DE69328118D1 - Verbesserter strangverdrängungstest und dafür verwendbarer komplex - Google Patents

Verbesserter strangverdrängungstest und dafür verwendbarer komplex

Info

Publication number
DE69328118D1
DE69328118D1 DE69328118T DE69328118T DE69328118D1 DE 69328118 D1 DE69328118 D1 DE 69328118D1 DE 69328118 T DE69328118 T DE 69328118T DE 69328118 T DE69328118 T DE 69328118T DE 69328118 D1 DE69328118 D1 DE 69328118D1
Authority
DE
Germany
Prior art keywords
complex
strand displacement
displacement test
improved strand
improved
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69328118T
Other languages
English (en)
Other versions
DE69328118T2 (de
Inventor
Scott Eadie
Neil Balgobin
Harvey Buck
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics Operations Inc
Original Assignee
Boehringer Mannheim Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim Corp filed Critical Boehringer Mannheim Corp
Application granted granted Critical
Publication of DE69328118D1 publication Critical patent/DE69328118D1/de
Publication of DE69328118T2 publication Critical patent/DE69328118T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
    • C12Q1/689—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C12Q1/6823—Release of bound markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
DE69328118T 1992-09-15 1993-09-15 Verbesserter strangverdrängungstest und dafür verwendbarer komplex Expired - Lifetime DE69328118T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/945,156 US5445933A (en) 1992-09-15 1992-09-15 Strand displacement assay and complex useful therefor
PCT/US1993/008707 WO1994006937A1 (en) 1992-09-15 1993-09-15 Improved strand displacement assay and complex useful therefor

Publications (2)

Publication Number Publication Date
DE69328118D1 true DE69328118D1 (de) 2000-04-20
DE69328118T2 DE69328118T2 (de) 2000-09-28

Family

ID=25482719

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69328118T Expired - Lifetime DE69328118T2 (de) 1992-09-15 1993-09-15 Verbesserter strangverdrängungstest und dafür verwendbarer komplex

Country Status (6)

Country Link
US (1) US5445933A (de)
EP (1) EP0672186B1 (de)
JP (1) JP3436538B2 (de)
DE (1) DE69328118T2 (de)
ES (1) ES2145062T3 (de)
WO (1) WO1994006937A1 (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2751000B1 (fr) * 1996-07-12 1998-10-30 Inst Nat Sante Rech Med Adn specifiques des bacteries de l'espece neisseria meningitidis, leurs procedes d'obtention et leurs applications biologiques
DE69736667T2 (de) * 1996-07-16 2007-09-06 Gen-Probe Inc., San Diego Verfahren zum nachweis und amplifikation von nukleinsäuresequenzen unter verbrauch von modifizierten oligonukleotiden mit erhöhter zielschmelztemperatur (tm)
US7070925B1 (en) 1996-07-16 2006-07-04 Gen-Probe Incorporated Method for determining the presence of an RNA analyte in a sample using a modified oligonucleotide probe
US5994068A (en) 1997-03-11 1999-11-30 Wisconsin Alumni Research Foundation Nucleic acid indexing
US6255051B1 (en) 1997-11-06 2001-07-03 Mosaic Technologies Inc. Multiple sequential polynucleotide displacement reactions for signal amplification and processing
US6322968B1 (en) * 1997-11-21 2001-11-27 Orchid Biosciences, Inc. De novo or “universal” sequencing array
US6365346B1 (en) 1998-02-18 2002-04-02 Dade Behring Inc. Quantitative determination of nucleic acid amplification products
US6270973B1 (en) 1998-03-13 2001-08-07 Promega Corporation Multiplex method for nucleic acid detection
US6235480B1 (en) 1998-03-13 2001-05-22 Promega Corporation Detection of nucleic acid hybrids
US6277578B1 (en) 1998-03-13 2001-08-21 Promega Corporation Deploymerization method for nucleic acid detection of an amplified nucleic acid target
US6268146B1 (en) 1998-03-13 2001-07-31 Promega Corporation Analytical methods and materials for nucleic acid detection
US6703211B1 (en) 1998-03-13 2004-03-09 Promega Corporation Cellular detection by providing high energy phosphate donor other than ADP to produce ATP
US6312902B1 (en) 1998-03-13 2001-11-06 Promega Corporation Nucleic acid detection
US6270974B1 (en) 1998-03-13 2001-08-07 Promega Corporation Exogenous nucleic acid detection
US7090975B2 (en) * 1998-03-13 2006-08-15 Promega Corporation Pyrophosphorolysis and incorporation of nucleotide method for nucleic acid detection
US6391551B1 (en) 1998-03-13 2002-05-21 Promega Corporation Detection of nucleic acid hybrids
US6361945B1 (en) * 1998-07-02 2002-03-26 Gen-Probe Incorporated Molecular torches
AU6412799A (en) * 1998-10-05 2000-04-26 Mosaic Technologies Reverse displacement assay for detection of nucleic acid sequences
EP1235930A2 (de) * 1999-04-02 2002-09-04 Mosaic Technologies Electrophoretische anlyse von zielmolekülen unter benutzung von adapter molekülen
US7005265B1 (en) 2002-06-20 2006-02-28 Wenhong Fan Nonenzymatic catalytic signal amplification for nucleic acid hybridization assays
DK1778867T3 (da) * 2004-07-01 2010-08-02 Gen Probe Inc Fremgangsmåder og sammensætninger til detektering af nucleinsyrer i en biologisk prøve
WO2009140374A2 (en) 2008-05-13 2009-11-19 Gen-Probe Incorporated Inactivatable target capture oligomers for use in the selective hybridization and capture of target nucleic acid sequences
AU2009324884B2 (en) 2008-11-25 2013-10-03 Gen-Probe Incorporated Compositions and methods for detecting small RNAs, and uses thereof
US20130071839A1 (en) * 2011-09-02 2013-03-21 Georg Seelig Systems and methods for detecting biomarkers of interest
US9851330B2 (en) * 2015-03-20 2017-12-26 Konica Minolta Laboratory U.S.A., Inc. Rapid, highly-sensitive, and highly-specific nucleic acid detection

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4766064A (en) * 1984-05-07 1988-08-23 Allied Corporation Displacement polynucleotide assay employing polyether and diagnostic kit
US4766062A (en) * 1984-05-07 1988-08-23 Allied Corporation Displacement polynucleotide assay method and polynucleotide complex reagent therefor
US4767699A (en) * 1985-05-02 1988-08-30 Allied Corporation Diagnostic reagent, kit and method employing polynucleotide displacement, separation, enzymatic cleavage and adenosine phosphate detection
US4735897A (en) * 1985-05-02 1988-04-05 Allied Corporation Method and kit for detecting polyriboadenosine segments and messenger RNA
US4795701A (en) * 1985-07-17 1989-01-03 Allied Corporation Homogeneous polynucleotide displacement assay method kit and reagent complex
US4725536A (en) * 1985-09-19 1988-02-16 Genetics Institute, Inc. Reagent polynucleotide complex with multiple target binding regions, and kit and methods
US4725537A (en) * 1985-09-19 1988-02-16 Allied Corporation Assay, reagent and kit employing nucleic acid strand displacement and restriction endonuclease cleavage
EP0219842A1 (de) * 1985-10-23 1987-04-29 Allied Corporation Nukleinsäuretest mittels Segmentpaarhemmung oder -konkurrenz
US4752566A (en) * 1985-12-17 1988-06-21 Genetics Institute, Inc. Displacement polynucleotide method and reagent complex employing labeled probe polynucleotide
AU6834187A (en) * 1985-12-17 1987-07-15 Genetics Institute Inc. Displacement polynucleotide method and reagent complex
US4818680A (en) * 1985-12-18 1989-04-04 Mary Collins Method and kit involving displacement and rehybridization of labeled polynucleotide
ATE375392T1 (de) * 1990-05-03 2007-10-15 Cornell Res Foundation Inc Ein system der dna amplifikation zur detektion genetischer erkrankungen durch eine thermostabile ligase

Also Published As

Publication number Publication date
DE69328118T2 (de) 2000-09-28
WO1994006937A1 (en) 1994-03-31
ES2145062T3 (es) 2000-07-01
JPH08501689A (ja) 1996-02-27
EP0672186A1 (de) 1995-09-20
EP0672186A4 (de) 1995-12-20
JP3436538B2 (ja) 2003-08-11
US5445933A (en) 1995-08-29
EP0672186B1 (de) 2000-03-15

Similar Documents

Publication Publication Date Title
DE69328118D1 (de) Verbesserter strangverdrängungstest und dafür verwendbarer komplex
DE69331967D1 (de) Gefässstent und zugehörige einführungsvorrichtung
DE69529340D1 (de) Gesteuertes biopsiegerät und analysegerät
DE69328363D1 (de) Nichtinvasives testverfahren
DE69425782D1 (de) Hyterosalpingographie und selektive Salpingographie
DE69516366D1 (de) Messverfahren und Messvorrichtung
DE59510271D1 (de) Messfühler
NO933900D0 (no) Sondeelement
DE69228369D1 (de) Berührungslose Testsonde
DE69419291D1 (de) Formmessapparat
DE68928033D1 (de) Stereosynthesizer und entsprechendes verfahren
DE69314830D1 (de) Koordinatenmessgerät und Messverfahren
DE69301477D1 (de) Arbeitsstation und Träger
DE69331573D1 (de) Blutabnahme-vorrichtung
DE59306558D1 (de) Analysenvorrichtung
DE69325124D1 (de) Sauerstoffmesssonde
DE69332613D1 (de) Thermoelementfühler
DE59308700D1 (de) Mittel zur festigung der haare
NO941247D0 (no) Sondeanordning
DE69630698D1 (de) Hubvorrichtung für eine person
DE69318286D1 (de) Metrologischer gerät
DE59405241D1 (de) Sauerstoffmessfühler
NO925027D0 (no) Pulsstyrt doseringsapparat
DE69332071D1 (de) Verbesserte Instrumentationssonde
DE69614491D1 (de) 5HT1Dalpha und 5HT2A Ligande

Legal Events

Date Code Title Description
8327 Change in the person/name/address of the patent owner

Owner name: ROCHE DIAGNOSTICS CORP., INDIANAPOLIS, IND., US

8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: ROCHE DIAGNOSTICS OPERATIONS, INC., INDIANAPOLIS,

8328 Change in the person/name/address of the agent

Representative=s name: DURM & PARTNER, 76137 KARLSRUHE