DE69118520D1 - Sechsbindige liganden für radiographische abbildungsagenzien - Google Patents
Sechsbindige liganden für radiographische abbildungsagenzienInfo
- Publication number
- DE69118520D1 DE69118520D1 DE69118520T DE69118520T DE69118520D1 DE 69118520 D1 DE69118520 D1 DE 69118520D1 DE 69118520 T DE69118520 T DE 69118520T DE 69118520 T DE69118520 T DE 69118520T DE 69118520 D1 DE69118520 D1 DE 69118520D1
- Authority
- DE
- Germany
- Prior art keywords
- ligands
- imaging agents
- hexagonal
- radiographic imaging
- preorganized
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000003446 ligand Substances 0.000 title abstract 3
- 239000012216 imaging agent Substances 0.000 title abstract 2
- 230000000536 complexating effect Effects 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- RDOXTESZEPMUJZ-WBJZHHNVSA-N methoxybenzene Chemical group CO[13C]1=[13CH][13CH]=[13CH][13CH]=[13CH]1 RDOXTESZEPMUJZ-WBJZHHNVSA-N 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
- C07F13/005—Compounds without a metal-carbon linkage
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
- A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/004—Acyclic, carbocyclic or heterocyclic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur, selenium or tellurium
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
- C07C229/10—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
- C07C229/16—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of hydrocarbon radicals substituted by amino or carboxyl groups, e.g. ethylenediamine-tetra-acetic acid, iminodiacetic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/50—Organo-phosphines
- C07F9/5027—Polyphosphines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Optics & Photonics (AREA)
- Physics & Mathematics (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/627,176 US5243073A (en) | 1990-12-14 | 1990-12-14 | Hexadentate ligands useful in radiographic imaging agents |
| PCT/US1991/009406 WO1992010466A1 (en) | 1990-12-14 | 1991-12-11 | Hexadentate ligands useful in radiographic imaging agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69118520D1 true DE69118520D1 (de) | 1996-05-09 |
| DE69118520T2 DE69118520T2 (de) | 1996-08-29 |
Family
ID=24513538
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69118520T Expired - Fee Related DE69118520T2 (de) | 1990-12-14 | 1991-12-11 | Sechsbindige liganden für radiographische abbildungsagenzien |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US5243073A (de) |
| EP (1) | EP0515670B1 (de) |
| JP (1) | JPH05505624A (de) |
| AT (1) | ATE136292T1 (de) |
| AU (1) | AU641072B2 (de) |
| CA (1) | CA2076016A1 (de) |
| DE (1) | DE69118520T2 (de) |
| WO (1) | WO1992010466A1 (de) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5338864A (en) * | 1992-07-06 | 1994-08-16 | Mallinckrodt Medical, Inc. | Hexadentate ligands useful in radiographic imaging agents |
| EP0690727A4 (de) * | 1993-01-06 | 1996-03-06 | Mallinckrodt Medical Inc | Sechszähnige liganden für die verwendung in röntgenographischen bildgebenden wirkstoffen |
| CA2167167A1 (en) * | 1993-07-19 | 1995-02-02 | Alfred Pollak | Hydrazino-type radionuclide chelators having an n3s configuration |
| US5858327A (en) * | 1993-09-03 | 1999-01-12 | Resolutions Pharmaceuticals, Inc. | Hydrazino-type N2 S2 radionuclide chelating compounds |
| US5574140A (en) * | 1993-09-03 | 1996-11-12 | Resolution Pharmaceutical Inc. | Hydrazino-type N2 S2 chelators |
| CA2190727C (en) * | 1994-05-19 | 2006-07-18 | Sudhakar Kasina | Aromatic amine substituted bridged nitrogen and sulfur donor atom ligands for imaging |
| US6005083A (en) * | 1997-03-28 | 1999-12-21 | Neorx Corporation | Bridged aromatic substituted amine ligands with donor atoms |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT42469B (de) * | 1909-03-30 | 1910-06-10 | Siemens Schuckertwerke Wien | Drehstrom-Generator. |
| SU785302A1 (ru) * | 1978-11-01 | 1980-12-07 | Калининский Сельскохозяйственный Институт | Мезо-2,3-диаминобутан- -ди нтарна кислота в качестве комплексона |
| US4444690A (en) * | 1982-02-25 | 1984-04-24 | University Patents, Inc. | Technetium chelates |
| GB8426845D0 (en) * | 1984-10-24 | 1984-11-28 | Amersham Int Plc | Complexes of technetium-99m |
| US4795626A (en) * | 1985-05-10 | 1989-01-03 | University Of Cincinnati | 99m Tc.sup.(III) myocardial imaging agents which are non-reducable in vivo |
| US4925650A (en) * | 1988-11-16 | 1990-05-15 | Mallinckrodt, Inc. | Technetium -99m complex for examining the renal function |
-
1990
- 1990-12-14 US US07/627,176 patent/US5243073A/en not_active Expired - Fee Related
-
1991
- 1991-12-11 WO PCT/US1991/009406 patent/WO1992010466A1/en active IP Right Grant
- 1991-12-11 EP EP92903254A patent/EP0515670B1/de not_active Expired - Lifetime
- 1991-12-11 CA CA002076016A patent/CA2076016A1/en not_active Abandoned
- 1991-12-11 AT AT92903254T patent/ATE136292T1/de active
- 1991-12-11 AU AU91502/91A patent/AU641072B2/en not_active Ceased
- 1991-12-11 JP JP92503714A patent/JPH05505624A/ja active Pending
- 1991-12-11 DE DE69118520T patent/DE69118520T2/de not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP0515670A1 (de) | 1992-12-02 |
| US5243073A (en) | 1993-09-07 |
| CA2076016A1 (en) | 1992-06-15 |
| EP0515670B1 (de) | 1996-04-03 |
| AU9150291A (en) | 1992-07-08 |
| DE69118520T2 (de) | 1996-08-29 |
| JPH05505624A (ja) | 1993-08-19 |
| ATE136292T1 (de) | 1996-04-15 |
| AU641072B2 (en) | 1993-09-09 |
| WO1992010466A1 (en) | 1992-06-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |