DE69420556D1 - Assay für troponin i aus dem herzmuskel - Google Patents

Assay für troponin i aus dem herzmuskel

Info

Publication number
DE69420556D1
DE69420556D1 DE69420556T DE69420556T DE69420556D1 DE 69420556 D1 DE69420556 D1 DE 69420556D1 DE 69420556 T DE69420556 T DE 69420556T DE 69420556 T DE69420556 T DE 69420556T DE 69420556 D1 DE69420556 D1 DE 69420556D1
Authority
DE
Germany
Prior art keywords
troponin
assay
heart muscle
cardiac troponin
binding partner
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69420556T
Other languages
English (en)
Other versions
DE69420556T2 (de
Inventor
Richard Wicks
Leslie Zartman
Annette Vargas
Stacy Torretti
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fortron Bioscience Inc
Original Assignee
Fortron Bioscience Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fortron Bioscience Inc filed Critical Fortron Bioscience Inc
Publication of DE69420556D1 publication Critical patent/DE69420556D1/de
Application granted granted Critical
Publication of DE69420556T2 publication Critical patent/DE69420556T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6887—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids from muscle, cartilage or connective tissue
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4716—Muscle proteins, e.g. myosin, actin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701—Details
    • G01N2333/4712—Muscle proteins, e.g. myosin, actin, protein
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/975—Kit
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/807—Apparatus included in process claim, e.g. physical support structures
    • Y10S436/808—Automated or kit
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/811—Test for named disease, body condition or organ function

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Urology & Nephrology (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
DE69420556T 1993-05-17 1994-05-16 Assay für troponin i aus dem herzmuskel Expired - Lifetime DE69420556T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6316893A 1993-05-17 1993-05-17
PCT/US1994/005468 WO1994027156A1 (en) 1993-05-17 1994-05-16 Assay for cardiac troponin i

Publications (2)

Publication Number Publication Date
DE69420556D1 true DE69420556D1 (de) 1999-10-14
DE69420556T2 DE69420556T2 (de) 2000-03-23

Family

ID=22047398

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69420556T Expired - Lifetime DE69420556T2 (de) 1993-05-17 1994-05-16 Assay für troponin i aus dem herzmuskel

Country Status (8)

