DE69220875T2 - Verbessertes Verfahren zur Herstellung von 4-Halogenchinazoline - Google Patents

Verbessertes Verfahren zur Herstellung von 4-Halogenchinazoline

Info

Publication number
DE69220875T2
DE69220875T2 DE69220875T DE69220875T DE69220875T2 DE 69220875 T2 DE69220875 T2 DE 69220875T2 DE 69220875 T DE69220875 T DE 69220875T DE 69220875 T DE69220875 T DE 69220875T DE 69220875 T2 DE69220875 T2 DE 69220875T2
Authority
DE
Germany
Prior art keywords
haloquinazolines
production
improved process
hydroxyquinazolines
dialkylformamide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69220875T
Other languages
English (en)
Other versions
DE69220875D1 (de
Inventor
Jimmy J Tai
James W Ringer
Karl L Krumel
Richard C Krauss
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dow AgroSciences LLC
Original Assignee
DowElanco LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by DowElanco LLC filed Critical DowElanco LLC
Publication of DE69220875D1 publication Critical patent/DE69220875D1/de
Application granted granted Critical
Publication of DE69220875T2 publication Critical patent/DE69220875T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/30—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE69220875T 1991-10-07 1992-10-06 Verbessertes Verfahren zur Herstellung von 4-Halogenchinazoline Expired - Lifetime DE69220875T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/772,523 US5214144A (en) 1991-10-07 1991-10-07 Process for the preparation of 4-haloquinazolines

Publications (2)

Publication Number Publication Date
DE69220875D1 DE69220875D1 (de) 1997-08-21
DE69220875T2 true DE69220875T2 (de) 1997-11-20

Family

ID=25095358

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69220875T Expired - Lifetime DE69220875T2 (de) 1991-10-07 1992-10-06 Verbessertes Verfahren zur Herstellung von 4-Halogenchinazoline

Country Status (11)

Country Link
US (1) US5214144A (de)
EP (1) EP0537600B1 (de)
JP (1) JPH05222004A (de)
KR (1) KR100218608B1 (de)
AT (1) ATE155461T1 (de)
AU (1) AU648933B2 (de)
BR (1) BR9203883A (de)
DE (1) DE69220875T2 (de)
ES (1) ES2104787T3 (de)
HU (1) HU213830B (de)
IL (1) IL103362A (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5747498A (en) 1996-05-28 1998-05-05 Pfizer Inc. Alkynyl and azido-substituted 4-anilinoquinazolines
AU727200B2 (en) * 1996-03-15 2000-12-07 Dow Agrosciences Llc Halogenation catalyst
US6706721B1 (en) * 1998-04-29 2004-03-16 Osi Pharmaceuticals, Inc. N-(3-ethynylphenylamino)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine mesylate anhydrate and monohydrate
UA74803C2 (uk) 1999-11-11 2006-02-15 Осі Фармасьютікалз, Інк. Стійкий поліморф гідрохлориду n-(3-етинілфеніл)-6,7-біс(2-метоксіетокси)-4-хіназолінаміну, спосіб його одержання (варіанти) та фармацевтичне застосування
US7087613B2 (en) * 1999-11-11 2006-08-08 Osi Pharmaceuticals, Inc. Treating abnormal cell growth with a stable polymorph of N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine hydrochloride
CN103265497B (zh) * 2013-05-16 2014-11-26 苏州明锐医药科技有限公司 一种替尼类抗肿瘤药合成所需中间体4-氯-6-氨基-7-羟基喹唑啉及其制备方法
CN106496146A (zh) * 2016-10-18 2017-03-15 江西师范大学 一种二氢喹唑啉酮和喹唑啉酮衍生物的磺酸类离子液体催化调控合成方法
CN108299315A (zh) * 2018-03-01 2018-07-20 杨子辉 一种杀螨剂喹螨醚的制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1880447A (en) * 1932-10-04 Max haedtmann
US450870A (en) * 1891-04-21 Bag-fastening
GB1088102A (en) * 1964-01-10 1967-10-25 Wellcome Found Halogen substituted pyrido-pyrimidines
US3998951A (en) * 1974-03-13 1976-12-21 Fmc Corporation Substituted 2-arylquinazolines as fungicides
US4510307A (en) * 1980-08-20 1985-04-09 Asahi Kasei Kogyo Kabushiki Kaisha 6-Quinazolinesulfonyl derivatives and process for preparation thereof
US4672116A (en) * 1985-12-20 1987-06-09 Ortho Pharmaceutical Corporation Substituted 5,6-dialkoxyquinazoline derivatives
IL89027A (en) * 1988-01-29 1993-01-31 Lilly Co Eli Quinazoline derivatives, process for their preparation and fungicidal, insecticidal and miticidal compositions containing them

Also Published As

Publication number Publication date
IL103362A (en) 1996-09-12
EP0537600B1 (de) 1997-07-16
HUT62868A (en) 1993-06-28
KR100218608B1 (ko) 1999-09-01
JPH05222004A (ja) 1993-08-31
HU213830B (en) 1997-10-28
ES2104787T3 (es) 1997-10-16
DE69220875D1 (de) 1997-08-21
HU9203164D0 (en) 1992-12-28
US5214144A (en) 1993-05-25
AU648933B2 (en) 1994-05-05
KR930007916A (ko) 1993-05-20
IL103362A0 (en) 1993-03-15
BR9203883A (pt) 1993-04-27
AU2623992A (en) 1993-04-08
ATE155461T1 (de) 1997-08-15
EP0537600A1 (de) 1993-04-21

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