DE69327914T2 - Verbesserungen and Radiomarkierung - Google Patents
Verbesserungen and RadiomarkierungInfo
- Publication number
- DE69327914T2 DE69327914T2 DE69327914T DE69327914T DE69327914T2 DE 69327914 T2 DE69327914 T2 DE 69327914T2 DE 69327914 T DE69327914 T DE 69327914T DE 69327914 T DE69327914 T DE 69327914T DE 69327914 T2 DE69327914 T2 DE 69327914T2
- Authority
- DE
- Germany
- Prior art keywords
- hydroxyalkyl
- alkylcarboxy
- tetra
- hydroxy
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic System
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic System
- C07F13/005—Compounds without a metal-carbon linkage
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
- A61K51/0476—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from monodendate ligands, e.g. sestamibi
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
- A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1093—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
- C07C229/10—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
- C07C229/12—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of acyclic carbon skeletons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB929209641A GB9209641D0 (en) | 1992-05-02 | 1992-05-02 | Improvements in radiolabelling |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69327914D1 DE69327914D1 (de) | 2000-04-06 |
DE69327914T2 true DE69327914T2 (de) | 2000-06-29 |
Family
ID=10714995
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69327914T Expired - Fee Related DE69327914T2 (de) | 1992-05-02 | 1993-04-07 | Verbesserungen and Radiomarkierung |
Country Status (19)
Country | Link |
---|---|
US (1) | US5350837A (de) |
EP (1) | EP0569132B1 (de) |
JP (1) | JP3271259B2 (de) |
KR (1) | KR100293777B1 (de) |
AT (1) | ATE190063T1 (de) |
AU (1) | AU663581B2 (de) |
CA (1) | CA2094380C (de) |
DE (1) | DE69327914T2 (de) |
DK (1) | DK0569132T3 (de) |
ES (1) | ES2143489T3 (de) |
FI (1) | FI931968A (de) |
GB (1) | GB9209641D0 (de) |
GR (1) | GR3033379T3 (de) |
HK (1) | HK1013828A1 (de) |
NO (1) | NO306407B1 (de) |
NZ (1) | NZ247445A (de) |
PT (1) | PT569132E (de) |
TW (1) | TW227564B (de) |
ZA (1) | ZA932844B (de) |
Families Citing this family (43)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5744120A (en) * | 1993-03-30 | 1998-04-28 | The Dupont Merick Pharmaceutical Company | Ternary radiopharmaceutical complexes |
US5879657A (en) * | 1993-03-30 | 1999-03-09 | The Dupont Merck Pharmaceutical Company | Radiolabeled platelet GPIIb/IIIa receptor antagonists as imaging agents for the diagnosis of thromboembolic disorders |
US5480970A (en) * | 1993-12-22 | 1996-01-02 | Resolution Pharmaceuticals | Metal chelators |
US5569745A (en) * | 1994-02-25 | 1996-10-29 | Resolution Pharmaceuticals Inc. | Peptide-Chelator conjugates |
ZA955642B (en) * | 1994-07-07 | 1997-05-06 | Ortho Pharma Corp | Lyophilized imaging agent formulation |
US5662885A (en) * | 1994-07-22 | 1997-09-02 | Resolution Pharmaceuticals Inc. | Peptide derived radionuclide chelators |
US5942210A (en) * | 1994-11-15 | 1999-08-24 | Cytogen Corporation | Methods for lyoprotecting a macromolecule using tricine |
WO1997033627A2 (en) * | 1996-03-13 | 1997-09-18 | Du Pont Pharmaceuticals Company | New ternary radiopharmaceutical complexes |
US5879659A (en) * | 1996-03-13 | 1999-03-09 | Dupont Pharmaceuticals Company | Ternary radiopharmaceutical complexes |
US20030124053A1 (en) * | 1996-10-07 | 2003-07-03 | Barrett John Andrew | Radiopharmaceuticals for imaging infection and inflammation |
US6416733B1 (en) * | 1996-10-07 | 2002-07-09 | Bristol-Myers Squibb Pharma Company | Radiopharmaceuticals for imaging infection and inflammation |
US6403054B1 (en) | 1997-05-28 | 2002-06-11 | Bristol-Myers Squibb Pharma Company | Ternary ligand complexes useful as radiopharmaceuticals |
US6524553B2 (en) * | 1998-03-31 | 2003-02-25 | Bristol-Myers Squibb Pharma Company | Quinolone vitronectin receptor antagonist pharmaceuticals |
US6537520B1 (en) * | 1998-03-31 | 2003-03-25 | Bristol-Myers Squibb Pharma Company | Pharmaceuticals for the imaging of angiogenic disorders |
US6548663B1 (en) | 1998-03-31 | 2003-04-15 | Bristol-Myers Squibb Pharma Company | Benzodiazepine vitronectin receptor antagonist pharmaceuticals |
WO1999051628A1 (en) | 1998-04-03 | 1999-10-14 | Du Pont Pharmaceuticals Company | Radiopharmaceuticals for imaging infection and inflammation and for imaging and treatment of cancer |
US6794518B1 (en) | 1998-12-18 | 2004-09-21 | Bristol-Myers Squibb Pharma Company | Vitronectin receptor antagonist pharmaceuticals |
US6569402B1 (en) * | 1998-12-18 | 2003-05-27 | Bristol-Myers Squibb Pharma Company | Vitronectin receptor antagonist pharmaceuticals |
CN1356913A (zh) | 1998-12-18 | 2002-07-03 | 杜邦药品公司 | 玻连蛋白受体拮抗剂药物 |
US6511649B1 (en) | 1998-12-18 | 2003-01-28 | Thomas D. Harris | Vitronectin receptor antagonist pharmaceuticals |
AU2371400A (en) | 1998-12-18 | 2000-07-03 | Du Pont Pharmaceuticals Company | Vitronectin receptor antagonist pharmaceuticals |
US6346547B1 (en) * | 1999-02-08 | 2002-02-12 | Checkpoint, Genetics, Inc. | N-substituted amino acids, antioxidant pharmaceutical compositions containing n-substituted amino acids and methods for preventing cardiovascular diseases and/or preventing and/or treating antioxidant responsive diseases therewith |
US6808698B1 (en) | 1999-03-26 | 2004-10-26 | Bristol-Myers Squibb Pharma Company | Method for localization of blood clots |
US6534038B2 (en) | 2000-04-07 | 2003-03-18 | Bristol-Myers Squibb Pharma Company | Ternary ligand complexes useful as radiopharmaceuticals |
WO2002036173A2 (en) * | 2000-11-03 | 2002-05-10 | Bristol-Myers Squibb Pharma Company | Simultaneous dual isotope imaging of cardiac perfusion and cardiac inflammation |
US6776977B2 (en) | 2001-01-09 | 2004-08-17 | Bristol-Myers Squibb Pharma Company | Polypodal chelants for metallopharmaceuticals |
US6517814B2 (en) | 2001-01-09 | 2003-02-11 | Bristol-Myers Squibb Pharma Company | Macrocyclic chelants useful for metallopharmaceuticals |
US6838074B2 (en) | 2001-08-08 | 2005-01-04 | Bristol-Myers Squibb Company | Simultaneous imaging of cardiac perfusion and a vitronectin receptor targeted imaging agent |
HUP0401904A3 (en) * | 2001-08-08 | 2009-01-28 | Bristol Myers Squibb Pharma Co | Simultaneous imaging of cardiac perfusion and a vitronectin receptor targeted imaging agent |
US7319149B2 (en) * | 2003-06-13 | 2008-01-15 | Bristol-Myers Squibb Pharma Company | Chelants and macrocyclic metal complex radiopharmaceuticals thereof |
US7317104B2 (en) | 2003-06-13 | 2008-01-08 | Bristol-Myers Squibb Pharma Company | Chelants and macrocyclic metal complex radiopharmaceuticals thereof |
US20050106100A1 (en) * | 2003-09-03 | 2005-05-19 | Harris Thomas D. | Compounds containing matrix metalloproteinase substrates and methods of their use |
CN101252954A (zh) * | 2005-06-30 | 2008-08-27 | 布里斯托尔-迈尔斯斯奎布药品公司 | 作为显像剂的酰肼偶联物 |
US9447310B2 (en) | 2008-04-17 | 2016-09-20 | Thomas P. Daly | Biological buffers with wide buffering ranges |
US8034951B2 (en) * | 2008-04-17 | 2011-10-11 | Thomas Daly | Biological buffers with wide buffering ranges |
US7635791B2 (en) * | 2008-04-17 | 2009-12-22 | Tpat Ip Llc | Biological buffers with wide buffering ranges |
US20170313920A1 (en) | 2010-10-06 | 2017-11-02 | Thomas P. Daly | Biological Buffers with Wide Buffering Ranges |
US7939659B2 (en) * | 2008-04-17 | 2011-05-10 | Thomas Daly | Biological buffers with wide buffering ranges |
US8334402B2 (en) | 2008-04-17 | 2012-12-18 | Thomas Daly | Biological buffers with wide buffering ranges |
US8822728B2 (en) | 2008-04-17 | 2014-09-02 | Thomas Daly | Biological buffers with wide buffering ranges |
US8519141B2 (en) | 2008-04-17 | 2013-08-27 | Thomas Daly | Biological buffers with wide buffering ranges |
US9090638B2 (en) | 2008-04-17 | 2015-07-28 | Thomas Daly | Biological buffers with wide buffering ranges |
US9475754B2 (en) | 2011-10-06 | 2016-10-25 | Thomas P. Daly | Biological buffers with wide buffering ranges |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE7504915L (sv) * | 1974-04-30 | 1975-10-31 | Solco Basel Ag | Medel for att diagnostiskt synliggora neoplastiska vevnader. |
US4017596A (en) * | 1975-03-03 | 1977-04-12 | Research Corporation | Radiopharmaceutical chelates and method of external imaging |
US4425280A (en) * | 1981-03-30 | 1984-01-10 | Ferro Corporation | Metal amino acids |
US4772724A (en) * | 1986-12-02 | 1988-09-20 | Warner-Lambert Canada Inc. | Essentially pure acid hydroxyl ligand aluminum complexes and their preparation |
US5198208A (en) * | 1987-07-16 | 1993-03-30 | Nycomed Imaging As | Aminopolycarboxylic acids and derivatives thereof |
IL93432A (en) * | 1989-02-24 | 1994-02-27 | Johnson Mathey Inc | Hydrazines and hydrazides, their conjugates with macromolecules, and such conjugates labeled with metallic ions |
-
1992
- 1992-05-02 GB GB929209641A patent/GB9209641D0/en active Pending
-
1993
- 1993-04-07 DE DE69327914T patent/DE69327914T2/de not_active Expired - Fee Related
- 1993-04-07 DK DK93302712T patent/DK0569132T3/da active
- 1993-04-07 PT PT93302712T patent/PT569132E/pt unknown
- 1993-04-07 AT AT93302712T patent/ATE190063T1/de not_active IP Right Cessation
- 1993-04-07 EP EP93302712A patent/EP0569132B1/de not_active Expired - Lifetime
- 1993-04-07 ES ES93302712T patent/ES2143489T3/es not_active Expired - Lifetime
- 1993-04-19 CA CA002094380A patent/CA2094380C/en not_active Expired - Fee Related
- 1993-04-20 NZ NZ247445A patent/NZ247445A/en unknown
- 1993-04-22 ZA ZA932844A patent/ZA932844B/xx unknown
- 1993-04-23 AU AU37173/93A patent/AU663581B2/en not_active Ceased
- 1993-04-27 TW TW082103251A patent/TW227564B/zh active
- 1993-04-30 JP JP10392093A patent/JP3271259B2/ja not_active Expired - Fee Related
- 1993-04-30 FI FI931968A patent/FI931968A/fi not_active IP Right Cessation
- 1993-04-30 NO NO931585A patent/NO306407B1/no not_active IP Right Cessation
- 1993-05-03 KR KR1019930007574A patent/KR100293777B1/ko not_active IP Right Cessation
- 1993-05-03 US US08/055,312 patent/US5350837A/en not_active Expired - Fee Related
-
1998
- 1998-12-23 HK HK98115229A patent/HK1013828A1/xx not_active IP Right Cessation
-
2000
- 2000-05-05 GR GR20000401064T patent/GR3033379T3/el not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
ES2143489T3 (es) | 2000-05-16 |
CA2094380C (en) | 2002-02-12 |
FI931968A (fi) | 1993-11-03 |
EP0569132A1 (de) | 1993-11-10 |
GB9209641D0 (en) | 1992-06-17 |
JP3271259B2 (ja) | 2002-04-02 |
PT569132E (pt) | 2000-08-31 |
NO931585L (no) | 1993-11-03 |
NO931585D0 (no) | 1993-04-30 |
CA2094380A1 (en) | 1993-11-03 |
JPH0665169A (ja) | 1994-03-08 |
ZA932844B (en) | 1994-06-21 |
EP0569132B1 (de) | 2000-03-01 |
GR3033379T3 (en) | 2000-09-29 |
HK1013828A1 (en) | 1999-09-10 |
ATE190063T1 (de) | 2000-03-15 |
NZ247445A (en) | 1995-07-26 |
NO306407B1 (no) | 1999-11-01 |
AU663581B2 (en) | 1995-10-12 |
DE69327914D1 (de) | 2000-04-06 |
FI931968A0 (fi) | 1993-04-30 |
AU3717393A (en) | 1993-11-04 |
DK0569132T3 (da) | 2000-07-31 |
US5350837A (en) | 1994-09-27 |
KR100293777B1 (ko) | 2001-11-22 |
KR930023028A (ko) | 1993-12-18 |
TW227564B (de) | 1994-08-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8328 | Change in the person/name/address of the agent |
Representative=s name: ZEITLER, VOLPERT, KANDLBINDER, 80539 MUENCHEN |
|
8339 | Ceased/non-payment of the annual fee |