DE69324763D1 - Vorrichtung und Verfahren zur Analyse von HDL-Cholesterin in Vollblut - Google Patents
Vorrichtung und Verfahren zur Analyse von HDL-Cholesterin in VollblutInfo
- Publication number
- DE69324763D1 DE69324763D1 DE69324763T DE69324763T DE69324763D1 DE 69324763 D1 DE69324763 D1 DE 69324763D1 DE 69324763 T DE69324763 T DE 69324763T DE 69324763 T DE69324763 T DE 69324763T DE 69324763 D1 DE69324763 D1 DE 69324763D1
- Authority
- DE
- Germany
- Prior art keywords
- serum
- plasma
- whole blood
- ldl
- separates
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/49—Blood
- G01N33/491—Blood by separating the blood components
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/60—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving cholesterol
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/92—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving lipids, e.g. cholesterol, lipoproteins, or their receptors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/04—Endocrine or metabolic disorders
- G01N2800/044—Hyperlipemia or hypolipemia, e.g. dyslipidaemia, obesity
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
- Y10T436/25375—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Biophysics (AREA)
- Organic Chemistry (AREA)
- Urology & Nephrology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Pathology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Genetics & Genomics (AREA)
- Endocrinology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Ecology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/959,400 US5460974A (en) | 1992-10-13 | 1992-10-13 | Method of assaying whole blood for HDL cholesterol |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69324763D1 true DE69324763D1 (de) | 1999-06-10 |
DE69324763T2 DE69324763T2 (de) | 1999-09-16 |
Family
ID=25502013
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69324763T Expired - Lifetime DE69324763T2 (de) | 1992-10-13 | 1993-10-13 | Vorrichtung und Verfahren zur Analyse von HDL-Cholesterin in Vollblut |
Country Status (10)
Country | Link |
---|---|
US (1) | US5460974A (de) |
EP (1) | EP0597268B1 (de) |
JP (1) | JPH06201704A (de) |
AT (1) | ATE179800T1 (de) |
AU (1) | AU661414B2 (de) |
CA (1) | CA2108105C (de) |
DE (1) | DE69324763T2 (de) |
DK (1) | DK0597268T3 (de) |
ES (1) | ES2130202T3 (de) |
GR (1) | GR3030682T3 (de) |
Families Citing this family (58)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
USRE39915E1 (en) | 1989-09-01 | 2007-11-06 | Roche Diagnostics Gmbh | Method for the determination of HDL cholesterol by means of a rapid diagnostic agent with an integrated fractionating step |
DE3929032C2 (de) * | 1989-09-01 | 1998-09-03 | Boehringer Mannheim Gmbh | Verfahren zur Bestimmung von HDL-Cholesterin mittels eines Schnelldiagnostikums mit integriertem Fraktionierschritt |
US5460974A (en) * | 1992-10-13 | 1995-10-24 | Miles Inc. | Method of assaying whole blood for HDL cholesterol |
US5543047A (en) | 1992-11-06 | 1996-08-06 | Pall Corporation | Filter with over-laid pleats in intimate contact |
US5290703A (en) * | 1992-12-14 | 1994-03-01 | Miles, Inc. | Method for the separation of high density lipoprotein from blood samples |
FI940823A0 (fi) * | 1994-02-22 | 1994-02-22 | Orion Yhtymae Oy | Analysatorkyvett foer turbidimetriska och nefelometriska bestaemningar av helblodsprov |
WO1995031720A1 (en) * | 1994-05-15 | 1995-11-23 | Troell, Martha, T. | Method and apparatus for the collection, storage, and real time analysis of blood and other bodily fluids |
AU3483495A (en) * | 1994-09-28 | 1996-04-19 | Spectral Diagnostics Inc. | Method and device for determination of proteins |
WO1996015453A1 (en) * | 1994-11-14 | 1996-05-23 | Spectral Diagnostics Inc. | Method and device for determination of proteins employing antigen/antibody reactions |
ES2268706T3 (es) * | 1995-05-09 | 2007-03-16 | Beckman Coulter, Inc. | Dispositivos y procedimientos para separar componentes celulares de la sangre de la porcion liquida de la sangre. |
US5755231A (en) * | 1995-05-17 | 1998-05-26 | Plus Bio, Inc. | Test strip including integral specimen flow retarding structure |
US5716851A (en) * | 1996-01-16 | 1998-02-10 | Bayer Corporation | Glass/cellulose as protein reagent |
JPH10284055A (ja) | 1997-02-04 | 1998-10-23 | Mitsubishi Electric Corp | リチウムイオン二次電池用電極およびそれを用いたリチウムイオン二次電池 |
JP2000070241A (ja) * | 1998-08-31 | 2000-03-07 | Nissho Corp | 急速凝固用真空採血管 |
KR100682082B1 (ko) * | 1999-03-01 | 2007-02-12 | 시스멕스 가부시키가이샤 | 생체시료성분의 측정방법 |
US20080260593A1 (en) * | 2000-03-22 | 2008-10-23 | Dewalch Norman Binz | Method and apparatus for processing substances in a single container |
AU2000267325A1 (en) * | 2000-08-28 | 2002-03-13 | Sapporo Immuno Diagnostic Laboratory | Simple implement for collecting/recovering liquid sample |
US6689615B1 (en) * | 2000-10-04 | 2004-02-10 | James Murto | Methods and devices for processing blood samples |
SE0003662D0 (sv) * | 2000-10-11 | 2000-10-11 | Pharmacia Diagnostics Ab | Assay method and kit therefor |
KR20020032753A (ko) * | 2000-10-27 | 2002-05-04 | 김희태 | 혈중 콜레스테롤의 농도 측정 방법 및 이를 위한 측정용키트 |
US7029863B2 (en) * | 2001-03-14 | 2006-04-18 | The Children's Hospital Of Philadelphia | Cell culture system for determining the cholesterol efflux potential for serum |
EP1428022A1 (de) * | 2001-09-12 | 2004-06-16 | National Research Council of Canada | Ein verfahren zum simultanen und direkten nachweis von serumcholesterol in hdl und ldl mittels infrarot spektroskopie |
AU2002364741A1 (en) | 2001-12-21 | 2003-07-15 | Polymer Technology Systems, Inc. | Test strip and method for determining hdl cholesterol concentration from whole blood of plasma |
DE10204606C1 (de) * | 2002-01-18 | 2003-10-16 | Cholestech Corp | Vorrichtung und Verfahren für Lipoproteine hoher Dichte |
JP4191051B2 (ja) * | 2002-02-27 | 2008-12-03 | 三光純薬株式会社 | 血漿又は血清分離具 |
EP1357383B1 (de) * | 2002-04-09 | 2005-11-09 | Cholestech Corporation | Verfahren und Vorrichtung zur Quantifizierung von Lipoprotein-Cholesterol hoher Dichte |
EP1540353A4 (de) * | 2002-09-16 | 2007-01-24 | Polymer Technology Systems Inc | Teststreifen und verfahren zur bestimmung der ldl-cholesterinkonzentration aus vollblut |
JP4210783B2 (ja) * | 2002-09-26 | 2009-01-21 | アークレイ株式会社 | 分析用具 |
JP4262466B2 (ja) | 2002-10-28 | 2009-05-13 | アークレイ株式会社 | 分析用具および分析装置 |
TWI333545B (en) * | 2003-04-02 | 2010-11-21 | Cholestech Corp | Adhered membranes retaining porosity and biological activity |
US7625721B2 (en) | 2004-02-03 | 2009-12-01 | Polymer Technology Systems, Inc. | Non-precipitating bodily fluid analysis system |
US7435577B2 (en) | 2004-02-03 | 2008-10-14 | Polymer Technology Systems, Inc. | Direct measurement of chlolesterol from low density lipoprotein with test strip |
EP1779119B1 (de) * | 2004-08-17 | 2012-08-01 | Polymer Technology Systems, Inc. | Nichtkomplexbildendes körperflüssigkeitsanalyseverfahren |
