DE69128788D1 - 1,2-dihydro-3h-dibenzoisochinolin-1,3-dione als antitumormittel - Google Patents

1,2-dihydro-3h-dibenzoisochinolin-1,3-dione als antitumormittel

Info

Publication number
DE69128788D1
DE69128788D1 DE69128788T DE69128788T DE69128788D1 DE 69128788 D1 DE69128788 D1 DE 69128788D1 DE 69128788 T DE69128788 T DE 69128788T DE 69128788 T DE69128788 T DE 69128788T DE 69128788 D1 DE69128788 D1 DE 69128788D1
Authority
DE
Germany
Prior art keywords
lower alkyl
taken together
independently hydrogen
aryl
carbon atoms
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69128788T
Other languages
English (en)
Other versions
DE69128788T2 (de
Inventor
David Alberts
Robert Dorr
William Remers
Salah Sami
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Research Corp Technologies Inc
Original Assignee
Research Corp Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Research Corp Technologies Inc filed Critical Research Corp Technologies Inc
Publication of DE69128788D1 publication Critical patent/DE69128788D1/de
Application granted granted Critical
Publication of DE69128788T2 publication Critical patent/DE69128788T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/18—Ring systems of four or more rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
DE69128788T 1990-06-26 1991-06-19 1,2-dihydro-3h-dibenzoisochinolin-1,3-dione als antitumormittel Expired - Fee Related DE69128788T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US54359690A 1990-06-26 1990-06-26
PCT/US1991/004364 WO1992000281A1 (en) 1990-06-26 1991-06-19 1,2-dihydro-3h-dibenzisoquinoline-1,3-dione anticancer agents

Publications (2)

Publication Number Publication Date
DE69128788D1 true DE69128788D1 (de) 1998-02-26
DE69128788T2 DE69128788T2 (de) 1998-06-10

Family

ID=24168698

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69128788T Expired - Fee Related DE69128788T2 (de) 1990-06-26 1991-06-19 1,2-dihydro-3h-dibenzoisochinolin-1,3-dione als antitumormittel

Country Status (9)

Country Link
EP (1) EP0536208B1 (de)
JP (1) JP2992769B2 (de)
AT (1) ATE162526T1 (de)
AU (1) AU643539B2 (de)
CA (1) CA2085598C (de)
DE (1) DE69128788T2 (de)
ES (1) ES2113886T3 (de)
IE (1) IE912200A1 (de)
WO (1) WO1992000281A1 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5635506A (en) * 1990-06-26 1997-06-03 Research Corporation Technologies, Inc. 1, 2-dihydro-3H-dibenzisoquinoline-1,3-dione anticancer agents
JP3543196B2 (ja) * 1992-09-11 2004-07-14 リサーチ コーポレーション テクノロジーズ インコーポレーテッド ６−エトキシ−２−［２’−（ジメチルアミノ）エチル］−１，２−ジヒドロ−３Ｈ−ジベンズ（ｄｅｈ）−イソキノリン−１，３−ジオン
AU2306595A (en) * 1994-04-28 1995-11-29 Knoll Aktiengesellschaft Dihydrodibenzo(de,h)isoquinolines derivatives and their use as anti-cancer agents
US5703089A (en) * 1994-04-28 1997-12-30 Knoll Aktiengesellschaft Dihydrodibenzisoquinolinediones
ES2229272T3 (es) * 1995-05-31 2005-04-16 Eisai Co., Ltd. Derivados de heterociclos policiclicos condensados.
US6291425B1 (en) * 1999-09-01 2001-09-18 Guilford Pharmaceuticals Inc. Compounds, methods and pharmaceutical compositions for treating cellular damage, such as neural or cardiovascular tissue damage
WO2008033891A2 (en) * 2006-09-12 2008-03-20 Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Azonafide derived tumor and cancer targeting compounds
DE102007038422A1 (de) 2007-08-14 2009-02-19 Heinz Prof. Dr. Langhals Aceanthren- und Anthracencarbonsäureimide

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1253252A (en) * 1914-04-15 1918-01-15 Basf Ag Bluish-green vat dyes and process of making them.
US3940398A (en) * 1975-01-23 1976-02-24 E. R. Squibb & Sons, Inc. 2-[[4-(Azine or diazine or triazine)-1-piperazinyl]alkyl]-1H-benz[de]isoquinoline-1,3(2H)-diones
ES459497A1 (es) * 1977-06-04 1978-04-16 Made Labor Sa Un metodo para la preparacion industrial de naftalimidas y sus derivados.
US4665071A (en) * 1984-02-21 1987-05-12 Warner-Lambert Company 3,6-disubstituted-1,8-naphthalimides and methods for their production and use

Also Published As

Publication number Publication date
IE912200A1 (en) 1992-01-01
EP0536208A1 (de) 1993-04-14
WO1992000281A1 (en) 1992-01-09
AU643539B2 (en) 1993-11-18
EP0536208B1 (de) 1998-01-21
JPH05508639A (ja) 1993-12-02
CA2085598C (en) 2002-09-17
ATE162526T1 (de) 1998-02-15
EP0536208A4 (en) 1993-05-05
DE69128788T2 (de) 1998-06-10
AU8050191A (en) 1992-01-23
JP2992769B2 (ja) 1999-12-20
CA2085598A1 (en) 1991-12-27
ES2113886T3 (es) 1998-05-16

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee