DE69128473D1 - SUBSTANCES ACTIVE AT SIGMA BINDING POINTS - Google Patents

SUBSTANCES ACTIVE AT SIGMA BINDING POINTS

Info

Publication number
DE69128473D1
DE69128473D1 DE69128473T DE69128473T DE69128473D1 DE 69128473 D1 DE69128473 D1 DE 69128473D1 DE 69128473 T DE69128473 T DE 69128473T DE 69128473 T DE69128473 T DE 69128473T DE 69128473 D1 DE69128473 D1 DE 69128473D1
Authority
DE
Germany
Prior art keywords
binding points
sigma binding
substances active
sigma
binding site
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69128473T
Other languages
German (de)
Inventor
Ronald H Erickson
Kenneth J Natalie
Michael J Pontecorvo
Waclaw Janusz Rzeszotarski
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eisai Corp of North America
Original Assignee
Guilford Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Guilford Pharmaceuticals Inc filed Critical Guilford Pharmaceuticals Inc
Application granted granted Critical
Publication of DE69128473D1 publication Critical patent/DE69128473D1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
    • C07D311/28—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only
    • C07D311/30—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only not hydrogenated in the hetero ring, e.g. flavones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Psychiatry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Materials For Photolithography (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Sigma binding site agents having the formula <IMAGE> wherein A1, A2, A3, B, y and 2 are defined in the specification, W is halogen, which are novel intermediates useful in preparing the presently binding site agents.
DE69128473T 1990-06-04 1991-06-04 SUBSTANCES ACTIVE AT SIGMA BINDING POINTS Expired - Lifetime DE69128473D1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US53312790A 1990-06-04 1990-06-04
US07/700,296 US5278174A (en) 1990-06-04 1991-05-17 Sigma binding site agents
PCT/US1991/003732 WO1991018597A1 (en) 1990-06-04 1991-06-04 Sigma binding site agents

Publications (1)

Publication Number Publication Date
DE69128473D1 true DE69128473D1 (en) 1998-01-29

Family

ID=27064068

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69128473T Expired - Lifetime DE69128473D1 (en) 1990-06-04 1991-06-04 SUBSTANCES ACTIVE AT SIGMA BINDING POINTS

Country Status (11)

Country Link
US (2) US5278174A (en)
EP (1) EP0533804B1 (en)
JP (1) JPH05509084A (en)
AT (1) ATE161177T1 (en)
AU (1) AU665517B2 (en)
CA (1) CA2083500A1 (en)
DE (1) DE69128473D1 (en)
IE (1) IE911875A1 (en)
IL (1) IL98262A (en)
NZ (1) NZ238257A (en)
WO (1) WO1991018597A1 (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05255089A (en) * 1991-12-18 1993-10-05 Sanwa Kagaku Kenkyusho Co Ltd Antiviral agent
SG65570A1 (en) * 1992-02-25 1999-06-22 Recordati Chem Pharm Heterobicyclic compounds
US5474994A (en) * 1992-05-26 1995-12-12 Recordati S.A., Chemical And Pharmaceutical Company Bicyclic heterocyclic derivatives having α1 -adrenergic and 5HT1A
US5605896A (en) * 1992-02-25 1997-02-25 Recordati S.A., Chemical And Pharmaceutical Company Bicyclic heterocyclic derivatives having α1 adrenergic and 5HT1A activities
IT1258315B (en) * 1992-04-10 1996-02-22 Recordati Chem Pharm FLAVONE DERIVATIVES
CN1040434C (en) * 1992-05-26 1998-10-28 瑞柯戴堤化学制药公司 Heterobicyclic compounds
FR2693196B1 (en) * 1992-07-03 1994-12-23 Lipha Benzopyranone or benzothiopyranone derivatives, process for their preparation and pharmaceutical composition containing them.
FR2694005B1 (en) * 1992-07-21 1994-08-26 Adir New aminoalkylchromones, methods for their preparation and pharmaceutical compositions containing them.
IL112764A0 (en) * 1994-03-18 1995-05-26 Ferrer Int New chromene derivatives
ES2101620B1 (en) * 1994-03-18 1998-04-01 Ferrer Int NEW COMPOUND DERIVED FROM CHROMENE.
US5482942A (en) * 1994-06-28 1996-01-09 American Home Products Corporation (3,4-dioxocyclobuten-1-yl)chromene, indene, and dihydronaphthalenone derivatives as smooth muscle relaxants
IL118657A0 (en) * 1996-06-14 1996-10-16 Arad Dorit Inhibitors for picornavirus proteases
KR100447918B1 (en) * 1996-07-25 2005-09-28 동아제약주식회사 Flavones and flavanone compounds with protective gastrointestinal tract including large intestine
IL122591A0 (en) 1997-12-14 1998-06-15 Arad Dorit Pharmaceutical compositions comprising cystein protease inhibitors
JP2000286254A (en) * 1999-03-31 2000-10-13 Hitachi Ltd Semiconductor integrated circuit device and manufacture thereof
CN102267971B (en) 2011-08-03 2013-03-27 华中科技大学 Alicyclic-o[c] benzopyrone derivative and application thereof
EA028382B1 (en) * 2012-03-23 2017-11-30 ПиТиСи ТЕРАПЬЮТИКС, ИНК. Compounds for treating spinal muscular atrophy

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1018874B (en) * 1954-08-18 1957-11-07 Chemiewerk Homburg Ag Process for the preparation of N-substituted 2-methyl-7-aminoalkoxy-chromones
US3046275A (en) * 1958-05-30 1962-07-24 Chemiewerk Homburg Zweignieder N-substituted 2-phenyl-7-aminoalkoxy chromones
DE1054091B (en) * 1958-05-30 1959-04-02 Chemiewerk Homburg Ag Process for the preparation of N-substituted 2-phenyl-7-aminoalkoxy-chromones
DE1223849B (en) * 1960-10-11 1966-09-01 Hans Voigt Chem Pharm Fabrik D Process for the preparation of lactic acid 7- (N-beta-dimethylaminoaethoxy) -flavone
DE1134384B (en) * 1960-10-18 1962-08-09 Hans Voigt Chem Pharm Fabrik D Process for the preparation of salts from xanthine acetic acid and flavone derivatives
DE1222072B (en) * 1961-03-06 1966-08-04 Voigt Dr Med Hans Process for the preparation of N-substituted 7-aminoalkoxyflavones
CA928298A (en) * 1968-06-24 1973-06-12 Kramer Josef Process for the preparation of 3-alkylflavanones
GB1261111A (en) * 1969-04-25 1972-01-19 Science Union & Cie New benzothiopyran derivatives and process for preparing them
US3907830A (en) * 1970-05-27 1975-09-23 Chinoin Gyogyszer Es Vegyeszet Isoflavone derivatives
US3864362A (en) * 1970-05-27 1975-02-04 Chinoin Gyogyszer Es Vegyeszet Iso flavones
US3906031A (en) * 1971-03-15 1975-09-16 Research Corp Novel 9-fluorenylmethoxycarbonyl compounds
US3835175A (en) * 1971-03-15 1974-09-10 Research Corp 9-fluorenylmethanol haloformates, carbonates and thiocarbonates
DE2123923A1 (en) * 1971-05-14 1972-11-23 Boehringer Mannheim Gmbh, 6800 Mannheim Square bracket on omega- (Flavon-7yl-oxy) -alkyl Square bracket on -pigerazine derivatives and process for their preparation
HU166380B (en) * 1973-07-09 1975-03-28
DE2950135A1 (en) * 1979-12-13 1981-06-19 Merck Patent Gmbh, 6100 Darmstadt BASIC AETHER, PHARMACEUTICAL PREPARATIONS CONTAINING THEM AND METHOD FOR THE PRODUCTION THEREOF
US4394519A (en) * 1982-01-19 1983-07-19 Research Corporation Amino acid blocking agents
US4678787A (en) * 1985-01-30 1987-07-07 Warner-Lambert Company 4H-1-benzopyran-4-ones and their sulfur containing analogs
IN164232B (en) * 1986-04-11 1989-02-04 Hoechst India
US4797498A (en) * 1986-07-18 1989-01-10 Pennwalt Corporation Flavonoxypropanolamines and esters of flavonoxypropanolamines as antiarrhythmic agents

Also Published As

Publication number Publication date
IL98262A (en) 1997-11-20
IE911875A1 (en) 1991-12-04
US5278174A (en) 1994-01-11
WO1991018597A1 (en) 1991-12-12
JPH05509084A (en) 1993-12-16
NZ238257A (en) 1993-03-26
IL98262A0 (en) 1992-06-21
EP0533804A1 (en) 1993-03-31
EP0533804B1 (en) 1997-12-17
ATE161177T1 (en) 1998-01-15
EP0533804A4 (en) 1993-04-21
AU8192391A (en) 1991-12-31
CA2083500A1 (en) 1991-12-05
US5359098A (en) 1994-10-25
AU665517B2 (en) 1996-01-11

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Legal Events

Date Code Title Description
8332 No legal effect for de