DE69128473D1 - An sigma-bindungsstellen wirkende stoffe - Google Patents
An sigma-bindungsstellen wirkende stoffeInfo
- Publication number
- DE69128473D1 DE69128473D1 DE69128473T DE69128473T DE69128473D1 DE 69128473 D1 DE69128473 D1 DE 69128473D1 DE 69128473 T DE69128473 T DE 69128473T DE 69128473 T DE69128473 T DE 69128473T DE 69128473 D1 DE69128473 D1 DE 69128473D1
- Authority
- DE
- Germany
- Prior art keywords
- binding points
- sigma binding
- substances active
- sigma
- binding site
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
- C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
- C07D311/28—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only
- C07D311/30—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only not hydrogenated in the hetero ring, e.g. flavones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Psychiatry (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Materials For Photolithography (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US53312790A | 1990-06-04 | 1990-06-04 | |
US07/700,296 US5278174A (en) | 1990-06-04 | 1991-05-17 | Sigma binding site agents |
PCT/US1991/003732 WO1991018597A1 (en) | 1990-06-04 | 1991-06-04 | Sigma binding site agents |
Publications (1)
Publication Number | Publication Date |
---|---|
DE69128473D1 true DE69128473D1 (de) | 1998-01-29 |
Family
ID=27064068
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69128473T Expired - Lifetime DE69128473D1 (de) | 1990-06-04 | 1991-06-04 | An sigma-bindungsstellen wirkende stoffe |
Country Status (11)
Country | Link |
---|---|
US (2) | US5278174A (de) |
EP (1) | EP0533804B1 (de) |
JP (1) | JPH05509084A (de) |
AT (1) | ATE161177T1 (de) |
AU (1) | AU665517B2 (de) |
CA (1) | CA2083500A1 (de) |
DE (1) | DE69128473D1 (de) |
IE (1) | IE911875A1 (de) |
IL (1) | IL98262A (de) |
NZ (1) | NZ238257A (de) |
WO (1) | WO1991018597A1 (de) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH05255089A (ja) * | 1991-12-18 | 1993-10-05 | Sanwa Kagaku Kenkyusho Co Ltd | 抗ウイルス剤 |
EP0558245A1 (de) * | 1992-02-25 | 1993-09-01 | RECORDATI S.A. CHEMICAL and PHARMACEUTICAL COMPANY | Heterobicyclische Verbindungen als Alpha-1-Adrenergene und 5HT1A-Rezeptor-Antagonisten |
US5605896A (en) * | 1992-02-25 | 1997-02-25 | Recordati S.A., Chemical And Pharmaceutical Company | Bicyclic heterocyclic derivatives having α1 adrenergic and 5HT1A activities |
US5474994A (en) * | 1992-05-26 | 1995-12-12 | Recordati S.A., Chemical And Pharmaceutical Company | Bicyclic heterocyclic derivatives having α1 -adrenergic and 5HT1A |
IT1258315B (it) * | 1992-04-10 | 1996-02-22 | Recordati Chem Pharm | Derivati del flavone |
CN1040434C (zh) * | 1992-05-26 | 1998-10-28 | 瑞柯戴堤化学制药公司 | 杂二环化合物 |
FR2693196B1 (fr) * | 1992-07-03 | 1994-12-23 | Lipha | Dérivés de benzopyranone ou de benzothiopyranone, procédé de préparation et composition pharmaceutique les contenant. |
FR2694005B1 (fr) * | 1992-07-21 | 1994-08-26 | Adir | Nouvelles aminoalkylchromones, leurs procédés de préparation et les compositions pharmaceutiques qui les contiennent. |
ES2101620B1 (es) * | 1994-03-18 | 1998-04-01 | Ferrer Int | Nuevo compuesto derivado del cromeno. |
IL112764A0 (en) * | 1994-03-18 | 1995-05-26 | Ferrer Int | New chromene derivatives |
US5482942A (en) * | 1994-06-28 | 1996-01-09 | American Home Products Corporation | (3,4-dioxocyclobuten-1-yl)chromene, indene, and dihydronaphthalenone derivatives as smooth muscle relaxants |
IL118657A0 (en) * | 1996-06-14 | 1996-10-16 | Arad Dorit | Inhibitors for picornavirus proteases |
KR100447918B1 (ko) * | 1996-07-25 | 2005-09-28 | 동아제약주식회사 | 대장을포함한위장관보호작용을갖는플라본및플라바논화합물 |
IL122591A0 (en) | 1997-12-14 | 1998-06-15 | Arad Dorit | Pharmaceutical compositions comprising cystein protease inhibitors |
JP2000286254A (ja) * | 1999-03-31 | 2000-10-13 | Hitachi Ltd | 半導体集積回路装置およびその製造方法 |
CN102267971B (zh) | 2011-08-03 | 2013-03-27 | 华中科技大学 | 脂环并[c]苯并吡喃酮衍生物及其应用 |
BR112014023483B1 (pt) * | 2012-03-23 | 2022-05-10 | Ptc Therapeutics, Inc | Composto e seu uso, composição farmacêutica e seu uso |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1018874B (de) * | 1954-08-18 | 1957-11-07 | Chemiewerk Homburg Ag | Verfahren zur Herstellung von N-substituierten 2-Methyl-7-aminoalkoxy-chromonen |
DE1054091B (de) * | 1958-05-30 | 1959-04-02 | Chemiewerk Homburg Ag | Verfahren zur Herstellung von N-substituierten 2-Phenyl-7-aminoalkoxy-chromonen |
US3046275A (en) * | 1958-05-30 | 1962-07-24 | Chemiewerk Homburg Zweignieder | N-substituted 2-phenyl-7-aminoalkoxy chromones |
DE1223849B (de) * | 1960-10-11 | 1966-09-01 | Hans Voigt Chem Pharm Fabrik D | Verfahren zur Herstellung von milchsaurem 7-(N-beta-Dimethylaminoaethoxy)-flavon |
DE1134384B (de) * | 1960-10-18 | 1962-08-09 | Hans Voigt Chem Pharm Fabrik D | Verfahren zur Herstellung von Salzen aus Xanthinessigsaeure- und Flavonderivaten |
DE1222072B (de) * | 1961-03-06 | 1966-08-04 | Voigt Dr Med Hans | Verfahren zur Herstellung von N-substituierten 7-Aminoalkoxyflavonen |
CA928298A (en) * | 1968-06-24 | 1973-06-12 | Kramer Josef | Process for the preparation of 3-alkylflavanones |
GB1261111A (en) * | 1969-04-25 | 1972-01-19 | Science Union & Cie | New benzothiopyran derivatives and process for preparing them |
US3907830A (en) * | 1970-05-27 | 1975-09-23 | Chinoin Gyogyszer Es Vegyeszet | Isoflavone derivatives |
US3864362A (en) * | 1970-05-27 | 1975-02-04 | Chinoin Gyogyszer Es Vegyeszet | Iso flavones |
US3906031A (en) * | 1971-03-15 | 1975-09-16 | Research Corp | Novel 9-fluorenylmethoxycarbonyl compounds |
US3835175A (en) * | 1971-03-15 | 1974-09-10 | Research Corp | 9-fluorenylmethanol haloformates, carbonates and thiocarbonates |
DE2123923A1 (de) * | 1971-05-14 | 1972-11-23 | Boehringer Mannheim Gmbh, 6800 Mannheim | 4-eckige Klammer auf omega- (Flavon-7yl-oxy) -alkyl eckige Klammer zu -pigerazin-Derivate und Verfahren zu ihrer Herstellung |
HU166380B (de) * | 1973-07-09 | 1975-03-28 | ||
DE2950135A1 (de) * | 1979-12-13 | 1981-06-19 | Merck Patent Gmbh, 6100 Darmstadt | Basischer aether, diese enthaltende pharmazeutische zubereitungen und verfahren zu ihrer herstellung |
US4394519A (en) * | 1982-01-19 | 1983-07-19 | Research Corporation | Amino acid blocking agents |
US4678787A (en) * | 1985-01-30 | 1987-07-07 | Warner-Lambert Company | 4H-1-benzopyran-4-ones and their sulfur containing analogs |
IN164232B (de) * | 1986-04-11 | 1989-02-04 | Hoechst India | |
US4797498A (en) * | 1986-07-18 | 1989-01-10 | Pennwalt Corporation | Flavonoxypropanolamines and esters of flavonoxypropanolamines as antiarrhythmic agents |
-
1991
- 1991-05-17 US US07/700,296 patent/US5278174A/en not_active Expired - Fee Related
- 1991-05-24 IL IL98262A patent/IL98262A/xx not_active IP Right Cessation
- 1991-05-24 NZ NZ238257A patent/NZ238257A/xx unknown
- 1991-05-31 IE IE187591A patent/IE911875A1/en unknown
- 1991-06-04 JP JP3511464A patent/JPH05509084A/ja active Pending
- 1991-06-04 EP EP91911691A patent/EP0533804B1/de not_active Expired - Lifetime
- 1991-06-04 DE DE69128473T patent/DE69128473D1/de not_active Expired - Lifetime
- 1991-06-04 CA CA002083500A patent/CA2083500A1/en not_active Abandoned
- 1991-06-04 AU AU81923/91A patent/AU665517B2/en not_active Ceased
- 1991-06-04 AT AT91911691T patent/ATE161177T1/de active
- 1991-06-04 WO PCT/US1991/003732 patent/WO1991018597A1/en active IP Right Grant
-
1993
- 1993-11-15 US US08/151,825 patent/US5359098A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP0533804A4 (en) | 1993-04-21 |
IE911875A1 (en) | 1991-12-04 |
EP0533804A1 (de) | 1993-03-31 |
WO1991018597A1 (en) | 1991-12-12 |
NZ238257A (en) | 1993-03-26 |
AU665517B2 (en) | 1996-01-11 |
US5278174A (en) | 1994-01-11 |
CA2083500A1 (en) | 1991-12-05 |
IL98262A (en) | 1997-11-20 |
US5359098A (en) | 1994-10-25 |
JPH05509084A (ja) | 1993-12-16 |
AU8192391A (en) | 1991-12-31 |
EP0533804B1 (de) | 1997-12-17 |
ATE161177T1 (de) | 1998-01-15 |
IL98262A0 (en) | 1992-06-21 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8332 | No legal effect for de |