DE69233122D1 - Verfahren zur Herstellung von Hybridomen - Google Patents

Verfahren zur Herstellung von Hybridomen

Info

Publication number
DE69233122D1
DE69233122D1 DE69233122T DE69233122T DE69233122D1 DE 69233122 D1 DE69233122 D1 DE 69233122D1 DE 69233122 T DE69233122 T DE 69233122T DE 69233122 T DE69233122 T DE 69233122T DE 69233122 D1 DE69233122 D1 DE 69233122D1
Authority
DE
Germany
Prior art keywords
hybridomas
production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69233122T
Other languages
English (en)
Other versions
DE69233122T2 (de
Inventor
Katsumi Fujiwara
Kenya Shitara
So Ohta
Nobuo Hanai
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kyowa Kirin Co Ltd
Original Assignee
Kyowa Hakko Kogyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Kogyo Co Ltd filed Critical Kyowa Hakko Kogyo Co Ltd
Application granted granted Critical
Publication of DE69233122D1 publication Critical patent/DE69233122D1/de
Publication of DE69233122T2 publication Critical patent/DE69233122T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • C12N5/12—Fused cells, e.g. hybridomas
    • C12N5/16—Animal cells
    • C12N5/163—Animal cells one of the fusion partners being a B or a T lymphocyte
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/734—Complement-dependent cytotoxicity [CDC]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C12N2510/02—Cells for production

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DE1992633122 1991-04-10 1992-04-10 Verfahren zur Herstellung von Hybridomen Expired - Lifetime DE69233122T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP07751891A JP3150991B2 (ja) 1991-04-10 1991-04-10 ハイブリドーマの製造法
JP7751891 1991-04-10

Publications (2)

Publication Number Publication Date
DE69233122D1 true DE69233122D1 (de) 2003-08-14
DE69233122T2 DE69233122T2 (de) 2004-04-22

Family

ID=13636190

Family Applications (1)

Application Number Title Priority Date Filing Date
DE1992633122 Expired - Lifetime DE69233122T2 (de) 1991-04-10 1992-04-10 Verfahren zur Herstellung von Hybridomen

Country Status (4)

Country Link
EP (1) EP0508472B1 (de)
JP (1) JP3150991B2 (de)
CA (1) CA2065681A1 (de)
DE (1) DE69233122T2 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0598998B1 (de) * 1992-09-07 2004-05-19 Kyowa Hakko Kogyo Co., Ltd Humanisierte Antikörper, die mit dem GM2-Gangliosid reagieren
US5912000A (en) * 1994-09-23 1999-06-15 Zonagen, Inc. Chitosan induced immunopotentiation
ATE223235T1 (de) * 1994-09-23 2002-09-15 Zonagen Inc Chitosan induzierte verstärkung
EP2107115A1 (de) 2007-01-24 2009-10-07 Kyowa Hakko Kirin Co., Ltd. Genetisch rekombinante antikörperzusammensetzung zur anbindung insbesondere an gangliosid gm2
WO2009105150A2 (en) 2008-01-28 2009-08-27 Thomas Jefferson University Method of making hybrid cells that express useful antibodies
WO2014088040A1 (ja) 2012-12-06 2014-06-12 国立大学法人 金沢大学 中皮腫の治療方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4444887A (en) * 1979-12-10 1984-04-24 Sloan-Kettering Institute Process for making human antibody producing B-lymphocytes
JPH0673471B2 (ja) * 1985-12-24 1994-09-21 コニカ株式会社 モノクローナル抗体
JPH0787798B2 (ja) * 1987-04-27 1995-09-27 コニカ株式会社 モノクロ−ナル抗体の製造方法
SE461985B (sv) * 1988-09-13 1990-04-23 Bioinvent Int Ab In vitro immunisering av lymfocytinnehaallande cellpopulationer och materialsats daerfoer
JPH02135098A (ja) * 1988-11-16 1990-05-23 Mect Corp Ｎ−グリコリル型ｇｍ↓２を認識するモノクローナル抗体及びそれを産生するハイブリドーマ
JPH041138A (ja) * 1990-04-13 1992-01-06 Kyowa Hakko Kogyo Co Ltd 抗腫瘍剤
AU657482B2 (en) * 1990-05-22 1995-03-16 Regents Of The University Of California, The Novel methods for producing antigen-specific, high-affinity human monoclonal antibodies

Also Published As

Publication number Publication date
EP0508472A2 (de) 1992-10-14
EP0508472B1 (de) 2003-07-09
JP3150991B2 (ja) 2001-03-26
EP0508472A3 (en) 1993-08-04
JPH04311385A (ja) 1992-11-04
CA2065681A1 (en) 1992-10-11
DE69233122T2 (de) 2004-04-22

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: KYOWA HAKKO KIRIN CO., LTD., TOKYO, JP