DE69329441T2 - Verfahren zur Entfernung der schützenden Gruppe von Carboxygruppe - Google Patents

Verfahren zur Entfernung der schützenden Gruppe von Carboxygruppe

Info

Publication number
DE69329441T2
DE69329441T2 DE69329441T DE69329441T DE69329441T2 DE 69329441 T2 DE69329441 T2 DE 69329441T2 DE 69329441 T DE69329441 T DE 69329441T DE 69329441 T DE69329441 T DE 69329441T DE 69329441 T2 DE69329441 T2 DE 69329441T2
Authority
DE
Germany
Prior art keywords
group
protective
carboxy
carboxy group
protective group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69329441T
Other languages
English (en)
Other versions
DE69329441D1 (de
Inventor
Kazuhiko Kondo
Hiroshi Horikawa
Tameo Iwasaki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tanabe Seiyaku Co Ltd
Original Assignee
Tanabe Seiyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tanabe Seiyaku Co Ltd filed Critical Tanabe Seiyaku Co Ltd
Publication of DE69329441D1 publication Critical patent/DE69329441D1/de
Application granted granted Critical
Publication of DE69329441T2 publication Critical patent/DE69329441T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D463/00—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D463/02—Preparation
    • C07D463/06—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/02—Preparation
    • C07D477/06—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
    • C07D477/08—Modification of a carboxyl group directly attached in position 2, e.g. esterification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/88—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D505/00—Heterocyclic compounds containing 5-oxa-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Cephalosporin Compounds (AREA)
DE69329441T 1992-06-18 1993-06-18 Verfahren zur Entfernung der schützenden Gruppe von Carboxygruppe Expired - Lifetime DE69329441T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP20286692 1992-06-18
JP32503192 1992-12-04

Publications (2)

Publication Number Publication Date
DE69329441D1 DE69329441D1 (de) 2000-10-26
DE69329441T2 true DE69329441T2 (de) 2001-03-01

Family

ID=26513608

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69329441T Expired - Lifetime DE69329441T2 (de) 1992-06-18 1993-06-18 Verfahren zur Entfernung der schützenden Gruppe von Carboxygruppe

Country Status (3)

Country Link
US (1) US5587474A (de)
EP (1) EP0574940B1 (de)
DE (1) DE69329441T2 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE239025T1 (de) * 1993-02-12 2003-05-15 Suntory Ltd Verfahren zur desilycierung von silyletherverbindungen
US5688786A (en) * 1994-04-01 1997-11-18 Microcide Pharmaceuticals, Inc. β-lactam antibiotics
EP0676236A1 (de) * 1994-04-05 1995-10-11 Pfizer Inc. Verfahren zur Entfernung der Allylgruppe oder Allyloxycarbonylgruppe
WO1996038450A1 (en) * 1995-05-31 1996-12-05 Microcide Pharmaceuticals, Inc. Cephalosporin antibiotics
US6426421B1 (en) 1999-11-24 2002-07-30 Massachusetts Institute Of Technology Protecting groups useful in the synthesis of polysaccharides, natural products, and combinatorial libraries
WO2008035153A2 (en) * 2006-08-02 2008-03-27 Orchid Chemicals & Pharmaceuticals Limited Process for the preparation of beta-lactam antibiotic
ES2391713T3 (es) * 2008-07-30 2012-11-29 Ranbaxy Laboratories Limited Proceso para la preparación de compuestos de carbapenem
WO2011032192A1 (de) 2009-09-15 2011-03-24 Nabriva Therapeutics Ag Substituierte clavulansäure
WO2011048583A1 (en) 2009-10-23 2011-04-28 Ranbaxy Laboratories Limited Process for the preparation of carbapenem compounds
CA2936749C (en) 2010-06-11 2019-07-09 Joshua R. Giguere Transition metal-catalyzed processes for the preparation of n-allyl compounds and use thereof
US10695322B2 (en) 2016-01-29 2020-06-30 The Johns Hopkins University Inhibitors of bacterial growth

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4174316A (en) * 1978-08-14 1979-11-13 Merck & Co., Inc. 4-Iodomethylazetidin-2-one
US4260627A (en) * 1978-10-24 1981-04-07 Merck & Co., Inc. 1-, 6- And 2-substituted-1-carba-2-penem-3-carboxylic acids
IL59081A0 (en) * 1979-01-10 1980-05-30 Schering Corp 2-penem compounds and a method for preparing them
US4314942A (en) * 1979-01-10 1982-02-09 Schering Corporation Deprotection of allylic esters, carbonates and carbamates catalyzed by palladium compounds
JPS58103358A (ja) * 1981-10-23 1983-06-20 メルク・エンド・カムパニ−・インコ−ポレ−テツド 抗生物質中間体の製造方法
JPS6058987A (ja) * 1983-09-09 1985-04-05 Sumitomo Chem Co Ltd 新規なβ−ラクタム化合物およびその製造法
JPS60202886A (ja) * 1984-03-27 1985-10-14 Sankyo Co Ltd １―置換カルバペネム―３―カルボン酸誘導体
EP0160876A1 (de) * 1984-04-23 1985-11-13 Merck & Co. Inc. 1-Hetero-6-[1-hydroxyethyl]-2-SR8-1-carbadethiapen-2-em-3-carbonsäuren
JPS615081A (ja) * 1984-06-18 1986-01-10 Sankyo Co Ltd １−置換カルバペネム−３−カルボン酸誘導体の製造法
US4788282A (en) * 1985-06-07 1988-11-29 Bristol-Myers Company Deprotection of allylic esters and ethers
ATE93861T1 (de) * 1985-09-11 1993-09-15 Ciba Geigy Ag Synthese von beta-lactamverbindungen.
JPH082908B2 (ja) * 1986-02-28 1996-01-17 武田薬品工業株式会社 セフアロスポリン化合物の製造方法
EP0384732A3 (de) * 1989-02-23 1991-12-04 Merck & Co. Inc. Freigabeverfahren für Allylester mit regenerierbarem, polymergestütztem Pd (O)
SE463532B (sv) * 1989-05-02 1990-12-03 Dart Engineering Ag Tryckmedelsassisterad anordning vid hopkopplingsbara han och hondelar
JP2992314B2 (ja) * 1989-07-26 1999-12-20 サントリー株式会社 アリル基の除去方法
JP2949363B2 (ja) * 1990-06-05 1999-09-13 サントリー株式会社 アリル基の脱離方法
WO1992002521A1 (en) * 1990-07-27 1992-02-20 Fujisawa Pharmaceutical Co., Ltd. 1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid compounds
CA2050255C (en) * 1990-09-07 1997-02-04 Tameo Iwasaki 1-methylcarbapenem derivatives and process for preparation thereof

Also Published As

Publication number Publication date
DE69329441D1 (de) 2000-10-26
EP0574940A1 (de) 1993-12-22
US5587474A (en) 1996-12-24
EP0574940B1 (de) 2000-09-20

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition