DE69231739D1 - Aus alternden zellen abgeleitete hemmer der dns-synthese - Google Patents

Aus alternden zellen abgeleitete hemmer der dns-synthese

Info

Publication number
DE69231739D1
DE69231739D1 DE69231739T DE69231739T DE69231739D1 DE 69231739 D1 DE69231739 D1 DE 69231739D1 DE 69231739 T DE69231739 T DE 69231739T DE 69231739 T DE69231739 T DE 69231739T DE 69231739 D1 DE69231739 D1 DE 69231739D1
Authority
DE
Germany
Prior art keywords
dna synthesis
synthesis inhibitors
aging cells
inhibitors derived
aging
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69231739T
Other languages
English (en)
Other versions
DE69231739T2 (de
Inventor
R Smith
Noda, Ph D
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Baylor College of Medicine
Original Assignee
Baylor College of Medicine
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baylor College of Medicine filed Critical Baylor College of Medicine
Application granted granted Critical
Publication of DE69231739D1 publication Critical patent/DE69231739D1/de
Publication of DE69231739T2 publication Critical patent/DE69231739T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/23—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a GST-tag
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/61—Fusion polypeptide containing an enzyme fusion for detection (lacZ, luciferase)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C12N2310/111—Antisense spanning the whole gene, or a large part of it
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/322—2'-R Modification

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Epidemiology (AREA)
  • Nanotechnology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Dispersion Chemistry (AREA)
  • Immunology (AREA)
  • Medical Informatics (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
DE69231739T 1991-12-16 1992-12-15 Aus alternden zellen abgeleitete hemmer der dns-synthese Expired - Lifetime DE69231739T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US80852391A 1991-12-16 1991-12-16
US07/970,462 US5302706A (en) 1991-12-16 1992-11-02 Senescent cell derived inhibitors of DNA synthesis
PCT/US1992/010904 WO1993012251A1 (en) 1991-12-16 1992-12-15 Senescent cell derived inhibitors of dna synthesis

Publications (2)

Publication Number Publication Date
DE69231739D1 true DE69231739D1 (de) 2001-04-19
DE69231739T2 DE69231739T2 (de) 2001-09-13

Family

ID=27123138

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69231739T Expired - Lifetime DE69231739T2 (de) 1991-12-16 1992-12-15 Aus alternden zellen abgeleitete hemmer der dns-synthese

Country Status (12)

Country Link
US (3) US5302706A (de)
EP (1) EP0640143B1 (de)
JP (1) JP3865766B2 (de)
AT (1) ATE199740T1 (de)
AU (1) AU673992B2 (de)
CA (1) CA2125974C (de)
DE (1) DE69231739T2 (de)
DK (1) DK0640143T3 (de)
ES (1) ES2157215T3 (de)
GR (1) GR3035905T3 (de)
PT (1) PT640143E (de)
WO (1) WO1993012251A1 (de)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6372249B1 (en) * 1991-12-16 2002-04-16 Baylor College Of Medicine Senscent cell-derived inhibitors of DNA synthesis
US5302706A (en) * 1991-12-16 1994-04-12 Baylor College Of Medicine Senescent cell derived inhibitors of DNA synthesis
US5744300A (en) * 1993-03-24 1998-04-28 Geron Corporation Methods and reagents for the identification and regulation of senescence-related genes
JP3822232B2 (ja) * 1993-08-30 2006-09-13 ベイラー・カレッジ・オブ・メディシン 老化細胞由来ｄｎａ合成阻害因子
DE69435309D1 (de) * 1993-08-30 2010-09-30 Baylor College Medicine Inhibitoren der dna synthese aus alternden zellen
US6051376A (en) * 1994-09-30 2000-04-18 The Trustees Of Columbia University In The City Of New York Uses of mda-6
EP1650303B1 (de) 1993-10-27 2008-05-28 The Trustees of Columbia University of the City of New York Methode zur Bildung einer subtrahierten cDNA Bank und ihre Verwendung
WO1995013375A1 (en) * 1993-11-10 1995-05-18 The Johns Hopkins University Tumor suppressor waf1
US5491069A (en) * 1994-02-18 1996-02-13 The Regents Of The University Of California Biomarkers of cell senescence
US5856121A (en) * 1994-02-24 1999-01-05 Case Western Reserve University Growth arrest homebox gene
AU2589095A (en) * 1994-05-16 1995-12-05 Washington University Cell membrane fusion composition and method
WO1995031995A1 (en) * 1994-05-24 1995-11-30 Baylor College Of Medicine Mimetics of senescent cell derived inhibitors of dna synthesis
US5631156A (en) * 1994-06-21 1997-05-20 The University Of Michigan DNA encoding and 18 KD CDK6 inhibiting protein
WO1996012506A1 (en) * 1994-10-24 1996-05-02 Baylor College Of Medecine Senescent cell-derived inhibitors of dna synthesis
GB9422175D0 (en) 1994-11-03 1994-12-21 Univ Dundee Indentification of the p21 waf1-pcna interaction site and therapeutic applications thereof
WO1996015245A1 (en) * 1994-11-11 1996-05-23 Arch Development Corporation A process of inhibiting non-neoplastic pathological cell proliferation
US5700927A (en) * 1994-12-23 1997-12-23 The Children's Medical Center Corporation Tbc1 gene and uses thereof
AU5103996A (en) 1995-03-09 1996-10-02 Bavarian Nordic Research Institute A/S Vectors carrying therapeutic genes encoding antimicrobial peptides for gene therapy
US6149945A (en) * 1995-03-20 2000-11-21 Alberta Cancer Board Human fibroblast diffusable factors
US6025480A (en) * 1995-04-03 2000-02-15 Sloan-Kettering Institute For Cancer Research Isolated nucleic acid molecules encoding P57KIP2
US6322548B1 (en) 1995-05-10 2001-11-27 Eclipse Surgical Technologies Delivery catheter system for heart chamber
GB9509557D0 (en) 1995-05-11 1995-07-05 Univ Dundee PCNA binding substance
US5840059A (en) * 1995-06-07 1998-11-24 Cardiogenesis Corporation Therapeutic and diagnostic agent delivery
US6224584B1 (en) 1997-01-14 2001-05-01 Eclipse Surgical Technologies, Inc. Therapeutic and diagnostic agent delivery
WO1997003681A1 (en) * 1995-07-20 1997-02-06 Worcester Foundation For Biomedical Research, Inc. Methods for selectively killing or inhibiting the growth of cells expressing the waf1 gene
US6143211A (en) * 1995-07-21 2000-11-07 Brown University Foundation Process for preparing microparticles through phase inversion phenomena
US5705350A (en) * 1995-08-29 1998-01-06 Duke University Transcription factor complexes in senescent cells
US7087582B1 (en) 1995-09-26 2006-08-08 Regents Of The University Of Michigan Combination for site-specifically transforming cells in vivo comprising a double-balloon catheter and nucleic acid comprising a gene encoding P21
ES2176500T3 (es) * 1995-10-13 2002-12-01 Austrian Nordic Biotherapeutic Vectores retroviricos que llevan inhibidores 1 derivados de celulas senescentes (sdi-1) o secuencias de nucleotidos antisentido de sdi-1.
US7074398B1 (en) 1995-10-13 2006-07-11 Gsf-Forschungszentrum Fuer Umwelt Und Gesundheit Gmbh Retroviral vectors carrying senescent cell derived inhibitors 1 (SDI-1)or antisense SDI-1 nucleotide sequences
GB9600518D0 (en) * 1996-01-11 1996-03-13 Ludwig Inst Cancer Res Regulator of cell proliferation
US5958769A (en) * 1996-01-18 1999-09-28 Fred Hutchinson Cancer Research Center Compositions and methods for mediating cell cycle progression
JP2000503538A (ja) * 1996-01-18 2000-03-28 フレッド ハッチンソン カンサー リサーチ センター 細胞周期を仲介する組成物および方法
US20030027777A1 (en) * 1996-04-10 2003-02-06 Andrew Koff Methods for enhancing animal growth and cell proliferation by elimination of the cyclin-dependent kinase inhibitor function of p27Kip1
DE69736351D1 (de) * 1996-05-08 2006-08-31 Cyclacel Ltd Methoden und mittel zur hemmung der cdk4-aktivität
AU714393B2 (en) * 1996-11-21 2000-01-06 Board Of Regents Of The University Of Nebraska, The Antisense oligonucleotide compositions for selectively killing cancer cells
AU739057B2 (en) 1996-12-26 2001-10-04 Shirankai Kyoto University Faculty Of Medicine Alumni Association Inc. Novel polypeptide, novel DNA, and novel antibody
US6218109B1 (en) 1997-09-05 2001-04-17 Baylor College Of Medicine Mammalian checkpoint genes and proteins
US20030165888A1 (en) * 2001-07-18 2003-09-04 Brown Bob D. Oligonucleotide probes and primers comprising universal bases for diagnostic purposes
US6518017B1 (en) * 1997-10-02 2003-02-11 Oasis Biosciences Incorporated Combinatorial antisense library
IL135574A0 (en) 1997-10-27 2001-05-20 Agouron Pharma Substituted 4-amino-thiazol-2-yl compounds as cdk inhibitors
US6489305B1 (en) * 1998-05-08 2002-12-03 Canji, Inc. Methods and compositions for the treatment of ocular diseases
US7691370B2 (en) * 1998-10-15 2010-04-06 Canji, Inc. Selectivity replicating viral vector
KR20020013519A (ko) * 1999-04-08 2002-02-20 추후제출 보편적 및/또는 축퇴성 염기를 포함하는 안티센스올리고뉴클레오티드
US6706491B1 (en) * 1999-04-09 2004-03-16 The Board Of Trustees Of The University Of Illinois Reagents and methods for identifying and modulating expression of genes regulated by p21
US20020156247A1 (en) * 2000-01-12 2002-10-24 Elledge Stephen J. Mammalian checkpoint genes and proteins
BRPI0416920A (pt) * 2003-11-24 2007-01-23 Canji Inc redução de cicatriz dérmica
US20080125404A1 (en) * 2004-08-27 2008-05-29 Cyclacel Limited Purine and Pyrimidine Cdk Inhitbitors and Their use for The Treatment of Autoimmune Diseases

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI890312A (fi) * 1988-01-25 1989-07-26 Oncogen Amfiregulin: ett nytt bifunktionellt tillvaext modulerande glykoprotein.
CA2070393A1 (en) * 1989-10-18 1991-04-19 Charles M. Cohen Biosynthetic constructs of tgf-beta
AU7766091A (en) * 1990-04-04 1991-10-30 American National Red Cross, The Modified heparin binding growth factors
IE20010427A1 (en) * 1990-04-10 2003-03-05 Canji Inc Gene therapy for cell proliferative diseases
US5302706A (en) * 1991-12-16 1994-04-12 Baylor College Of Medicine Senescent cell derived inhibitors of DNA synthesis

Also Published As

Publication number Publication date
JP3865766B2 (ja) 2007-01-10
CA2125974C (en) 1999-06-29
DE69231739T2 (de) 2001-09-13
ES2157215T3 (es) 2001-08-16
GR3035905T3 (en) 2001-08-31
CA2125974A1 (en) 1993-06-24
PT640143E (pt) 2001-09-27
US5840845A (en) 1998-11-24
US5424400A (en) 1995-06-13
DK0640143T3 (da) 2001-07-16
JPH07502651A (ja) 1995-03-23
EP0640143A4 (de) 1996-10-23
ATE199740T1 (de) 2001-03-15
EP0640143B1 (de) 2001-03-14
EP0640143A1 (de) 1995-03-01
AU3324393A (en) 1993-07-19
AU673992B2 (en) 1996-12-05
WO1993012251A1 (en) 1993-06-24
US5302706A (en) 1994-04-12

Similar Documents

Publication Publication Date Title
DE69231739T2 (de) Aus alternden zellen abgeleitete hemmer der dns-synthese
DK1029921T3 (da) Serpinresistent t-PA, mutanter, gener
DE69433647D1 (de) Menschliche proteaseinhibitoren vom kunitztyp
DK0762897T3 (da) Fremgangsmåde til forebyggelse af aggregering af proteiner/peptider ved rehydratisering eller optøning
DE69231469T2 (de) Verwendung von gentisinsäure oder gentisylalkohol zur stabilisierung von radio-markierten peptiden und proteinen
TR199902545T2 (xx) Kalp damar hastal�klar�n�n �nlenmesinde siklooksijenaz-2 inhibit�rlerini kullanma y�ntemi
DE69226558D1 (de) Verfahren zur Korrosionverminderung von an Hochtemperaturwasser ausgesetzten Komponenten
DE69609193D1 (de) Neosäure als korrosinsinhibitoren
DK332684D0 (da) Modificerede protease-inhibitorer samt deres fremstilling og anvendelse
UA35574C2 (uk) Похідні заміщеної гетероциклом фенілциклогексанкарбонової кислоти, суміші їх ізомерів або окремі ізомери та їх солі
ES2071331T3 (es) Detergente con contenido de proteasa e inhibidor, y nuevos inhibidores para uso en dicho detergente.
NL7713091A (nl) Derivaten van de trypsine-callicreine-remmer uit runderorganen (bpti) met proteasen remmende werking en antiflogistische werking, alsmede de bereiding van dergelijke derivaten en preparaten, die deze derivaten bevatten.
SV2002000244A (es) Metodos y compuestos para inhibir mrp1 ref.x-13353
AU7303301A (en) Isolated nucleic acid molecules which encode t cell inducible factors, or interleukin-21, the proteins encoded, and uses thereof
IT1174756B (it) Composizioni antisolari contenenti almeno un composto di ammide viniloga e relativo impiego
IT8047515A0 (it) Elementi di filo di acciaio di rinforzo in particolare di composizioni di gomma
ES2152313T3 (es) Gen grb-3-3, sus variantes y sus utilizaciones.
IT1105058B (it) Amminoacidi alfa-acetilenici utili in particolare come inibitori di decarbossilasi di amminoacidi aromatici e relativo procedimento di produzione
IT1051482B (it) Emulsione acquosa stabile di i..i 2..tricloro..1..2..2..trifluoretano .. particolarmente utile come detergente
AR009818A1 (es) Proteasas y sus variantes que tienen inhibidores de proteasa peptida fundidos en ellas
IT1056979B (it) Lega per oggetti molto resistenti lla corrosione e o capaci di sopportare grandi sollecitazione meccaniche
CH529560A (de) Verwendung von biologischen Proteasen-Inhibitoren als Desodorantien
IT1058544B (it) Perfezionamenti introdotti nella costruzione di nuclei per realitanze
DE60108729D1 (de) Phosphoglycerat-kinase-1-promotor aus rhizopus oryzae und dessen verwendung
ATE443148T1 (de) Transkriptionale regulator-nukleinsäuren, polypeptide und verfahren ihrer anwendung

Legal Events

Date Code Title Description
8364 No opposition during term of opposition