DE69119278T2 - Monoklonaler Antikörper, der mit einer neuen HLA-Determinante auf MHC-Klasse-I-Moleküle reagiert, und Verfahren zur Aktivierung von Lymphozyten - Google Patents
Monoklonaler Antikörper, der mit einer neuen HLA-Determinante auf MHC-Klasse-I-Moleküle reagiert, und Verfahren zur Aktivierung von LymphozytenInfo
- Publication number
- DE69119278T2 DE69119278T2 DE69119278T DE69119278T DE69119278T2 DE 69119278 T2 DE69119278 T2 DE 69119278T2 DE 69119278 T DE69119278 T DE 69119278T DE 69119278 T DE69119278 T DE 69119278T DE 69119278 T2 DE69119278 T2 DE 69119278T2
- Authority
- DE
- Germany
- Prior art keywords
- monoclonal antibody
- reacts
- molecules
- mhc class
- lymphocytes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2833—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against MHC-molecules, e.g. HLA-molecules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/74—Inducing cell proliferation
Landscapes
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US49579690A | 1990-03-19 | 1990-03-19 |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69119278D1 DE69119278D1 (de) | 1996-06-13 |
DE69119278T2 true DE69119278T2 (de) | 1997-01-23 |
Family
ID=23970023
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69119278T Expired - Fee Related DE69119278T2 (de) | 1990-03-19 | 1991-03-19 | Monoklonaler Antikörper, der mit einer neuen HLA-Determinante auf MHC-Klasse-I-Moleküle reagiert, und Verfahren zur Aktivierung von Lymphozyten |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP0448057B1 (de) |
JP (1) | JPH05268986A (de) |
AT (1) | ATE137802T1 (de) |
CA (1) | CA2038397A1 (de) |
DE (1) | DE69119278T2 (de) |
DK (1) | DK0448057T3 (de) |
ES (1) | ES2087923T3 (de) |
GR (1) | GR3020108T3 (de) |
Families Citing this family (46)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7479269B2 (en) | 1988-11-23 | 2009-01-20 | Genetics Institute, Llc | Methods for selectively enriching TH1 and TH2 cells |
US6534055B1 (en) | 1988-11-23 | 2003-03-18 | Genetics Institute, Inc. | Methods for selectively stimulating proliferation of T cells |
US6685941B1 (en) | 1988-11-23 | 2004-02-03 | The Regents Of The University Of Michigan | Methods of treating autoimmune disease via CTLA-4Ig |
US6905680B2 (en) | 1988-11-23 | 2005-06-14 | Genetics Institute, Inc. | Methods of treating HIV infected subjects |
US5714167A (en) | 1992-06-15 | 1998-02-03 | Emisphere Technologies, Inc. | Active agent transport systems |
US5629020A (en) | 1994-04-22 | 1997-05-13 | Emisphere Technologies, Inc. | Modified amino acids for drug delivery |
US5578323A (en) | 1992-06-15 | 1996-11-26 | Emisphere Technologies, Inc. | Proteinoid carriers and methods for preparation and use thereof |
US6331318B1 (en) | 1994-09-30 | 2001-12-18 | Emisphere Technologies Inc. | Carbon-substituted diketopiperazine delivery systems |
US5447728A (en) * | 1992-06-15 | 1995-09-05 | Emisphere Technologies, Inc. | Desferrioxamine oral delivery system |
US5443841A (en) | 1992-06-15 | 1995-08-22 | Emisphere Technologies, Inc. | Proteinoid microspheres and methods for preparation and use thereof |
US5693338A (en) | 1994-09-29 | 1997-12-02 | Emisphere Technologies, Inc. | Diketopiperazine-based delivery systems |
US6221367B1 (en) | 1992-06-15 | 2001-04-24 | Emisphere Technologies, Inc. | Active agent transport systems |
US5541155A (en) | 1994-04-22 | 1996-07-30 | Emisphere Technologies, Inc. | Acids and acid salts and their use in delivery systems |
US5451410A (en) * | 1993-04-22 | 1995-09-19 | Emisphere Technologies, Inc. | Modified amino acids for encapsulating active agents |
US6099856A (en) | 1992-06-15 | 2000-08-08 | Emisphere Technologies, Inc. | Active agent transport systems |
US5811127A (en) | 1992-06-15 | 1998-09-22 | Emisphere Technologies, Inc. | Desferrioxamine oral delivery system |
US5792451A (en) | 1994-03-02 | 1998-08-11 | Emisphere Technologies, Inc. | Oral drug delivery compositions and methods |
US5401516A (en) | 1992-12-21 | 1995-03-28 | Emisphere Technologies, Inc. | Modified hydrolyzed vegetable protein microspheres and methods for preparation and use thereof |
US5709861A (en) | 1993-04-22 | 1998-01-20 | Emisphere Technologies, Inc. | Compositions for the delivery of antigens |
US5643957A (en) | 1993-04-22 | 1997-07-01 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
US5958457A (en) | 1993-04-22 | 1999-09-28 | Emisphere Technologies, Inc. | Compositions for the delivery of antigens |
US7175843B2 (en) | 1994-06-03 | 2007-02-13 | Genetics Institute, Llc | Methods for selectively stimulating proliferation of T cells |
CA2191586A1 (en) * | 1994-06-03 | 1995-12-14 | Carl H. June | Methods for selectively stimulating proliferation of t cells |
US5650386A (en) | 1995-03-31 | 1997-07-22 | Emisphere Technologies, Inc. | Compositions for oral delivery of active agents |
US5965121A (en) | 1995-03-31 | 1999-10-12 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
US6090958A (en) | 1995-03-31 | 2000-07-18 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
US5866536A (en) | 1995-03-31 | 1999-02-02 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
US6001347A (en) | 1995-03-31 | 1999-12-14 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
US5989539A (en) | 1995-03-31 | 1999-11-23 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
CN1151836C (zh) | 1995-03-31 | 2004-06-02 | 艾米斯菲尔技术有限公司 | 用作传送活性剂的化合物和组合物 |
US5820881A (en) | 1995-04-28 | 1998-10-13 | Emisphere Technologies, Inc. | Microspheres of diamide-dicarboxylic acids |
US5750147A (en) | 1995-06-07 | 1998-05-12 | Emisphere Technologies, Inc. | Method of solubilizing and encapsulating itraconazole |
US6051258A (en) | 1995-06-07 | 2000-04-18 | Emisphere Technologies, Inc. | Proteinoid emulsions and methods for preparation and use thereof |
US5824345A (en) | 1995-06-07 | 1998-10-20 | Emisphere Technologies, Inc. | Fragrances and flavorants |
US5667806A (en) | 1995-06-07 | 1997-09-16 | Emisphere Technologies, Inc. | Spray drying method and apparatus |
WO1997010197A1 (en) | 1995-09-11 | 1997-03-20 | Emisphere Technologies, Inc. | METHOD FOR PREPARING φ-AMINOALKANOIC ACID DERIVATIVES FROM CYCLOALKANONES |
EP0904065A4 (de) | 1996-06-14 | 2000-06-14 | Emisphere Tech Inc | Mikroverkapselte duftstoffe und herstellungsverfahren |
US5990166A (en) | 1997-02-07 | 1999-11-23 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
US5939381A (en) | 1997-02-07 | 1999-08-17 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
US5876710A (en) | 1997-02-07 | 1999-03-02 | Emisphere Technologies Inc. | Compounds and compositions for delivering active agents |
US5804688A (en) | 1997-02-07 | 1998-09-08 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
US5879681A (en) | 1997-02-07 | 1999-03-09 | Emisphere Technolgies Inc. | Compounds and compositions for delivering active agents |
US6060513A (en) | 1997-02-07 | 2000-05-09 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
US6313088B1 (en) | 1997-02-07 | 2001-11-06 | Emisphere Technologies, Inc. | 8-[(2-hydroxy-4-methoxy benzoyl) amino]-octanoic acid compositions for delivering active agents |
US5863944A (en) | 1997-04-30 | 1999-01-26 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
US5962710A (en) | 1997-05-09 | 1999-10-05 | Emisphere Technologies, Inc. | Method of preparing salicyloylamino acids |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4658020A (en) * | 1979-04-26 | 1987-04-14 | Ortho Pharmaceutical Corporation | Monoclonal antibody to human helper T cells |
US4637983A (en) * | 1979-10-09 | 1987-01-20 | Ortho Pharmaceutical Corporation | Hybrid cell line for producing monoclonal antibody to human cytotoxic and suppressor T cells, antibody, and methods |
FI105320B (fi) * | 1988-04-04 | 2000-07-31 | Oncogen | Menetelmä vasta-aineheterokonjugaattien valmistamiseksi, joita käytetään imusoluaktiivisuuden säätelyssä ja diagnoosissa |
AU5678890A (en) * | 1989-05-11 | 1990-11-29 | Public Health Research Institute Of The City Of New York, Inc., The | A method for the activation of t cells |
-
1991
- 1991-03-14 JP JP3154151A patent/JPH05268986A/ja active Pending
- 1991-03-15 CA CA002038397A patent/CA2038397A1/en not_active Abandoned
- 1991-03-19 DK DK91104259.6T patent/DK0448057T3/da active
- 1991-03-19 ES ES91104259T patent/ES2087923T3/es not_active Expired - Lifetime
- 1991-03-19 EP EP91104259A patent/EP0448057B1/de not_active Expired - Lifetime
- 1991-03-19 DE DE69119278T patent/DE69119278T2/de not_active Expired - Fee Related
- 1991-03-19 AT AT91104259T patent/ATE137802T1/de not_active IP Right Cessation
-
1996
- 1996-05-31 GR GR960400244T patent/GR3020108T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
DK0448057T3 (da) | 1996-05-28 |
CA2038397A1 (en) | 1991-09-20 |
JPH05268986A (ja) | 1993-10-19 |
ATE137802T1 (de) | 1996-05-15 |
GR3020108T3 (en) | 1996-08-31 |
DE69119278D1 (de) | 1996-06-13 |
EP0448057B1 (de) | 1996-05-08 |
EP0448057A1 (de) | 1991-09-25 |
ES2087923T3 (es) | 1996-08-01 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE69119278T2 (de) | Monoklonaler Antikörper, der mit einer neuen HLA-Determinante auf MHC-Klasse-I-Moleküle reagiert, und Verfahren zur Aktivierung von Lymphozyten | |
ATE152170T1 (de) | Verfahren zur aktivierung der zytolytischen wirkung von lymphozyten unter verwendung von anti-cd28-antikörper | |
ATE301471T1 (de) | Verwendung von antikörpen gegen cd45ro leukozytenantigen zur immunmodulation | |
NO943625D0 (no) | Monoklonale antistoffer mot interferonreseptoren med nöytraliserende aktivitet mot type-I-interferon | |
DE19975033I2 (de) | CD25-bindende Molek}le | |
FI913927A0 (fi) | Rekombinantantikropp specifik foer cd3. | |
ATE113845T1 (de) | Monoklonale antikörper gegen glycolipid-antigene und ihre verwendung. | |
DE68925593T2 (de) | Antikörper-Heterokonjugate zur Regulation der Lymphozytenaktivität | |
ATE71411T1 (de) | Monoklonale antikoerper mit spezifitaet fuer membran-assoziierte antigene. | |
ES2116789T3 (es) | Anticuerpos monoclonales (mak) contra antigenos asociados a tumores, su preparacion y empleo. | |
ATE166230T1 (de) | Verwendung von anti-icam antikörpern zur herstellung eines präparats für die behandlung von endotoxinschock | |
DE69125485D1 (de) | Verfahren und zwischenprodukte synthetischer antikörperderivate | |
DE3581288D1 (de) | Antileishmania monoklonale antikoerper, diese antikoerper ausscheidende hybridomas, von diesen antikoerpern erkannte leishmaniaantigene, verfahren zur herstellung und verwendung von diesen monoklonalen antikoerpern und antigenen. | |
ES2070820T3 (es) | Anticuerpos monoclonales especificos de la apolipoproteina b, producidos por dos nuevos hibridomas. | |
ATE108333T1 (de) | Herstellung und verwendung von anti- helminthischen wirkstoffen und schutzantigenen. | |
DE69029858D1 (de) | Behandlung von einer autoimmun-krankheit | |
DE3787121T2 (de) | Verfahren zur Herstellung und Verwendung von Katzenleukämievirus-Antigenen. | |
ATE43610T1 (de) | Acino-foetale differenzierungsproteine verbunden mit krebs des pankreas, antiserum und monoklonale antikoerper gegen diese proteine und verfahren zu ihrer herstellung. | |
DE3580524D1 (de) | Monoklonaler antikoerper geeignet zur spezifischen unterscheidung von humanen hepatokarzinomzellen. | |
EP0314993A3 (de) | 1,7,9,15-Tetraoxa-4,12-diaza-8-silaspiro-[7.7]-pentadecane, Verfahren zu ihrer Herstellung und ihre Verwendung | |
EP0554670A3 (en) | Specific antibodies against activated platelets, their production and applications in diagnostics and therapeutics | |
DE69012034D1 (de) | Monoklonaler Antikörper gegen Exotoxin A von Pseudomonas aeruginosa. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |