DE69232062D1 - Nanopartikel aus Polyoxyäthylen-Polymilchsäure Blockcopolymeren - Google Patents

Nanopartikel aus Polyoxyäthylen-Polymilchsäure Blockcopolymeren

Info

Publication number
DE69232062D1
DE69232062D1 DE69232062T DE69232062T DE69232062D1 DE 69232062 D1 DE69232062 D1 DE 69232062D1 DE 69232062 T DE69232062 T DE 69232062T DE 69232062 T DE69232062 T DE 69232062T DE 69232062 D1 DE69232062 D1 DE 69232062D1
Authority
DE
Germany
Prior art keywords
polyoxyethylene
polylactic acid
block copolymers
acid block
nanoparticles made
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69232062T
Other languages
English (en)
Other versions
DE69232062T2 (de
Inventor
Gilles Spenlehauer
Didier Bazile
Michel Veillard
Homme Christian Prud
Jean-Paul Michalon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharma SA
Original Assignee
Aventis Pharma SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma SA filed Critical Aventis Pharma SA
Application granted granted Critical
Publication of DE69232062D1 publication Critical patent/DE69232062D1/de
Publication of DE69232062T2 publication Critical patent/DE69232062T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • A61K9/5153—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/765—Polymers containing oxygen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/70—Nanostructure
    • Y10S977/773—Nanoparticle, i.e. structure having three dimensions of 100 nm or less
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/70—Nanostructure
    • Y10S977/788—Of specified organic or carbon-based composition
    • Y10S977/795—Composed of biological material
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/915—Therapeutic or pharmaceutical composition

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nanotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Medicinal Preparation (AREA)
  • Macromonomer-Based Addition Polymer (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
DE69232062T 1991-06-28 1992-06-25 Nanopartikel aus Polyoxyäthylen-Polymilchsäure Blockcopolymeren Expired - Lifetime DE69232062T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9108041A FR2678168B1 (fr) 1991-06-28 1991-06-28 Nanoparticules ayant un temps de capture par le dysteme reticulo endothelial allonge.

Publications (2)

Publication Number Publication Date
DE69232062D1 true DE69232062D1 (de) 2001-10-25
DE69232062T2 DE69232062T2 (de) 2002-04-25

Family

ID=9414444

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69232062T Expired - Lifetime DE69232062T2 (de) 1991-06-28 1992-06-25 Nanopartikel aus Polyoxyäthylen-Polymilchsäure Blockcopolymeren

Country Status (16)

Country Link
US (1) US5683723A (de)
EP (2) EP0520888B1 (de)
JP (1) JP3465260B2 (de)
AT (1) ATE205718T1 (de)
CA (1) CA2102186C (de)
DE (1) DE69232062T2 (de)
DK (1) DK0520888T3 (de)
ES (1) ES2162793T3 (de)
FI (1) FI109576B (de)
FR (1) FR2678168B1 (de)
GR (1) GR3036773T3 (de)
IE (1) IE922110A1 (de)
MX (1) MX9203353A (de)
NO (1) NO306119B1 (de)
PT (1) PT520888E (de)
WO (1) WO1993000101A1 (de)

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US5981719A (en) 1993-03-09 1999-11-09 Epic Therapeutics, Inc. Macromolecular microparticles and methods of production and use
US6090925A (en) 1993-03-09 2000-07-18 Epic Therapeutics, Inc. Macromolecular microparticles and methods of production and use
US5543158A (en) * 1993-07-23 1996-08-06 Massachusetts Institute Of Technology Biodegradable injectable nanoparticles
US5565215A (en) * 1993-07-23 1996-10-15 Massachusettes Institute Of Technology Biodegradable injectable particles for imaging
GB2281697A (en) * 1993-09-14 1995-03-15 Euro Celtique Sa Laxative compositions in capsules
FR2721510B1 (fr) * 1994-06-22 1996-07-26 Rhone Poulenc Rorer Sa Nanoparticules filtrables dans des conditions stériles.
US6007845A (en) * 1994-07-22 1999-12-28 Massachusetts Institute Of Technology Nanoparticles and microparticles of non-linear hydrophilic-hydrophobic multiblock copolymers
WO1996033233A1 (fr) * 1995-04-19 1996-10-24 Kazunori Kataoka Copolymeres en blocs heterotelecheliques et procede de production
PT752245E (pt) * 1995-07-05 2002-09-30 Europ Economic Community Nanoparticulas biocompativeis e biodegradaveis destinadas a absorcao e administracao de farmacos proteinaceos
US5766629A (en) 1995-08-25 1998-06-16 Sangstat Medical Corporation Oral cyclosporin formulations
KR0180334B1 (ko) 1995-09-21 1999-03-20 김윤 블럭 공중합체 미셀을 이용한 약물전달체 및 이에 약물을 봉입하는 방법
FR2742357B1 (fr) * 1995-12-19 1998-01-09 Rhone Poulenc Rorer Sa Nanoparticules stabilisees et filtrables dans des conditions steriles
US5611344A (en) * 1996-03-05 1997-03-18 Acusphere, Inc. Microencapsulated fluorinated gases for use as imaging agents
US6211249B1 (en) * 1997-07-11 2001-04-03 Life Medical Sciences, Inc. Polyester polyether block copolymers
EP1280557B1 (de) 2000-05-12 2012-06-20 Samyang Corporation Methode für die herstellung von polymermizellen vermittels phasentrennung eines block-copolymers
US7217770B2 (en) * 2000-05-17 2007-05-15 Samyang Corporation Stable polymeric micelle-type drug composition and method for the preparation thereof
SK5902003A3 (en) * 2000-11-01 2003-08-05 Merck Patent Gmbh Methods and compositions for the treatment of diseases of the eye
KR100354828B1 (ko) * 2001-03-12 2002-10-05 주식회사 씨엠리서치 생분해성 폴리에스테르의 제조방법 및 그에 의해 제조된생분해성 폴리에스테르
US20040185101A1 (en) * 2001-03-27 2004-09-23 Macromed, Incorporated. Biodegradable triblock copolymers as solubilizing agents for drugs and method of use thereof
US6638994B2 (en) 2001-03-30 2003-10-28 Regan Crooks Aqueous suspension of nanoparticles comprising an agrochemical active ingredient
US6939564B2 (en) 2001-06-08 2005-09-06 Labopharm, Inc. Water-soluble stabilized self-assembled polyelectrolytes
CN1325046C (zh) * 2001-08-31 2007-07-11 麦吉尔大学 可生物降解的多聚纳米微囊及其应用
WO2003068253A1 (en) * 2002-02-14 2003-08-21 Merck Patent Gmbh Methods and compositions for the treatment of eye diseases
US6780324B2 (en) 2002-03-18 2004-08-24 Labopharm, Inc. Preparation of sterile stabilized nanodispersions
US20060165987A1 (en) * 2002-04-05 2006-07-27 Patrice Hildgen Stealthy polymeric biodegradable nanospheres and uses thereof
US7649023B2 (en) 2002-06-11 2010-01-19 Novartis Ag Biodegradable block copolymeric compositions for drug delivery
WO2005078017A1 (ja) * 2004-02-16 2005-08-25 Mitsui Chemicals, Inc. 共重合体を含む脂肪族ポリエステル樹脂組成物
US8012457B2 (en) 2004-06-04 2011-09-06 Acusphere, Inc. Ultrasound contrast agent dosage formulation
US20060198891A1 (en) 2004-11-29 2006-09-07 Francois Ravenelle Solid formulations of liquid biologically active agents
WO2008018932A2 (en) * 2006-05-01 2008-02-14 The Board Of Trustees Of The Leland Stanford Junior University Method and use of nano-scale devices for reduction of tissue injury in ischemic and reperfusion injury
JP2010504318A (ja) * 2006-09-22 2010-02-12 ラボファーム インコーポレイテッド ｐＨ標的化薬剤送達のための組成物及び方法
JP2008195656A (ja) 2007-02-14 2008-08-28 Nipro Corp 人工酸素運搬体製剤
WO2008135828A2 (en) 2007-05-03 2008-11-13 Pfizer Products Inc. Nanoparticles comprising a drug, ethylcellulose, and a bile salt
WO2008135855A2 (en) 2007-05-03 2008-11-13 Pfizer Products Inc. Nanoparticles comprising a cholesteryl ester transfer protein inhibitor and a nonionizable polymer
WO2008149230A2 (en) 2007-06-04 2008-12-11 Pfizer Products Inc. Nanoparticles comprising drug, a non-ionizable cellulosic polymer and tocopheryl polyethylene glycol succinate
US8974827B2 (en) 2007-06-04 2015-03-10 Bend Research, Inc. Nanoparticles comprising a non-ionizable cellulosic polymer and an amphiphilic non-ionizable block copolymer
EP2231169B1 (de) 2007-12-06 2016-05-04 Bend Research, Inc. Pharmazeutische zusammensetzungen mit nanopartikeln und resuspensionsmaterial
US9233078B2 (en) 2007-12-06 2016-01-12 Bend Research, Inc. Nanoparticles comprising a non-ionizable polymer and an Amine-functionalized methacrylate copolymer
JP5574445B2 (ja) * 2009-03-06 2014-08-20 国立大学法人 岡山大学 生分解性多孔質中空微粒子、その製造方法および用途
EP2382966A1 (de) 2010-03-12 2011-11-02 DSM IP Assets B.V. Mizellenzusammensetzungen und Herstellungsverfahren dafür
EP2634179A1 (de) 2012-02-28 2013-09-04 Sanofi Funktionale PLA-PEG-Copolymere, Nanopartikel, Herstellung und Verwendung zur gezielten Arzneimittelabgabe und Abbildung
US9951183B2 (en) 2014-08-08 2018-04-24 Dsm Ip Assets, B.V. Amphiphilic blockcopolymers comprising reduction sensitive biodegradable polyesteramides
CA2969840A1 (en) 2014-12-09 2016-06-16 Sweetwater Energy, Inc. Rapid pretreatment
EP3583223A4 (de) 2017-02-16 2020-12-23 Sweetwater Energy, Inc. Hochdruckzonenbildung zur vorbehandlung
EP4077490A1 (de) 2019-12-22 2022-10-26 Sweetwater Energy, Inc. Verfahren zum herstellen spezialisierter lignin- und ligninprodukte aus biomasse
WO2023030474A1 (zh) * 2021-09-03 2023-03-09 先声药业有限公司 一种疏水性药物聚合物胶束及其制备方法

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WO1978000011A1 (en) * 1977-06-07 1978-12-21 Garching Instrumente Form of implant medicament and preparation process
DE3378250D1 (en) 1982-04-22 1988-11-24 Ici Plc Continuous release formulations
GB8416234D0 (en) 1984-06-26 1984-08-01 Ici Plc Biodegradable amphipathic copolymers
IL82834A (en) * 1987-06-09 1990-11-05 Yissum Res Dev Co Biodegradable polymeric materials based on polyether glycols,processes for the preparation thereof and surgical artiicles made therefrom
US5078994A (en) * 1990-04-12 1992-01-07 Eastman Kodak Company Microgel drug delivery system
US5238714A (en) * 1990-10-02 1993-08-24 Board Of Regents, The University Of Texas System Efficient microcapsule preparation and method of use
US5410016A (en) * 1990-10-15 1995-04-25 Board Of Regents, The University Of Texas System Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers

Also Published As

Publication number Publication date
DK0520888T3 (da) 2001-11-12
NO934358L (no) 1993-12-01
US5683723A (en) 1997-11-04
PT520888E (pt) 2002-02-28
GR3036773T3 (en) 2002-01-31
NO934358D0 (no) 1993-12-01
FI935868A (fi) 1993-12-27
MX9203353A (es) 1992-12-01
CA2102186C (fr) 2005-09-13
FR2678168A1 (fr) 1992-12-31
DE69232062T2 (de) 2002-04-25
EP0591374A1 (de) 1994-04-13
IE922110A1 (en) 1992-12-30
WO1993000101A1 (fr) 1993-01-07
EP0520888B1 (de) 2001-09-19
ATE205718T1 (de) 2001-10-15
FI109576B (fi) 2002-09-13
JPH06508831A (ja) 1994-10-06
CA2102186A1 (fr) 1992-12-29
FI935868A0 (fi) 1993-12-27
NO306119B1 (no) 1999-09-20
ES2162793T3 (es) 2002-01-16
EP0520888A1 (de) 1992-12-30
JP3465260B2 (ja) 2003-11-10
FR2678168B1 (fr) 1993-09-03

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Legal Events

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Representative=s name: PFENNING MEINIG & PARTNER GBR, 80339 MUENCHEN

8328 Change in the person/name/address of the agent

Representative=s name: MAIWALD PATENTANWALTSGESELLSCHAFT MBH, 80335 MUENC

R071 Expiry of right

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