DE69313106D1 - Substituierte 1,1,2,-triphenylbutene und ihre verwendung zur behandlung und diagnose von krebs - Google Patents

Substituierte 1,1,2,-triphenylbutene und ihre verwendung zur behandlung und diagnose von krebs

Info

Publication number
DE69313106D1
DE69313106D1 DE69313106T DE69313106T DE69313106D1 DE 69313106 D1 DE69313106 D1 DE 69313106D1 DE 69313106 T DE69313106 T DE 69313106T DE 69313106 T DE69313106 T DE 69313106T DE 69313106 D1 DE69313106 D1 DE 69313106D1
Authority
DE
Germany
Prior art keywords
pct
cancers
sec
date
useful
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69313106T
Other languages
English (en)
Other versions
DE69313106T2 (de
Inventor
Karen Edwards
Michael Brodrick Road Jarman
Charles Laughton
Stephen Rainbow S End R Neidle
Ian Hardcastle
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BTG International Ltd
Original Assignee
British Technology Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB929209509A external-priority patent/GB9209509D0/en
Priority claimed from GB939303982A external-priority patent/GB9303982D0/en
Application filed by British Technology Group Ltd filed Critical British Technology Group Ltd
Application granted granted Critical
Publication of DE69313106D1 publication Critical patent/DE69313106D1/de
Publication of DE69313106T2 publication Critical patent/DE69313106T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C217/06—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
    • C07C217/14—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring
    • C07C217/18—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE69313106T 1992-05-01 1993-04-29 Substituierte 1,1,2,-triphenylbutene und ihre verwendung zur behandlung und diagnose von krebs Expired - Fee Related DE69313106T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB929209509A GB9209509D0 (en) 1992-05-01 1992-05-01 Substituted 1,1,2-triphenylbutenes
GB939303982A GB9303982D0 (en) 1993-02-26 1993-02-26 Substituted 1,1,2 triphenylbutenes
PCT/GB1993/000889 WO1993022275A1 (en) 1992-05-01 1993-04-29 Substituted 1,1,2-triphenylbutenes and their use in the treatment and diagnosis of cancer

Publications (2)

Publication Number Publication Date
DE69313106D1 true DE69313106D1 (de) 1997-09-18
DE69313106T2 DE69313106T2 (de) 1998-01-22

Family

ID=26300810

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69313106T Expired - Fee Related DE69313106T2 (de) 1992-05-01 1993-04-29 Substituierte 1,1,2,-triphenylbutene und ihre verwendung zur behandlung und diagnose von krebs

Country Status (9)

Country Link
US (1) US5589500A (de)
EP (1) EP0638064B1 (de)
JP (1) JP3153554B2 (de)
AT (1) ATE156803T1 (de)
AU (1) AU674146B2 (de)
CA (1) CA2134772A1 (de)
DE (1) DE69313106T2 (de)
ES (1) ES2107030T3 (de)
WO (1) WO1993022275A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2262798A (en) * 1991-12-24 1993-06-30 British Aerospace An aircraft cargo container
DE4311870C2 (de) * 1993-04-10 1998-07-30 Altramed Holdings Ltd Verwendung eines Anti-Östrigens zur Therapie und Prophylaxe von Demenz-Erkrankungen
US6084117A (en) * 1999-11-22 2000-07-04 Albemarle Corporation Production of silated haloarenes by selective silylation of polyhaloarenes
US6599921B2 (en) 2001-02-22 2003-07-29 Nanodesign, Inc. Non-steroidal estrogen receptor ligands
US7196119B2 (en) 2003-10-21 2007-03-27 The Regents Of The University Of California Development of new selective estrogen receptor modulators
WO2015138340A1 (en) * 2014-03-11 2015-09-17 Repros Therapeutics Inc. Clomiphene synthesis using a single solvent

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2196003A (en) * 1986-09-11 1988-04-20 Nat Res Dev Iodo-and bromo-tamoxifen derivatives
EP0677507B1 (de) * 1993-10-25 1998-04-08 Taiho Pharmaceutical Company Limited Verfahren zur herstellung von säure-additions-salzen des z-isomers von triphenylethylen-derivaten

Also Published As

Publication number Publication date
EP0638064A1 (de) 1995-02-15
CA2134772A1 (en) 1993-11-11
AU4267393A (en) 1993-11-29
US5589500A (en) 1996-12-31
DE69313106T2 (de) 1998-01-22
WO1993022275A1 (en) 1993-11-11
ES2107030T3 (es) 1997-11-16
EP0638064B1 (de) 1997-08-13
JP3153554B2 (ja) 2001-04-09
AU674146B2 (en) 1996-12-12
ATE156803T1 (de) 1997-08-15
JPH07506357A (ja) 1995-07-13

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: BTG INTERNATIONAL LTD., LONDON, GB

8339 Ceased/non-payment of the annual fee