DE69229512D1 - Verfahren und Zusammensetzung mit Haloperoxydase zur Behandlung von Infektionen und Kontrolle der Flora - Google Patents
Verfahren und Zusammensetzung mit Haloperoxydase zur Behandlung von Infektionen und Kontrolle der FloraInfo
- Publication number
- DE69229512D1 DE69229512D1 DE69229512T DE69229512T DE69229512D1 DE 69229512 D1 DE69229512 D1 DE 69229512D1 DE 69229512 T DE69229512 T DE 69229512T DE 69229512 T DE69229512 T DE 69229512T DE 69229512 D1 DE69229512 D1 DE 69229512D1
- Authority
- DE
- Germany
- Prior art keywords
- microbe
- target
- haloperoxidase
- peroxide
- halide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Revoked
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/46—Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N63/00—Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
- A01N63/50—Isolated enzymes; Isolated proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/44—Oxidoreductases (1)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L12/00—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor
- A61L12/08—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor using chemical substances
- A61L12/082—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor using chemical substances in combination with specific enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L12/00—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor
- A61L12/08—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor using chemical substances
- A61L12/12—Non-macromolecular oxygen-containing compounds, e.g. hydrogen peroxide or ozone
- A61L12/124—Hydrogen peroxide; Peroxy compounds
- A61L12/126—Hydrogen peroxide; Peroxy compounds neutralised with catalase or peroxidase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/38—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/252—Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
- A61L2300/254—Enzymes, proenzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Materials Engineering (AREA)
- Hematology (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pest Control & Pesticides (AREA)
- Communicable Diseases (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Oncology (AREA)
- Plant Pathology (AREA)
- Virology (AREA)
- Agronomy & Crop Science (AREA)
- Dentistry (AREA)
- Wood Science & Technology (AREA)
- Environmental Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US66099491A | 1991-02-21 | 1991-02-21 |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69229512D1 true DE69229512D1 (de) | 1999-08-12 |
DE69229512T2 DE69229512T2 (de) | 2000-03-30 |
Family
ID=24651753
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69233698T Expired - Lifetime DE69233698T2 (de) | 1991-02-21 | 1992-02-21 | Haloperoxidase zur Behandlung von Infektionen und Kontrolle der Flora |
DE69229512T Revoked DE69229512T2 (de) | 1991-02-21 | 1992-02-21 | Verfahren und Zusammensetzung mit Haloperoxydase zur Behandlung von Infektionen und Kontrolle der Flora |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69233698T Expired - Lifetime DE69233698T2 (de) | 1991-02-21 | 1992-02-21 | Haloperoxidase zur Behandlung von Infektionen und Kontrolle der Flora |
Country Status (11)
Country | Link |
---|---|
US (1) | US6294168B1 (de) |
EP (2) | EP0923939B1 (de) |
JP (2) | JP4063317B2 (de) |
KR (1) | KR930703012A (de) |
AT (2) | ATE181837T1 (de) |
AU (1) | AU663869B2 (de) |
CA (1) | CA2061601C (de) |
DE (2) | DE69233698T2 (de) |
IE (1) | IE920514A1 (de) |
IL (1) | IL100997A (de) |
WO (1) | WO1992014484A1 (de) |
Families Citing this family (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5565197A (en) * | 1991-02-21 | 1996-10-15 | Exoxemis, Inc. | Method which utilizes a haloperoxidase composition to inhibit the growth of microorganisms which cause sexually transmitted diseases |
US5756090A (en) * | 1991-02-21 | 1998-05-26 | Eoe, Inc. | Oxygen activatable formulations for disinfection or sterilization |
WO1994023742A1 (en) * | 1993-04-15 | 1994-10-27 | Exoxemis, Inc. | Methods and compositions for the prevention or treatment of sexually transmitted diseases |
AU2085995A (en) * | 1994-03-31 | 1995-10-23 | Stichting Scheikundig Onderzoek In Nederland | Antifouling paint containing haloperoxidases and method to determine halide concentrations |
NL9401048A (nl) * | 1994-03-31 | 1995-11-01 | Stichting Scheikundig Onderzoe | Haloperoxidasen. |
DE4430327C1 (de) * | 1994-08-27 | 1996-05-09 | Degussa | Enzymatische, aktiven Sauerstoff liefernde Mischung sowie Verfahren zur enzymatischen Herstellung von Persäuren |
AU703034B2 (en) * | 1995-10-25 | 1999-03-11 | Eoe, Inc. | Microporous pathogen-killing composition |
WO1997042825A1 (en) * | 1996-05-09 | 1997-11-20 | Novo Nordisk A/S | Antimicrobial peroxidase compositions |
EP0849585A3 (de) * | 1996-12-18 | 1998-09-02 | Kabushiki Kaisha Egawa | Vorrichtung zur Kontrolle der Funktion von Mikroben und Zellen, Verfahren zu deren Steuerung, sowie Vorrichtung zur Detektion einer mikrobischen Umgebung |
AU6469698A (en) * | 1997-03-24 | 1998-10-20 | Clorox Company, The | A chloroperoxidase enzyme system for generating hypochlorous acid and hypochlorite (in situ) |
US6251386B1 (en) | 1997-08-14 | 2001-06-26 | Novo Nordisk A/S | Antimicrobial composition containing a haloperoxidase, a hydrogen peroxide source, a halide source and an ammonium source |
US6492110B1 (en) | 1998-11-02 | 2002-12-10 | Uab Research Foundation | Reference clones and sequences for non-subtype B isolates of human immunodeficiency virus type 1 |
US6605751B1 (en) | 1997-11-14 | 2003-08-12 | Acrymed | Silver-containing compositions, devices and methods for making |
US7063970B1 (en) | 1999-05-06 | 2006-06-20 | Norozymes A/S | Enzymatic preservation of water based paints |
AU2742401A (en) | 1999-12-30 | 2001-07-16 | Acrymed | Methods and compositions for improved delivery devices |
CN1315523A (zh) * | 2000-03-28 | 2001-10-03 | 上海博德基因开发有限公司 | 一种新的多肽——人过氧化酶18和编码这种多肽的多核苷酸 |
CN1315532A (zh) * | 2000-03-29 | 2001-10-03 | 上海博德基因开发有限公司 | 一种新的多肽——人过氧化酶11和编码这种多肽的多核苷酸 |
WO2002047483A1 (en) * | 2000-12-15 | 2002-06-20 | Novozymes A/S | Use of haloperoxidase, peroxide and carboxylic acid |
US20040086453A1 (en) * | 2001-01-22 | 2004-05-06 | Howes Randolph M. | Compositions, methods, apparatuses, and systems for singlet oxygen delivery |
US20030118472A1 (en) * | 2001-08-08 | 2003-06-26 | Mckee Mary Mowrey | Disinfecting and cleaning system for contact lenses |
SE0200876L (sv) * | 2002-03-22 | 2003-09-23 | Krister Tano | Nässpray mot öroninflammationer |
US8361553B2 (en) | 2004-07-30 | 2013-01-29 | Kimberly-Clark Worldwide, Inc. | Methods and compositions for metal nanoparticle treated surfaces |
AU2005280443B2 (en) | 2004-07-30 | 2011-02-03 | Avent, Inc. | Antimicrobial silver compositions |
US10251392B2 (en) | 2004-07-30 | 2019-04-09 | Avent, Inc. | Antimicrobial devices and compositions |
EP1809264B1 (de) | 2004-09-20 | 2016-04-13 | Avent, Inc. | Antimikrobielle amorphe zusammensetzungen |
US20070264355A1 (en) * | 2005-12-14 | 2007-11-15 | Binary, Llc | Binary compositions and methods for sterilization |
WO2007127236A2 (en) | 2006-04-28 | 2007-11-08 | Acrymed, Inc. | Antimicrobial site dressings |
JP5558458B2 (ja) | 2008-03-20 | 2014-07-23 | タノメド・アクチボラゲット | 普通感冒の治療用の医薬の製造における物質の使用 |
US8945540B2 (en) * | 2008-05-09 | 2015-02-03 | Exoxemis, Inc. | Compositions for enhancing the antibacterial activity of myeloperoxidase and methods of use thereof |
AU2012281172B2 (en) | 2011-07-11 | 2016-11-17 | Exoxemis, Inc. | Eosinophil peroxidase compositions and methods of their use |
EP2671449A1 (de) | 2012-06-06 | 2013-12-11 | Construction Research & Technology GmbH | Verwendung von Vanadiumpentoxidpartikeln als Biozid |
KR101434553B1 (ko) | 2012-09-04 | 2014-08-26 | 녹십자수의약품(주) | 어류의 스쿠티카충 및 병원성 세균 구제용 조성물 및 이들의 구제방법 |
US9814234B2 (en) | 2014-01-14 | 2017-11-14 | Exoxemis, Inc. | Bioactive heme-haloperoxidase compositions and methods of their use |
EP3245871A1 (de) | 2014-04-30 | 2017-11-22 | Matoke Holdings Limited | Antimikrobielle zusammensetzungen |
KR101647557B1 (ko) * | 2014-10-23 | 2016-08-10 | 동아대학교 산학협력단 | 과산화수소를 포함하는 푸자리움 푸지쿠로이의 선택배지 및 이의 용도 |
CN109414485B (zh) * | 2016-05-27 | 2022-08-12 | 埃欧艾米斯公司 | 用于抑制脂多糖和脂质a的髓过氧化物酶组合物和方法 |
DE102016120736A1 (de) | 2016-10-31 | 2018-05-03 | Johannes-Gutenberg-Universität Mainz | Biozider Stoff und damit hergestellte Produkte |
GB2566516A (en) | 2017-09-15 | 2019-03-20 | Univ Oxford Innovation Ltd | Electrochemical recognition and quantification of cytochrome c oxidase expression in bacteria |
GB201716986D0 (en) | 2017-10-16 | 2017-11-29 | Matoke Holdings Ltd | Antimicrobial compositions |
WO2020014493A1 (en) * | 2018-07-13 | 2020-01-16 | Allen Robert C | Haloperoxidase compositions and uses thereof |
GB2589863A (en) * | 2019-12-09 | 2021-06-16 | Institute Of Tech Sligo | Antimicrobial composition |
CN112259158B (zh) * | 2020-09-16 | 2023-03-28 | 青岛蔚蓝生物股份有限公司 | 一种在食品热处理加工过程中益生菌存活量的预测模型 |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2679533A (en) | 1951-11-03 | 1954-05-25 | California Research Corp | Addition products of halogen and quaternary ammonium germicides and method for making the same |
GB2108387B (en) * | 1979-12-28 | 1984-03-21 | Green Cross Corp | A pharmaceutical composition containing myeloperoxidase |
US4473550A (en) * | 1981-01-16 | 1984-09-25 | Rosenbaum Robert S | Bactericidal compositions and methods |
US4473500A (en) * | 1981-05-12 | 1984-09-25 | Ciba-Geigy Corporation | Monoazo pigments derived from aminophthalimides and substituted acetoacetarylides or 2-hydroxy-3-naphthoylarylides |
JPS592686A (ja) * | 1982-06-25 | 1984-01-09 | Green Cross Corp:The | ミエロペルオキシダ−ゼの粉末製剤 |
US4588586A (en) * | 1983-01-03 | 1986-05-13 | Kessler Jack H | Method for disinfecting a contact lens |
