DE69315698D1 - Antivirale schwefel-analoge von 1,5-dideoxy-1,5-imino-d-glucitol (deoxynojirimycin) - Google Patents

Antivirale schwefel-analoge von 1,5-dideoxy-1,5-imino-d-glucitol (deoxynojirimycin)

Info

Publication number
DE69315698D1
DE69315698D1 DE69315698T DE69315698T DE69315698D1 DE 69315698 D1 DE69315698 D1 DE 69315698D1 DE 69315698 T DE69315698 T DE 69315698T DE 69315698 T DE69315698 T DE 69315698T DE 69315698 D1 DE69315698 D1 DE 69315698D1
Authority
DE
Germany
Prior art keywords
deoxynojirimycin
glucitol
dideoxy
imino
antiviral
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69315698T
Other languages
English (en)
Other versions
DE69315698T2 (de
Inventor
Francis Koszyk
Richard Mueller
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GD Searle LLC
Original Assignee
GD Searle LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GD Searle LLC filed Critical GD Searle LLC
Publication of DE69315698D1 publication Critical patent/DE69315698D1/de
Application granted granted Critical
Publication of DE69315698T2 publication Critical patent/DE69315698T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/54—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Saccharide Compounds (AREA)
DE69315698T 1992-09-09 1993-09-08 Antivirale schwefel-analoge von 1,5-dideoxy-1,5-imino-d-glucitol (deoxynojirimycin) Expired - Fee Related DE69315698T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/942,572 US5268482A (en) 1992-04-01 1992-09-09 2- and 3-sulfur derivatives of 1,5-iminosugars
PCT/US1993/008219 WO1994005635A1 (en) 1992-09-09 1993-09-08 Anti-viral sulfur-analogues of 1,5-dideoxy-1,5-imino-d-glucitol (deoxynojirimycin)

Publications (2)

Publication Number Publication Date
DE69315698D1 true DE69315698D1 (de) 1998-01-22
DE69315698T2 DE69315698T2 (de) 1998-04-09

Family

ID=25478293

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69315698T Expired - Fee Related DE69315698T2 (de) 1992-09-09 1993-09-08 Antivirale schwefel-analoge von 1,5-dideoxy-1,5-imino-d-glucitol (deoxynojirimycin)

Country Status (11)

Country Link
US (1) US5268482A (de)
EP (1) EP0659180B1 (de)
JP (1) JP3342490B2 (de)
AT (1) ATE161008T1 (de)
AU (1) AU4843093A (de)
CA (1) CA2140930A1 (de)
DE (1) DE69315698T2 (de)
DK (1) DK0659180T3 (de)
ES (1) ES2110119T3 (de)
GR (1) GR3026003T3 (de)
WO (1) WO1994005635A1 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5451679A (en) * 1994-03-08 1995-09-19 G. D. Searle & Co. 2-chloro and 2-bromo derivatives of 1,5-iminosugars
BRPI0613224A2 (pt) * 2005-06-08 2010-12-28 Amicus Therapeutics Inc método para estabilizar um açúcar triflatado, método para aumentar o rendimento da reação de um produto de açúcar e composição de açúcar triflatado estabilizada
JP2008543784A (ja) * 2005-06-08 2008-12-04 アミカス セラピューティックス インコーポレイテッド 結晶性糖組成物および作製方法
EP2027137B1 (de) * 2005-06-08 2015-02-18 Amicus Therapeutics, Inc. Aufreinigung von imino- und aminozuckern

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO154918C (no) * 1977-08-27 1987-01-14 Bayer Ag Analogifremgangsmaate til fremstilling av terapeutisk aktive derivater av 3,4,5-trihydroksypiperidin.
GB2020278B (en) * 1978-05-03 1983-02-23 Nippon Shinyaku Co Ltd Moranoline dervitives
US4182763A (en) * 1978-05-22 1980-01-08 Mead Johnson & Company Buspirone anti-anxiety method
DE3620645A1 (de) * 1985-12-20 1987-07-02 Bayer Ag 3-amino-4,5-dihydroxypiperidine, verfahren zu ihrer herstellung und ihre verwendung
EP0252962B1 (de) * 1985-12-23 1995-08-23 Fred Hutchinson Cancer Research Center Regulierung der retroviralen replikation, infektion und pathogenese
US4849430A (en) * 1988-03-09 1989-07-18 Monsanto Company Method of inhibiting virus
US5144037A (en) * 1988-11-03 1992-09-01 G. D. Searle & Co. 1,5-dideoxy-1,5-imino-d-glucitol derivatives
US5003072A (en) * 1988-11-03 1991-03-26 G. D. Searle & Co. 1,5-dideoxy-1,5-imino-D-glucitol derivatives
US4957926A (en) * 1988-12-22 1990-09-18 Monsanto Company Method of treating herpesviruses
EP0407701A3 (en) * 1989-05-15 1992-04-22 Fujisawa Pharmaceutical Co., Ltd. Antiretroviral pyrroline and pyrrolidine sulfonic acid derivatives
US4983401A (en) * 1989-05-22 1991-01-08 Kinaform Technology, Inc. Sustained release pharmaceutical preparations having pH controlled membrane coatings
US5011829A (en) * 1989-06-02 1991-04-30 G. D. Searle & Co. Pharmaceutical composition and method of inhibiting virus
US5026713A (en) * 1989-08-29 1991-06-25 Monsanto Company 1,3-dideoxy-3-fluoronojirimycin which inhibits glycosidase activity
ATE129997T1 (de) * 1989-07-27 1995-11-15 Monsanto Co Glykosidasehemmende piperidinverbindungen.
US5025021A (en) * 1989-07-27 1991-06-18 Monsanto Company 1,2-dideoxy-2-fluoronojirimycin as glycosidase inhibitors
US5030638A (en) * 1990-02-26 1991-07-09 G. D. Searle & Co. Method of antiviral enhancement