US20060062690A1 (en) | 2004-08-17 | 2006-03-23 | Polymer Technology Systems, Inc. | Apparatus and method of manufacturing bodily fluid test strip |
JP3955618B2 (ja) * | 2005-01-28 | 2007-08-08 | 松下電器産業株式会社 | 血液処理装置及び血液導入方法 |
NZ540060A (de) * | 2005-05-16 | 2008-01-31 | Lab Tek Internat Ltd | |
ATE483165T1 (de) | 2007-01-09 | 2010-10-15 | Cholestech Corp | Vorrichtung und verfahren zur messung des ldl- assoziierten cholesterols |
US8247235B2 (en) | 2007-06-08 | 2012-08-21 | Quest Diagnostics Investments Incorporated | Lipoprotein analysis by differential charged-particle mobility |
WO2009110089A1 (ja) * | 2008-03-07 | 2009-09-11 | 株式会社ティー・ワイ・エー | 体液成分の分析器具 |
JP5313537B2 (ja) * | 2008-04-10 | 2013-10-09 | 富士フイルム株式会社 | 高密度リポ蛋白コレステロール測定用乾式分析素子 |
US9354200B1 (en) | 2008-08-07 | 2016-05-31 | Quest Diagnostics Investments Incorporated | Detection apparatus for differential-charged particle mobility analyzer |
KR101058743B1 (ko) * | 2009-06-04 | 2011-08-24 | 주식회사 인포피아 | 콜레스테롤 측정 스트립 및 이를 이용한 콜레스테롤 검출 방법 |
KR101470108B1 (ko) * | 2009-07-14 | 2014-12-05 | 도꾸리쯔교세이호진 상교기쥬쯔 소고겡뀨죠 | 당단백질의 측정 방법, 간질환의 검사 방법, 당단백질 정량용 시약 및 간질환 병태 지표 당쇄 마커 당단백질 |
CN102695716B (zh) | 2009-07-14 | 2016-03-02 | 独立行政法人产业技术综合研究所 | 肝病病情指标糖链标记物 |
US9250211B2 (en) * | 2010-12-30 | 2016-02-02 | Quest Diagnostics Investments Incorporated | Magnetic separation of lipoproteins using dextran sulfate |
US20120282634A1 (en) * | 2011-04-22 | 2012-11-08 | Polymer Technology Systems, Inc. | Blood separation system and method for a dry test strip |
US9207184B2 (en) | 2012-05-04 | 2015-12-08 | Polymer Technology Systems, Inc. | Systems and methods for non-fasting LDL cholesterol assays |
US9702807B2 (en) | 2012-06-16 | 2017-07-11 | Ningbo Alabama, Llc | Measurement of serum lipoproteins |
US9239280B2 (en) * | 2012-06-16 | 2016-01-19 | Atherotech, Inc. | Measurement of serum lipoproteins |
US20150258267A1 (en) * | 2012-08-08 | 2015-09-17 | Koninklijke Philips N.V. | Plasma separation using a drop of blood |
EP2969143A1 (de) * | 2013-03-14 | 2016-01-20 | Instrumentation Laboratory Company | Abtrennung von plasma aus blut mittels filtrationsvorrichtung und verfahren dafür |
US20150260631A1 (en) * | 2014-03-17 | 2015-09-17 | Health Diagnostic Laboratory, Inc. | System and method for assessing quanitites or sizes of lipoprotein particles from lipoprotein particle compositions |
US10788480B2 (en) * | 2014-11-07 | 2020-09-29 | The Johns Hopkins University | Aggregation-assisted separation of plasma from whole blood |
US10518260B1 (en) * | 2019-05-01 | 2019-12-31 | Nano Discovery, Inc. | Device for separation of plasma or serum from blood cells and methods of using the device |
US20210001333A1 (en) * | 2019-07-03 | 2021-01-07 | King Abdulaziz University | Microfluidic device for measuring the enzymatic activity of thiopurin s-methyltransferase |
JP7361198B2 (ja) * | 2019-07-19 | 2023-10-13 | シーメンス・ヘルスケア・ダイアグノスティックス・インコーポレイテッド | 接線流溶血検出血液検査装置 |
CN112941144B (zh) * | 2021-03-01 | 2022-02-15 | 江西英大生物技术有限公司 | 小而密低密度脂蛋白胆固醇测定试剂盒 |
CN115381800B (zh) * | 2022-07-05 | 2023-08-25 | 中国科学院生态环境研究中心 | 一种肝x受体的选择性激动剂及应用 |
Family Cites Families (44)
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US3092465A (en) * | 1960-03-25 | 1963-06-04 | Miles Lab | Diagnostic test device for blood sugar |
US3146163A (en) * | 1962-01-23 | 1964-08-25 | John H Brewer | Apparatus for separating certain components from blood |