US4516817A (en) * | 1983-04-25 | 1985-05-14 | Deters Paul M | Electrical jumper assembly |
US4576817A (en) * | 1984-06-07 | 1986-03-18 | Laclede Professional Products, Inc. | Enzymatic bandages and pads |
LU85479A1 (fr) * | 1984-07-25 | 1986-02-12 | Oleofina Sa | Compositions antibacteriennes de nourriture pour animaux et procede pour les preparer |
US4937072A (en) * | 1986-05-12 | 1990-06-26 | Kessler Jack H | In situ sporicidal disinfectant |
DK501686A (da) * | 1986-10-20 | 1988-04-21 | Otto Melchior Poulsen | Enzymholdigt, baktericidt middel samt tandplejemidler og saarbehandlingsmidler, som indeholder det |
US4996146A (en) | 1987-02-20 | 1991-02-26 | Kessler Jack H | Rapid sterilization enzymatic process with persistence |
FR2632525B1 (fr) | 1988-06-14 | 1992-07-31 | Improbio | Application therapeutique de la myeloperoxydase humaine |
WO1990003185A1 (en) * | 1988-09-28 | 1990-04-05 | Ideon Corporation | Combination enzyme immunotherapeutics |
FR2646777B1 (fr) * | 1989-05-12 | 1993-09-03 | Bio Serae Lab | Procede de preparation d'un produit particulaire antimicrobien, produit antimicrobien obtenu et applications |
GB9002422D0 (en) * | 1990-02-03 | 1990-04-04 | Boots Co Plc | Anti-microbial compositions |
-
1992
- 1992-02-14 JP JP50731092A patent/JP4063317B2/ja not_active Expired - Lifetime
- 1992-02-14 WO PCT/US1992/001237 patent/WO1992014484A1/en active Search and Examination
- 1992-02-14 KR KR1019930702510A patent/KR930703012A/ko not_active Application Discontinuation
- 1992-02-14 AU AU15364/92A patent/AU663869B2/en not_active Expired
- 1992-02-18 IL IL10099792A patent/IL100997A/en not_active IP Right Cessation
- 1992-02-18 IE IE051492A patent/IE920514A1/en not_active IP Right Cessation
- 1992-02-20 CA CA002061601A patent/CA2061601C/en not_active Expired - Lifetime
- 1992-02-21 DE DE69233698T patent/DE69233698T2/de not_active Expired - Lifetime
- 1992-02-21 AT AT92301448T patent/ATE181837T1/de not_active IP Right Cessation
- 1992-02-21 AT AT98122809T patent/ATE365048T1/de not_active IP Right Cessation
- 1992-02-21 DE DE69229512T patent/DE69229512T2/de not_active Revoked
- 1992-02-21 EP EP98122809A patent/EP0923939B1/de not_active Expired - Lifetime
- 1992-02-21 EP EP92301448A patent/EP0500387B1/de not_active Revoked
-
1994
- 1994-07-07 US US08/271,583 patent/US6294168B1/en not_active Expired - Lifetime
-
2004
- 2004-06-04 JP JP2004167857A patent/JP2004300157A/ja not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
CA2061601C (en) | 2003-04-08 |
IL100997A0 (en) | 1992-11-15 |
KR930703012A (ko) | 1993-11-29 |
IL100997A (en) | 1996-09-12 |
DE69233698T2 (de) | 2008-02-28 |
CA2061601A1 (en) | 1992-08-22 |
EP0500387A2 (de) | 1992-08-26 |
EP0500387B1 (de) | 1999-07-07 |
US6294168B1 (en) | 2001-09-25 |
EP0923939B1 (de) | 2007-06-20 |
IE20000984A1 (en) | 2001-05-30 |
JP2004300157A (ja) | 2004-10-28 |
EP0500387A3 (en) | 1992-10-28 |
EP0923939A1 (de) | 1999-06-23 |
WO1992014484A1 (en) | 1992-09-03 |
JPH06505482A (ja) | 1994-06-23 |
ATE365048T1 (de) | 2007-07-15 |
IE920514A1 (en) | 1992-08-26 |
JP4063317B2 (ja) | 2008-03-19 |
DE69229512T2 (de) | 2000-03-30 |
AU1536492A (en) | 1992-09-15 |
DE69233698D1 (de) | 2007-08-02 |
ATE181837T1 (de) | 1999-07-15 |
AU663869B2 (en) | 1995-10-26 |
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