DE69011235T2 - Derivate von N-(Vincristinyl-23) und N-(Noranhydro-5-vinblastinyl-23) von Amino-1-methylphosphonsäure, ihre Verfahren zur Herstellung und sie enthaltende pharmazeutische Zusammensetzungen. - Google Patents

Derivate von N-(Vincristinyl-23) und N-(Noranhydro-5-vinblastinyl-23) von Amino-1-methylphosphonsäure, ihre Verfahren zur Herstellung und sie enthaltende pharmazeutische Zusammensetzungen.

Info

Publication number
DE69011235T2
DE69011235T2 DE69011235T DE69011235T DE69011235T2 DE 69011235 T2 DE69011235 T2 DE 69011235T2 DE 69011235 T DE69011235 T DE 69011235T DE 69011235 T DE69011235 T DE 69011235T DE 69011235 T2 DE69011235 T2 DE 69011235T2
Authority
DE
Germany
Prior art keywords
radical
carbon atoms
denotes
linear
hydrogen atom
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69011235T
Other languages
English (en)
Other versions
DE69011235D1 (de
Inventor
Gilbert Lavielle
Patrick Hautefaye
Alain Pierre
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ADIR SARL
Original Assignee
ADIR SARL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ADIR SARL filed Critical ADIR SARL
Publication of DE69011235D1 publication Critical patent/DE69011235D1/de
Application granted granted Critical
Publication of DE69011235T2 publication Critical patent/DE69011235T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
DE69011235T 1989-08-04 1990-08-03 Derivate von N-(Vincristinyl-23) und N-(Noranhydro-5-vinblastinyl-23) von Amino-1-methylphosphonsäure, ihre Verfahren zur Herstellung und sie enthaltende pharmazeutische Zusammensetzungen. Expired - Fee Related DE69011235T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8910554A FR2651348B1 (de) 1989-08-04 1989-08-04

Publications (2)

Publication Number Publication Date
DE69011235D1 DE69011235D1 (de) 1994-09-08
DE69011235T2 true DE69011235T2 (de) 1995-03-09

Family

ID=9384495

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69011235T Expired - Fee Related DE69011235T2 (de) 1989-08-04 1990-08-03 Derivate von N-(Vincristinyl-23) und N-(Noranhydro-5-vinblastinyl-23) von Amino-1-methylphosphonsäure, ihre Verfahren zur Herstellung und sie enthaltende pharmazeutische Zusammensetzungen.

Country Status (15)

Country Link
US (1) US5100881A (de)
EP (1) EP0412015B1 (de)
JP (1) JPH075619B2 (de)
AT (1) ATE109485T1 (de)
AU (1) AU625885B2 (de)
CA (1) CA2022538C (de)
DE (1) DE69011235T2 (de)
DK (1) DK0412015T3 (de)
ES (1) ES2060979T3 (de)
FR (1) FR2651348B1 (de)
IE (1) IE66007B1 (de)
NZ (1) NZ234771A (de)
OA (1) OA09299A (de)
PT (1) PT94906B (de)
ZA (1) ZA905924B (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5508463A (en) * 1994-03-17 1996-04-16 Trustees Of The University Of Pennsylvania α-aminophosphonates
EP2266607A3 (de) 1999-10-01 2011-04-20 Immunogen, Inc. Immunokonjugate für Krebsbehandlung

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3354163A (en) * 1966-12-15 1967-11-21 Eli Lillty And Company Nu-desmethylvinblastine
HU165986B (de) * 1973-02-16 1974-12-28
US4307100A (en) * 1978-08-24 1981-12-22 Agence Nationale De Valorisation De La Recherche (Anvar) Nor bis-indole compounds usable as medicaments
US4210584A (en) * 1979-01-15 1980-07-01 Eli Lilly And Company Vindesine synthesis
LU84640A1 (fr) * 1983-02-10 1984-11-08 Onmichem S A Nouveau procede d'obtention de la vincristine et du sulfate de vincristine
US4619935A (en) * 1983-03-17 1986-10-28 Eli Lilly And Company Stable oncolytic formulations
US4522750A (en) * 1984-02-21 1985-06-11 Eli Lilly And Company Cytotoxic compositions of transferrin coupled to vinca alkaloids
FR2623504B1 (fr) * 1987-11-25 1990-03-09 Adir Nouveaux derives n-(vinblastinoyl-23) d'acide amino-1 methylphosphonique, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
US4923876A (en) * 1988-04-18 1990-05-08 Cetus Corporation Vinca alkaloid pharmaceutical compositions

Also Published As

Publication number Publication date
PT94906B (pt) 1997-03-31
JPH03118388A (ja) 1991-05-20
IE66007B1 (en) 1995-11-29
FR2651348A1 (de) 1991-03-01
ZA905924B (en) 1991-05-29
DE69011235D1 (de) 1994-09-08
EP0412015B1 (de) 1994-08-03
CA2022538A1 (fr) 1991-02-05
DK0412015T3 (da) 1994-11-28
EP0412015A1 (de) 1991-02-06
ATE109485T1 (de) 1994-08-15
PT94906A (pt) 1991-04-18
CA2022538C (fr) 1996-09-24
OA09299A (fr) 1992-09-15
IE902808A1 (en) 1991-02-27
AU6014990A (en) 1991-02-07
ES2060979T3 (es) 1994-12-01
JPH075619B2 (ja) 1995-01-25
FR2651348B1 (de) 1993-01-22
NZ234771A (en) 1992-05-26
US5100881A (en) 1992-03-31
AU625885B2 (en) 1992-07-16

Similar Documents

Publication Publication Date Title
DE69103206D1 (de) Neue Derivate des Aminopiperidins, Aminopyrrolidins und des Aminoperhydroazepins, Verfahren zur Herstellung und diese enthaltende Arzneimittel.
NZ234110A (en) Dibenzoazepine, -oxepine and -cycloheptane substituted alkylidene amines; pharmaceutical compositions containing such compounds or various other aryl substituted amines
OA08972A (fr) Nouveaux dérivés N-(vinblastinoyl-23) d'acide amino-1 méthylphosphonique, leursprocédés de préparation et les compositions pharmaceutiques qui les contiennent
DE69011235D1 (de) Derivate von N-(Vincristinyl-23) und N-(Noranhydro-5-vinblastinyl-23) von Amino-1-methylphosphonsäure, ihre Verfahren zur Herstellung und sie enthaltende pharmazeutische Zusammensetzungen.
ATE69611T1 (de) Piperazinylalkylpiperazindion-derivate, ihre verfahren zur herstellung und diese enthaltende pharmazeutische zusammenstellungen.
NZ246598A (en) Trazodone derivatives; compounds and preparation, pharmaceutical compositions; intermediate compounds
ATE16383T1 (de) Neue heteroaryloxypropanolamine, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel.
MX9206149A (es) N-(mercaptoacil)amino acidos, metodos para su preparcion y uso terapeutico, y composiciones farmaceuticas que los contienen
ATE56442T1 (de) 2,6-piperazin-dion-derivate, ihre verfahren zur herstellung und sie enthaltende pharmazeutische zusammensetzungen.
ATE85056T1 (de) Tetracyclische indolderivate.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee