding unit dose syringe guard
US6159184A (en) * 1997-03-10 2000-12-12 Safety Syringes, Inc. Disposable self-shielding unit dose syringe guard
US6004296A (en) * 1997-09-30 1999-12-21 Becton Dickinson France, S.A. Lockable safety shield assembly for a prefillable syringe
US6719730B2 (en) 1998-04-17 2004-04-13 Becton, Dickinson And Company Safety shield system for prefilled syringes
US6679864B2 (en) 1998-04-17 2004-01-20 Becton Dickinson And Company Safety shield system for prefilled syringes
US6319233B1 (en) 1998-04-17 2001-11-20 Becton, Dickinson And Company Safety shield system for prefilled syringes
JP2000107289A (ja) * 1998-10-05 2000-04-18 Showa Yakuhin Kako Kk カートリッジ式歯科用注射器ユニット
US6030366A (en) * 1998-11-09 2000-02-29 Safety Syringes, Inc. Syringe guard system for a unit dose syringe
US6036675A (en) * 1999-02-03 2000-03-14 Specialized Health Products, Inc. Safety sterile cartride unit apparatus and methods
US20020193740A1 (en) 1999-10-14 2002-12-19 Alchas Paul G. Method of intradermally injecting substances
US6569123B2 (en) 1999-10-14 2003-05-27 Becton, Dickinson And Company Prefillable intradermal injector
US6569143B2 (en) 1999-10-14 2003-05-27 Becton, Dickinson And Company Method of intradermally injecting substances
US6382204B1 (en) * 1999-10-14 2002-05-07 Becton Dickinson And Company Drug delivery system including holder and drug container
US6494865B1 (en) 1999-10-14 2002-12-17 Becton Dickinson And Company Intradermal delivery device including a needle assembly
US6776776B2 (en) * 1999-10-14 2004-08-17 Becton, Dickinson And Company Prefillable intradermal delivery device
US6843781B2 (en) * 1999-10-14 2005-01-18 Becton, Dickinson And Company Intradermal needle
AU2001264130A1 (en) * 2000-06-15 2001-12-24 Hambley Limited Hypodermic syringe with passive aspiration feature
JP2004531578A (ja) * 2001-06-29 2004-10-14 ベクトン・ディキンソン・アンド・カンパニー ワクチンおよび遺伝子治療剤のマイクロカニューレによる皮内送達
US20060018877A1 (en) * 2001-06-29 2006-01-26 Mikszta John A Intradermal delivery of vacccines and therapeutic agents
FR2830765B1 (fr) * 2001-10-15 2004-07-23 Plastic Omnium Cie Dispositif de securite pour une seringue
US7045089B2 (en) * 2002-01-11 2006-05-16 Afromowitz Martin A Fabrication of molds and mold components using a photolithographic technique and structures made therefrom
US6976976B2 (en) 2002-03-27 2005-12-20 Safety Syringes, Inc. Syringe with needle guard injection device
DE10254195A1 (de) * 2002-11-20 2004-06-09 Pajunk Ohg Besitzverwaltung Ampullenhalter
US20040186437A1 (en) * 2003-03-20 2004-09-23 Frenette Claude E. Content-coded medical syringe, syringe set and syringe content identification method
JP2005021351A (ja) * 2003-07-01 2005-01-27 Kyo Meisei ディスポーザブルシリンジ
US7500963B2 (en) * 2003-07-22 2009-03-10 Safety Syringes, Inc. Systems and methods for automatic medical injection with safeguard
KR200333670Y1 (ko) * 2003-08-25 2003-11-19 방영철 일회용 안전주사기
US8372044B2 (en) * 2005-05-20 2013-02-12 Safety Syringes, Inc. Syringe with needle guard injection device
US7766937B2 (en) * 2006-03-13 2010-08-03 Mini-Lap Technologies, Inc. Minimally invasive surgical assembly and methods
GB0815748D0 (en) * 2008-08-29 2008-10-08 Liversidge Barry P Medical needle assembly
CA2751564C (en) * 2009-02-06 2019-09-10 Joshua Horvath Pen needle to facilitate manipulation by users having physical or visual impairment
US9326757B2 (en) 2009-12-31 2016-05-03 Teleflex Medical Incorporated Surgical instruments for laparoscopic aspiration and retraction
US9301833B2 (en) * 2012-04-20 2016-04-05 Staar Surgical Company Pre-loaded injector for use with intraocular lens
CA2854003C (en) 2011-11-07 2020-07-14 Safety Syringes, Inc. Contact trigger release needle guard
KR102160315B1 (ko) * 2012-04-20 2020-09-28 스타 서지컬 컴퍼니 안구내 렌즈와 사용하기 위한 사전-장전 인젝터
EP2953672A1 (de) * 2013-02-08 2015-12-16 Sanofi-Aventis Deutschland GmbH Arzneimittelabgabevorrichtung mit nadelschutz
USD734490S1 (en) * 2013-10-03 2015-07-14 3M Innovative Properties Company Mixing tip
USD739932S1 (en) * 2014-03-03 2015-09-29 Sanofi Medicament injection device
BR112017004765B1 (pt) 2014-09-09 2022-08-23 Staar Surgical Company Lente configurada para implantação em um olho de um humano
BR112018068184B1 (pt) 2016-03-09 2023-02-14 Staar Surgical Company Lente configurada para implantação em um olho de um ser humano
EP3299082A1 (de) 2016-09-21 2018-03-28 3M Innovative Properties Company Mischeranordnung und vorrichtung zur ausgabe eines zahnmaterials
US10774164B2 (en) 2018-08-17 2020-09-15 Staar Surgical Company Polymeric composition exhibiting nanogradient of refractive index
USD894381S1 (en) 2019-03-29 2020-08-25 Retractable Technologies, Inc. Syringe barrel
USD914874S1 (en) 2019-07-12 2021-03-30 Retractable Technologies, Inc Syringe barrel
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US3046985A (en) * 1958-12-19 1962-07-31 Saenz Candelario Dental syringe adapter
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US4747837A (en) * 1987-05-01 1988-05-31 Hauck Martin W Syringe needle recapping protective device
US4772272A (en) * 1987-05-11 1988-09-20 Mcfarland Barton C Needle protective sleeve
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US5112307A (en) * 1990-04-24 1992-05-12 Habley Medical Technology Corp. Dental syringe having a medication filled carpule and an automatically-detaching piston stem
US5279581A (en) * 1990-05-09 1994-01-18 Firth John R Disposable self-shielding hypodermic syringe
WO1992018183A1 (en) * 1991-04-15 1992-10-29 Sherwood Medical Company Combined syringe and needle shield
SA90100123B1 (ar) * 1991-04-16 1995-12-23 عمر محمد محمد الزين حقنة طبيب الاسنان ذات الحماية الذاتية
US5163917A (en) * 1991-09-26 1992-11-17 Norman Huefner Barrel mounted needle guard for hypodermic syringes

Also Published As

Publication number Publication date
DE69429000T2 (de) 2002-06-20
EP0713404B1 (de) 2001-11-07
EP0713404A4 (de) 1997-07-09
US5437647A (en) 1995-08-01
WO1995004565A1 (en) 1995-02-16
JPH09501085A (ja) 1997-02-04
EP0713404A1 (de) 1996-05-29
JP3704349B2 (ja) 2005-10-12
CA2168567A1 (en) 1995-02-16
ATE208219T1 (de) 2001-11-15

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