ATE156803T1 - Substituierte 1,1,2,-triphenylbutene und ihre verwendung zur behandlung und diagnose von krebs - Google Patents

Substituierte 1,1,2,-triphenylbutene und ihre verwendung zur behandlung und diagnose von krebs

Info

Publication number
ATE156803T1
ATE156803T1 AT93911884T AT93911884T ATE156803T1 AT E156803 T1 ATE156803 T1 AT E156803T1 AT 93911884 T AT93911884 T AT 93911884T AT 93911884 T AT93911884 T AT 93911884T AT E156803 T1 ATE156803 T1 AT E156803T1
Authority
AT
Austria
Prior art keywords
pct
cancers
treatment
sec
date
Prior art date
Application number
AT93911884T
Other languages
English (en)
Inventor
Karen Jennifer Edwards
Michael Jarman
Charles Anthony Victo Laughton
Stephen Neidle
Ian Robert Hardcastle
Original Assignee
British Tech Group
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB929209509A external-priority patent/GB9209509D0/en
Priority claimed from GB939303982A external-priority patent/GB9303982D0/en
Application filed by British Tech Group filed Critical British Tech Group
Application granted granted Critical
Publication of ATE156803T1 publication Critical patent/ATE156803T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C217/06—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
    • C07C217/14—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring
    • C07C217/18—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT93911884T 1992-05-01 1993-04-29 Substituierte 1,1,2,-triphenylbutene und ihre verwendung zur behandlung und diagnose von krebs ATE156803T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB929209509A GB9209509D0 (en) 1992-05-01 1992-05-01 Substituted 1,1,2-triphenylbutenes
GB939303982A GB9303982D0 (en) 1993-02-26 1993-02-26 Substituted 1,1,2 triphenylbutenes

Publications (1)

Publication Number Publication Date
ATE156803T1 true ATE156803T1 (de) 1997-08-15

Family

ID=26300810

Family Applications (1)

Application Number Title Priority Date Filing Date
AT93911884T ATE156803T1 (de) 1992-05-01 1993-04-29 Substituierte 1,1,2,-triphenylbutene und ihre verwendung zur behandlung und diagnose von krebs

Country Status (9)

Country Link
US (1) US5589500A (de)
EP (1) EP0638064B1 (de)
JP (1) JP3153554B2 (de)
AT (1) ATE156803T1 (de)
AU (1) AU674146B2 (de)
CA (1) CA2134772A1 (de)
DE (1) DE69313106T2 (de)
ES (1) ES2107030T3 (de)
WO (1) WO1993022275A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2262798A (en) * 1991-12-24 1993-06-30 British Aerospace An aircraft cargo container
DE4311870C2 (de) * 1993-04-10 1998-07-30 Altramed Holdings Ltd Verwendung eines Anti-Östrigens zur Therapie und Prophylaxe von Demenz-Erkrankungen
US6084117A (en) * 1999-11-22 2000-07-04 Albemarle Corporation Production of silated haloarenes by selective silylation of polyhaloarenes
US6599921B2 (en) 2001-02-22 2003-07-29 Nanodesign, Inc. Non-steroidal estrogen receptor ligands
US7196119B2 (en) 2003-10-21 2007-03-27 The Regents Of The University Of California Development of new selective estrogen receptor modulators
MX2016011567A (es) * 2014-03-11 2016-12-07 Repros Therapeutics Inc Sintesis de clomifeno usando un solvente unico.

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2196003A (en) * 1986-09-11 1988-04-20 Nat Res Dev Iodo-and bromo-tamoxifen derivatives
CA2150230C (en) * 1993-10-25 1998-10-27 Fumihiko Shinozaki Process for producing acid-addition salt of z-isomer of triphenylethylene compound

Also Published As

Publication number Publication date
DE69313106T2 (de) 1998-01-22
JP3153554B2 (ja) 2001-04-09
ES2107030T3 (es) 1997-11-16
EP0638064B1 (de) 1997-08-13
WO1993022275A1 (en) 1993-11-11
AU4267393A (en) 1993-11-29
EP0638064A1 (de) 1995-02-15
DE69313106D1 (de) 1997-09-18
JPH07506357A (ja) 1995-07-13
AU674146B2 (en) 1996-12-12
US5589500A (en) 1996-12-31
CA2134772A1 (en) 1993-11-11

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee