DE69223504D1 - Bicycloazamakrocyclophosphon-Säure, Komplexe, Konjugate, Kontrastmittel und Herstellung - Google Patents
Bicycloazamakrocyclophosphon-Säure, Komplexe, Konjugate, Kontrastmittel und HerstellungInfo
- Publication number
- DE69223504D1 DE69223504D1 DE69223504T DE69223504T DE69223504D1 DE 69223504 D1 DE69223504 D1 DE 69223504D1 DE 69223504 T DE69223504 T DE 69223504T DE 69223504 T DE69223504 T DE 69223504T DE 69223504 D1 DE69223504 D1 DE 69223504D1
- Authority
- DE
- Germany
- Prior art keywords
- complexes
- conjugates
- preparation
- contrast agents
- bicycloazamacrocyclophosphonic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000002253 acid Substances 0.000 title abstract 2
- 239000002872 contrast media Substances 0.000 title abstract 2
- -1 complexes Substances 0.000 title 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 abstract 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 150000002500 ions Chemical class 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0497—Organic compounds conjugates with a carrier being an organic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6524—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having four or more nitrogen atoms as the only ring hetero atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Optics & Photonics (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US80555191A | 1991-12-10 | 1991-12-10 | |
| PCT/US1992/010668 WO1993011802A1 (en) | 1991-12-10 | 1992-12-10 | Bicycloazamacrocyclophosphonic acid, conjugates, contrast agents and preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69223504D1 true DE69223504D1 (de) | 1998-01-22 |
| DE69223504T2 DE69223504T2 (de) | 1998-04-02 |
Family
ID=25191891
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69223504T Expired - Fee Related DE69223504T2 (de) | 1991-12-10 | 1992-12-10 | Bicycloazamakrocyclophosphon-Säure, Komplexe, Konjugate, Kontrastmittel und Herstellung |
Country Status (18)
| Country | Link |
|---|---|
| EP (2) | EP0570575B1 (de) |
| JP (1) | JPH07502043A (de) |
| CN (1) | CN1038328C (de) |
| AT (1) | ATE160943T1 (de) |
| AU (1) | AU3246893A (de) |
| CA (1) | CA2103556C (de) |
| DE (1) | DE69223504T2 (de) |
| DK (1) | DK0570575T3 (de) |
| ES (1) | ES2110593T3 (de) |
| GR (1) | GR3026121T3 (de) |
| HK (1) | HK1006654A1 (de) |
| HU (1) | HUT66220A (de) |
| IL (1) | IL104060A (de) |
| MX (1) | MX9207166A (de) |
| RU (1) | RU2114115C1 (de) |
| SG (1) | SG46598A1 (de) |
| WO (1) | WO1993011802A1 (de) |
| ZA (1) | ZA929576B (de) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5385893A (en) * | 1993-05-06 | 1995-01-31 | The Dow Chemical Company | Tricyclopolyazamacrocyclophosphonic acids, complexes and derivatives thereof, for use as contrast agents |
| EP0696290A1 (de) * | 1993-05-06 | 1996-02-14 | The Dow Chemical Company | Bicyclopolyazamacrocyclophosphonsäure, ihre komplexe und konjugate zur verwendung als contrastmittel, und verfahren zu ihrer herstellung |
| US6207826B1 (en) | 1995-03-27 | 2001-03-27 | Isis Pharmaceuticals, Inc. | Macrocyclic compounds having nitrogen-containing linkages |
| EP0817787A4 (de) * | 1995-03-27 | 2000-09-13 | Isis Pharmaceuticals Inc | Makrozyklische stickstoffverbindungen |
| US5834456A (en) * | 1996-02-23 | 1998-11-10 | The Dow Chemical Company | Polyazamacrocyclofluoromonoalkylphosphonic acids, and their complexes, for use as contrast agents |
| CA2251924C (en) * | 1996-04-19 | 2006-05-30 | The Dow Chemical Company | Fluorescent chelates as visual tissue specific imaging agents |
| US5888476A (en) * | 1996-11-13 | 1999-03-30 | Mallinckrodt Medical, Inc. | Magnetic resonance blood pool agents |
| US6440389B1 (en) | 2000-07-19 | 2002-08-27 | The General Hospital Corporation | Fluorescent agents for real-time measurement of organ function |
| US8211401B2 (en) * | 2008-12-05 | 2012-07-03 | Molecular Insight Pharmaceuticals, Inc. | Technetium- and rhenium-bis(heteroaryl) complexes and methods of use thereof for inhibiting PSMA |
| NO331773B1 (no) * | 2009-12-18 | 2012-03-26 | Ge Healthcare As | Mangankelater, sammensetninger omfattende slike og anvendelse av disse som kontrastmidler for magnettomografi (MR) |
| GB201610738D0 (en) | 2016-06-20 | 2016-08-03 | Ge Healthcare As | Chelate compounds |
| ES2813077T3 (es) * | 2016-12-21 | 2021-03-22 | Ge Healthcare As | Compuestos quelatos de manganeso basados en macrociclo de tetraazabiciclo adecuados como agentes de imagen de IRM |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3825040A1 (de) * | 1988-07-20 | 1990-01-25 | Schering Ag, 13353 Berlin | 5- oder 6-ring- enthaltende makrocyclische polyaza-verbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel |
| DE4001655A1 (de) * | 1990-01-18 | 1991-07-25 | Schering Ag | 6-ring enthaltende makrocyclische tetraaza-verbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel |
| FR2644785B1 (fr) * | 1989-03-24 | 1991-07-05 | Guerbet Sa | Nouveaux ligands macrocycliques azotes, procede de preparation, complexes metalliques formes par ces ligands et composition de diagnostic les contenant |
| DE3938992A1 (de) * | 1989-11-21 | 1991-05-23 | Schering Ag | Kaskadenpolymer-gebundene komplexbildner, deren komplexe und konjugate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel |
| EP0511275A1 (de) * | 1990-01-19 | 1992-11-04 | Nycomed Imaging As | Komplexbildner |
| GB9001245D0 (en) * | 1990-01-19 | 1990-03-21 | Salutar Inc | Compounds |
-
1992
- 1992-12-10 SG SG1996006488A patent/SG46598A1/en unknown
- 1992-12-10 RU RU93053767A patent/RU2114115C1/ru active
- 1992-12-10 DE DE69223504T patent/DE69223504T2/de not_active Expired - Fee Related
- 1992-12-10 HU HU9302312A patent/HUT66220A/hu unknown
- 1992-12-10 WO PCT/US1992/010668 patent/WO1993011802A1/en active IP Right Grant
- 1992-12-10 IL IL10406092A patent/IL104060A/en not_active IP Right Cessation
- 1992-12-10 AT AT93901000T patent/ATE160943T1/de not_active IP Right Cessation
- 1992-12-10 EP EP93901000A patent/EP0570575B1/de not_active Expired - Lifetime
- 1992-12-10 ES ES93901000T patent/ES2110593T3/es not_active Expired - Lifetime
- 1992-12-10 DK DK93901000T patent/DK0570575T3/da active
- 1992-12-10 AU AU32468/93A patent/AU3246893A/en not_active Abandoned
- 1992-12-10 MX MX9207166A patent/MX9207166A/es not_active IP Right Cessation
- 1992-12-10 EP EP96107948A patent/EP0735040A3/de not_active Withdrawn
- 1992-12-10 ZA ZA929576A patent/ZA929576B/xx unknown
- 1992-12-10 CN CN92115368A patent/CN1038328C/zh not_active Expired - Fee Related
- 1992-12-10 JP JP5511072A patent/JPH07502043A/ja active Pending
- 1992-12-10 CA CA002103556A patent/CA2103556C/en not_active Expired - Fee Related
-
1998
- 1998-02-12 GR GR980400293T patent/GR3026121T3/el unknown
- 1998-06-23 HK HK98106042A patent/HK1006654A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| AU3246893A (en) | 1993-07-19 |
| HU9302312D0 (en) | 1993-12-28 |
| HUT66220A (en) | 1994-10-28 |
| SG46598A1 (en) | 1998-02-20 |
| DK0570575T3 (da) | 1998-08-24 |
| IL104060A0 (en) | 1993-05-13 |
| HK1006654A1 (en) | 1999-03-12 |
| ATE160943T1 (de) | 1997-12-15 |
| WO1993011802A1 (en) | 1993-06-24 |
| IL104060A (en) | 1998-12-06 |
| CA2103556C (en) | 2002-04-16 |
| MX9207166A (es) | 1993-07-01 |
| CN1074447A (zh) | 1993-07-21 |
| ZA929576B (en) | 1994-06-10 |
| RU2114115C1 (ru) | 1998-06-27 |
| DE69223504T2 (de) | 1998-04-02 |
| JPH07502043A (ja) | 1995-03-02 |
| EP0735040A2 (de) | 1996-10-02 |
| EP0570575A1 (de) | 1993-11-24 |
| ES2110593T3 (es) | 1998-02-16 |
| EP0570575B1 (de) | 1997-12-10 |
| EP0735040A3 (de) | 1997-02-26 |
| GR3026121T3 (en) | 1998-05-29 |
| CN1038328C (zh) | 1998-05-13 |
| CA2103556A1 (en) | 1993-06-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |