DE69216221D1 - Verbindungen mit guanidin-struktur und diese enthaltende pharmazeutische zusammensetzungen - Google Patents
Verbindungen mit guanidin-struktur und diese enthaltende pharmazeutische zusammensetzungenInfo
- Publication number
- DE69216221D1 DE69216221D1 DE69216221T DE69216221T DE69216221D1 DE 69216221 D1 DE69216221 D1 DE 69216221D1 DE 69216221 T DE69216221 T DE 69216221T DE 69216221 T DE69216221 T DE 69216221T DE 69216221 D1 DE69216221 D1 DE 69216221D1
- Authority
- DE
- Germany
- Prior art keywords
- pct
- connections
- pharmaceutical compositions
- compositions containing
- guanidine structure
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/20—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D239/22—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
- C07C279/08—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/88—Nitrogen atoms, e.g. allantoin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR919114414A FR2684103B1 (fr) | 1991-11-22 | 1991-11-22 | Nouveaux composes a structure guanidique et composition pharmaceutique les contenant. |
PCT/FR1992/001080 WO1993010102A1 (fr) | 1991-11-22 | 1992-11-20 | Nouveaux composes a structure guanidique et composition pharmaceutique les contenant |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69216221D1 true DE69216221D1 (de) | 1997-02-06 |
DE69216221T2 DE69216221T2 (de) | 1997-05-28 |
Family
ID=9419217
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69216221T Expired - Lifetime DE69216221T2 (de) | 1991-11-22 | 1992-11-20 | Verbindungen mit guanidin-struktur und diese enthaltende pharmazeutische zusammensetzungen |
Country Status (10)
Country | Link |
---|---|
US (2) | US5480884A (de) |
EP (1) | EP0572635B1 (de) |
JP (1) | JPH06505027A (de) |
AT (1) | ATE146780T1 (de) |
CA (1) | CA2101058A1 (de) |
DE (1) | DE69216221T2 (de) |
DK (1) | DK0572635T3 (de) |
ES (1) | ES2098023T3 (de) |
FR (1) | FR2684103B1 (de) |
WO (1) | WO1993010102A1 (de) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2065054A1 (de) | 2007-11-29 | 2009-06-03 | Bayer Schering Pharma Aktiengesellschaft | Kombinationen mit einem Prostaglandin und Verwendungen davon |
DE102007059752A1 (de) | 2007-12-10 | 2009-06-18 | Bayer Schering Pharma Aktiengesellschaft | Funktionalisierte, feste Polymernanopartikel enthaltend Epothilone |
EP2070521A1 (de) | 2007-12-10 | 2009-06-17 | Bayer Schering Pharma Aktiengesellschaft | Nanopartikel mit modifizierter Oberfläche |
EP2210584A1 (de) | 2009-01-27 | 2010-07-28 | Bayer Schering Pharma Aktiengesellschaft | Stabile Polymerzusammensetzung mit einem Epothilon und einem amphiphilischen Blockpolymer |
EP3725775A1 (de) | 2009-02-17 | 2020-10-21 | Syntrix Biosystems, Inc. | Pyridin- und pyrimidincarboxamide als cxcr2-modulatoren |
WO2012027289A1 (en) * | 2010-08-23 | 2012-03-01 | Syntrix Biosystems Inc. | Aminopyridine- and aminopyrimidinecarboxamides as cxcr2 modulators |
CA2858806A1 (en) | 2011-12-23 | 2013-06-27 | Innate Pharma | Enzymatic conjugation of polypeptides |
US10132799B2 (en) | 2012-07-13 | 2018-11-20 | Innate Pharma | Screening of conjugated antibodies |
EP2916872B1 (de) | 2012-11-09 | 2019-02-27 | Innate Pharma | Kennungen für tgase-vermittelte konjugation |
US10611824B2 (en) | 2013-03-15 | 2020-04-07 | Innate Pharma | Solid phase TGase-mediated conjugation of antibodies |
US10071169B2 (en) | 2013-06-20 | 2018-09-11 | Innate Pharma | Enzymatic conjugation of polypeptides |
CN105517577A (zh) | 2013-06-21 | 2016-04-20 | 先天制药公司 | 多肽的酶促偶联 |
US8969365B2 (en) | 2013-08-02 | 2015-03-03 | Syntrix Biosystems, Inc. | Thiopyrimidinecarboxamides as CXCR1/2 modulators |
US10561676B2 (en) | 2013-08-02 | 2020-02-18 | Syntrix Biosystems Inc. | Method for treating cancer using dual antagonists of CXCR1 and CXCR2 |
US10046002B2 (en) | 2013-08-02 | 2018-08-14 | Syntrix Biosystems Inc. | Method for treating cancer using chemokine antagonists |
US10660909B2 (en) | 2016-11-17 | 2020-05-26 | Syntrix Biosystems Inc. | Method for treating cancer using chemokine antagonists |
WO2019092148A1 (en) | 2017-11-10 | 2019-05-16 | Innate Pharma | Antibodies with functionalized glutamine residues |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE413930A (de) * | 1935-02-23 | 1936-03-31 | ||
DE3312516A1 (de) * | 1983-04-07 | 1984-10-11 | Brigitte Dr. 7400 Tübingen Pfeiffer | Kernsubstituierte phenylalkylenguanidinderivate, verfahren zu ihrer herstellung und sie enthaltende arzneimittel |
US4814007A (en) * | 1986-01-16 | 1989-03-21 | Henkel Corporation | Recovery of precious metals |
US4772609A (en) * | 1986-06-26 | 1988-09-20 | Harbor Branch Oceanographic Institution, Inc. | Antiviral guanidine derivatives and compositions therefor |
IT1232783B (it) * | 1989-09-04 | 1992-03-05 | Sclavo Spa | Metodo per l'alchilazione di gruppi guanidinici |
US5262568A (en) * | 1990-03-02 | 1993-11-16 | State Of Oregon | Tri- and tetra-substituted guanidines and their use as excitatory amino acid antagonists |
CA2075154A1 (en) * | 1991-08-06 | 1993-02-07 | Neelakantan Balasubramanian | Peptide aldehydes as antithrombotic agents |
-
1991
- 1991-11-22 FR FR919114414A patent/FR2684103B1/fr not_active Expired - Fee Related
-
1992
- 1992-11-20 DE DE69216221T patent/DE69216221T2/de not_active Expired - Lifetime
- 1992-11-20 CA CA002101058A patent/CA2101058A1/fr not_active Abandoned
- 1992-11-20 WO PCT/FR1992/001080 patent/WO1993010102A1/fr active IP Right Grant
- 1992-11-20 ES ES93901791T patent/ES2098023T3/es not_active Expired - Lifetime
- 1992-11-20 US US08/090,188 patent/US5480884A/en not_active Expired - Lifetime
- 1992-11-20 DK DK93901791.9T patent/DK0572635T3/da active
- 1992-11-20 JP JP5509043A patent/JPH06505027A/ja active Pending
- 1992-11-20 EP EP93901791A patent/EP0572635B1/de not_active Expired - Lifetime
- 1992-11-20 AT AT93901791T patent/ATE146780T1/de active
-
1995
- 1995-06-07 US US08/479,226 patent/US5719187A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
ATE146780T1 (de) | 1997-01-15 |
ES2098023T3 (es) | 1997-04-16 |
US5719187A (en) | 1998-02-17 |
US5480884A (en) | 1996-01-02 |
JPH06505027A (ja) | 1994-06-09 |
EP0572635B1 (de) | 1996-12-27 |
DE69216221T2 (de) | 1997-05-28 |
EP0572635A1 (de) | 1993-12-08 |
EP0572635A4 (de) | 1993-09-17 |
FR2684103A1 (fr) | 1993-05-28 |
DK0572635T3 (da) | 1997-06-16 |
FR2684103B1 (fr) | 1994-09-02 |
CA2101058A1 (fr) | 1993-05-23 |
WO1993010102A1 (fr) | 1993-05-27 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |