DE69123073T2 - Stabilisierung von Polypeptidfragmenten gegen proteolytischen Abbau - Google Patents

Stabilisierung von Polypeptidfragmenten gegen proteolytischen Abbau

Info

Publication number
DE69123073T2
DE69123073T2 DE69123073T DE69123073T DE69123073T2 DE 69123073 T2 DE69123073 T2 DE 69123073T2 DE 69123073 T DE69123073 T DE 69123073T DE 69123073 T DE69123073 T DE 69123073T DE 69123073 T2 DE69123073 T2 DE 69123073T2
Authority
DE
Germany
Prior art keywords
stabilization
polypeptide fragments
proteolytic degradation
fragments against
against proteolytic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69123073T
Other languages
English (en)
Other versions
DE69123073D1 (de
Inventor
Bill Coty
Pyare Khanna
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics Corp
Original Assignee
Microgenics Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Microgenics Corp filed Critical Microgenics Corp
Publication of DE69123073D1 publication Critical patent/DE69123073D1/de
Application granted granted Critical
Publication of DE69123073T2 publication Critical patent/DE69123073T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
DE69123073T 1990-04-03 1991-04-02 Stabilisierung von Polypeptidfragmenten gegen proteolytischen Abbau Expired - Fee Related DE69123073T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/503,836 US5212081A (en) 1990-04-03 1990-04-03 Stabilization of polypeptide fragments against proteolytic degradation

Publications (2)

Publication Number Publication Date
DE69123073D1 DE69123073D1 (de) 1996-12-19
DE69123073T2 true DE69123073T2 (de) 1997-04-10

Family

ID=24003724

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69123073T Expired - Fee Related DE69123073T2 (de) 1990-04-03 1991-04-02 Stabilisierung von Polypeptidfragmenten gegen proteolytischen Abbau

Country Status (7)

Country Link
US (1) US5212081A (de)
EP (1) EP0450898B1 (de)
JP (1) JPH0774805B2 (de)
AU (1) AU631305B2 (de)
CA (1) CA2039530C (de)
DE (1) DE69123073T2 (de)
ES (1) ES2096623T3 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5427912A (en) * 1993-08-27 1995-06-27 Boehringer Mannheim Corporation Electrochemical enzymatic complementation immunoassay
WO1996011264A1 (fr) * 1994-10-11 1996-04-18 Ajinomoto Co., Inc. Transglutaminase stabilisee et preparation enzymatique contenant cette transglutaminase
JP2935578B2 (ja) * 1994-12-19 1999-08-16 ベーリンガー マンハイム コーポレイション 改善された直線性を有する競合結合アッセイ

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2930736A (en) * 1957-01-07 1960-03-29 Nat Drug Co Stabilized trypsin compositions containing partially hydrolyzed gelatin and method of making
US4058596A (en) * 1971-10-13 1977-11-15 Colgate-Palmolive Company Stabilized toothpastes containing an enzyme
GB1488988A (en) * 1975-11-25 1977-10-19 Boehringer Mannheim Gmbh Stabilising agent for enzymes
DE3019612A1 (de) * 1980-05-22 1981-11-26 Boehringer Mannheim Gmbh, 6800 Mannheim Stabilisiertes thrombinpraeparat
US4378428A (en) * 1981-03-30 1983-03-29 Baker Instruments Corporation Method for carrying out non-isotopic immunoassays, labeled analytes and kits for use in such assays
US4708929A (en) * 1984-10-29 1987-11-24 Microgenics Corporation Methods for protein binding enzyme complementation assays
US4956274A (en) * 1987-04-06 1990-09-11 Microgenics Corporation Reagent stabilization in enzyme-donor and acceptor assay
DE3726634A1 (de) * 1987-08-11 1989-02-23 Biotest Ag Stabilisiertes peroxidasepraeparat
IL87327A0 (en) * 1987-09-03 1989-01-31 Technicon Instr Aqueous enzyme compositions comprising proteolytic inhibitors as stabilizers

Also Published As

Publication number Publication date
EP0450898B1 (de) 1996-11-13
EP0450898A3 (en) 1992-12-09
AU7403091A (en) 1991-10-10
US5212081A (en) 1993-05-18
AU631305B2 (en) 1992-11-19
DE69123073D1 (de) 1996-12-19
CA2039530A1 (en) 1991-10-04
ES2096623T3 (es) 1997-03-16
CA2039530C (en) 1999-05-25
EP0450898A2 (de) 1991-10-09
JPH04222597A (ja) 1992-08-12
JPH0774805B2 (ja) 1995-08-09

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: ROCHE DIAGNOSTICS CORP., INDIANAPOLIS, IND., US

8339 Ceased/non-payment of the annual fee