DE69232616D1 - Saponin-antigen-konjugate und ihre verwendung - Google Patents

Saponin-antigen-konjugate und ihre verwendung

Info

Publication number
DE69232616D1
DE69232616D1 DE69232616T DE69232616T DE69232616D1 DE 69232616 D1 DE69232616 D1 DE 69232616D1 DE 69232616 T DE69232616 T DE 69232616T DE 69232616 T DE69232616 T DE 69232616T DE 69232616 D1 DE69232616 D1 DE 69232616D1
Authority
DE
Germany
Prior art keywords
saponin
antigen conjugates
saponins
conjugates
antigen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69232616T
Other languages
English (en)
Other versions
DE69232616T2 (de
Inventor
Charlotte A Kensil
Sean Soltysik
Dante J Marciani
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Agenus Inc
Original Assignee
Antigenics LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Antigenics LLC filed Critical Antigenics LLC
Publication of DE69232616D1 publication Critical patent/DE69232616D1/de
Application granted granted Critical
Publication of DE69232616T2 publication Critical patent/DE69232616T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J17/005—Glycosides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/385—Haptens or antigens, bound to carriers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/256—Polyterpene radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55577—Saponins; Quil A; QS21; ISCOMS
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6012—Haptens, e.g. di- or trinitrophenyl (DNP, TNP)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6087—Polysaccharides; Lipopolysaccharides [LPS]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/62—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier
    • A61K2039/627—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier characterised by the linker
DE69232616T 1991-09-18 1992-09-17 Saponin-antigen-konjugate und ihre verwendung Expired - Lifetime DE69232616T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US76275491A 1991-09-18 1991-09-18
US07/906,880 US5583112A (en) 1987-05-29 1992-07-02 Saponin-antigen conjugates and the use thereof
PCT/US1992/007801 WO1993005789A1 (en) 1991-09-18 1992-09-17 Saponin-antigen conjugates and the use thereof

Publications (2)

Publication Number Publication Date
DE69232616D1 true DE69232616D1 (de) 2002-06-27
DE69232616T2 DE69232616T2 (de) 2002-09-05

Family

ID=27117183

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69232616T Expired - Lifetime DE69232616T2 (de) 1991-09-18 1992-09-17 Saponin-antigen-konjugate und ihre verwendung

Country Status (12)

Country Link
US (1) US5583112A (de)
EP (1) EP0606317B1 (de)
JP (1) JP3717511B2 (de)
AT (1) ATE217795T1 (de)
AU (1) AU662562B2 (de)
CA (1) CA2118928C (de)
DE (1) DE69232616T2 (de)
DK (1) DK0606317T3 (de)
ES (1) ES2174837T3 (de)
NO (1) NO940949L (de)
NZ (1) NZ244410A (de)
WO (1) WO1993005789A1 (de)

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US5688772A (en) * 1994-08-01 1997-11-18 University Of Saskatchewan Quinoa saponin compositions and methods of use
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US6080408A (en) 1994-08-22 2000-06-27 Connaught Laboratories Limited Human immunodeficiency virus type 1 nucleic acids devoid of long terminal repeats capable of encoding for non-infectious, immunogenic, retrovirus-like particles
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AU732856B2 (en) * 1997-05-20 2001-05-03 Galenica Pharmaceuticals, Inc. Triterpene saponin analogs having adjuvant and immunostimulatory activity
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ATE435661T1 (de) * 1997-08-29 2009-07-15 Antigenics Inc Adjuvant qs-21 enthaltende zusammensetzungen mit polysorbate oder cyclodextrin als hilfsmittel
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US20010034330A1 (en) * 1998-08-10 2001-10-25 Charlotte Kensil Innate immunity-stimulating compositions of CpG and saponin and methods thereof
AU5565599A (en) * 1998-08-14 2000-03-06 Dante J. Marciani Chemically modified saponins and the use thereof as adjuvants
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US8143386B2 (en) * 1999-04-07 2012-03-27 Corixa Corporation Fusion proteins of mycobacterium tuberculosis antigens and their uses
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US20040146521A1 (en) * 1999-06-01 2004-07-29 Schenk Dale B. Prevention and treatment of synucleinopathic disease
UA81216C2 (en) * 1999-06-01 2007-12-25 Prevention and treatment of amyloid disease
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AU779978B2 (en) * 1999-10-07 2005-02-24 Corixa Corporation Fusion proteins of mycobacterium tuberculosis
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AU2001241738A1 (en) * 2000-02-25 2001-09-03 Corixa Corporation Compounds and methods for diagnosis and immunotherapy of tuberculosis
EP1267918A4 (de) 2000-03-31 2007-06-27 Purdue Research Foundation Behandlungsverfahren unter verwendung von ligand-immunogen-konjugaten
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US7700751B2 (en) 2000-12-06 2010-04-20 Janssen Alzheimer Immunotherapy Humanized antibodies that recognize β-amyloid peptide
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US20030224013A1 (en) * 2002-04-19 2003-12-04 Cole Garry T. Methods for protection against Coccidioides spp. infection using Coccidioides spp. urea amidohydrolase (Ure) protein
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US20080014194A1 (en) * 2003-10-31 2008-01-17 Elan Pharmaceuticals, Inc. Prevention and Treatment of Synucleinopathic and Amyloidogenic Disease
US9034337B2 (en) 2003-10-31 2015-05-19 Prothena Biosciences Limited Treatment and delay of outset of synucleinopathic and amyloidogenic disease
US8506959B2 (en) * 2002-11-01 2013-08-13 Neotope Biosciences Limited Prevention and treatment of synucleinopathic and amyloidogenic disease
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Also Published As

Publication number Publication date
ATE217795T1 (de) 2002-06-15
DK0606317T3 (da) 2002-09-16
NO940949D0 (no) 1994-03-16
AU662562B2 (en) 1995-09-07
NO940949L (no) 1994-05-16
WO1993005789A1 (en) 1993-04-01
EP0606317A4 (en) 1995-12-20
US5583112A (en) 1996-12-10
JPH07504156A (ja) 1995-05-11
NZ244410A (en) 1995-03-28
DE69232616T2 (de) 2002-09-05
ES2174837T3 (es) 2002-11-16
CA2118928C (en) 2005-07-05
JP3717511B2 (ja) 2005-11-16
CA2118928A1 (en) 1993-04-01
EP0606317B1 (de) 2002-05-22
AU2666492A (en) 1993-04-27
EP0606317A1 (de) 1994-07-20

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