DE69333815D1 - Gentranskription und ionisierende strahlung: methoden und zusammensetzungen - Google Patents
Gentranskription und ionisierende strahlung: methoden und zusammensetzungenInfo
- Publication number
- DE69333815D1 DE69333815D1 DE69333815T DE69333815T DE69333815D1 DE 69333815 D1 DE69333815 D1 DE 69333815D1 DE 69333815 T DE69333815 T DE 69333815T DE 69333815 T DE69333815 T DE 69333815T DE 69333815 D1 DE69333815 D1 DE 69333815D1
- Authority
- DE
- Germany
- Prior art keywords
- encoding
- compositions
- methods
- polypeptide
- ionizing radiation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0023—Agression treatment or altering
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/525—Tumour necrosis factor [TNF]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/82—Translation products from oncogenes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/635—Externally inducible repressor mediated regulation of gene expression, e.g. tetR inducible by tetracyline
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/67—General methods for enhancing the expression
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
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- G—PHYSICS
- G03—PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
- G03G—ELECTROGRAPHY; ELECTROPHOTOGRAPHY; MAGNETOGRAPHY
- G03G15/00—Apparatus for electrographic processes using a charge pattern
- G03G15/20—Apparatus for electrographic processes using a charge pattern for fixing, e.g. by using heat
- G03G15/2003—Apparatus for electrographic processes using a charge pattern for fixing, e.g. by using heat using heat
- G03G15/2014—Apparatus for electrographic processes using a charge pattern for fixing, e.g. by using heat using heat using contact heat
- G03G15/2017—Structural details of the fixing unit in general, e.g. cooling means, heat shielding means
- G03G15/2025—Structural details of the fixing unit in general, e.g. cooling means, heat shielding means with special means for lubricating and/or cleaning the fixing unit, e.g. applying offset preventing fluid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/61—Fusion polypeptide containing an enzyme fusion for detection (lacZ, luciferase)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/71—Fusion polypeptide containing domain for protein-protein interaction containing domain for transcriptional activaation, e.g. VP16
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/80—Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor
- C07K2319/81—Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor containing a Zn-finger domain for DNA binding
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/001—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/001—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
- C12N2830/002—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination inducible enhancer/promoter combination, e.g. hypoxia, iron, transcription factor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/80—Vector systems having a special element relevant for transcription from vertebrates
- C12N2830/85—Vector systems having a special element relevant for transcription from vertebrates mammalian
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- G—PHYSICS
- G03—PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
- G03G—ELECTROGRAPHY; ELECTROPHOTOGRAPHY; MAGNETOGRAPHY
- G03G2215/00—Apparatus for electrophotographic processes
- G03G2215/20—Details of the fixing device or porcess
- G03G2215/207—Type of toner image to be fixed
- G03G2215/2083—Type of toner image to be fixed duplex
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Toxicology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Oncology (AREA)
- General Physics & Mathematics (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US943812 | 1992-09-11 | ||
