DE69410956T2 - Naphthylessigsäurederivate als PGEZ Agonisten und Antagonisten - Google Patents
Naphthylessigsäurederivate als PGEZ Agonisten und AntagonistenInfo
- Publication number
- DE69410956T2 DE69410956T2 DE69410956T DE69410956T DE69410956T2 DE 69410956 T2 DE69410956 T2 DE 69410956T2 DE 69410956 T DE69410956 T DE 69410956T DE 69410956 T DE69410956 T DE 69410956T DE 69410956 T2 DE69410956 T2 DE 69410956T2
- Authority
- DE
- Germany
- Prior art keywords
- alkyl
- agonists
- acid derivatives
- antagonists
- pgez
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000000556 agonist Substances 0.000 title abstract 2
- 239000005557 antagonist Substances 0.000 title abstract 2
- PRPINYUDVPFIRX-UHFFFAOYSA-N 1-naphthaleneacetic acid Chemical class C1=CC=C2C(CC(=O)O)=CC=CC2=C1 PRPINYUDVPFIRX-UHFFFAOYSA-N 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- GHRYSOFWKRRLMI-UHFFFAOYSA-N 1-naphthyloxyacetic acid Chemical class C1=CC=C2C(OCC(=O)O)=CC=CC2=C1 GHRYSOFWKRRLMI-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- XEYBRNLFEZDVAW-ARSRFYASSA-N dinoprostone Chemical compound CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1C\C=C/CCCC(O)=O XEYBRNLFEZDVAW-ARSRFYASSA-N 0.000 abstract 1
- 229960002986 dinoprostone Drugs 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- XEYBRNLFEZDVAW-UHFFFAOYSA-N prostaglandin E2 Natural products CCCCCC(O)C=CC1C(O)CC(=O)C1CC=CCCCC(O)=O XEYBRNLFEZDVAW-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
- C07C311/12—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings
- C07C311/13—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings the carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
- C07C311/23—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atoms of the sulfonamide groups bound to acyclic carbon atoms
- C07C311/25—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atoms of the sulfonamide groups bound to acyclic carbon atoms of a saturated carbon skeleton containing rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/18—Sulfonamides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
- C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C311/08—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/20—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
- C07C311/23—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atoms of the sulfonamide groups bound to acyclic carbon atoms
- C07C311/27—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atoms of the sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
- C07C311/28—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
- C07C311/29—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP34085493 | 1993-12-09 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69410956D1 DE69410956D1 (de) | 1998-07-16 |
| DE69410956T2 true DE69410956T2 (de) | 1999-03-25 |
Family
ID=18340925
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69410956T Expired - Fee Related DE69410956T2 (de) | 1993-12-09 | 1994-12-07 | Naphthylessigsäurederivate als PGEZ Agonisten und Antagonisten |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US5624959A (de) |
| EP (1) | EP0657422B1 (de) |
| KR (1) | KR100191946B1 (de) |
| CN (1) | CN1111612A (de) |
| AT (1) | ATE167181T1 (de) |
| CA (1) | CA2137711A1 (de) |
| DE (1) | DE69410956T2 (de) |
| DK (1) | DK0657422T3 (de) |
| ES (1) | ES2118333T3 (de) |
| GR (1) | GR3027694T3 (de) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6197993B1 (en) | 1996-07-02 | 2001-03-06 | Ono Pharmaceutical Co., Ltd. | Naphthyloxyacetic acid derivatives and a pharmaceutical composition comprising them as an active ingredient |
| WO1997005091A1 (fr) * | 1995-07-26 | 1997-02-13 | Ono Pharmaceutical Co., Ltd. | Derives d'acide naphtyloxyacetique et medicaments integrant ces derives comme principes actifs |
| GB9702194D0 (en) * | 1997-02-04 | 1997-03-26 | Lilly Co Eli | Sulphonide derivatives |
| AU8750298A (en) * | 1997-08-28 | 1999-03-22 | Ono Pharmaceutical Co. Ltd. | Peroxisome proliferator-activated receptor controllers |
| CA2322139A1 (en) | 1998-02-24 | 1999-09-02 | Eli Lilly And Company | Sulphonamide derivatives |
| HUP0201291A3 (en) | 1999-04-28 | 2002-11-28 | Sanofi Aventis Deutschland | Di-aryl acid derivatives as ppar receptor ligands and pharmaceutical compositions containing them |
| GB0124124D0 (en) * | 2001-10-08 | 2001-11-28 | Medical Res Council | Methods of treatment |
| AU2003272962A1 (en) * | 2002-10-10 | 2004-05-04 | Shuh Narumiya | Remedies for allergic diseases |
| SI2035369T1 (sl) * | 2006-07-05 | 2014-11-28 | Fibrotech Therapeutics Pty Ltd | Terapevtske spojine |
| DE102007013855A1 (de) | 2007-03-20 | 2008-09-25 | Merck Patent Gmbh | Substituierte Tetrahydrochinoline |
| US20080265343A1 (en) * | 2007-04-26 | 2008-10-30 | International Business Machines Corporation | Field effect transistor with inverted t shaped gate electrode and methods for fabrication thereof |
| AU2008341010B2 (en) * | 2007-12-21 | 2013-04-18 | Certa Therapeutics Pty. Ltd. | Halogenated analogues of anti-fibrotic agents |
| CN102149676A (zh) * | 2008-08-15 | 2011-08-10 | 霍夫曼-拉罗奇有限公司 | 单芳基氨基四氢化萘类 |
| EP2321268A2 (de) * | 2008-08-15 | 2011-05-18 | F. Hoffmann-La Roche AG | Biarylaminotetraline |
| CA2734104A1 (en) * | 2008-08-15 | 2010-02-18 | F. Hoffmann-La Roche Ag | Substituted aminotetralines |
| KR101322496B1 (ko) | 2008-11-17 | 2013-10-29 | 에프. 호프만-라 로슈 아게 | 나프틸아세트산 |
| JP5373104B2 (ja) | 2008-11-17 | 2013-12-18 | エフ．ホフマン−ラ ロシュ アーゲー | Ｃｒｔｈ２アンタゴニスト又は部分アゴニストとして使用されるナフチル酢酸 |
| AU2009315713A1 (en) | 2008-11-17 | 2010-05-20 | F. Hoffmann-La Roche Ag | Naphthylacetic acids |
| CN105153188B (zh) | 2009-10-22 | 2018-06-01 | 法博太科制药有限公司 | 抗纤维化剂的稠环类似物 |
| US8470884B2 (en) | 2011-11-09 | 2013-06-25 | Hoffmann-La Roche Inc. | Alkenyl naphthylacetic acids |
| CN102964279B (zh) * | 2012-12-12 | 2014-05-07 | 中国药科大学 | 一类具有外周镇痛作用的κ阿片受体激动剂 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3623941A1 (de) * | 1986-07-16 | 1988-01-28 | Bayer Ag | Substituierte amino-5,6,7,8-tetrahydronaphthyl-oxyessigsaeuren, verfahren zu deren herstellung sowie die verwendung als arzneimittel |
| DE3642105A1 (de) * | 1986-12-10 | 1988-06-16 | Bayer Ag | Substituierte aminomethyl-5,6,7,8-tetrahydronaphtyl-oxyessigsaeuren, neue zwischenprodukte, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln |
-
1994
- 1994-12-07 DE DE69410956T patent/DE69410956T2/de not_active Expired - Fee Related
- 1994-12-07 DK DK94309088T patent/DK0657422T3/da active
- 1994-12-07 AT AT94309088T patent/ATE167181T1/de not_active IP Right Cessation
- 1994-12-07 ES ES94309088T patent/ES2118333T3/es not_active Expired - Lifetime
- 1994-12-07 EP EP94309088A patent/EP0657422B1/de not_active Expired - Lifetime
- 1994-12-08 KR KR1019940033236A patent/KR100191946B1/ko not_active IP Right Cessation
- 1994-12-08 US US08/355,187 patent/US5624959A/en not_active Expired - Lifetime
- 1994-12-09 CN CN94112786A patent/CN1111612A/zh active Pending
- 1994-12-09 CA CA002137711A patent/CA2137711A1/en not_active Abandoned
-
1996
- 1996-12-17 US US08/768,291 patent/US5723493A/en not_active Expired - Fee Related
-
1998
- 1998-08-20 GR GR980401871T patent/GR3027694T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ATE167181T1 (de) | 1998-06-15 |
| ES2118333T3 (es) | 1998-09-16 |
| DE69410956D1 (de) | 1998-07-16 |
| KR950017941A (ko) | 1995-07-22 |
| DK0657422T3 (da) | 1998-10-12 |
| EP0657422B1 (de) | 1998-06-10 |
| CN1111612A (zh) | 1995-11-15 |
| US5624959A (en) | 1997-04-29 |
| GR3027694T3 (en) | 1998-11-30 |
| US5723493A (en) | 1998-03-03 |
| CA2137711A1 (en) | 1995-06-10 |
| KR100191946B1 (ko) | 1999-06-15 |
| EP0657422A1 (de) | 1995-06-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8332 | No legal effect for de | ||
| 8370 | Indication related to discontinuation of the patent is to be deleted | ||
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |