DE69321218D1 - Klonierung und expression von humanisierten monoklonalen antikörpern gegen menschliches interleukin-4 - Google Patents

Klonierung und expression von humanisierten monoklonalen antikörpern gegen menschliches interleukin-4

Info

Publication number
DE69321218D1
DE69321218D1 DE69321218T DE69321218T DE69321218D1 DE 69321218 D1 DE69321218 D1 DE 69321218D1 DE 69321218 T DE69321218 T DE 69321218T DE 69321218 T DE69321218 T DE 69321218T DE 69321218 D1 DE69321218 D1 DE 69321218D1
Authority
DE
Germany
Prior art keywords
human interleukin
pct
monoclonal antibodies
cloning
expression
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69321218T
Other languages
English (en)
Other versions
DE69321218T2 (de
Inventor
John Abrams
Barbara Dalie
Hung Le
Kenneth Miller
Nicholas Murgolo
Hanh Nguyen
Michael Pearce
Stephen Tindall
Paul Zavodny
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme Corp
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of DE69321218D1 publication Critical patent/DE69321218D1/de
Application granted granted Critical
Publication of DE69321218T2 publication Critical patent/DE69321218T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
    • C07K16/464—Igs containing CDR-residues from one specie grafted between FR-residues from another
    • C07K16/465—Igs containing CDR-residues from one specie grafted between FR-residues from another with additional modified FR-residues
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C07K16/247—IL-4
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
DE69321218T 1992-02-19 1993-02-18 Klonierung und expression von humanisierten monoklonalen antikörpern gegen menschliches interleukin-4 Expired - Fee Related DE69321218T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US84165992A 1992-02-19 1992-02-19
PCT/US1993/001301 WO1993017106A1 (en) 1992-02-19 1993-02-18 Cloning and expression of humanized monoclonal antibodies against human interleukin-4

Publications (2)

Publication Number Publication Date
DE69321218D1 true DE69321218D1 (de) 1998-10-29
DE69321218T2 DE69321218T2 (de) 1999-02-18

Family

ID=25285411

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69321218T Expired - Fee Related DE69321218T2 (de) 1992-02-19 1993-02-18 Klonierung und expression von humanisierten monoklonalen antikörpern gegen menschliches interleukin-4

Country Status (18)

Country Link
US (2) US5863537A (de)
EP (1) EP0627002B1 (de)
JP (1) JPH07502901A (de)
KR (1) KR0158240B1 (de)
CN (1) CN1076966A (de)
AT (1) ATE171472T1 (de)
AU (1) AU684041B2 (de)
CA (1) CA2130436C (de)
DE (1) DE69321218T2 (de)
DK (1) DK0627002T3 (de)
ES (1) ES2121078T3 (de)
HK (1) HK1008831A1 (de)
IL (1) IL104782A0 (de)
MX (1) MX9300913A (de)
NZ (1) NZ249677A (de)
SG (1) SG52215A1 (de)
WO (1) WO1993017106A1 (de)
ZA (1) ZA931148B (de)

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EP0604693A1 (de) * 1992-12-29 1994-07-06 Schering-Plough Monoklonale Antikörper gegen den menschlichen Interleukin-4-Rezeptor und Hybridomen die diese produzieren
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US5597710A (en) * 1994-03-10 1997-01-28 Schering Corporation Humanized monoclonal antibodies against human interleukin-4
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US5705154A (en) * 1995-03-08 1998-01-06 Schering Corporation Humanized monoclonal antibodies against human interleukin-4
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US7491509B2 (en) 2003-02-03 2009-02-17 Fraunhofer Usa, Inc. System for expression of genes in plants
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US20110223168A1 (en) * 2002-12-27 2011-09-15 Greg Winter Ligand that has binding specificity for il-4 and/or il-13
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ES2532609T3 (es) * 2004-02-20 2015-03-30 Ibio, Inc. Sistemas y métodos para expresión clonales en plantas
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US7976577B2 (en) 2005-04-14 2011-07-12 Acufocus, Inc. Corneal optic formed of degradation resistant polymer
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EA200801515A1 (ru) * 2006-01-24 2009-02-27 Домантис Лимитед Лиганды, которые связывают il-4 и/или il-13
CA2642056A1 (en) * 2006-02-13 2007-08-23 Fraunhofer Usa, Inc. Hpv antigens, vaccine compositions, and related methods
US8277816B2 (en) * 2006-02-13 2012-10-02 Fraunhofer Usa, Inc. Bacillus anthracis antigens, vaccine compositions, and related methods
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DE69321218T2 (de) * 1992-02-19 1999-02-18 Schering Corp Klonierung und expression von humanisierten monoklonalen antikörpern gegen menschliches interleukin-4

Also Published As

Publication number Publication date
MX9300913A (es) 1994-08-31
AU684041B2 (en) 1997-12-04
US5770403A (en) 1998-06-23
ZA931148B (en) 1993-08-18
KR950700414A (ko) 1995-01-16
CA2130436A1 (en) 1993-09-02
DE69321218T2 (de) 1999-02-18
KR0158240B1 (ko) 1998-11-16
EP0627002B1 (de) 1998-09-23
US5863537A (en) 1999-01-26
SG52215A1 (en) 1998-09-28
ATE171472T1 (de) 1998-10-15
EP0627002A1 (de) 1994-12-07
AU3666293A (en) 1993-09-13
NZ249677A (en) 1996-08-27
CN1076966A (zh) 1993-10-06
HK1008831A1 (en) 1999-05-21
WO1993017106A1 (en) 1993-09-02
DK0627002T3 (da) 1999-06-14
IL104782A0 (en) 1993-06-10
CA2130436C (en) 2001-04-10
JPH07502901A (ja) 1995-03-30
ES2121078T3 (es) 1998-11-16

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