US07/943,812 US6605712B1 (en) | 1990-12-20 | 1992-09-11 | Gene transcription and ionizing radiation: methods and compositions |
PCT/US1993/008432 WO1994006916A1 (en) | 1992-09-11 | 1993-09-08 | Gene transcription and ionizing radiation: methods and compositions |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69333815D1 true DE69333815D1 (de) | 2005-06-23 |
DE69333815T2 DE69333815T2 (de) | 2006-02-02 |
Family
ID=25480308
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69333815T Expired - Lifetime DE69333815T2 (de) | 1992-09-11 | 1993-09-08 | Gentranskription und ionisierende strahlung: methoden und zusammensetzungen |
Country Status (10)
Country | Link |
---|---|
US (5) | US6605712B1 (de) |
EP (1) | EP0662137B8 (de) |
JP (1) | JPH08501448A (de) |
AT (1) | ATE295889T1 (de) |
AU (1) | AU686112B2 (de) |
CA (1) | CA2144406C (de) |
DE (1) | DE69333815T2 (de) |
ES (1) | ES2242181T3 (de) |
PT (1) | PT662137E (de) |
WO (1) | WO1994006916A1 (de) |
Families Citing this family (68)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6605712B1 (en) * | 1990-12-20 | 2003-08-12 | Arch Development Corporation | Gene transcription and ionizing radiation: methods and compositions |
AUPM322393A0 (en) * | 1993-12-24 | 1994-01-27 | Austin Research Institute, The | Mucin carbohydrate compounds and their use in immunotherapy |
US6524832B1 (en) | 1994-02-04 | 2003-02-25 | Arch Development Corporation | DNA damaging agents in combination with tyrosine kinase inhibitors |
US5571797A (en) * | 1994-05-11 | 1996-11-05 | Arch Development Corporation | Method of inducing gene expression by ionizing radiation |
US7592317B1 (en) | 1994-08-11 | 2009-09-22 | The University Of Chicago | Constitutive gene expression in conjuction with ionizing radiation |
US6548643B1 (en) | 1994-11-16 | 2003-04-15 | Austin Research Institute | Antigen carbohydrate compounds and their use in immunotherapy |
US8021667B2 (en) | 1994-11-16 | 2011-09-20 | Macfarlane Burnet Institute For Medical Research And Public Health Ltd | Compositions for immunotherapy and uses thereof |
AU4994596A (en) * | 1995-03-01 | 1996-09-18 | Cornell Research Foundation Inc. | Interdependent adenoviral vectors and methods of using same |
JPH0959151A (ja) * | 1995-08-24 | 1997-03-04 | Kao Corp | NF−κB活性化抑制剤 |
US6080728A (en) * | 1996-07-16 | 2000-06-27 | Mixson; A. James | Carrier: DNA complexes containing DNA encoding anti-angiogenic peptides and their use in gene therapy |
US7112338B2 (en) * | 1997-03-12 | 2006-09-26 | The Regents Of The University Of California | Cationic liposome delivery of taxanes to angiogenic blood vessels |
US5837283A (en) * | 1997-03-12 | 1998-11-17 | The Regents Of The University Of California | Cationic lipid compositions targeting angiogenic endothelial cells |
ES2322212T3 (es) | 1997-09-29 | 2009-06-17 | The Macfarlane Burnet Institute For Medical Research And Public Health Ltd | Composicion de antigeno y linea celular que lleva el receptor manosa. |
EP1049491A1 (de) * | 1998-01-06 | 2000-11-08 | Roman Perez-Soler | Gentherapie von tumoren unter verwendung eines nichtviralen verabreichungssystems |
US7049140B1 (en) * | 1999-04-29 | 2006-05-23 | Vanderbilt University | X-ray guided drug delivery |
BR0013866A (pt) * | 1999-09-09 | 2002-05-14 | Univ California | Distribuição de lipossomas catiÈnicos de taxanos aos vasos sanguineos angiogênicos |
AU782115B2 (en) * | 1999-09-22 | 2005-07-07 | Ortho-Mcneil Pharmaceutical, Inc. | Cell based assay |
US6867036B1 (en) | 1999-11-23 | 2005-03-15 | Mayo Foundation For Medical Education And Research | Gene expression by positive feedback activation of a cell type-specific promoter |
WO2001090339A2 (en) * | 2000-05-23 | 2001-11-29 | Warner-Lambert Company | Methods and compositions to activate genes in cells |
US6579522B1 (en) * | 2000-06-27 | 2003-06-17 | Genvec, Inc. | Replication deficient adenoviral TNF vector |
US6794137B2 (en) * | 2000-09-08 | 2004-09-21 | New York University | Gene markers useful for detecting skin damage in response to ultraviolet radiation |
US7105292B2 (en) * | 2000-09-08 | 2006-09-12 | New York University | Screening methods used to identify compounds that modulate a response of a cell to ultraviolet radiation exposure |
CA2439687A1 (en) | 2001-03-01 | 2002-09-12 | Hollis-Eden Pharmaceuticals, Inc. | Use of certain steroids for treatment of blood cell deficiencies |
JP2004532213A (ja) * | 2001-04-06 | 2004-10-21 | ザ ユニヴァーシティ オヴ シカゴ | Egr−1プロモーター活性の化学療法誘導 |
US8034791B2 (en) | 2001-04-06 | 2011-10-11 | The University Of Chicago | Activation of Egr-1 promoter by DNA damaging chemotherapeutics |
US20040242523A1 (en) * | 2003-03-06 | 2004-12-02 | Ana-Farber Cancer Institue And The Univiersity Of Chicago | Chemo-inducible cancer gene therapy |
US7906102B2 (en) | 2001-10-03 | 2011-03-15 | Vanderbilt University | Ligands to radiation-induced molecules |
US7306925B2 (en) | 2001-11-09 | 2007-12-11 | Vanderbilt University | Phage antibodies to radiation-inducible neoantigens |
US20030086903A1 (en) * | 2001-11-02 | 2003-05-08 | Genvec, Inc. | Therapeutic regimen for treating cancer |
ATE458500T1 (de) * | 2003-11-14 | 2010-03-15 | Genvec Inc | Pharmazeutische verbindung zur behandlung von lokal fortgeschrittenem primär inoperablen pankreaskarzinom (lapc). |
EP1544307A1 (de) * | 2003-12-18 | 2005-06-22 | AXXAM S.r.l. | Chimärer LAC9 Rezeptor und dessen Verwendungen |
WO2006017741A2 (en) * | 2004-08-06 | 2006-02-16 | Georgetown University | Radiation inducible iex-1 promoter |
DE602005024148D1 (de) * | 2004-08-25 | 2010-11-25 | Univ Chicago | Verwendung der kombination aus temozolomid und tnf-alpha zur behandlung von glioblastoma |
WO2006039045A2 (en) * | 2004-09-01 | 2006-04-13 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Adenoviral vectors able to transduce apcs, potential use in immune response generation |
US20060234272A1 (en) * | 2005-03-31 | 2006-10-19 | The Regents Of The University Of California | Using gene panels to predict tissue sensitivity to ionizing radiation |
DK2019671T3 (en) | 2006-05-05 | 2014-12-08 | Univ Michigan | Intermediates for the preparation of bivalent SMAC mimetics |
US20080076122A1 (en) * | 2006-09-26 | 2008-03-27 | The Regents Of The University Of California | Characterizing exposure to ionizing radiation |
AR060702A1 (es) | 2007-04-27 | 2008-07-10 | Fundacion Inst Leloir | Promotor inducible por especies reactivas del oxigeno y vector que lo comprende |
KR101048096B1 (ko) | 2008-10-09 | 2011-07-11 | 한국원자력연구원 | 방사선 유도성 프로모터 |
US9605844B2 (en) * | 2009-09-01 | 2017-03-28 | Cree, Inc. | Lighting device with heat dissipation elements |
PE20121282A1 (es) | 2009-11-12 | 2012-10-12 | Univ Michigan | Antagonistas de espiro-oxindol de mdm2 |
NZ611866A (en) | 2010-11-12 | 2015-04-24 | Univ Michigan | Spiro-oxindole mdm2 antagonists |
AU2012253339B2 (en) | 2011-05-11 | 2016-03-31 | Sanofi | Spiro-oxindole MDM2 antagonists |
WO2013019730A1 (en) | 2011-07-29 | 2013-02-07 | The Washington University | Antibodies to tip-1 and grp78 |
EP3511717A3 (de) * | 2011-09-29 | 2019-09-25 | Meso Scale Technologies, LLC. | Biodosimetriepaneele und verfahren |
WO2013149124A1 (en) | 2012-03-29 | 2013-10-03 | The Regents Of The University Of Michigan | Small molecule inhibitors of mcl-1 and uses thereof |
WO2013166043A1 (en) | 2012-05-02 | 2013-11-07 | Children's Hospital Medical Center | Rejuvenation of precursor cells |
AU2015247646B2 (en) | 2014-04-17 | 2019-06-06 | The Regents Of The University Of Michigan | MDM2 inhibitors and therapeutic methods using the same |
WO2016014939A1 (en) | 2014-07-24 | 2016-01-28 | Washington University | Compositions targeting radiation-induced molecules and methods of use thereof |