Country Link
US (2) US5756682A (de)
EP (1) EP0699306B1 (de)
JP (1) JPH09503050A (de)
AT (1) ATE184400T1 (de)
AU (1) AU689777B2 (de)
CA (1) CA2162121A1 (de)
DE (1) DE69420556T2 (de)
WO (1) WO1994027156A1 (de)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2729761B1 (fr) * 1995-01-19 1997-12-05 Pasteur Sanofi Diagnostics Procede de dosage ultrasensible de la troponine i cardiaque
FR2729759A1 (fr) * 1995-01-19 1996-07-26 Pasteur Sanofi Diagnostics Procede de dosage ultrasensible de la troponine i cardiaque
US6165981A (en) * 1995-03-07 2000-12-26 Dade Behring Inc. Stabilizing solutions for proteins and peptides
US6991907B1 (en) 1995-04-18 2006-01-31 Biosite, Inc. Methods for the assay of troponin I and T and complexes of troponin I and T and selection of antibodies for use in immunoassays
US5795725A (en) * 1995-04-18 1998-08-18 Biosite Diagnostics Incorporated Methods for the assay of troponin I and T and selection of antibodies for use in immunoassays
US6627404B1 (en) 1995-04-18 2003-09-30 Biosite, Inc. Methods for improving the recovery of troponin I and T in membranes, filters and vessels
DE69633780T3 (de) 1995-04-18 2011-05-05 Biosite Incorporated, San Diego Verfahren zum assay von troponin i und t und komplexen von troponin i und t und auswahl von antikörpern zur verwendung in immunoassays
FR2734267B1 (fr) * 1995-05-16 1997-08-01 Pasteur Sanofi Diagnostics Composition stabilisee de troponine pour immunoessais et procede de preparation d'une telle composition stabilisee
DE19548028A1 (de) * 1995-12-21 1997-06-26 Bayer Ag Verfahren zur Herstellung eines synthetischen Kalibrators für den Einsatz in Sandwich-Immunoassays, bestehend aus einem Antikörper gegen einen der im Assay benutzten Antikörper und einer Sequenz des Analyten
DE69713517D1 (de) 1996-10-15 2002-07-25 Medical Analysis Systems Inc Verfahren zur Stabilisierung von Troponin I (CTnI) durch Konjugation mit einem activen Polymer
DE19647927A1 (de) * 1996-11-20 1998-05-28 Bayer Ag Verfahren zur Herstellung einer stabilen Troponin I Präparation und dessen Verwendung als Kalibrator in Immunoassays
FR2756827B1 (fr) * 1996-12-05 1999-01-29 Pasteur Sanofi Diagnostics Composes synthetiques biepitopiques utilisables comme etalons dans les dosages biologiques de la troponine i
US6156521A (en) * 1997-12-19 2000-12-05 Biosite Diagnostics, Inc. Methods for the recovery and measurement of troponin complexes
WO1998029726A2 (en) * 1996-12-27 1998-07-09 Coulter International Corp. Method of detecting and determining the concentration of total troponin i in a biological sample
US5947124A (en) * 1997-03-11 1999-09-07 Biosite Diagnostics Incorporated Diagnostic for determining the time of a heart attack
JP2002508839A (ja) * 1997-05-29 2002-03-19 メディカル アナリシス システムズ，インコーポレイテッド 共有結合したトロポニン複合体
US6248869B1 (en) * 1997-05-29 2001-06-19 Medical Analysis Systems, Inc. Troponin I forms and use of the same
US7384751B1 (en) 1997-07-16 2008-06-10 Queen's University At Kingston Methods of diagnosing muscle damage
AU6117099A (en) * 1998-10-21 2000-05-08 Spectral Diagnostics Inc. Cardiac troponin i polypeptide fragments and uses in diagnostics
US6190916B1 (en) * 1999-06-29 2001-02-20 Spectral Diagnostics, Inc. Troponin I composition
US7618782B1 (en) * 1999-10-18 2009-11-17 Queen's University At Kingston Methods of diagnosing muscle damage
US7078486B2 (en) 1999-12-10 2006-07-18 Spectral Diagnostics, Inc. Single-chain polypeptides comprising troponin I and troponin C
AU8742301A (en) 2000-08-21 2002-03-04 Univ Kingston Methods and kits for separation and detection of proteins in biological samples
US6538104B2 (en) 2001-04-27 2003-03-25 Medical Analysis Systems, Inc. Stabilization of cardiac troponin I subunits and complexes
US20040018577A1 (en) * 2002-07-29 2004-01-29 Emerson Campbell John Lewis Multiple hybrid immunoassay
US7196169B2 (en) 2002-10-11 2007-03-27 Queen's University At Kingston Isolated post-translationally modified mammalian proteins for monitoring and diagnosing muscle damage
US20040096983A1 (en) * 2002-11-14 2004-05-20 Jacobs Merrit N. Wash process for a sample being analyzed
DE602004030898D1 (de) * 2003-04-16 2011-02-17 Tasuku Honjo Screening-verfahren für heilmittel gegen herzkrankheit und medizinische zusammensetzung zur behandlung von herzkrankheit
US7473548B2 (en) 2003-04-25 2009-01-06 Medtronic, Inc. Optical detector for enzyme activation
FI20030652A0 (fi) * 2003-04-30 2003-04-30 Susann Eriksson Parannettu immunomääritys
US20050096516A1 (en) * 2003-10-30 2005-05-05 Orhan Soykan Optical detector of organic analyte
US20050164409A1 (en) * 2003-12-10 2005-07-28 Kiernan Urban A. Method and apparatus for mass spectrometric immunoassay analysis of specific biological fluid proteins
US20110076697A1 (en) * 2009-04-28 2011-03-31 Innovative Laboratory Technologies, Inc. Lateral-flow immuno-chromatographic assay devices
US9000769B2 (en) 2009-11-23 2015-04-07 Proxim Diagnostics Controlled electrochemical activation of carbon-based electrodes
US20110306148A1 (en) 2010-06-14 2011-12-15 Siemens Healthcare Diagnostics Inc. Composition for use as an assay reagent
ES2627337T3 (es) 2010-08-26 2017-07-27 F. Hoffmann-La Roche Ag Uso de biomarcadores para controlar una medicación en un sujeto que padece insuficiencia cardíaca
WO2013015822A1 (en) 2011-07-25 2013-01-31 Mikhail Briman Cartridge for diagnostic testing
US8603759B2 (en) * 2011-12-06 2013-12-10 Panasonic Corporation Recombinant protein capable of binding specifically and quickly to troponin I derived from human myocardium
KR101492696B1 (ko) * 2011-12-09 2015-02-12 경북대학교 산학협력단 심근 트로포닌 ⅰ과 특이적으로 결합하는 폴리펩타이드 및 이의 용도
US8663933B2 (en) 2011-12-16 2014-03-04 Panasonic Corporation Recombinant protein capable of binding specifically and quickly to troponin I derived from human myocardium
JPWO2013088587A1 (ja) * 2011-12-16 2015-04-27 パナソニックヘルスケア株式会社 ヒト心筋由来トロポニンｉに特異的にかつ速やかに結合できる組み換えタンパク質
US8603760B2 (en) * 2011-12-20 2013-12-10 Panasonic Corporation Recombinant protein capable of binding specifically and quickly to troponin I derived from human myocardium
US10175250B2 (en) * 2012-06-11 2019-01-08 Gabriela Venturini Da Silva Nitrated cardiac troponin I as a biomarker of cardiac ischemia
CA3103560C (en) 2014-09-26 2023-01-17 Somalogic, Inc. Cardiovascular risk event prediction and uses thereof
CN109912713B (zh) * 2019-01-08 2022-09-13 美康生物科技股份有限公司 用于免疫诊断试剂配制的肌钙蛋白i抗体的制备方法及获得的菌株

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Publication number Priority date Publication date Assignee Title
US4614712A (en) * 1983-02-25 1986-09-30 The Upjohn Company Immunoassays with luciferase labeled ligands or receptors
US4912033A (en) * 1985-11-14 1990-03-27 Washington University Creatine kinase MB determination method
GB2200358B (en) * 1987-01-27 1991-02-27 Univ Birmingham Materials for in vivo detection of cardiac damage, and methods for their preparation
DE3922873A1 (de) * 1989-04-25 1990-10-31 Boehringer Mannheim Gmbh Spezifische antikoerper gegen troponin t, ihre herstellung und verwendung in einem reagenz zur bestimmung von hermuskelnekrosen
CA2027434C (en) * 1990-10-12 1999-01-05 George Jackowski Diagnostic kit for diagnosing and distinguishing chest pain in early onset thereof
DE4243648A1 (de) * 1992-12-23 1994-07-07 Boehringer Mannheim Gmbh Verfahren zur Bestimmung von Herzmuskelnekrosen mittels Antikörper gegen das N-terminale Troponin I-Peptid

Also Published As

Publication number Publication date
US5834220A (en) 1998-11-10
WO1994027156A1 (en) 1994-11-24
EP0699306B1 (de) 1999-09-08
AU6834894A (en) 1994-12-12
CA2162121A1 (en) 1994-11-24
JPH09503050A (ja) 1997-03-25
EP0699306A1 (de) 1996-03-06
US5756682A (en) 1998-05-26
DE69420556T2 (de) 2000-03-23
ATE184400T1 (de) 1999-09-15
AU689777B2 (en) 1998-04-09

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Legal Events

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