DE69232426T2 - Zusammensetzungen zur behandlung und vorbeugung von krebs - Google Patents
Zusammensetzungen zur behandlung und vorbeugung von krebsInfo
- Publication number
- DE69232426T2 DE69232426T2 DE69232426T DE69232426T DE69232426T2 DE 69232426 T2 DE69232426 T2 DE 69232426T2 DE 69232426 T DE69232426 T DE 69232426T DE 69232426 T DE69232426 T DE 69232426T DE 69232426 T2 DE69232426 T2 DE 69232426T2
- Authority
- DE
- Germany
- Prior art keywords
- compositions
- treating
- preventing cancer
- pharmaceutically acceptable
- stereoisomer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
- A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
- A61K38/212—IFN-alpha
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Virology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/779,744 US6037376A (en) | 1991-10-21 | 1991-10-21 | Methods for therapy of cancer |
PCT/US1992/008875 WO1993007866A2 (en) | 1991-10-21 | 1992-10-13 | Compositions and methods for therapy and prevention of cancer, aids, and anemia |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69232426D1 DE69232426D1 (de) | 2002-03-28 |
DE69232426T2 true DE69232426T2 (de) | 2002-10-10 |
Family
ID=25117401
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69233754T Expired - Lifetime DE69233754D1 (de) | 1991-10-21 | 1992-10-13 | Pharmazeutische Zubereitungen zur Behandlung von Hemoglobulinopathien der Beta-Chain |
DE69233743T Expired - Lifetime DE69233743D1 (de) | 1991-10-21 | 1992-10-13 | Antivirale Mittel enthaltend Phenylessigsäurederivate |
DE69232426T Expired - Lifetime DE69232426T2 (de) | 1991-10-21 | 1992-10-13 | Zusammensetzungen zur behandlung und vorbeugung von krebs |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69233754T Expired - Lifetime DE69233754D1 (de) | 1991-10-21 | 1992-10-13 | Pharmazeutische Zubereitungen zur Behandlung von Hemoglobulinopathien der Beta-Chain |
DE69233743T Expired - Lifetime DE69233743D1 (de) | 1991-10-21 | 1992-10-13 | Antivirale Mittel enthaltend Phenylessigsäurederivate |
Country Status (9)
Country | Link |
---|---|
US (2) | US6037376A (de) |
EP (4) | EP1484058B1 (de) |
AT (3) | ATE418975T1 (de) |
DE (3) | DE69233754D1 (de) |
DK (1) | DK1484059T3 (de) |
ES (2) | ES2312884T3 (de) |
HK (1) | HK1067551A1 (de) |
IL (1) | IL103471A0 (de) |
NZ (1) | NZ244850A (de) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI249519B (en) | 2000-08-29 | 2006-02-21 | Nobex Corp | Immunoregulatory compounds and derivatives and methods of treating diseases therewith |
US7090839B2 (en) | 2000-09-01 | 2006-08-15 | Hidden Valley, N.V. | Method of treatment of human immunodeficiency diseases |
US6538030B2 (en) | 2000-09-20 | 2003-03-25 | Yih-Lin Chung | Treating radiation fibrosis |
US6372938B1 (en) | 2001-05-21 | 2002-04-16 | Stanislaw R. Burzynski | Synthesis of 4-phenylbutyric acid |
US8048924B2 (en) * | 2001-08-29 | 2011-11-01 | Biocon Limited | Methods and compositions employing 4-aminophenylacetic acid compounds |
EP1291015A1 (de) * | 2001-09-10 | 2003-03-12 | Lunamed AG | Darreichungsformen mit verlängerter Wirkstofffreisetzung |
EP1487432B1 (de) * | 2002-03-26 | 2013-03-06 | Eastern Virginia Medical School | Suramin und seine derivate als topisches mikrobizides mittel und kontrazeptivum |
US20040229948A1 (en) * | 2002-04-12 | 2004-11-18 | Summar Marshall L. | Method for preventing hepatic encephalopathic episodes |