US3298789A (en) * | 1964-12-14 | 1967-01-17 | Miles Lab | Test article for the detection of glucose |
US3552925A (en) * | 1967-07-13 | 1971-01-05 | Miles Lab | Whole blood separation method and test using same |
US3552928A (en) * | 1967-07-19 | 1971-01-05 | Miles Lab | Whole blood separation means and test system using same |
US3607093A (en) * | 1968-02-15 | 1971-09-21 | Schering Corp | Devices for testing biological liquids |
US4059405A (en) * | 1972-04-11 | 1977-11-22 | Damon Corporation | Method and apparatus for analysis of constituent carried in fibrous medium |
US4045176A (en) * | 1975-06-13 | 1977-08-30 | Proksch Gary J | Preparation of optically clear serum |
CA1095819A (en) * | 1977-01-14 | 1981-02-17 | Eastman Kodak Company | Element for analysis of liquids |
US4126416A (en) * | 1977-11-21 | 1978-11-21 | The Trustees Of Boston University | Method for determining the level of LDL cholesterol in blood plasma |
US4190628A (en) * | 1977-11-21 | 1980-02-26 | Trustees Of Boston University | Kit for determining the level of LDL cholesterol in body fluids |
JPS587332Y2 (ja) * | 1978-06-06 | 1983-02-08 | 富士写真フイルム株式会社 | 多層血液化学分析材料 |
DE2963844D1 (en) * | 1978-07-04 | 1982-11-18 | Goella Lab | Method and reagents for measuring the cholesterol content in serum |
US4188188A (en) * | 1978-09-27 | 1980-02-12 | Bio-Rad Laboratories, Inc. | High density lipoprotein cholesterol assay |
US4258001A (en) * | 1978-12-27 | 1981-03-24 | Eastman Kodak Company | Element, structure and method for the analysis or transport of liquids |
US4234317A (en) * | 1979-05-24 | 1980-11-18 | Analytical Products, Inc. | Apparatus and method for fractionation of lipoproteins |
US4816224A (en) * | 1980-08-05 | 1989-03-28 | Boehringer Mannheim Gmbh | Device for separating plasma or serum from whole blood and analyzing the same |
DE3029579C2 (de) * | 1980-08-05 | 1985-12-12 | Boehringer Mannheim Gmbh, 6800 Mannheim | Verfahren und Mittel zur Abtrennung von Plasma oder Serum aus Vollblut |
DE3117455A1 (de) * | 1981-05-02 | 1982-11-25 | Boehringer Mannheim Gmbh | Reagens zur praezipitation apo-b-haltiger lipoproteine, verfahren zu dessen herstellung und dessen verwendung bei der bestimmung von hdl-cholesterin |
US4409106A (en) * | 1981-09-08 | 1983-10-11 | Asahi Kasei Kogyo Kabushiki Kaisha | Apparatus and method for separating blood components |
DE3208253A1 (de) * | 1982-03-08 | 1983-09-15 | Boehringer Mannheim Gmbh, 6800 Mannheim | Verfahren zur spezifischen bestimmung des cholesterins der ldl-fraktion im serum |
DE3338836A1 (de) * | 1983-10-26 | 1985-05-09 | Boehringer Mannheim Gmbh | Verfahren zur bestimmung der low density lipoproteine (ldl) und reagenz zu seiner durchfuehrung |
US4594327A (en) * | 1983-11-02 | 1986-06-10 | Syntex (U.S.A.) Inc. | Assay method for whole blood samples |
JPS6138608A (ja) * | 1984-07-31 | 1986-02-24 | Fuji Photo Film Co Ltd | 全血からの血漿の分離器具および分離方法 |
US4678757A (en) * | 1985-04-11 | 1987-07-07 | Smithkline Diagnostics, Inc. | Device and method for whole blood separation and analysis |
DE3523969A1 (de) * | 1985-07-04 | 1987-01-08 | Boehringer Mannheim Gmbh | Gerinnungsneutrale, hydrophile glasfasern |
US4761381A (en) * | 1985-09-18 | 1988-08-02 | Miles Inc. | Volume metering capillary gap device for applying a liquid sample onto a reactive surface |
IL79945A (en) * | 1986-09-04 | 1991-06-10 | I D L International Diagnostic | Method for the quantitative determination of total cholesterol in blood |
US4801687A (en) * | 1986-10-27 | 1989-01-31 | Bioprobe International, Inc. | Monoclonal antibody purification process using protein A |
US4753776A (en) * | 1986-10-29 | 1988-06-28 | Biotrack, Inc. | Blood separation device comprising a filter and a capillary flow pathway exiting the filter |
DE3636851A1 (de) * | 1986-10-29 | 1988-05-11 | Boehringer Mannheim Gmbh | Verfahren und reagenz zur spezifischen bestimmung des cholesterins der hdl-fraktion |
US5135719A (en) * | 1986-10-29 | 1992-08-04 | Biotrack, Inc. | Blood separation device comprising a filter and a capillary flow pathway exiting the filter |
US4774192A (en) * | 1987-01-28 | 1988-09-27 | Technimed Corporation | A dry reagent delivery system with membrane having porosity gradient |
CA1310905C (en) * | 1987-06-19 | 1992-12-01 | Marvin A. Genshaw | Process and device for separating and testing whole blood |
US5215886A (en) * | 1987-06-22 | 1993-06-01 | Patel P Jivan | HDL determination in whole blood |
US5064541A (en) * | 1989-04-07 | 1991-11-12 | Abbott Laboratories | Devices and methods for the collection of a predetermined volume of plasma or serum |
US5135716A (en) * | 1989-07-12 | 1992-08-04 | Kingston Diagnostics, L.P. | Direct measurement of HDL cholesterol via dry chemistry strips |
DE3929032C2 (de) * | 1989-09-01 | 1998-09-03 | Boehringer Mannheim Gmbh | Verfahren zur Bestimmung von HDL-Cholesterin mittels eines Schnelldiagnostikums mit integriertem Fraktionierschritt |
US5118613A (en) * | 1989-11-17 | 1992-06-02 | Abbott Laboratories | Determination of hdl whole blood |
US5110724A (en) * | 1990-04-02 | 1992-05-05 | Cholestech Corporation | Multi-analyte assay device |
DE4015589A1 (de) * | 1990-05-15 | 1991-11-21 | Boehringer Mannheim Gmbh | Vorrichtung und deren verwendung zur abtrennung von plasma aus vollblut |
US5139685A (en) * | 1991-03-26 | 1992-08-18 | Gds Technology, Inc. | Blood separation filter assembly and method |
US5186843A (en) * | 1991-07-22 | 1993-02-16 | Ahlstrom Filtration, Inc. | Blood separation media and method for separating plasma from whole blood |
US5460974A (en) * | 1992-10-13 | 1995-10-24 | Miles Inc. | Method of assaying whole blood for HDL cholesterol |
-
1992
- 1992-10-13 US US07/959,400 patent/US5460974A/en not_active Expired - Lifetime
-
1993
- 1993-10-08 CA CA002108105A patent/CA2108105C/en not_active Expired - Lifetime
- 1993-10-12 AU AU48988/93A patent/AU661414B2/en not_active Ceased
- 1993-10-13 JP JP5255837A patent/JPH06201704A/ja active Pending
- 1993-10-13 DK DK93116548T patent/DK0597268T3/da active
- 1993-10-13 AT AT93116548T patent/ATE179800T1/de not_active IP Right Cessation
- 1993-10-13 DE DE69324763T patent/DE69324763T2/de not_active Expired - Lifetime
- 1993-10-13 ES ES93116548T patent/ES2130202T3/es not_active Expired - Lifetime
- 1993-10-13 EP EP93116548A patent/EP0597268B1/de not_active Expired - Lifetime
-
1999
- 1999-07-05 GR GR990401764T patent/GR3030682T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
AU661414B2 (en) | 1995-07-20 |
CA2108105A1 (en) | 1994-04-14 |
ES2130202T3 (es) | 1999-07-01 |
US5460974A (en) | 1995-10-24 |
EP0597268B1 (de) | 1999-05-06 |
EP0597268A1 (de) | 1994-05-18 |
AU4898893A (en) | 1994-08-04 |
JPH06201704A (ja) | 1994-07-22 |
ATE179800T1 (de) | 1999-05-15 |
CA2108105C (en) | 2001-07-17 |
GR3030682T3 (en) | 1999-11-30 |
DK0597268T3 (da) | 1999-11-01 |
DE69324763T2 (de) | 1999-09-16 |
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