DE69115765T2 - Herstellung von optisch aktiven arylaliphatischen Carbonsäuren - Google Patents

Herstellung von optisch aktiven arylaliphatischen Carbonsäuren

Info

Publication number
DE69115765T2
DE69115765T2 DE69115765T DE69115765T DE69115765T2 DE 69115765 T2 DE69115765 T2 DE 69115765T2 DE 69115765 T DE69115765 T DE 69115765T DE 69115765 T DE69115765 T DE 69115765T DE 69115765 T2 DE69115765 T2 DE 69115765T2
Authority
DE
Germany
Prior art keywords
production
carboxylic acids
optically active
arylaliphatic carboxylic
arylaliphatic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69115765T
Other languages
English (en)
Other versions
DE69115765D1 (de
Inventor
Thanikavelu Manimaran
Fred John Impastato
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Albemarle Corp
Original Assignee
Albemarle Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Albemarle Corp filed Critical Albemarle Corp
Publication of DE69115765D1 publication Critical patent/DE69115765D1/de
Application granted granted Critical
Publication of DE69115765T2 publication Critical patent/DE69115765T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/48—Separation; Purification; Stabilisation; Use of additives
    • C07C67/60—Separation; Purification; Stabilisation; Use of additives by treatment giving rise to chemical modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/42—Separation; Purification; Stabilisation; Use of additives
    • C07C51/487—Separation; Purification; Stabilisation; Use of additives by treatment giving rise to chemical modification

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE69115765T 1990-06-18 1991-06-17 Herstellung von optisch aktiven arylaliphatischen Carbonsäuren Expired - Fee Related DE69115765T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/539,121 US5015764A (en) 1990-06-18 1990-06-18 Preparation of optically active aliphatic carboxylic acids

Publications (2)

Publication Number Publication Date
DE69115765D1 DE69115765D1 (de) 1996-02-08
DE69115765T2 true DE69115765T2 (de) 1996-05-15

Family

ID=24149874

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69115765T Expired - Fee Related DE69115765T2 (de) 1990-06-18 1991-06-17 Herstellung von optisch aktiven arylaliphatischen Carbonsäuren

Country Status (5)

Country Link
US (1) US5015764A (de)
EP (1) EP0462776B1 (de)
JP (1) JP2981026B2 (de)
CA (1) CA2043649A1 (de)
DE (1) DE69115765T2 (de)

Families Citing this family (38)

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HU219242B (en) 1991-05-13 2001-03-28 Boots Co Plc S(+)-ibuprofen sodium salt dihydrate, pharmaceutical composition comprising this compound and process for production of them
CA2074932A1 (en) * 1991-08-23 1993-02-24 Hiroyuki Nohira Optical resolution of (+)-2-(4-isobutylphenyl) propionic acid
US5302751A (en) * 1992-01-21 1994-04-12 Ethyl Corporation Profen resolution
US5220053A (en) * 1992-01-24 1993-06-15 Ethyl Corporation Preparation of optically active aliphatic carboxylic acids
US5235095A (en) * 1992-01-24 1993-08-10 Ethyl Corporation Preparation of optically active aliphatic carboxylic acids
US5235101A (en) * 1992-01-24 1993-08-10 Ethyl Corporation Preparation by flotation of optically active aliphatic carboxylic acids
US5235100A (en) * 1992-01-24 1993-08-10 Ethyl Corporation Preparation of optically active aliphatic carboxylic acids
US5256816A (en) * 1992-10-14 1993-10-26 Ethyl Corporation Enantiomeric resolution
US5248813A (en) * 1992-10-14 1993-09-28 Ethyl Corporation Enantiomeric resolution
US5278337A (en) * 1992-10-14 1994-01-11 Ethyl Corporation Enantiomeric resolution of aryl-substituted aliphatic carboxylic acids
US5380867A (en) * 1992-12-02 1995-01-10 Hoechst Celanese Corporation Selective precipitation of α-aryl carboxylic acid salts
ATE151740T1 (de) * 1992-12-02 1997-05-15 Knoll Ag Verfahren zur herstellung von im wesentlichen enantiomeren der phenylpropionsäuren
US5332834A (en) * 1992-12-02 1994-07-26 Hoechst Celanese Corporation Racemization of an enantomerically enriched α-aryl carboxylic acid
DE69513827T2 (de) * 1994-06-13 2000-06-29 Mitsubishi Rayon Co Verfahren zur herstellung von optisch aktiven alpha-substituierten carbonsäurederivaten
US5621140A (en) * 1994-12-22 1997-04-15 Syntex (U.S.A.) Inc. Resolution of ibuprofen
JPH11505525A (ja) * 1995-05-05 1999-05-21 ヘキスト・セラニーズ・コーポレーション ジアステレオマーエステルの蒸留分離を含むラセミ体α−アリールプロピオン酸の光学的に純粋なα−アリールプロピオン酸への転化
US5677469A (en) * 1995-05-18 1997-10-14 Sepracor, Inc. Process for resolving chiral acids with 1-aminoindan-2-ols
WO1997047572A1 (en) * 1996-06-10 1997-12-18 Albemarle Corporation Racemization process for optically active carboxylic acids or salts or esters thereof
US5859292A (en) * 1997-12-11 1999-01-12 Albemarle Corporation Preparation of high purity sodium (S)-2(6-methoxy-2-naphthyl)propionate
US5874614A (en) * 1997-12-11 1999-02-23 Albemarle Corporation Sodium (S)-2-(6-methoxy-2-naphthyl)propionate monohydrate
IN189741B (de) * 1998-11-09 2003-04-19 Council Scient Ind Res
EP1029846A1 (de) * 1999-02-17 2000-08-23 Sekhsaria Chemicals Ltd. Racematspaltung von Alpha-Arylpropionsäuren
JP2003530437A (ja) * 2000-04-13 2003-10-14 マヨ ファウンデーション フォー メディカル エデュケーション アンド リサーチ Ａβ４２低下物質
WO2004071431A2 (en) * 2003-02-05 2004-08-26 Myriad Genetics, Inc. Method and composition for treating neurodegenerative disorders
CA2532207A1 (en) * 2003-07-11 2005-07-21 Myriad Genetics, Inc. Pharmaceutical methods, dosing regimes and dosage forms for the treatment of alzheimer's disease
US20050137262A1 (en) * 2003-12-22 2005-06-23 Hu Patrick C. Highly concentrated pourable aqueous solutions of potassium ibuprofen, their preparation and their uses
WO2006001877A2 (en) * 2004-04-13 2006-01-05 Myriad Genetics, Inc. Combination treatment for neurodegenerative disorders comprising r-flurbiprofen
WO2005108683A1 (en) * 2004-04-29 2005-11-17 Keystone Retaining Wall Systems, Inc. Veneers for walls, retaining walls and the like
WO2006020852A2 (en) * 2004-08-11 2006-02-23 Myriad Genetics, Inc. Pharmaceutical composition and method for treating neurodegenerative disorders
WO2006020850A2 (en) * 2004-08-11 2006-02-23 Myriad Genetics, Inc. Pharmaceutical composition and method for treating neurodegenerative disorders
WO2006020853A2 (en) * 2004-08-11 2006-02-23 Myriad Genetics, Inc. Pharmaceutical composition and method for treating neurodegenerative disorders
NZ564789A (en) * 2005-07-22 2010-07-30 Myriad Genetics Inc High drug load formulations and dosage forms
EP2046119A2 (de) * 2006-07-07 2009-04-15 Myriad Genetics, Inc. Behandlung von psychiatrischen störungen
EP2117302A1 (de) * 2007-02-01 2009-11-18 Myriad Genetics, Inc. Arzneiwirkstoffpräparate, pharmazeutische zusammensetzungen und verabreichungsformen
KR100978776B1 (ko) 2008-04-11 2010-08-30 주식회사 엔지켐 광학활성 이부프로펜의 라세미화방법
GB0811851D0 (en) * 2008-06-30 2008-07-30 Aesica Pharmaceuticals Ltd Process
WO2010050499A1 (ja) * 2008-10-29 2010-05-06 三菱瓦斯化学株式会社 光学活性有機カルボン酸の製造方法
GB201216893D0 (en) 2012-09-21 2012-11-07 Aesica Pharmaceuticals Ltd Drug substance preparations, pharmaceutical compositions and dosage forms comprising s-(+)-flurbiprofen

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3109018A (en) * 1961-06-15 1963-10-29 Chemetron Corp Resolution of dl-menthol
DE2826952A1 (de) * 1978-06-20 1980-01-10 Bayer Ag Enantiomerentrennung von chiralen carbonsaeuren
GB2035308A (en) * 1978-10-27 1980-06-18 Ici Ltd Process for separating optical isomers of cyclopropane carboxylic esters
IT1222013B (it) * 1987-07-10 1990-08-31 Chimica Profarmaco Spa Ind Processo di risoluzione ottica di acido 2 (6 metossi 2 naftil) propionico
US4786731A (en) * 1987-08-05 1988-11-22 The Dow Chemical Company Resolution of enantiomers of 2-(phenyl or phenoxy/propionic acids using optically active alkanolamines
US4885375A (en) * 1988-05-18 1989-12-05 Marion Laboratories, Inc. Resolution of 3-(4-methoxyphenyl)glycidic acid with in situ conversion to alkyl esters

Also Published As

Publication number Publication date
EP0462776A2 (de) 1991-12-27
US5015764A (en) 1991-05-14
JPH04230225A (ja) 1992-08-19
CA2043649A1 (en) 1991-12-19
EP0462776B1 (de) 1995-12-27
DE69115765D1 (de) 1996-02-08
EP0462776A3 (en) 1992-10-21
JP2981026B2 (ja) 1999-11-22

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee