DE69402863T2 - Regulierung der stellen-spezifischen rekombination durch stellen-spezifische fusionsproteine, die aus rekombinase und nuklearem rezeptor bestehen - Google Patents

Regulierung der stellen-spezifischen rekombination durch stellen-spezifische fusionsproteine, die aus rekombinase und nuklearem rezeptor bestehen

Info

Publication number
DE69402863T2
DE69402863T2 DE69402863T DE69402863T DE69402863T2 DE 69402863 T2 DE69402863 T2 DE 69402863T2 DE 69402863 T DE69402863 T DE 69402863T DE 69402863 T DE69402863 T DE 69402863T DE 69402863 T2 DE69402863 T2 DE 69402863T2
Authority
DE
Germany
Prior art keywords
job
recombinase
recombination
fusion proteins
regulation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69402863T
Other languages
English (en)
Other versions
DE69402863D1 (de
Inventor
Francis Stewart
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Europaisches Laboratorium fuer Molekularbiologie EMBL
Original Assignee
Europaisches Laboratorium fuer Molekularbiologie EMBL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Europaisches Laboratorium fuer Molekularbiologie EMBL filed Critical Europaisches Laboratorium fuer Molekularbiologie EMBL
Application granted granted Critical
Publication of DE69402863D1 publication Critical patent/DE69402863D1/de
Publication of DE69402863T2 publication Critical patent/DE69402863T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/721—Steroid/thyroid hormone superfamily, e.g. GR, EcR, androgen receptor, oestrogen receptor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Endocrinology (AREA)
  • General Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
DE69402863T 1993-06-28 1994-06-28 Regulierung der stellen-spezifischen rekombination durch stellen-spezifische fusionsproteine, die aus rekombinase und nuklearem rezeptor bestehen Expired - Lifetime DE69402863T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP93110298A EP0632054A1 (de) 1993-06-28 1993-06-28 Regulation stellenspezifischer Rekombination mittels stellungsspezifischer Rekombinase/Kernrezeptor-Fusionsproteine
PCT/EP1994/002088 WO1995000555A1 (en) 1993-06-28 1994-06-28 Regulation of site-specific recombination by site-specific recombinase/nuclear receptor fusion proteins

Publications (2)

Publication Number Publication Date
DE69402863D1 DE69402863D1 (de) 1997-05-28
DE69402863T2 true DE69402863T2 (de) 1997-07-31

Family

ID=8213015

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69402863T Expired - Lifetime DE69402863T2 (de) 1993-06-28 1994-06-28 Regulierung der stellen-spezifischen rekombination durch stellen-spezifische fusionsproteine, die aus rekombinase und nuklearem rezeptor bestehen

Country Status (9)

Country Link
US (1) US6040430A (de)
EP (2) EP0632054A1 (de)
JP (1) JP2986915B2 (de)
AT (1) ATE152123T1 (de)
AU (1) AU7227994A (de)
CA (1) CA2166198C (de)
DE (1) DE69402863T2 (de)
ES (1) ES2101552T3 (de)
WO (1) WO1995000555A1 (de)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0937098B1 (de) * 1995-06-07 2002-08-14 Invitrogen Corporation Rekombinatorische klonierung in vitro unter verwendung genmanipulierter rekombinationsorte
US6720140B1 (en) 1995-06-07 2004-04-13 Invitrogen Corporation Recombinational cloning using engineered recombination sites
US6964861B1 (en) * 1998-11-13 2005-11-15 Invitrogen Corporation Enhanced in vitro recombinational cloning of using ribosomal proteins
US6143557A (en) * 1995-06-07 2000-11-07 Life Technologies, Inc. Recombination cloning using engineered recombination sites
FR2749857B1 (fr) * 1996-06-12 1998-08-14 Centre Nat Rech Scient Generation de molecules replicatives in vivo
US5851808A (en) * 1997-02-28 1998-12-22 Baylor College Of Medicine Rapid subcloning using site-specific recombination
US20030124555A1 (en) * 2001-05-21 2003-07-03 Invitrogen Corporation Compositions and methods for use in isolation of nucleic acid molecules
US7351578B2 (en) * 1999-12-10 2008-04-01 Invitrogen Corp. Use of multiple recombination sites with unique specificity in recombinational cloning
WO1999021977A1 (en) * 1997-10-24 1999-05-06 Life Technologies, Inc. Recombinational cloning using nucleic acids having recombination sites
CN101125873A (zh) * 1997-10-24 2008-02-20 茵维特罗根公司 利用具重组位点的核酸进行重组克隆
US5929301A (en) * 1997-11-18 1999-07-27 Pioneer Hi-Bred International Nucleic acid sequence encoding FLP recombinase
US7102055B1 (en) 1997-11-18 2006-09-05 Pioneer Hi-Bred International, Inc. Compositions and methods for the targeted insertion of a nucleotide sequence of interest into the genome of a plant
AU745960C (en) 1997-11-18 2003-09-18 Pioneer Hi-Bred International, Inc. A novel method for the integration of foreign DNA into eukaryoticgenomes
AU757672B2 (en) 1997-11-18 2003-02-27 Pioneer Hi-Bred International, Inc. A method for directional stable transformation of eukaryotic cells
EP1034286B1 (de) 1997-11-18 2010-01-06 Pioneer Hi-Bred International, Inc. Mobilisierung eines viralen genoms aus t-dna durch ortsspezifische rekombinationssysteme
US6720475B1 (en) 1997-11-18 2004-04-13 Pioneer Hi-Bred International, Inc. Modified nucleic acid sequence encoding FLP recombinase
ATE443074T1 (de) 1999-03-02 2009-10-15 Life Technologies Corp Zubereitungen und methoden zur verwendung in rekombinatorischem klonen von nukleinsäuren
GB9924604D0 (en) * 1999-10-18 1999-12-22 European Molecular Biology Lab Embl Genetic switch
DE19956272B4 (de) 1999-11-23 2004-09-16 Mpb Cologne Gmbh Molecular Plant & Protein Biotechnology Verfahren zur gesteuerten Nach-Ernte-Produktion von Proteinen in Wirtsorganismen
CA2392753A1 (en) 1999-12-10 2001-06-14 Invitrogen Corporation Use of multiple recombination sites with unique specificity in recombinational cloning
EP1118668A1 (de) * 2000-01-07 2001-07-25 ARTEMIS Pharmaceuticals GmbH Übertragung von Rekombinasen zur induzierbaren Genveränderung
DE10024740A1 (de) * 2000-05-19 2001-11-29 Mpb Cologne Gmbh Molecular Pla Verfahren zur gesteuerten Eliminierung gewünschter DNA-Sequenzen in Wirtsorganismen
US7244560B2 (en) 2000-05-21 2007-07-17 Invitrogen Corporation Methods and compositions for synthesis of nucleic acid molecules using multiple recognition sites
DE10038573A1 (de) * 2000-08-03 2002-02-21 Mpb Cologne Gmbh Molecular Pla Verfahren zur Selektion auf Wirtszellen mit eliminierten DNA-Sequenzen
US7198924B2 (en) * 2000-12-11 2007-04-03 Invitrogen Corporation Methods and compositions for synthesis of nucleic acid molecules using multiple recognition sites
FR2814642B1 (fr) 2000-10-03 2005-07-01 Ass Pour Le Dev De La Rech En Souris transgenique pour la recombinaison ciblee mediee par la cre-er modifiee
EP1322152A2 (de) * 2000-10-03 2003-07-02 ADEREGEM (Association pour le Développement de la Recherche en Génétique Moléculaire Transgene maus zur gezielten rekombination vermittelt durch verändertes cre-er
US7560622B2 (en) 2000-10-06 2009-07-14 Pioneer Hi-Bred International, Inc. Methods and compositions relating to the generation of partially transgenic organisms
EP1390394A4 (de) * 2001-04-19 2004-05-26 Invitrogen Corp Zusammensetzungen und verfahren zur rekombinationsklonierung von nukleinsäuremolekülen
EP1264891A1 (de) * 2001-05-31 2002-12-11 Plant Research International B.V. Veränderung des Pflanzen Genoms durch induzierbaren, ortsspezifischen Rekombination von Transgenen
US7351877B2 (en) 2002-03-29 2008-04-01 Syngenta Participations Ag Lambda integrase mediated recombination in plants
AU2003253992A1 (en) * 2002-07-18 2004-02-09 Robert P. Bennett Viral vectors containing recombination sites
EP1644538A4 (de) * 2003-06-26 2006-11-08 Invitrogen Corp Verfahren und zusammensetzungen zum nachweis von promotoraktivität und zur expression von fusionsproteinen
EP1697534B1 (de) 2003-12-01 2010-06-02 Life Technologies Corporation Rekombinationsstellen enthaltende nukleinsäuremoleküle und verfahren zur verwendung davon
US7935862B2 (en) 2003-12-02 2011-05-03 Syngenta Participations Ag Targeted integration and stacking of DNA through homologous recombination
EP1752544B1 (de) * 2004-02-12 2013-08-21 Japan Science and Technology Agency Sonde zum nachweis eines agonisten oder antagonisten eines nukleären rezeptors sowie verfahren zum screening eines agonisten oder antagonisten zu einem nukleären rezeptor unter verwendung davon
WO2008008160A2 (en) * 2006-07-07 2008-01-17 Fred Hutchinson Cancer Research Center High efficiency flp site-specific recombination in mammalian cells using an optimized flp gene
US9234193B2 (en) 2011-05-31 2016-01-12 Keygene N.V. Pest resistant plants
WO2013058655A1 (en) 2011-10-19 2013-04-25 Keygene N.V. Methods and compositions for producing drimenol
WO2014142647A1 (en) 2013-03-14 2014-09-18 Wageningen Universiteit Fungals strains with improved citric acid and itaconic acid production
CN108291234A (zh) 2015-09-04 2018-07-17 主基因有限公司 倍数孢子体形成基因
CA3138988A1 (en) 2019-05-29 2020-12-03 Keygene N.V. Gene for parthenogenesis
AU2021363100A1 (en) 2020-10-13 2023-05-25 Keygene N.V. Modified promoter of a parthenogenesis gene

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3482649D1 (de) * 1983-12-16 1990-08-09 Denis M Callewaert Stellenselektiver plasminogenaktivator und verfahren zu seiner herstellung und verwendung.
WO1993015191A1 (en) * 1992-01-24 1993-08-05 Life Technologies, Inc. Modulation of enzyme activities in the in vivo cloning of dna
US5589362A (en) * 1993-06-14 1996-12-31 Basf Aktiengesellschaft Tetracycline regulated transcriptional modulators with altered DNA binding specificities

Also Published As

Publication number Publication date
EP0707599B1 (de) 1997-04-23
EP0632054A1 (de) 1995-01-04
CA2166198C (en) 2002-01-08
JP2986915B2 (ja) 1999-12-06
ES2101552T3 (es) 1997-07-01
AU7227994A (en) 1995-01-17
ATE152123T1 (de) 1997-05-15
JPH08511681A (ja) 1996-12-10
EP0707599A1 (de) 1996-04-24
US6040430A (en) 2000-03-21
WO1995000555A1 (en) 1995-01-05
CA2166198A1 (en) 1995-01-05
DE69402863D1 (de) 1997-05-28

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Legal Events

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