DE69332456D1 - Verfahren und vorrichtung zur feststellung des down-syndroms durch nichtinvasive analyse von mütterlichem blut - Google Patents

Verfahren und vorrichtung zur feststellung des down-syndroms durch nichtinvasive analyse von mütterlichem blut

Info

Publication number
DE69332456D1
DE69332456D1 DE69332456T DE69332456T DE69332456D1 DE 69332456 D1 DE69332456 D1 DE 69332456D1 DE 69332456 T DE69332456 T DE 69332456T DE 69332456 T DE69332456 T DE 69332456T DE 69332456 D1 DE69332456 D1 DE 69332456D1
Authority
DE
Germany
Prior art keywords
trisomy
hcg
down syndrome
detecting
free beta
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69332456T
Other languages
English (en)
Inventor
James N Macri
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Application granted granted Critical
Publication of DE69332456D1 publication Critical patent/DE69332456D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • G01N33/76—Human chorionic gonadotropin including luteinising hormone, follicle stimulating hormone, thyroid stimulating hormone or their receptors

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Reproductive Health (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
DE69332456T 1992-08-07 1993-08-06 Verfahren und vorrichtung zur feststellung des down-syndroms durch nichtinvasive analyse von mütterlichem blut Expired - Lifetime DE69332456D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/925,844 US5324667A (en) 1989-01-17 1992-08-07 Method for detecting down sydrown by non-invasive maternal blood screening
PCT/US1993/007408 WO1994003804A1 (en) 1992-08-07 1993-08-06 Method and apparatus for detecting down syndrome by non-invasive maternal blood screening

Publications (1)

Publication Number Publication Date
DE69332456D1 true DE69332456D1 (de) 2002-12-05

Family

ID=25452336

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69332456T Expired - Lifetime DE69332456D1 (de) 1992-08-07 1993-08-06 Verfahren und vorrichtung zur feststellung des down-syndroms durch nichtinvasive analyse von mütterlichem blut

Country Status (9)

Country Link
US (1) US5324667A (de)
EP (1) EP0673508B1 (de)
JP (1) JP2877516B2 (de)
KR (1) KR0171451B1 (de)
AT (1) ATE227024T1 (de)
AU (1) AU689440B2 (de)
CA (1) CA2141668C (de)
DE (1) DE69332456D1 (de)
WO (1) WO1994003804A1 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5674983A (en) * 1989-01-03 1997-10-07 The United States Of America As Represented By The Department Of Health And Human Services Natural human chorionic gonadotropin β-core molecule
US5252489A (en) * 1989-01-17 1993-10-12 Macri James N Down syndrome screening method utilizing dried blood samples
US5668117A (en) * 1991-02-22 1997-09-16 Shapiro; Howard K. Methods of treating neurological diseases and etiologically related symptomology using carbonyl trapping agents in combination with previously known medicaments
US5594637A (en) * 1993-05-26 1997-01-14 Base Ten Systems, Inc. System and method for assessing medical risk
US6025149A (en) * 1995-07-07 2000-02-15 Yale University Urinary screening for down syndrome and other aneuploidies
US5716853A (en) * 1995-07-07 1998-02-10 Chiron Diagnostics Corporation Prenatal down syndrome screening with assays specific for UGP
US5606164A (en) * 1996-01-16 1997-02-25 Boehringer Mannheim Corporation Method and apparatus for biological fluid analyte concentration measurement using generalized distance outlier detection
GB9606261D0 (en) * 1996-03-25 1996-05-29 Johnson & Johnson Clin Diag Prenatal screening for fetal abnormalities
US5888740A (en) * 1997-09-19 1999-03-30 Genaco Biomedical Products, Inc. Detection of aneuploidy and gene deletion by PCR-based gene- dose co-amplification of chromosome specific sequences with synthetic sequences with synthetic internal controls
US7314760B2 (en) * 2003-06-10 2008-01-01 Stc. Unm Biochemical test for identifying pregnancies with Down's syndrome fetus
US7315787B2 (en) * 2003-10-07 2008-01-01 Ntd Laboratories, Inc. Multi-marker screening protocol for fetal abnormalities
EP1799861A2 (de) * 2004-09-20 2007-06-27 Proteogenix, Inc. Diagnose einer fötalen aneuploidie
WO2011144999A1 (en) 2010-05-17 2011-11-24 Sandra Reznik Plasma protein-a2 (papp-a2) as a marker for detecting risk of chromosomal abnormalities
GB201305317D0 (en) * 2013-03-22 2013-05-08 Iles Raymond K Prenatal screening for fetal abnormalities and disorders of pregnancy

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4016250A (en) * 1974-03-22 1977-04-05 Cornell Research Foundation, Inc. Method for testing for pregnancy
US4123224A (en) * 1975-12-17 1978-10-31 American Home Products Corporation Diagnostic test device
JPS54126723A (en) * 1978-03-23 1979-10-02 Teikoku Hormone Mfg Co Ltd Preparation of specific hcg and specific anti-hcg-beta-subunit antibody
US4565687A (en) * 1981-11-16 1986-01-21 The Reagents Of The University Of Michigan Monoclonal antibodies specific for the unbound β subunit of human chorionic gonadotropin
GR850899B (de) * 1984-04-12 1985-11-25 Gen Hospital Corp
US4874693A (en) * 1986-10-10 1989-10-17 Mark Bogart Method for assessing placental dysfunction
ATE91182T1 (de) * 1987-07-09 1993-07-15 3I Res Expl Ltd Praenatales screening fuer downs-syndrom.
US5037305A (en) * 1988-11-16 1991-08-06 Vivigen, Inc. Graphic method for reporting risk to a patient
DE69026153T3 (de) * 1989-01-17 2005-05-12 Macri, James N. Downsyndrom-screening-methode

Also Published As

Publication number Publication date
AU689440B2 (en) 1998-04-02
AU4804393A (en) 1994-03-03
US5324667A (en) 1994-06-28
EP0673508A4 (de) 1997-06-25
CA2141668C (en) 2007-01-02
WO1994003804A1 (en) 1994-02-17
JP2877516B2 (ja) 1999-03-31
EP0673508B1 (de) 2002-10-30
ATE227024T1 (de) 2002-11-15
KR0171451B1 (ko) 1999-05-01
CA2141668A1 (en) 1994-02-17
EP0673508A1 (de) 1995-09-27
JPH08503067A (ja) 1996-04-02

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Legal Events

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