US8946295B2 (en) | 2002-07-25 | 2015-02-03 | Sunny Pharmtech Inc. | Histone hyperacetylating agents for promoting wound healing and preventing scar formation |
US20060275370A1 (en) * | 2002-07-25 | 2006-12-07 | Yih-Lin Chung | Method and compositions for treatment of epithelial damage |
US8163764B2 (en) * | 2002-04-26 | 2012-04-24 | Asan Laboratories Company (Cayman) Limited | Skincare methods |
US8846039B2 (en) * | 2002-04-26 | 2014-09-30 | Asan Laboratories Company (Cayman), Limited | Method for ameliorating pruritus |
US6809118B2 (en) * | 2002-07-25 | 2004-10-26 | Yih-Lin Chung | Methods for therapy of radiation cutaneous syndrome |
US20040152784A1 (en) * | 2002-07-23 | 2004-08-05 | Special Products Limited | Pharmaceutical composition and method for treatment of a urea cycle deficiency or sickle-cell anaemia |
DE602004014895D1 (de) * | 2004-03-11 | 2008-08-21 | Asan Lab Company Cayman Ltd | Verwendung von Histone Deacetylase Hemmern zur Steigerung der therapeutischen Wirkung in der Radiotherapie und Chemotherapie |
EP1773767B1 (de) | 2004-07-07 | 2016-03-09 | Biocon Limited | Synthese von azogebundenen, das immunsystem regulierenden verbindungen |
JP2008511611A (ja) * | 2004-08-30 | 2008-04-17 | ルナメツド・インコーポレーテツド | 治療用4−フェニル酪酸制御放出製剤 |
US20060205818A1 (en) * | 2005-03-08 | 2006-09-14 | Burzynski Stanislaw R | Method for the treatment of von Hippel-Lindau (VHL) disease with phenylacetyl-derivatives |
US20070004805A1 (en) * | 2005-07-01 | 2007-01-04 | Navinta Llc | Process for preparation of liquid dosage form containing sodium 4-phenylbutyrate |
US20080292616A1 (en) * | 2005-08-19 | 2008-11-27 | Government Of The United Of America, Represented By The Secretary, Department Of Health And.... | Topical Formulations of Histone Deacetylase Inhibitors and Methods Using the Same |
US20090054497A1 (en) * | 2007-08-21 | 2009-02-26 | Nawaz Ahmad | Methods for attaining enhanced sexual wellness using anhydrous compositions |
US20090054498A1 (en) * | 2007-08-21 | 2009-02-26 | Nawaz Ahmad | Anhydrous Compositions Useful for Attaining Enhanced Sexual Wellness |
WO2010057083A1 (en) * | 2008-11-17 | 2010-05-20 | The Trustees Of The University Of Pennsylvania | Methods of treating cancer |
JP2020520935A (ja) * | 2017-05-19 | 2020-07-16 | メモリアル スローン ケタリング キャンサー センター | タンパク質の小胞体プロセッシングを改変する方法 |
JP7292434B2 (ja) * | 2020-01-21 | 2023-06-16 | 株式会社エビデント | 赤血球分化モニタリング装置および赤血球分化モニタリング方法 |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4028404A (en) * | 1967-07-31 | 1977-06-07 | Allen & Hanburys Limited | Acetic acid derivatives |
US3998966A (en) * | 1971-11-04 | 1976-12-21 | Syntex Corporation | Anti-inflammatory, analgesic, anti-pyretic and anti-pruritic 6-substituted 2-naphthyl acetic acid derivative-containing compositions and methods of use thereof |
CH576445A5 (de) * | 1972-03-10 | 1976-06-15 | Ciba Geigy Ag | |
CA1041541A (en) * | 1974-01-14 | 1978-10-31 | Giorgio Pifferi | Process for preparing 4-cyclopropyl-methyleneoxy-3-chlorophenylacetic acid and salts thereof |
GB1511645A (en) * | 1974-05-31 | 1978-05-24 | Univ Ife | Sickle cell anaemia treatment |
US4137309A (en) * | 1976-10-14 | 1979-01-30 | The Procter & Gamble Company | Therapeutic treatment |
US4282214A (en) * | 1978-07-31 | 1981-08-04 | The Procter & Gamble Company | Phenylacetate anti-inflammatory composition |
JPS57193437A (en) * | 1981-05-21 | 1982-11-27 | Ajinomoto Co Inc | Amino acid derivative |
