DE69403333T2 - Vorrichtungen zum übertragen von flüssigkeiten - Google Patents
Vorrichtungen zum übertragen von flüssigkeitenInfo
- Publication number
- DE69403333T2 DE69403333T2 DE69403333T DE69403333T DE69403333T2 DE 69403333 T2 DE69403333 T2 DE 69403333T2 DE 69403333 T DE69403333 T DE 69403333T DE 69403333 T DE69403333 T DE 69403333T DE 69403333 T2 DE69403333 T2 DE 69403333T2
- Authority
- DE
- Germany
- Prior art keywords
- channel
- flow
- channels
- site
- sample
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000007788 liquid Substances 0.000 title claims description 48
- 239000012530 fluid Substances 0.000 claims description 32
- 239000002699 waste material Substances 0.000 claims description 30
- 239000000126 substance Substances 0.000 claims description 15
- 239000003153 chemical reaction reagent Substances 0.000 claims description 14
- 239000011148 porous material Substances 0.000 claims description 13
- 238000000034 method Methods 0.000 claims description 12
- 230000009471 action Effects 0.000 claims description 9
- 239000012528 membrane Substances 0.000 claims description 9
- 238000012546 transfer Methods 0.000 claims description 8
- 238000000926 separation method Methods 0.000 claims description 7
- 238000011144 upstream manufacturing Methods 0.000 claims description 5
- 230000000007 visual effect Effects 0.000 claims description 3
- 230000032258 transport Effects 0.000 claims description 2
- 238000003556 assay Methods 0.000 claims 1
- 239000000523 sample Substances 0.000 description 73
- 238000004458 analytical method Methods 0.000 description 43
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 14
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 14
- 210000002966 serum Anatomy 0.000 description 11
- 235000012000 cholesterol Nutrition 0.000 description 6
- 108010001336 Horseradish Peroxidase Proteins 0.000 description 5
- 238000006243 chemical reaction Methods 0.000 description 5
- 239000004816 latex Substances 0.000 description 5
- 229920000126 latex Polymers 0.000 description 5
- 239000002245 particle Substances 0.000 description 5
- 239000000427 antigen Substances 0.000 description 4
- 102000036639 antigens Human genes 0.000 description 4
- 108091007433 antigens Proteins 0.000 description 4
- 239000000758 substrate Substances 0.000 description 4
- 210000002700 urine Anatomy 0.000 description 4
- 108010089254 Cholesterol oxidase Proteins 0.000 description 3
- 108010055297 Sterol Esterase Proteins 0.000 description 3
- 102000000019 Sterol Esterase Human genes 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 238000002405 diagnostic procedure Methods 0.000 description 3
- 210000003743 erythrocyte Anatomy 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 229920006395 saturated elastomer Polymers 0.000 description 3
- 239000012491 analyte Substances 0.000 description 2
- 230000004888 barrier function Effects 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 238000013461 design Methods 0.000 description 2
- 229940088597 hormone Drugs 0.000 description 2
- 239000005556 hormone Substances 0.000 description 2
- 238000011534 incubation Methods 0.000 description 2
- 230000002452 interceptive effect Effects 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 238000008620 Cholesterol Assay Methods 0.000 description 1
- 101100216185 Oryza sativa subsp. japonica AP25 gene Proteins 0.000 description 1
- 230000006978 adaptation Effects 0.000 description 1
- 238000010256 biochemical assay Methods 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 238000005094 computer simulation Methods 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 210000004180 plasmocyte Anatomy 0.000 description 1
- 230000035935 pregnancy Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0605—Metering of fluids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0621—Control of the sequence of chambers filled or emptied