JP6559785B2 (ja) | 2014-12-15 | 2019-08-14 | ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン | Egfr及びpi3kの小分子阻害剤 |
EP3285583B1 (de) | 2015-04-20 | 2021-03-17 | The Regents of The University of Michigan | Niedermolekulare mcl-1-inhibitoren und deren verwendungen |
SG11201808306PA (en) | 2016-03-24 | 2018-10-30 | Tragara Pharmaceuticals Inc | Treatment of cancer with tg02 |
EP3471712B1 (de) | 2016-06-20 | 2024-01-03 | The Regents of The University of Michigan | Kleinmolekülige inhibitoren von aldh und verwendungen davon |
WO2018148595A1 (en) | 2017-02-10 | 2018-08-16 | Washington University | Antibodies to tip1 and methods of use thereof |
EP3630083A4 (de) | 2017-05-23 | 2021-03-10 | The Regents of The University of Michigan | Dimethyl-nonatetraenyl-trimethyl-cyclohexyl-verbindungen und verwendungen davon |
JP7210534B2 (ja) | 2017-07-12 | 2023-01-23 | ザ・ボード・オブ・トラスティーズ・オブ・ザ・リーランド・スタンフォード・ジュニア・ユニバーシティ | H3k27m変異を有するがんの処置のための組成物および方法 |
JP7250764B2 (ja) | 2017-08-18 | 2023-04-03 | コセラ バイオサイエンス, インコーポレイテッド | Tg02の多形形態 |
JP2022524756A (ja) | 2019-03-06 | 2022-05-10 | ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン | 置換された二環式および四環式キノン類および関連する使用方法 |
CA3141414A1 (en) | 2019-06-12 | 2020-12-17 | Vanderbilt University | Dibenzylamines as amino acid transport inhibitors |
EP3983084A1 (de) | 2019-06-12 | 2022-04-20 | Vanderbilt University | Aminosäuretransportinhibitoren und deren verwendungen |
CN115667530A (zh) | 2020-03-24 | 2023-01-31 | 世代生物公司 | 非病毒dna载体和其用于表达因子ix治疗剂的用途 |
KR20230003478A (ko) | 2020-03-24 | 2023-01-06 | 제너레이션 바이오 컴퍼니 | 비-바이러스성 dna 벡터 및 고셰 치료제 발현을 위한 이의 용도 |
EP4161508A1 (de) | 2020-06-05 | 2023-04-12 | Henry Ford Health System | Dakalasvir zur verwendung bei der behandlung von lungen- und prostatakrebs |
EP4267554A1 (de) | 2020-12-22 | 2023-11-01 | Mekanistic Therapeutics LLC | Substituierte aminobenzylheteroarylverbindungen als egfr- und/oder pi3k-hemmer |
US20230133958A1 (en) | 2021-10-20 | 2023-05-04 | Mekanistic Therapeutics Llc | Compounds useful in modulating egfr and pi3k |
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- 1992-09-11 US US07/943,812 patent/US6605712B1/en not_active Expired - Lifetime
-
1993
- 1993-09-08 DE DE69333815T patent/DE69333815T2/de not_active Expired - Lifetime
- 1993-09-08 CA CA002144406A patent/CA2144406C/en not_active Expired - Lifetime
- 1993-09-08 WO PCT/US1993/008432 patent/WO1994006916A1/en active IP Right Grant
- 1993-09-08 JP JP6508137A patent/JPH08501448A/ja active Pending
- 1993-09-08 AU AU48509/93A patent/AU686112B2/en not_active Expired
- 1993-09-08 ES ES93921410T patent/ES2242181T3/es not_active Expired - Lifetime
- 1993-09-08 PT PT93921410T patent/PT662137E/pt unknown
- 1993-09-08 AT AT93921410T patent/ATE295889T1/de active
- 1993-09-08 EP EP93921410A patent/EP0662137B8/de not_active Expired - Lifetime
-
1995
- 1995-06-07 US US08/474,445 patent/US5770581A/en not_active Expired - Lifetime
-
1998
- 1998-06-22 US US09/102,997 patent/US6156736A/en not_active Expired - Fee Related
-
2000
- 2000-12-05 US US09/730,630 patent/US7041653B2/en not_active Expired - Fee Related
-
2005
- 2005-10-25 US US11/257,553 patent/US20060058258A1/en not_active Abandoned
Also Published As
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WO1994006916A1 (en) | 1994-03-31 |
EP0662137B1 (de) | 2005-05-18 |
ES2242181T3 (es) | 2005-11-01 |
US6605712B1 (en) | 2003-08-12 |
US6156736A (en) | 2000-12-05 |
JPH08501448A (ja) | 1996-02-20 |
US7041653B2 (en) | 2006-05-09 |
DE69333815T2 (de) | 2006-02-02 |
US20010006954A1 (en) | 2001-07-05 |
CA2144406C (en) | 2009-01-06 |
US20060058258A1 (en) | 2006-03-16 |
ATE295889T1 (de) | 2005-06-15 |
PT662137E (pt) | 2005-09-30 |
CA2144406A1 (en) | 1994-03-31 |
AU686112B2 (en) | 1998-02-05 |
US5770581A (en) | 1998-06-23 |
EP0662137A1 (de) | 1995-07-12 |
EP0662137B8 (de) | 2005-07-06 |
AU4850993A (en) | 1994-04-12 |
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