US4470970A (en) * | 1981-07-02 | 1984-09-11 | Burzynski Stanislaw R | Purified antineoplaston fractions and methods of treating neoplastic disease |
JPS58194814A (ja) * | 1982-05-11 | 1983-11-12 | Nippon Shinyaku Co Ltd | 免疫調節作用を有する薬剤 |
US4457942A (en) * | 1982-08-20 | 1984-07-03 | Brusilow Saul W | Process for waste nitrogen removal |
IT1170238B (it) * | 1982-12-06 | 1987-06-03 | Upjohn Co | Impiego di ibuprofene e flurbiprofene nella cura dell'erpete |
US4851404A (en) * | 1983-07-05 | 1989-07-25 | Miles Inc. | Method of treating hemoglobinopathy |
US5025029A (en) * | 1986-10-10 | 1991-06-18 | Children's Hospital Medical Center Of Northern California | Method for augmenting fetal hemoglobin |
US4822821A (en) * | 1986-10-10 | 1989-04-18 | Children's Hospital Medical Center Of Northern California | Method for augmenting fetal hemoglobin |
JPH02207021A (ja) * | 1989-02-07 | 1990-08-16 | Ono Pharmaceut Co Ltd | グアニジノ安息香酸誘導体を有効成分として含有する抗レトロウイルス剤 |
US5254587A (en) * | 1990-09-04 | 1993-10-19 | Burzynski Stanislaw R | Methods for treating AIDS |
-
1991
- 1991-10-21 US US07/779,744 patent/US6037376A/en not_active Expired - Fee Related
-
1992
- 1992-10-13 AT AT04015994T patent/ATE418975T1/de not_active IP Right Cessation
- 1992-10-13 DK DK04015995T patent/DK1484059T3/da active
- 1992-10-13 AT AT04015995T patent/ATE406883T1/de not_active IP Right Cessation
- 1992-10-13 DE DE69233754T patent/DE69233754D1/de not_active Expired - Lifetime
- 1992-10-13 EP EP04015994A patent/EP1484058B1/de not_active Expired - Lifetime
- 1992-10-13 ES ES04015995T patent/ES2312884T3/es not_active Expired - Lifetime
- 1992-10-13 DE DE69233743T patent/DE69233743D1/de not_active Expired - Lifetime
- 1992-10-13 ES ES92922550T patent/ES2171400T3/es not_active Expired - Lifetime
- 1992-10-13 AT AT92922550T patent/ATE213409T1/de not_active IP Right Cessation
- 1992-10-13 EP EP20000126981 patent/EP1108428A3/de not_active Withdrawn
- 1992-10-13 EP EP00126980A patent/EP1108427A3/de not_active Withdrawn
- 1992-10-13 EP EP04015995A patent/EP1484059B1/de not_active Expired - Lifetime
- 1992-10-13 DE DE69232426T patent/DE69232426T2/de not_active Expired - Lifetime
- 1992-10-20 IL IL103471A patent/IL103471A0/xx unknown
- 1992-10-21 NZ NZ244850A patent/NZ244850A/en not_active IP Right Cessation
-
1995
- 1995-06-07 US US08/484,817 patent/US5877213A/en not_active Expired - Fee Related
-
2005
- 2005-01-04 HK HK05100026A patent/HK1067551A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
HK1067551A1 (en) | 2005-04-15 |
ATE406883T1 (de) | 2008-09-15 |
ATE418975T1 (de) | 2009-01-15 |
ATE213409T1 (de) | 2002-03-15 |
EP1484059B1 (de) | 2008-09-03 |
DE69233743D1 (de) | 2008-10-16 |
IL103471A0 (en) | 1993-03-15 |
EP1108428A3 (de) | 2004-01-07 |
EP1484058A2 (de) | 2004-12-08 |
EP1108427A3 (de) | 2004-01-07 |
DE69232426D1 (de) | 2002-03-28 |
EP1484059A2 (de) | 2004-12-08 |
US6037376A (en) | 2000-03-14 |
ES2312884T3 (es) | 2009-03-01 |
EP1484059A3 (de) | 2005-04-20 |
DK1484059T3 (da) | 2008-12-01 |
EP1108427A2 (de) | 2001-06-20 |
US5877213A (en) | 1999-03-02 |
EP1108428A9 (de) | 2001-10-31 |
DE69233754D1 (de) | 2009-02-12 |
NZ244850A (en) | 1997-01-29 |
ES2171400T3 (es) | 2002-09-16 |
EP1108428A2 (de) | 2001-06-20 |
EP1484058B1 (de) | 2008-12-31 |
EP1484058A3 (de) | 2005-04-27 |
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