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502746—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means for controlling flow resistance, e.g. flow controllers, baffles
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Dispersion Chemistry (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Clinical Laboratory Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Sampling And Sample Adjustment (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB939307319A GB9307319D0 (en) | 1993-04-07 | 1993-04-07 | Liquid transfer devices |
| PCT/GB1994/000708 WO1994022579A1 (en) | 1993-04-07 | 1994-03-31 | Liquid transfer devices |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69403333D1 DE69403333D1 (de) | 1997-06-26 |
| DE69403333T2 true DE69403333T2 (de) | 1997-08-28 |
Family
ID=10733541
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69403333T Expired - Fee Related DE69403333T2 (de) | 1993-04-07 | 1994-03-31 | Vorrichtungen zum übertragen von flüssigkeiten |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US5618494A (cg-RX-API-DMAC10.html) |
| EP (1) | EP0693000B1 (cg-RX-API-DMAC10.html) |
| JP (1) | JPH08509060A (cg-RX-API-DMAC10.html) |
| CN (1) | CN1120820A (cg-RX-API-DMAC10.html) |
| AU (1) | AU6383294A (cg-RX-API-DMAC10.html) |
| CA (1) | CA2158766A1 (cg-RX-API-DMAC10.html) |
| DE (1) | DE69403333T2 (cg-RX-API-DMAC10.html) |
| GB (2) | GB9307319D0 (cg-RX-API-DMAC10.html) |
| TW (1) | TW267993B (cg-RX-API-DMAC10.html) |
| WO (1) | WO1994022579A1 (cg-RX-API-DMAC10.html) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9324310D0 (en) * | 1993-11-26 | 1994-01-12 | Univ Birmingham | Liquid transfer device |
| BR9710052A (pt) * | 1996-06-28 | 2000-01-11 | Caliper Techn Corp | Sistema microfluido com compensação para polarização eletroforética, eletropipetador, processos para introduzir materiais a partir de uma série de fontes em um sistema microfluido, para distribuir de maneira controlável uma corrente de fluido e para transportar amostras de fluido, sistema de amostragem, emprego de um substrato, emprego de um sistema microfluido, e, substrato. |
| AU727083B2 (en) * | 1997-04-25 | 2000-11-30 | Caliper Life Sciences, Inc. | Microfluidic devices incorporating improved channel geometries |
| GB9709821D0 (en) * | 1997-05-15 | 1997-07-09 | Clinical Diagnostic Chemicals | Allergy assay |
| US6379620B1 (en) * | 1998-11-16 | 2002-04-30 | Barry M. Tydings | Assaying device and method for in field urinalysis |
| US20020019059A1 (en) * | 1999-01-28 | 2002-02-14 | Calvin Y.H. Chow | Devices, systems and methods for time domain multiplexing of reagents |
| JP2003507715A (ja) * | 1999-08-13 | 2003-02-25 | カーティージャン テクノロジーズ、 インコーポレイテッド | 液体試料取扱い装置 |
| US6805838B2 (en) * | 2002-03-04 | 2004-10-19 | Barry M. Tydings | Assaying device and method for in field urinalysis |
| US8980561B1 (en) | 2006-08-22 | 2015-03-17 | Los Alamos National Security, Llc. | Nucleic acid detection system and method for detecting influenza |
| US20090047673A1 (en) * | 2006-08-22 | 2009-02-19 | Cary Robert B | Miniaturized lateral flow device for rapid and sensitive detection of proteins or nucleic acids |
| US20110160090A1 (en) * | 2008-05-05 | 2011-06-30 | Los Alamos National Laboratory | Nanocrystal-Based Lateral Flow Microarrays and Low-Voltage Signal Detection Systems |
| EP3067694A1 (en) | 2008-05-05 | 2016-09-14 | Los Alamos National Security, LLC | Lateral flow-based nucleic acid sample preparation device, integrated with passive fluid flow control |
| WO2011087813A2 (en) * | 2009-12-22 | 2011-07-21 | University Of Washington | Capillarity-based devices for performing chemical processes and associated systems and methods |
| DK2699698T4 (da) | 2011-04-20 | 2020-04-14 | Mesa Biotech Inc | Oscillerende amplifikations-reaktion for nukleinsyrer |
| US9528987B2 (en) | 2011-06-23 | 2016-12-27 | University Of Washington | Reagent patterning in capillarity-based analyzers and associated systems and methods |
| KR101283638B1 (ko) * | 2012-09-26 | 2013-07-08 | 주식회사 디브이씨 | 물체를 만난 유체의 흐름 관찰장치 |
| WO2014081460A1 (en) * | 2012-11-20 | 2014-05-30 | Kisner Mark | Chemical sequencing and control to expand and enhance detection capabilities utilizing a colorimetric test |
| WO2014116756A1 (en) | 2013-01-22 | 2014-07-31 | University Of Washington Through Its Center For Commercialization | Sequential delivery of fluid volumes and associated devices, systems and methods |
| TWI824991B (zh) | 2015-04-24 | 2023-12-11 | 美商梅薩生物科技股份有限公司 | 用於檢測目標核酸的卡匣及控制通過在用於檢測目標核酸的卡匣中之腔室的流體之垂直流的方法 |
| WO2024211341A2 (en) * | 2023-04-03 | 2024-10-10 | Burst Diagnostics Llc | Chemiluminescence microfluidic immunoassay device and methods of use thereof |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4323536A (en) * | 1980-02-06 | 1982-04-06 | Eastman Kodak Company | Multi-analyte test device |
| CA1292176C (en) * | 1985-09-18 | 1991-11-19 | Joel M. Blatt | Volume metering capillary gap device for applying a liquid sample onto a reactive surface |
| US4918025A (en) * | 1987-03-03 | 1990-04-17 | Pb Diagnostic Systems, Inc. | Self contained immunoassay element |
| GB8725458D0 (en) * | 1987-10-30 | 1987-12-02 | Unilever Plc | Chemical testing |
| US5275785A (en) * | 1987-10-30 | 1994-01-04 | Unilever Patent Holdings B.V. | Test device for detecting an analyte in a liquid sample |
| GB2216283A (en) * | 1988-03-30 | 1989-10-04 | Alroy & Stanley Associates Inc | Spectacles with extractable temples |
| IE69047B1 (en) * | 1989-03-23 | 1996-08-07 | Gary Harold Gregory Hen Thorpe | Liquid transfer devices |
| US5242606A (en) * | 1990-06-04 | 1993-09-07 | Abaxis, Incorporated | Sample metering port for analytical rotor having overflow chamber |
| GB9123903D0 (en) * | 1991-11-11 | 1992-01-02 | Bunce Roger A | Liquid transfer assay devices |
| GB9123922D0 (en) * | 1991-11-11 | 1992-01-02 | Bunce Roger A | Liquid transfer devices |
| US5223219A (en) * | 1992-04-10 | 1993-06-29 | Biotrack, Inc. | Analytical cartridge and system for detecting analytes in liquid samples |
-
1993
- 1993-04-07 GB GB939307319A patent/GB9307319D0/en active Pending
-
1994
- 1994-03-31 WO PCT/GB1994/000708 patent/WO1994022579A1/en not_active Ceased
- 1994-03-31 CN CN94191715A patent/CN1120820A/zh active Pending
- 1994-03-31 DE DE69403333T patent/DE69403333T2/de not_active Expired - Fee Related
- 1994-03-31 US US08/325,348 patent/US5618494A/en not_active Expired - Fee Related
- 1994-03-31 AU AU63832/94A patent/AU6383294A/en not_active Abandoned
- 1994-03-31 EP EP94911275A patent/EP0693000B1/en not_active Expired - Lifetime
- 1994-03-31 CA CA002158766A patent/CA2158766A1/en not_active Abandoned
- 1994-03-31 JP JP6521857A patent/JPH08509060A/ja active Pending
- 1994-03-31 GB GB9406449A patent/GB2276940B/en not_active Revoked
- 1994-04-07 TW TW083103018A patent/TW267993B/zh active
Also Published As
| Publication number | Publication date |
|---|---|
| EP0693000B1 (en) | 1997-05-21 |
| AU6383294A (en) | 1994-10-24 |
| GB9406449D0 (en) | 1994-05-25 |
| DE69403333D1 (de) | 1997-06-26 |
| US5618494A (en) | 1997-04-08 |
| GB2276940B (en) | 1997-01-22 |
| TW267993B (cg-RX-API-DMAC10.html) | 1996-01-11 |
| EP0693000A1 (en) | 1996-01-24 |
| WO1994022579A1 (en) | 1994-10-13 |
| JPH08509060A (ja) | 1996-09-24 |
| GB9307319D0 (en) | 1993-06-02 |
| CA2158766A1 (en) | 1994-10-13 |
| GB2276940A (en) | 1994-10-12 |
| CN1120820A (zh) | 1996-04-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8327 | Change in the person/name/address of the patent owner |
Owner name: BTG INTERNATIONAL LTD., LONDON, GB |
|
| 8339 | Ceased/non-payment of the annual fee |