Also Published As

Publication number Publication date
GR3026003T3 (en) 1998-04-30
EP0659180B1 (de) 1997-12-10
WO1994005635A1 (en) 1994-03-17
ES2110119T3 (es) 1998-02-01
AU4843093A (en) 1994-03-29
DK0659180T3 (da) 1998-08-24
ATE161008T1 (de) 1997-12-15
US5268482A (en) 1993-12-07
EP0659180A1 (de) 1995-06-28
CA2140930A1 (en) 1994-03-10
JP3342490B2 (ja) 2002-11-11
DE69315698T2 (de) 1998-04-09
JPH08501102A (ja) 1996-02-06

Similar Documents

Publication Publication Date Title
FI924397A (fi) Substituerade pyrimidiner
HUT65273A (en) Process for producing of n alkylidene piperidino compounds, their enantiomers and pharmaceutical compositions comprising them
DK260588D0 (da) Heterocykliske ketoner
ES2135543T3 (es) Piperidinas (4-aril-sustituidas) como antagonistas de los receptores de neuroquininas.
ATE288908T1 (de) Monozyclische n-heterozyclische thiosäure derivate als antikoagulans
IT8122675A0 (it) Mercaptoacil derivati di varie proline 4 sostituite e relative composizioni utili per il trattamento dell'ipertensione.
MXPA03011722A (es) Derivados de piperidina utiles como moduladores de actividad de quimiocina.
DK289888D0 (da) 2-substitueret-e-kondenserede oe1,2,4,aatriazolooe1,5-caapyrimidiner, farmaceutiske praeparater og anvendelser deraf
ATE277011T1 (de) Flouride von 4-substituierten piperidin-derivaten
EA199800109A1 (ru) Производные азетидинона для лечения атеросклероза
ATE133947T1 (de) 2,5-diaryl-tetrahydrofurane und deren analoge als paf-antagonisten
IT1264988B1 (it) Composizioni cosmetiche e dermatologiche per la protezione da radiazioni uv contenenti derivati dallo stilbene
ES2090948T3 (es) Derivados de carbinol terciario 2-sustituidos de 1,5-iminoazucares como compuestos antivirales.
ES2039361T3 (es) Derivados de 3-vinil- y 3-etinil-beta-carbolinas, su preparacion y su utilizacion como medicamentos.
DE69315698T2 (de) Antivirale schwefel-analoge von 1,5-dideoxy-1,5-imino-d-glucitol (deoxynojirimycin)
DK708188A (da) 5- og 6-leddede heterocycliske forbindelser og farmaceutisk acceptable saltderivater heraf til anvendelse ved behandling af aids
ES2150613T3 (es) Compuestos benzo-condensados de acepinona y piperidinona, utiles como inhibidores de ace y nep.
DK511383A (da) Fremgangsmaade til fremstilling af piperidindionderivater, der beskytter hjertemuskulaturen med en antiarythmisk aktivitet
ES2157962T3 (es) Procedimiento de preparacion de derivados con azufre del imidazol y productos intermedios obtenidos.
DK550584D0 (da) Aralkyl-(arylethynyl) aralkylaminer og fremgangsmaade til fremstilling deraf
DE69031154D1 (de) Substituierte Alkylpiperidine und deren Verwendung als Inhibitoren der Cholesterolsynthese
ATE116291T1 (de) Oxysulfonylcarbamate.
SE8900813D0 (sv) Foerfarande foer framstaellning av dihydropyridinderivat
DE3876193D1 (de) Aminomethylderivate von mono- und dithiocarbamaten als schmiermitteladditive.
DK394285D0 (da) Benzodisultamer, deres fremstilling og anvendelse

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee